Born in September 1977, Dr. Zhou Jianhua has been working in the Ultrasound Diagnosis and Interventional Treatment at Sun Yat-sen University Cancer Center since he graduated from undergraduate program from former Sun Yat-sen University of Medical Sciences in 2001. He was conferred upon the degree of Master of Clinical Medicine in 2005 and the degree of Doctor of Medicine in 2009 by Sun Yat-sen University. He furthered his studies at Thomas Jefferson University Hospital in the U.S. between September 2009 and August 2010, under the instruction of Professor Barry. B Goldberg, former president of the World Federation for Ultrasound in Medicine and Biology (WFUMB) and Professor Liu Jibin, participating in several pieces of research work and clinical work about ultrasonic contrast.

In 2009, he won the first Youth Talent Training Program of Sun Yat-sen University Cancer Center and in 2012, obtained support from the Guangzhou Pearl River Science & Technology Rising Star Project. He was elected to the Program for New Century Excellent Talents in University run by the Ministry of Education in 2013 and as a school-level trainee, the Hundred, Thousand, and Ten Thousand Talents Project of Guangdong Higher Education in 2012. He is now an associate chief physician in Ultrasound Diagnosis and Interventional Treatment, engaging himself in ultrasound diagnosis and interventional treatment of cancer. He specializes in ultrasound diagnosis and interventional treatment of such cancer as hepatobiliary cancer, urinary system cancer, breast cancer, thyroid cancer and lymphoma, with considerable experience of in-depth research into diagnosis of liver tumors by ultrasonic contrast and evaluation of its therapeutic effects.

Work experience
07/2001-12/2006 Physician, Sun Yat-sen University Cancer Center

01/2007-12/2010 Attending physician, Sun Yat-sen University Cancer Center

01/2011-present Associate chief physician, Sun Yat-sen University Cancer Center

09/1996-06/2001 Undergraduate, former Sun Yat-sen University of Medical Sciences

09/2001-12/2005 Master's degree student, Sun Yat-sen University

09/2006-06/2009 Doctoral student, Sun Yat-sen University

09/2009-08/2010 Thomas Jefferson University

Updated by International Office, Sun Yat-sen University Cancer Center

Dr. Xi Lin has been working in the Ultrasound Diagnosis and Interventional Treatment at Sun Yat-sen University Cancer Center since she graduated from undergraduate program from Sun Yat-sen University in 2002.She has been a chief physician in Ultrasound Diagnosis and Interventional Treatment since January 2018,as well as a supervisor of PhD student. She is also a vicechairman of the Fourth Superficial Organ and Peripheral Vessel Ultrasound Professional Committee of the Chinese Society of Ultrasound Medical Engineering; a vicechairman ofthe Ultrasound Medicine Professional Committee of Guangdong Medical Education Association; a member of the Ultrasound Medicine Expert Committee for the National Health Commission Capacity Building and Continuing EducationCenter.

Dr. Lin specializes in ultrasound diagnosis and interventional treatment of such cancer as hepatobiliary cancer, urinary system cancer, breast cancer, thyroid cancer, lymphoma and gynecological cancers. She has extensive experiencein conductingin-depth researchon theearly diagnosis of breast cancer and other superficial organ tumors. HerSCI papershave been publishedin world renowned journals such as Nature Communications,Radiology Artificial Intelligence, Medical Image Analysis.The research finding(Tang et al. Korean J Radiol. 2020 May) was cited at the section of Automated Breast Ultrasound and handheldultrasound in the BI-RADS atlas (version 6).

Early ultrasound diagnosis of breast tumors, includingrelated clinical and basic research work. Application of artificial intelligence intumors such as breast and ovarian cancer.

Dr. Lin graduated from undergraduate program from Sun Yat-sen University in 2002. She was conferred upon the degree of Master of Clinical Medicine in 2008 and the degree of Doctor of Clinical Medicine in 2011 by Sun Yat-sen University. She furthered her studies in Breast Screening and Diagnostic Imaging Centre at University of Western Australia between September 2010 and September 2011.

