Research

Metastasis Molecular Mechanism/Biomarkers for Individual Therapy
Rui-hua Xu’s Laboratory

Summary
Prof. Rui-hua Xu’s Laboratory belongs to the Department of Medical Oncology, Sun Yat-sen University Cancer Center and State Key Laboratory of Oncology in South China. Prof. Xu’s Lab is interested in:

1) Finding novel molecular mechanisms of gastrointestinal cancer metastasis;

2) Identifying potential diagnostic and prognostic biomarkers to guide individualized therapy for cancer patients;

3) Developing new strategies to overcome drug resistance of cancer cells;

4) Conducting clinical trials for developing optimal treatments for cancer patients.

Current Research Projects
1. Role of miR-214 in the regulation of colorectal cancer liver metastasis and its underlying mechanisms.

2. Defining new molecular subtypes and developing individualized therapy for advanced colorectal and gastric cancer.

3. Role of AMPK in the regulationof Kras and PI3K signaling pathway in colorectal cancer.

4. KH903 Clinical trial: a novelanti-angiogenic antibody in the treatment of cancer patients.

Selected peer-reviewedpublications (in nearly 3 years)
1. Xu RH and Huang P*. A new rolefor PHD in chemotherapy. Cancer Cell. 22(2):143-4. (2012)

2. Satoh T, Xu RH (co-firstauthor), Chung HC, Sun GP, Doi T, Xu JM, Tsuji A, Omuro Y, Li J, Wang JW, MiwaH, Qin SK, Chung IJ, Yeh KH, Feng JF, Mukaiyama A, Kobayashi M, Ohtsu A, BangYJ: Lapatinib plus paclitaxel versus paclitaxel alone in the second-linetreatment of HER2-amplified advanced gastric cancer in Asian populations:TyTAN-a randomized, phase III study. J Clin Oncol. 32(19):2039-2049. (2014)

3. Chen DL, Wang ZQ, Zeng ZL, WuWJ, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Ren C, Wang FH, Chiao LJ,Pelicano H, Huang P, Li YH, Xu RH*. Indentification of microRNA-214 as anegative regulator of colorectal cancer liver metastasis by way of regulationof fibroblast growth factor receptor 1 expression. Hepatology. 60:598-609.(2014)

4. Zeng ZL, Luo HY, Yang J, Wu WJ,Chen DL, Huang P, Xu RH*. Overexpression of the circadian clock gene Bmal1increases sensitivity to oxaliplatin in colorectal cancer. Clin Cancer Res.20(4):1042-52. (2014)

5. Qiu MZ, Li Q, Wang ZQ, Liu TS,Liu Q, Wei XL, Jin Y, Wang DS, Ren C, Bai L, Zhang DS, Wang FH, Li YH, Xu RH*.HER2-positive patients receiving trastuzumab treatment have a comparableprognosis with HER2-negative advanced gastric cancer patients: A prospectivecohort observation. Int J Cancer. 134(10):2468-77. (2014)

6. Chen DL, Wang DS, Wu WJ, ZengZL, Luo HY, Qiu MZ, Ren C, Zhang DS, Wang ZQ, Wang FH, Li YH, Kang TB, XuRH*.Overexpression of paxillin induced by miR-137 suppression promotes tumorprogression and metastasis in colorectal cancer. Carcinogenesis. 34(4):803-11.(2013)

7. Wu WJ, Zhang Y, Zeng ZL, Li XB,Hu KS, Luo HY, Yang J, Huang P, Xu RH*.β-phenylethyl isothiocyanate reversesplatinum resistance by a GSH-dependent mechanism in cancer cells withepithelial-mesenchymal transition phenotype. Biochem Pharmacol.85(4):486-96.(2013)

8. Chen DL, Zeng ZL, Yang J, RenC, Wang DS, Wu WJ, Xu RH*. L1cam promotes tumor progression and metastasis andis an independent unfavorable prognostic factor in gastric cancer. J HematolOncol. 6:43. (2013)

Contact Information
Rui-hua Xu, Ph.D.
Principle Investigator
Professor of Department of Medical Oncology
President of Sun Yat-sen University Cancer Center

Address
651 Dong Feng East Road,
Guangzhou 510060, PR China
Office: +86-20-87343333
Fax: +86-20-87343295
Email: xurh@sysucc.org.cn

Pathogenesis and etiology of NPC
Zeng Musheng's Laboratory

Summary
Prof. Musheng Zeng is a vice director and professor of Sun Yat-sen University Cancer Center. He gained his Ph.D. degree at Sun Yat-sen University in 1998 and had his Post-doc training in TennesseeState University and New England Medical Center, Tufts University from 1999 to2003. Prof. Musheng Zeng moved back to China to start his lab since 2003.

