Research
    Han Hongyu
    Title Chief Physician
    Profile

    Dr. Han Hongyu specializes in nutritional support and treatment for cancer patients, nutritional risk screening, nutritional assessment, risk monitoring of malnutrition, risk evaluation and prediction of nutrition-related diseases, personalized intra-intestinal and parenteral nutritional support and treatment, meeting patients’ nutritional demands and improving their nutritional status, promoting immunologic function and enhancing patients’ tolerance of operation, radiotherapy and chemotherapy.

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    Research Interest(s)

    Cancer nutrition, Clinical nutrition, Phytochemical Intervention of Cancer, Public health and nutrition 

    Education

    2010 Graduated from Sun Yat-sen University Cancer Center and obtained Doctoral Degree in Oncology. 

    Publications

    • Diallyl trisulfide inhibits gastric cancer stem cell properties through ΔNp63/sonic hedgehog pathway. Mol Carcinog. 2023 Nov;62(11):1673-1685. doi: 10.1002/mc.23607. Epub 2023 Jul 21.PMID: 37477518

    • Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression. J Nutr Biochem. 2023 Feb;112:109226. doi: 10.1016/j.jnutbio.2022.109226. Epub 2022 Nov 23.

    PMID: 36435292

    • ΔNp63α mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2. J Nutr Biochem.. 2022 Sep;107:109067. doi: 10.1016/j.jnutbio.2022.109067. Epub 2022 May 21.

    • ALK fusion variant 3a/b, concomitant mutations, and high PD-L1 expression were associated with unfavorable clinical response to second-generation ALK TKIs in patients with advanced ALK-rearranged non-small cell lung cancer (GASTO 1061) Lung Cancer. 2022 Jan 12;165:54-62. doi: 10.1016/j.lungcan.2022.01.006. Online ahead of print.

    • Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway. Front Cell Dev Biol. 2021 Jul 19;9:679806. doi: 10.3389/fcell.2021.679806. eCollection 2021.PMID: 34350176

    • TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition.Oncogenesis. 2020 Oct 10;9(10):89. doi: 10.1038/s41389-020-00273-z.PMID: 33040081 



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