Shao Jian-Yong | |
Title | Professor and Director |
Profile |
Jian-Yong Shao, MD/PhD, is the professor of oncology and director of Department of Molecular Diagnostics at Sun Yat-sen University Cancer Center (SYSUCC). He also served as the director of Tumor Gene Diagnostic Center in South China and the vice-director of pathology department at SYSUCC. He specializes in molecular and pathologic diagnosis of various cancers, and also works on promoting theuse of advanced molecular diagnostic techniques into the diagnosis and targeted therapy of tumors in clinical practice. Besides his clinical activities, he is appointed as vice-chairman of Chemotherapy Anti-Cancer Association in Guangzhou China, committee member of Molecular Pathology Quality Control Center, committee member of Lung Cancer Diagnosis and Treatment Quality Control Center of Ministry of Health in China, and committee member of Chinese Anti-Cancer Association. He has been editorial board member of Cancer Biology, AmericanJournal of Translational Research, ISRN Pathology, Chinese Journal of Cancer, World Journal of Oncology, and World Journal of Clinical Oncology. He successively presides over or is mainly responsible for two projects of National Major Fundamental Research Program of China (973 and 863 programs) and15 projects of Natural Science Foundation of China or Science Project of Guangdong Province, in addition to which he joins in 15 other research projects in China. He has authored or co-authored over 110 papers in authoritative magazines. He has achieved first prize of Science and Technology in Guangdongin 2010 for involving in completing research of “Study of foundation and of key technique of gene therapy in cancer”, and first prize of Nomination of National NaturalScience of Ministry of Education in 2002, first prize of Chinese MedicalScience and Technology Award in 2004, and second class prize of NationalNatural Science in China in 2005 for involving in completing research of “Molecular Genetics of Nasopharyngeal carcinoma”. |
shaojy@sysucc.org.cn | |
Phone | |
Research Interest(s) |
The mainscientific interests of Prof. Shao JY are the development of molecularclassification and molecular target therapy of cancer, including usingmolecular biological methods to identify new molecular signature for variouscancers, establishing molecular marker-based risk prediction model for cancertreatment, and bringing basic scientific discoveries into clinical practice. |
Education |
2000.07-2012.04:Received a Ph.D at KarolinskaInstitutet in Sweden 2000.07-2002.12:Received a Ph.D at SunYat-sen University Cancer Center in Guangdong, China 1999.10-2000.11:Engaged advanced studies ononcological molecular biology at Karolinska Institutet in Sweden 1997.01-1997.07:Engaged advanced studies onmolecular pathology at Chinese University of Hong kong 1989.09-1992.07:Received a Master degree at SunYat-sen University in Guangdong, China 1984.09-1989.07:Received a Bachelor degree at Bengbu MedicalCollege in Anhui, China
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Publications |