Zeng's laboratory majorly engage in the pathogenesis and etiology ofNasopharyngeal Carcinoma (NPC), especially the mechanism of EBV infection and transformation in nasopharyngeal epithelial cells. In endemic regions, NPC presents as a complex disease caused by an interaction of Epstein-Barr virus (EBV) chronic infection, environmental, and genetic factors, in a multistep carcinogenic process.

Current Research
Prof. Zeng has previously deeply studied on the genetically determined susceptibility of NPC patients and the variation of EBV, furthermore, completed the first full-length sequence analysis of an NPC-derived EBV strain.

He has already established the first cellular proto-oncogene immortalized nasopharyngeal epithelial cell line and preliminarily illuminated the mechanisms involved in the tumorigenesis of NPC, and found the functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer.

Most importantly, he recently established highly infective efficiency and stable in vitro epithelial cell model for EBV infection.
Moreover, he discovered that LMP2A induces EMT and stem-like cell self-renewal in NPC, suggesting a novel mechanism by which Epstein-Barr virus induces the initiation, metastasis and recurrence of NPC.

Contact Information
Zeng Mu-Sheng
Vice-President 
Principle Investigator
Professor of Experimental Research
Sun Yat-sen University

Address
651 Dong Feng Road, East Guangzhou, China 510060
Email: zengmsh@sysucc.org.cn
Phone: 020-87343191

Cellular and molecular mechanism of cancer metastasis
Chao-Nan Qian's Laboratory

Summary
The laboratory of Chao-Nan Qian, M.D., Ph.D.is within the State Key Laboratory of Oncology in South China, SYSUCC.  Qian's Lab is interested in understanding the cellular and molecular mechanism of cancer metastasis, tumor angiogenesis, and carcinogenesis, with multidisciplinary approaches and tools including in vitro molecular and biological assays, as well as in vivo animal models.

Current Research
1.       Molecular mechanisms underlying metastasis of nasopharyngeal carcinoma.

2.       Molecular mechanisms underlying angiogenesis of solid tumors.

3.       Molecular mechanisms underlying cancer onset in different ages.

Contact Information
Chao-Nan Qian, M.D., Ph.D.
Principle Investigator
Professor and Vice President
Sun Yat-sen University Cancer Center

Address
651 Dongfeng East Road
Guangzhou, Guangdong 510060
China
Office: +86-20-87343457; +86-20-87343606
Fax: +86-20-87343624

Genetic mechanisms and/or prediction biomarkers of cancer metastasis
Dan Xie's Laboratory

Summary
The laboratory of Dan Xie, M.D., Ph.D. is within the Sun Yat-Sen University Cancer Center for basic and translational  studies on cancer metastasis and anticancer drugs research. The Xie Lab is interested in understanding the genetic mechanisms and/or prediction biomarkers of cancer metastasis in several types of human cancers including colorectal,  hepatoceullar, esophageal, lung and ovarian carcinomas.

Current Research
1.      The molecular carcinogenic characteristics and clinical significance of new candidate oncogene EIF5A2 in colorectal cancer metastasis.

2.      The role of the Polycomb EZH2 in hepatocellular carcinoma metastasis and the screening and molecular mechanism of its silence of tumor suppressor.

3.      Studies on the molecular functions and mechanism of miRNA-148 in the malignant progress of primary hepatocellular carcinoma.

Contact Information
Dan Xie, M.D., Ph.D.
Principle Investigator
Professor
The State Key Laboratory of Oncology in Southern China
Deputy Head
The Department of Pathology
Sun Yat-Sen University Cancer Center

Address
Lab729, Building 2
No. 651, Dongfeng Road East
Guangzhou, 510060
China
Office: (8620) 87343193
Fax: (8620) 87343170
Email: xiedan@sysucc.org.cn

Clinical Research of new anti-tumor drugs
Jiang Wenqi's Laboratory

Summary
The laboratory of Professor Wenqi Jiang is within the State Key Laboratory of Oncology in South China of Sun Yat-sen University Cancer Center. The Jiang Lab is focus on the clinical research of new anti-tumor drugs, the mechanism of molecule-targeting agents, and the clinical apply of biotherapy in lymphoma and other cancer.