（1） Xiang H#, Xiao Y#, Li F#, Li C, Liu L, Deng T, Yan C, Zhou F, Wang X, Ou J, Lin Q, Hong R, Huang L, Luo L, Lin H, Lin X*, Chen H*. Development and validation of an interpretable model integrating multimodal information for improving ovarian cancer diagnosis. Nat Commun. 2024 Mar 27;15(1):2681.

（2） Deng T#, Liang J#, Yan C, Ni M, Xiang H, Li C, Ou J, Lin Q, Liu L, Tang G, Luo R, An X, Gao Y*, Lin X*. Development and validation of ultrasound-based radiomics model to predict germline BRCA mutations in patients with breast cancer. Cancer Imaging. 2024 Feb 29;24(1):31.

（3） Xiang H#, Wang X#, Xu M, Zhang Y, Zeng S, Li C, Liu L, Deng T, Tang G, Yan C, Ou J, Lin Q, He J, Sun P, Li A, Chen H, Heng PA, Lin X*. Deep Learning-assisted Diagnosis of Breast Lesions on US Images: A Multivendor, Multicenter Study. Radiol Artif Intell. 2023 Jul 12;5(5):e220185.

（4） Xiang H#, Huang YS, Lee CH, Chang Chien TY, Lee CK, Liu L, Li A, Lin X*, Chang RF*. 3-D Res-CapsNet convolutional neural network on automated breast ultrasound tumor diagnosis. Eur J Radiol. 2021 May;138:109608.

（5） Wang X#, Chen H*, Xiang H, Lin H, Lin X*, Heng PA. Deep virtual adversarial self-training with consistency regularization for semi-supervised medical image classification. Med Image Anal. 2021 May;70:102010.  

（6） Lin X#, Jia M, Zhou X, Bao L, Chen Y, Liu P, Feng R, Zhang X, Zhu L, Wang H, Zhu Y, Tang G, Feng W, Li A*, Qiao Y*. The diagnostic performance of automated versus handheld breast ultrasound and mammography in symptomatic outpatient women: a multicenter, cross-sectional study in China. Eur Radiol. 2021 Feb;31(2):947-957.   

（7） Wu X#, Zhang X#, Yu L#, Zhang C, Ye L, Ren D, Li Y, Sun X, Yu L, Ouyang Y, Chen X, Song L, Liu P*, Lin X*. Zinc finger protein 367 promotes metastasis by inhibiting the Hippo pathway in breast cancer. Oncogene 2020, 39(12): 2568-2582.  

（8） Tang G#, An X, Xiang H, Liu L, Li A, Lin X*. Automated Breast Ultrasound: Interobserver Agreement, Diagnostic Value, and Associated Clinical Factors of Coronal-Plane Image Features. Korean journal of radiology 2020, 21(5): 550-560.  

（9） An X#, Lin X#, Yang A, Jiang Q, Geng B, Huang M, Lu J, Xiang Z, Yuan Z, Wang S, Shi Y*, Zhu H*. Cavin3 Suppresses Breast Cancer Metastasis Inhibiting AKT Pathway. Frontiers in pharmacology 2020, 11: 01228.  

（10） Huang L#, Chen K#, Cai Z*, Chen F, Shen H, Zhao W, Yang S, Chen X, Tang G, Lin X*. DEPDC1 promotes cell proliferation and tumor growth via activation of E2F signaling in prostate cancer. Biochemical and biophysical research communications 2017, 490(3): 707-712.

Dr. Li An Hua is professor of the ultrasound department in Sun Yat-sen University Cancer Center. Dr. Li obtained her Bachelor in Medicine in China in 1982 and MSc degree in England in 2001. She acts as a express into Sun Yat-sen University in 2003, From that, she is working on ultrasound diagnosis and interventional treatment of tumors. 