1. WangHY, Yan LX, Shao Q, Fu S, Zhang ZC, Ye W, Zeng YX, Shao JY*. Profiling PlasmaMicroRNA in Nasopharyngeal Carcinoma with Deep Sequencing. Clin Chem. 2014 60:773-782 (IF=7.149) 2. FuS, Wang F, Shao Q, Zhang X, Duan LP, Zhang X, Zhang L, Shao JY*.Detection ofEML4-ALK Fusion Gene in Chinese Non-Small Cell Lung Cancer by Using a SensitiveQuantitative Real-Time Reverse Transcriptase PCR Techniqu. Diagn Mol Pathol.2014 Jan 30.(IF=1.861) 3. ZhangZC, Li YY, Wang HY, Fu S, Wang XP, Zeng MS, Zeng YX, Shao JY*.Knockdown ofmiR-214 Promotes Apoptosis and Inhibits Cell Proliferation in NasopharyngealCarcinoma. PLoS One. 2014 21;9(1):e86149. (IF=3.73) 4. JiaSW, Fu S, Wang F, Shao Q, Huang HB, Shao JY*. ALK gene copy number gain and itsclinical significance in hepatocellular carcinoma. World J Gastroenterol. 2014Jan 7;20(1):183-92. (IF=2.547) 5. ZhaoZR. Wang JF. Lin YB. Wang F. Fu S. Zhang SL. Su XD. Jiang L. Zhang YG. ShaoJY*. Long H..Mutation abundance affects the efficacy of EGFR tyrosine kinaseinhibitor readministration in non-small-cell lung cancer with acquiredresistance. Med Oncol. 2014 Jan;31(1):810. (IF=2.147) 6. LiYY, Fu S, Wang XP, Wang HY, Zeng MS, Shao JY*. Down-regulation of c9orf86 inhuman breast cancer cells inhibits cell proliferation, invasion and tumorgrowth and correlates with survival of breast cancer patients. PLoS One. 2013Aug 14;8(8):e71764. (IF=3.73) 7. WangF, Fu S, Shao Q, Zhou YB, Zhang X, Zhang X, Xue C, Lin JG, Huang LX, Zhang L,Zhang WM, and Shao JY*. High EGFR copy number predicts benefits from tyrosinekinase inhibitor treatment for non-small cell lung cancer patients withwild-type EGFR. J Transl Med. 2013; 11: 90. (IF= 3.459) 8. ZhangJX, Cai MB, Wang XP, Duan LP, Shao Q, Tong ZT, Liao DZ, Li YY, Huang MY, ZengYX, Shao JY*. Elevated DLL4 expression is correlated with VEGF and predictspoor prognosis of nasopharyngeal carcinoma. Med Oncol. 2013 Mar;30(1):390. (IF=2.147) 9. HuC, Wei W, Chen X, Woodman CB, Yao Y, Nicholls JM, Joab I, Sihota SK, Shao JY,Derkaoui KD, Amari A, Maloney SL, Bell AI, Murray PG, Dawson CW, YoungLS,Arrand JR. A global view of the oncogenic landscape in nasopharyngealcarcinoma: an integrated analysis at the genetic and expression levels. PLoSOne. 2012;7(7):e41055. (IF= 3.73) 10. CaiMB, Han HQ, Bei JX, Liu CC, Lei JJ, Cui Q, Feng QS, Wang HY, Zhang JX, Liang Y,Chen LZ, Kang TB, Shao JY, Zeng YX. Expression of human leukocyte antigen G isassociated with prognosis in nasopharyngeal carcinoma. Int J Biol Sci.2012;8(6):891-900. (IF= 3.168) 11. LiXJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, ZhengFJ, Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN. As an independent unfavorableprognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma throughinduction of epithelial-mesenchymal transition and activation of AKT signaling.Carcinogenesis. 2012 Jul;33(7):1302-9. (IF= 5.635) 12. CaiMB, Wang XP, Zhang JX, Han HQ, Liu CC, Bei JX, Peng RJ, Liang Y, Feng QS,WangHY, Chen LZ, Fu S, Kang T, Shao JY, Zeng YX. Expression of heat shock protein70 in nasopharyngeal carcinomas: different expression patterns correlate withdistinct clinical prognosis. J Transl Med. 2012 May 16;10:96. (IF= 3.459) 13. WangHY, Li YY, Shao Q, Hou JH, Wang F, Cai MB, Zeng YX, Shao JY*. Secreted proteinacidic and rich in cysteine (SPARC) is associated with nasopharyngeal carcinomametastasis and poor prognosis. J Transl Med. 2012;10(1):27. (IF= 3.459) 14. DuZM, Kou CW, Hu CF, Chen J, Wang HY, Yan LX, Ernberg I, Zeng YX, and Shao JY*.Clinical Significance of Elevated Spleen Tyrosine Kinase Expression inNasopharyngeal Carcinoma. Head and Neck,2012. doi: 10.1002/hed.21953. (IF= 2.833) 15. ZhangLJ, Cai L, Li Z, Wang WP, Guo K, Shao JY, Wang JY, Yu H, Rong TH. Relationshipbetween epidermal growth factor receptor gene mutation and copy number inChinese patients with non-small cell lung cancer. Chin J Cancer. 