Contact Information
Wenqi Jiang, M.D., Professor
Principle Investigator

Address
651 Dongfeng Road East
Office: +86 20 87343352
Email: jiangwq@sysucc.org.cn

Molecular phenotypes and staging of ovarian carcinoma
Liu Jihong's Laboratory

Summary
The laboratory of Jihong Liu, Professor, is within the Sun Yat-sen university cancer center. Liu's Lab is interested in the study of molecular phenotypes and staging of ovarian carcinoma, biomarkers for early diagnosis of ovarian cancer, as well as lymph node metastasis in cervical cancer. The ability to predict responses to chemotherapy is another key point of our research projects in ovarian cancer.

Current Research
1.Study of clinical classifications and molecular phenotypes in ovarian cancer

  Molecular features of different metastasis patterns in stage III ovarian cancer

  Establishment of an animal model for retroperitoneal lymph node metastasis

  Screening molecules related to lymph node metastasis in ovarian cancer

2.Study of molecular biology on lymph node metastasis in cervical cancer

  u  Biological functions of Sam68 and underlying molecular mechanisms relation to lymph node metastasis

  u  Relationship between Sam68 and angiogenesis

  u  Expression and clinical significance of URG4 in cervical cancer

Contact Information
Professor Jihong Liu
Department of Gynecologic Oncology
Sun Yat-sen University Cancer Center

Address
651 Dongfeng Road East
Guangzhou,China
Office:+86 20 87343102
Fax:+86 20 87343014
E-mail: liujih@mail.sysu.edu.cn

Prognosis prediction and comprehensive treatment of NPC
Ma Jun's Laboratory

Summary
The laboratory of Jun Ma, M.D. is interested in prognosis prediction and comprehensive treatment of nasopharyngeal carcinoma. He has done a solid job in improving the TNM staging system, identifying different prognostic factors, and investigating novel therapeutic strategies for nasopharyngeal carcinoma (NPC). Jun lab has published over 49 papers in prestigious, international peer-reviewed journals, such as Lancet Oncol, J Clin Oncol, Clin Cancer Res, Cancer, Radiology, Radiother Oncol, and Int J Radiat Oncol Biol Phys.

Current research
1. Establish novel TNM-biomarker-based prognostic classifiers.

2. Develop an individualized target volume delineation system for intensity modulated radiotherapy.

3. Identify effective drug therapy for the eradication of micrometastases. 

Contact Information
Jun Ma, M.D.
Principle Investigator
Professor
Department of Radiation Oncology
Sun Yat-sen University Cancer Center
State Key Laboratory of Oncology in South China

Address
651 Dongfeng Road East,
Guangzhou 510060,
People's Republic of China
Office:(+86) 020-87343469
Fax:(+86) 020-87343392
Email: majun@sysycc.org.cn

Brain cancer genetic resistanceBrain cancer genetic resistance/drug resistance in glioma/vasculogenic mimicry (VM) in glioma
Chen Zhong-ping's Laboratory

Summary
The laboratory of Neurosurgery/Neuro-oncology is one of the labs in Department of Experimental Research of Sun Yat-sen University Cancer Center (SYSUCC). The head of the lab is Dr. Zhong-ping Chen, who is also the chairman of Department of Neurosurgery/Neuro-oncology of SYSUCC. The lab’s directions are the following:
1) Genetic alterations leading to resistance of human brain tumors to chemotherapy, and has found that ERCC2, one of the important components in nucleotide excision repair (NER) system related to alkylating agent resistance in human tumor cell lines;

2) MGMT associated drug resistance in glioma has also been investigated and applied in his clinical practice;

3) Vasculogenic mimicry (VM) in glioma were first reported by us, which is anew circulation pattern exists in malignant gliomas.

As a successful surgeon, Dr. Chen also interests in microsurgery and multimodality treatment for primary and metastatic tumors in central nervous system, particularly gliomas. Dr Chen has been awarded Francis Mc Naughton Memorial Prize in 1998 (Canadian Neurological Society), WHO Prize for Chinese Young Professional in Mental Health & Neuroscience in 1993,and Wang Chong-cheng Academic Award for Chinese Neurosurgeon in 2006. More than200 papers have been published in leading scientific journals by our lab members,  including Cancer Research, Clinical Cancer Research, Journal of National Cancer Institute, Neurosurgery, Journal of Neurosurgery, Journal of Neuro-oncology, and Neuro-oncology.