In clinical practice, she focus on diagnosis those lesions exactly of breast, thyroid, liver, lymph node and so on. Include image guide biopsy. In clinical research practice, she interest in contrast imaging with ultrasound contrast agent and quantification analysis with perfusion imaging of tumor. In department manage practice, she pay attention to help young doctors and new technology of imaging into clinical practice. Dr.Li has published more than 90 research papers..

1. Zhou JH , Cao LH ,Zheng W, Liu M, Han F, Li AHContrast-Enhanced Gray-Scale Ultrasound for Quantitative Evaluation of Tumor Response to Chemotherapy: Preliminary Results With a Mouse Hepatoma Model AJR: 196,January 2011 13-17 （Americal Journal of Roentgenoloy）

2.Zhou JH ,Zheng W, Cao LH, Liu M, Luo RZ, Han f, Wu PH. Li AHOuantitative evaluation of viable tissue perfusion changes with congtrast-enhanced grayscale ultrasound in s mouse hepatoma model following treatment with different doses of thalidomide. Br J Radiol 2011 Jan 11 [Epub ahead of print]

3. Xiao Qing Pei, Long Zhong Liu, Wei Zheng, , Mu Yan Cai, Feng Han, Jie Hua He, An Hua Li, and Min Shan Chen, Contrast-enhanced ultrasonography of hepatocellular carcinoma: Correlation between quantitative parameters and arteries in neoangiogenesis or sinusoidal capillarization European Journal Radiology ,23 Feb 2011

4 Lin X, Wang J, Han F, Fu J, Li AH.Analysis of eighty-one cases with breast lesions using automated breast volume scanner and comparison with handheld ultrasound. Eur J Radiol. 2011 Mar 18. [Epub ahead of print]

5. Zhou JH ,Zheng W, Cao LH, Liu M, Luo RZ, Han f, Wu PH. Li AH Quantitative Assessment of Tumor Blood Flow in Mice after Treatemnt with Different Doses of an Antiangiogenic Agent with Contrast-enhanced Destraction-Replenishment US.. Raiology 2011 Vol 259.Num 2 406-413

6. Zhou JH ,Zheng W, Cao LH, Liu M, Luo RZ, Han f, Wu PH. Li AHContrast-enhanced ultrasonic parametric perfusion imaging in the evaluation of antiangiogenic tumor treatment.Eur J radiology2011 Feb21，[Epub ahead of print]

7 .Jianhua Zhou Wei Zheng Anhua Li et al: Antiangiogenic Tumor Treatment ：Noninvasive Monitoring with Contrast Pulse Sequence Imaging for Contrast-Enhanced Grayscale Ultrasound. Academic Radiology, 2010，17(5):646-51

8. J H ZHOU, MD, 1A H LI, MD,Haemodynamic parameters of the hepatic artery and vein can detect liver metastases: assessment using contrast-enhanced ultrasound，The British Journal of Radiology, 81 (2008), 113–119 

9. Ming-de Lu, Xiao-ling Yu, An-hua Li, et al.（Multiple center clinical trail of China）Comparison of Contrast Enhanced Ultrasound and Contrast Enhanced CT or MRI in Monitoring Percutaneous Thermal Ablation Procedure in Patients with Hepatocellular Carcinoma: A Multi-Center Study in ChinaUltrasound in Medicine & Biology, Volume 33, Issue 11, November 2007, 1736-174

Books

1. Li Anhua. Echocaidiography. Medical Imaging and Clinical, Feng gansheng, (Editor), The Hubei Science and Technology Press., 1994.