2012. Hai-YunWang, Bing-Yu Sun, Zhi-Hua Zhu, Ellen T. Chang, Ka-Fai To, Jacqueline S.G.Hwang, Hao Jiang,Michael Koon-Ming Kam, Gang Chen, Shie-Lee Cheah, Ming Lee,Zhi-Wei Liu, Jing Chen, Jia-Xing Zhang,Hui-Zhong Zhang, Jie-Hua He, Fa-LongChen, Xiao-Dong Zhu, Ma-Yan Huang, Ding-Zhun Liao, Jia Fu,Qiong Shao, Man-BoCai, Zi-Ming Du, Li-Xu Yan, Chun-Fang Hu, Ho-Keung Ng, Joseph T.S. Wee,Chao-NanQian, Qing Liu, Ingemar Ernberg, Weimin Ye, Hans-Olov Adami, Anthony T. Chan,Yi-Xin Zeng,and Shao JY*. An Eight-signature Classifier for Prediction ofNasopharnyngeal Carcinoma Survival. Journal of Clinical Oncology, 2011; 29(34):4516-4525. (IF=18.083) 16. DuZM, Hu LF, Wang HY, Yan LX, Zeng YX, Shao JY*, Ernberg I. Upregulation ofMiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A andDownregulates a Negative Prognostic Marker JMJD1A. PLoS One. 2011; 6(4):e19137.(IF= 3.73) 17. ZhangY, Yan LX, Wu QN, Du ZM, Chen J, Liao DZ, Huang MY, Hou JH, Wu QL, Zeng MS,Huang W, Zeng YX, Shao JY*. miR-125b is Methylated and Functions as A TumorSuppressor by Regulating the ETS1 proto-oncogene in Human Invasive Breast Cancer.Cancer Res. 2011;71(10):3552-62. (IF= 8.65) 18. LiXJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WQ, Zhang ZF, PetilloD, Lin Q, Bao YN, Zheng FJ, Claramae SC, N Gopalakrishna lyer, Kang BT, ZengYX, Khee CS, Jeffrey MT, Teh BT, Qian CN. Serglycin Is a Theranostic Target inNasopharyngeal Carcinoma that Promotes Metastasis. Cancer Res.2011;71(8):3162-3172. (IF= 8.65) 19. AnX, Wang FH, Ding PR, Deng L, Jiang WQ, Zhang L, Shao JY, Li YH. PlasmaEpstein-Barr virus DNA level strongly predicts survival in metastatic/recurrentnasopharyngeal carcinoma treated with palliative chemotherapy. Cancer 2011;117(16): 3750-7. (IF= 5.201) 20. YanLX, Wu QN, Zhang Y, Li YY, Liao DZ, Hou JH, Fu J, Zeng MS, Yun JP, Wu QL, ZengYX, Shao JY*. Knockdown of miR-21 in human breast cancer cell lines inhibitsproliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res.2011;13(1):R2. (IF= 5.872) 21. LiYH, Wang F, Shen L, Deng YM, Shao Q, Feng F, An X, Wang FH, Wang ZQ, Xu RH,Shao JY*. EGFR FISH Pattern of Chromosome 7 Disomy Predicts Resistance toCetuximab in KRAS Wild-type Metastatic Colorectal Cancer Patients. Clin. CancerRes. 2011;17(2):382-90. (IF= 7.837) 22. ShaoJY*, Cao Y, Miao XP, Huang MY, Deng L, Hao JJ, Liang XM, Hu LF, Ingemar E, LinDX, Zeng YX. A single nucleotide polymorphism in the Matrix Metalloproteinase-2promoter is closely associated with high risk of nasopharyngeal carcinoma inCantonese from southern China. Chin. J. Cancer, 2011;30(9):620-6. (IF= 0.448) 23. CaoY, Miao XP, Zeng YX, Lin DX, Shao JY*. Association between geneticpolymorphisms of CYP2A13, CYP2A6 and risk of nasopharyngeal carcinoma insouthern Chinese population. Cancer Biology, 2011;1(1). (IF= 3.287) 24. ZhangY, Hu CF, Chen J, Yan LX, Zeng YX, Shao JY*. LATS2 is de-methylated and overexpressedin nasopharyngeal carcinoma and predicts poor prognosis. BMC Cancer.2010;10:538. (IF= 3.333) 25. CaoY, Miao XP, Huang MY, Deng L, Lin DX, Zeng YX, Shao JY*. Polymorphisms of deathpathway genes FAS and FASL and risk of nasopharyngeal carcinoma. Mol. Carcinog.2010;49(11):944-50. (IF= 4.269) 26. CaoY, Miao XP, Huang MY, Deng L, Liang XM, Lin DX, Zeng YX, Shao JY*.Polymorphisms of methylenetetrahydrofolate reductase are associated with a highrisk of nasopharyngeal carcinoma in a smoking population from southern China.Mol. Carcinog. 