Current Research
1. Study of molecular mechanisms of VEGF regulating the transition from vasculogenic mimicry to tumor-derived vessels in glioma

2. The study of molecular typing and biomarker in gioma in Chinese population

3. The anticancer effect of combination therapy with temozolomide and levetiracetam inglioma

4. The mechanism of the DLL4-Notch1 regulated vasculogenic mimicry transition inglioma

5. The prognostic biomarkers study in glioblastoma multiforme

6. The role of delta-PI3K in the metastasis process of glioblastoma multiforme

Contact Information
Zhong-ping Chen, M.D., Ph.D.
Professor & Chairman
Department of Neurosurgery/Neuro-oncology
Sun Yat-sen University Cancer Center

Address
Sun Yat-sen University Cancer Center, Building 2, Room 926
651 Dongfeng Road East, Guangzhou,Guangdong, China, 510060
Tel & Fax: 86-20-87343169
Email: Chenzhp@sysucc.org.cn 

 

 

Molecular and cellular mechanisms of cancer
Liu Quentin's Laboratory

Summary
The Quentin Liu's lab is interested in understanding the molecular and cellular mechanisms of cancer through mammalian cell culture, animal models and clinical resources. We seek to identify diagnostic markers and therapeutic targets for cancer of various tissues. A unique three-dimensional culture system has been developed in our group to better interpret the in vivo microenvironment of cancer. We are currently investigating cancer stem cell biology and the differentiation of solid tumors, identifying the molecular mechanisms involved and the translational applications.

Current Research

1. Epigenetics, cancer stem cell biology and differentiation of cancer.

2. Molecular markers and targeted drugs for cancer.

3. Three-dimensional culture of normal/malignant cells.

Contact Information

Quentin Liu, MD, PhD

Principle Investigator

Professor of Cancer Biology

Director, Laboratory for Target Therapy,State Key Laboratory of Oncology, Cancer Center

Sun Yat-senUniversity (SYSU)

Address

651 Dongfeng Road East

Guangzhou, Guangdong 510060

Tel: 020-87343148

Email: liuq9@mail.sysu.edu.cn

Screening and validating tumor radiobiological markers and clinical prognostic indicators
Xia Yunfei's Laboratory

Summary
The laboratory of Prof. Yunfei Xia, is within the Sun Yat-sen University Cancer Center. The team of Prof. Xia is mainly engaged in screening and validating tumor radiobiological markers and clinical prognostic indicators.In basic research, Xia lab established spectroscopic techniques and parameters to detect the radio sensitivity of nasopharyngeal carcinoma based on free radicals, light biology, molecular biology and proteomics; revealed mechanisms of NPC radio-resistance such as p53-p21, DNA-PK / ATM-DNA repair pathways, cell cycle and apoptosis; screened predictive and prognostic indicators for nasopharyngeal carcinoma diagnosis by MALDI-TOF MS-based technologies. From Clinical scale, Xia lab divided NPC into four radiotherapy-related types as follows, Type I: radiosensitive and non-metastasis-prone, Type II: radioresistant and non-metastasis-prone, Type III: radiosensitive and metastasis-prone, and Type IV: radioresistant and metastasis-prone; found prognosis indicators of NPC from routine blood and biochemical  examinations and therefore established the prognosis model. Moreover, Xia lab proposed improved glioma postoperative radiation therapy biological target.

Current Research
1. Tumor radiobiological behavior related clinical and molecular typing research .

2. Study of nasopharyngeal carcinoma individualized treatment based on badiobiological behavior.

Contact Information
Yunfei Xia, prof.
Chief physician
Deputy director
Radiation Oncology Department of Sun Yat-sen university cancer center
Address: No. 651, Room 926 , Building 2, Sun Yat-sen university Cancer Center,Dongfeng East Road, Yuexiu District, Guangzhou.
Office: 020-87343169
Email: xiayf@sysucc.org.cn

Mechanisms involved in hepatocarcinogenesis and tumor metastasis
Yun Jing Pings' Laboratory

Summary
Dr. Yun is a certified anatomic pathologist, specialized in tumor pathology. He obtained his medical degree at Sun Yat-sen University