2. Li Anhua, Ocular sonography in children. Children Ultrasonic Diagnosis. Xia Bei (Editor), The Peoper’s Health Press, 20003. Li Anhua (Editor) , Breast ultrasonography, The Peoper’s Health Press (furture). 2004

Last Updated on: 2011 by International Office, Sun Yat-sen University Cancer Center

Dr. Zhang Liyuan, is an associate chief technician who engages in ECG diagnosis in the Department of Ultrasound Diagnosis and Interventional Treatment, at Sun Yat-sen University Cancer Center. Originally, she worked at Sun Yat-sen Memorial Hospital, SYSU, for the Department of Internal Medicine in 1984 and for the Electrocardiographic Room in 1987. She was promoted as an exceptional technician in charge in 1998 by virtue of her excellent work performances and remarkable scientific research. 

In 1999, as the ECG technical backbone, she was transferred to the Department of Ultrasound Diagnosis and Interventional Treatment at Sun Yat-sen University Cancer Center to work on ECG technology, strengthen the technical abilities of the Electrocardiographic Room and lead young doctors to improve their skills in ECG diagnosis and abilities in arhythmia diagnosis & differential diagnosis. She has obtained the Medical Practitioner's Qualification Certificate and been devoted to ECG diagnosis all these years. 

In 2011, she became an associate chief technician. Through her 27-year ECG technological profession, she has accumulated abundant work experience, acquired solid theoretical knowledge, been steadily proficient in ECG diagnosis reports, been adept at complex arhythmia diagnosis and differentiation, tackled a variety of difficult problems independently and played a backbone role in the Electrocardiographic Room. During her career, she has published over 30 papers as a lead author in public medical journals and core professional journals and undertaken one program funded by the National Natural Science Foundation of China, one project of Guangdong Provincial Natural Science Foundation and projects of Guangdong Provincial Department of Health. On April 8, 2011, she attended the 13th South China International Congress of Cardiology and gave a lecture on The Common ECG Expressions of Myocardial Damage of Chemotherapy Drugs.

09/1981-07/1984 Studied in Health School of former Zhongshan Medicine School

09/2002-07/2006 Majored in Medical Imaging, School of Continuing Education, SYSU

03/2007-2010 Majored in Clinical Medicine in School of Continuing Education, SYSU and received the Bachelor’s Degree in Clinical Medicine

1.12/2012 100 Case clinical analysis of QRS wave voltage reduction for patients with malignant tumor during chemotherapy.Lingnan Journal of Emergency Medicine.

2.2011 Occurrence of arrhythmia in patients with esophageal cancer during combined treatment.International Medicine and Health Guidance News, Issue23.

3.08/2011 Analysis of combined electrocardiographic QRS alternans in malignant tumor patients.Chinese Journal of Prevention and Control of Chronic Diseases.

4.06/2011 Clinical analysis of the arrhythmia of 300 patients with nasopharyngeal carcinoma.Lingnan Journal of Emergency Medicine.

5.10/2010 Changes of ECG during chemotherapy in patients with malignant tumor.Chinese Journal of Cardiac Pacing and Electrophysiology.

6.08/2010 Study on the change of ECG after chemotherapy and radiotherapy in treatment of patients with breast cancer.Chinese Journal of Primary Medicine and Pharmacy.

7.08/2010  Clinical analysis of the arrhythmia of 1000 patients with malignant tumor.Lingnan Journal of Emergency Medicine.

8.01/2008 Clinical analysis of 500 cases of malignant tumor complicated with ECG low voltage.Guangdong Medical Journal.

9.9.08/2006 Analysis of electrocardiogram of 1000 patients with malignant tumors during the treatment period.Lingnan Journal of Emergency Medicine.

10.10/2004 Electrocardiogram expressions caused by some tumors.Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease.

11.03/2003 Analysis of ECG in patients with lung cancer during the treatment.Chinese New Medicine.

12.08/2001 Analysis of electrocardiogram in 120 patients with breast cancer chemotherapy.The Journal of Practical Medicine.

13.05/2000 Analysis of acute myocardial infarction and ventricular arrhythmia.Journal of Clinical Eletrocardiology.

14.11/1999 Analysis of ECG in 316 cases of middle-aged and elderly patients.Journal of Practical Electrocardiology.