2010;49(11):928-34. (IF= 4.269) 27. KongQL, Hu LJ, Cao JY, Huang YJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ,Chen QY, Zhang X, Li MZ, Shao JY, Qian CN, Xia YF, Song LB, Zeng YX, ZengMS.Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymaltransition and increases the number of side population stem-like cancer cellsin nasopharyngeal carcinoma. PLoS Pathog. 2010; 6(6):e1000940. (IF= 8.136) 28. ValentineR, Dawson CW, Hu C, Shah KM, Owen TJ, Date KL, Maia SP, Shao J, Arrand JR,Young LS, O'Neil JD. Epstein-Barr virus-encoded EBNA1 inhibits the canonicalNF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation. MolCancer. 2010;9:1. (IF= 5.134) 29. GuoBH, Zhang X, Zhang HZ, Lin HL, Feng Y, Shao JY, Huang WL, Kung HF, Zeng MS. Lowexpression of Mel-18 predicts poor prognosis in patients with breast cancer.Ann Oncol. 2010;21(12):2361-9. (IF= 7.384) 30. ChenJ, Hu CF, Hou JH, Shao Q, Yan LX, Zhu XF, Zeng YX and Shao JY*. Epstein-BarrVirus Encoded Latent Membrane Protein 1 Regulates mTOR Signaling Pathway GenesWhich Predict Poor Prognosis of Nasopharyngeal Carcinoma. J. Transl. Med.2010;8:30. (IF= 3.459) 31. DuZM, Hu CF, Shao Q, Huang MY, Kou CW, Zhu XF, Zeng YX, Shao JY*. Upregulation ofcaveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cellmigration and correlated with poor prognosis of the patients. Int. J. Cancer.2009; 125(8):1832-41. (IF= 6.198) 32. YanLX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, Zeng YX, Shao JY*. MicroRNAmiR-21 Overexpression in Human Breast Cancer is Associated with AdvancedClinical Stage, Lymph Node Metastasis and Patient Poor Prognosis. RNA. 2008 14:2348-2360. (IF= 5.088) 33. PangLJ, Shao JY*, Liang XM, Xia YF, Zeng YX. Mitochondrial DNA somatic mutationsare frequent in nasopharyngeal carcinoma. Cancer Biol. Ther. 2008,7(2):198-207. (IF= 3.287) 34. LiYH, Hu CF, Shao Q, Huang MY, Hou JH, Xie D, Zeng YX, Shao JY*. ElevatedExpressions of Survivin and VEGF Protein Are Strong Independent Predictors ofSurvival in Advanced Nasopharyngeal Carcinoma. J Transl Med. 2008, 3;6(1):1.(IF= 3.459) 35. ZhuZH, Sun BY, Ma Y, Shao JY, Long H, Zhang X, Fu JH, Zhang LJ, Su XD, Wu QL, LingP, Chen M, Xie ZM, Hu Y, Rong TH. Three immunomarker support vectormachines-based prognostic classifiers for stage IB non-small-cell lung cancer.J Clin Oncol. 2009; 27(7): 1091-9. (IF= 18.038) 36. CheungAK, Lung HL, Hung SC, Law EW, Cheng Y, Yau WL, Bangarusamy DK, Miller LD, LiuET, Shao JY, Kou CW, Chua D, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML.Functional analysis of a cell cycle-associated, tumor-suppressive gene, proteintyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. Cancer Res.2008;68(19):8137-45. (IF= 8.65) 37. CaoY, Miao XP, Huang MY, Deng L, Hu LF, Ernberg I, Zeng YX, Lin DX, Shao JY*.Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in theCantonese population. BMC Cancer, 2006, 6:167. (IF= 3.333) 38. LiY, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF,Liu Q, Fu LW, Huang WEvaluation of Long-Term Toxicity of Ad/hIFN-gamma, anAdenoviral Vector Encoding the Human Interferon-gamma Gene, in NonhumanPrimates. Hum Gene Ther. 2008;19(8):827-39. (IF= 4.019) 39. LiuMZ, Xie D, Mai SJ, Tong ZT, Shao JY, Fu YS, Xia WJ, Kung HF, Guan XY, Zeng YX.Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely withadvanced tumor stage. Am J Clin Pathol. 2008;129(5):728-34. (IF= 2.881) 40. LiHL , Li S , Shao JY , Lin XB , Cao Y , Jiang WQ , Liu RY , Zhao P , Zhu XF ,Zeng MS , Guan ZZ , Huang W. Pharmacokinetic and pharmacodynamic study ofintratumoral injection of an adenovirus encoding endostatin in patients withadvanced tumors. Gene Ther. 2008;15(4):247-56. (IF= 4.321) 41. Song LB; Zeng MS; Liao WT, Zhang Ling, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF,Fu LW, HuangWL, Goberdhan PD, Vimia B, Zeng YX. Bmi-1 is a novel molecularmarker of nasopharyngeal carcinoma progression and immortalizes primary humannasopharyngeal epithelial cells. Cancer Res. 2006;6(12):6225-32. (IF= 8.65) 42. PanZG, Kashuba VI, Liu XQ, Shao JY, Zhang RH, Jiang JH, Guo C, Eugene Z, IngemarE, Zeng YX. High frequency somatic mutations in RASSF1A in nasopharyngealcarcinoma. Cancer Biol Ther. 2005;4(10):1116-22. (IF= 3.287) 43. PanZZ, Wan DS, Zhang CQ, Shao JY, Li LR, Chen G, Zhou ZW, Wang FL. Usingp53-immunostained large specimens to determine the distal intramural spreadmargin of rectal cancer. World J Gastroenterology,2006;12(10):1626-9. (IF= 2.547) 44. Shao JY, Li YH, Zhang Y, et al. Comparison of Plasma Epstein-Barr Viruses DNALevel and Serum EBV VCA/IgA Antibody Titers in Nasopharyngeal Carcinoma.Cancer, 2004, 100: 1162-1170. (IF= 5.201) 45. ShaoJY, Ernberg I, Biberfeld, et al. Immunostaining studies on nasopharyngealcarcinoma: Interaction of tumor cells, lymphocytes and expression of EBV LMP1.Anticancer Research, 2004, 24(4):2309-2318. (IF= 1.872) 46. ShaoJY, Gao HY, Li YH, Zhang Y, Lu YY, Zeng YX. Quantitative detection of commondeletion of mitochondrial DNA in hepatocellular carcinoma and hepatocellularnodular hyperplasia. World J Gastroenterol. 2004;10(11):1560-4. (IF= 2.547) 47. ShaoJY, Gao HY, Li YH, et al. High frequency of common deletion (4981 bp) inmitochondrial DNA in nasopharyngeal carcinoma and its correlation with patientage and clinical stages. Cancer Biology & Therapy, 2004, 3(12):1270-1274.(IF= 3.287) 48. Shao JY, Zhang Y, Li YH, et al. Comparison of Epstein-Barr virus DNA level inplasma, peripheral blood cell and tumor tissue in nasopharyngeal carcinoma:correlations with clinical parameters. Anticancer Research, 2004,24(6):4059-4066. (IF= 1.713) 49. Shao JY, Li YH, Wu QL, et al. High frequency loss of heterozygosity on thelong arm of chromosome 13 and 14 in nasopharyngeal carcinoma in Southern China.Chinese Medical Journal, 2002, 115(4):571-575. (IF= 0.901) 50. Shao JY, Huang XM, Yu XJ, et al. Loss of Heterozygosity and its correlation withclinical outcome and Epstein-Barr Virus Infection in Nasopharyngeal Carcinoma.Anticancer Research, 2001, 21(4): 3021-3030. (IF= 1.713) 51. Shao JY, Wang HY, Huang XM, et al. Genome-wide allelotype analysis of sporadicprimary nasopharyngeal carcinoma from southern China. Int. J Oncology, 2000,17: 1267-1275. (IF= 2.657) 52. XiaomingH, Haiqiang M, Manquan D, Jianyong S, Yong S, Kela L, Xiaoman L, Tengbo H.Examination of nasopharyngeal epithelium with contact endoscopy. ActaOtolaryngol, 2001: 121: 95-102. (IF= 1.106) 53. GuoX, Min HQ, Zeng MS, Qian CN, Huang XM, Shao JY, Hou JH. nm23-H1 expression innasopharyngeal carcinoma: correlation with clinical outcomes. Int. J. Cancer,79(6):596-600, 1998. 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