15.09/1999 Development of heart rate variability computer system.Modern Medical Equipment and Application. 

16.05/1999 ECG ST-segment elevation and ST-T normalization of myocardial ischemia induced by exercise test.Journal of Clinical Eletrocardiology.

17.1990-1998 More than ten published papers

Updated March 2021 by International Office, Sun Yat-sen University Cancer Center

Ultrasound evaluation of the effect of cancer chemotherapy, shear wave elastography (shear wave elasticity imaging), ultrasound imaging (contrast-enhanced ultrasonography) diagnostic and research work 

Sponsored research projects funded: 

1. VEGFR2-targeted ultrasound contrast experimental study in mice quantitative analysis and evaluation of anti-tumor treatment of pancreatic cancer (National Natural Science Foundation, project approval number: 81201103, 2013.1-2015.12) 

2 CEUS quantitative analysis of cervical cancer and its role in the effect of neoadjuvant chemotherapy to determine the (Guangdong Province Medical Research Foundation, Project Grant No.: B2011116,2012.1-2013.12) 

3 Quantitative ultrasound imaging studies in cancer neoadjuvant chemotherapy application (center study start fund 2013-4)

2011.8-2012.7, England St Thomas' Hospital (School of Medicine, King's College London) (St. Thomas • King's College London) Visiting Scholar 

2007.9-2010.6 Dr. Sun Yat-sen Graduate. 

2001.9-2005.12 Sun Yat-sen Graduate 

1996.9-2001.6 Zhongshan Medical University undergraduate

(1) Pei XQ, Liu LZ, Xiong YH, Zou RH, Chen MS, Li AH, Cai MY. Quantitative analysis of contrast-enhanced ultrasonography: differentiating focal nodular hyperplasia from hepatocellular carcinoma. Br J Radiol, 2013 Epub 2013 Feb 7.

(2) Pei XQ, Liu LZ, Zheng W, Mu Yan Cai, Feng Han, Jie Hua He, An Hua Li, Min Shan Chen. Contrast-enhanced ultrasonography of hepatocellular carcinoma: Correlation between quantitative parameters and arteries in neoangiogenesis or sinusoidal capillarization. Eur J Radiol,2012; 81:e182-e188. 

(3) Pei XQ, Liu LZ, Liu M, Zheng W, Han F, Li AH. Contrast-enhanced ultrasonography of hepatocellular carcinoma: correlation between quantitative parameters and histologic grading. Br J Radiol,2012 Sep; 85(1017):e740-7.

(4) Cai MY, Luo RZ, Chen JW, Pei XQ, Lu JB, Hou JH, Yun JP. Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma.. PLoS One. 2012;7(2):e328-38

(5) Pei XQ, Liu LZ, ZhengW, et al. Contrast-enhanced Ultrasonography of Hepatocellular Carcinoma: correlation between quantitative parameters and arteries in neoangiogenesis. Chin J Ultrasonogr, 2011, 20(3):222-225.

(6) Pei XQ, Chen MS, Liu LZ,et al. Study on Dynamic vascular curve f(t) of contrast-enhanced ultrasound in differential diagnosis hepatocellular carcinoma from focal nodular hyperplasia. Chin J Ultrasound Med. 2010, 6(5): 444-448.

(7) Pei XQ, Liu LZ, Li JY,et al. Misdiagnosis Analysis of Contrast-enhanced Ultrasonography for Focal Liver Lesions. Chin J Ultrasonogr, 2010，19（4）:314-316.

(8) Pei XQ, Liu LZ，Liu M,et al. Effect of cirrhosic liver on dynamic vascular curves analysis of hepatocellular carcinomas at contrast-enhanced ultrasound. Chin J Ultrasonogr.Chin J Ultrasonogr, 2010,19(7): 576-579.

Last Updated on: 2013 by International Office, Sun Yat-sen University Cancer Center