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    Mou Yonggao
    Title Chief surgeon, Director of the Department
    Profile

    With over 30 years of clinical experience, he has trained more than 30 master’s and doctoral students. He has led over 10 scientific research projects, including the National Natural Science Foundation of China and major scientific and technological plans of Guangdong Province. He has published more than 100 academic papers in journals such as JNS and Neuro-oncology, and has authored two books published by the People’s Medical Publishing House. He holds 16 utility model patents, 5 invention patents, and has 2 translational patents. He has received the First Prize of Guangdong Provincial Medical Science and Technology Award and the 6th “National Famous Doctor - Outstanding Contribution” Award from People’s Daily. He is a Senior Expert in Health Care in Guangdong Province and a Clinical Medical Scientist at Sun Yat-sen University Cancer Center, specializing as the Chief Expert in Glioma.


    Chairman of the Neuro-Oncology Expert Committee of the Chinese Society of Clinical Oncology (CSCO)
    Chairman of the Brain Glioma Professional Committee of the Chinese Anti-Cancer Association
    Incoming Chairman of the Neurosurgery Branch of the Guangdong Medical Association
    Member of the Neurosurgery Branch of the Chinese Medical Doctors Association
    Deputy Leader of the Chinese Brain Metastasis Tumor Collaborative Group
    Vice Chairman of the Neuro-Oncology Branch of the Chinese Society for Neuroscience
    Vice Chairman of the Neuro-Oncology Subcommittee of the Chinese Anti-Cancer Association
    Email mouyg@sysucc.org.cn
    Phone
    Research Interest(s)

    The diagnosis and microsurgery of central nervous system tumors; comprehensive treatment of gliomas (surgery, chemotherapy, targeted therapy, and immunotherapy); translational research and clinical treatment of brain metastases.
    Education

    1985.9-1990.6 Binzhou Medical College, Bachelor of Clinical medicine ;

    1997.9-2000.6  Sun Yat-sen University, Master of Neurosurgery

    2002.9-2005.6   Sun Yat-sen University, Doctor of Neurosurgery

    2007.11-12  Kaohsiung Medical University, Post Doctor Fellowship

    2009.6.-12  M.D. Anderson Cancer Center, Visiting Scholar
    Publications


    1. Duan H, Ren J, Wei S, Yang Z, Li C, Wang Z, Li M, Wei Z, Liu Y, Wang X et al: Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target. Genome Med 2024, 16(1):138. PMID: 39593114

    2.Duan H, Xie Y, Wu S, Zhao G, Zeng Z, Hu H, Yu Y, Hu W, Yang Y, Chen Y et al: Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma. J Transl Med 2024, 22(1):880. PMID: 39350123; PMCID: PMC11443721.

    3.Yang W, Han Y, He C, Zhong S, Ren F, Chen Z, Mou Y, Sai K. Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis. BMC Cancer. 2024 Jan 23;24(1):118. doi: 10.1186/s12885-024-11865-y. PMID: 38262954; PMCID: PMC10807081.

    4. Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, Fei Peng, Vinay K. Puduvalli, Ke Sai, Yunqian Li, Ye Cheng & Yonggao Mou .Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis.BMC Medicine.2023 Dec 5;21(1):487.

    5. Wang T, Zhou Y, Fan Y, Duan H, Guo X, Chang J, Jiang Y, Li C, Fu Z, Gao Y, Guo X, Sidlauskas K, He Z, Da Costa C, Sheng X, Wu D, Yuan J, Li H, He Y, Mou Y, Li N. PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia. Adv Sci (Weinh). 2023 Jul;10(20):e2205949.

    6. Guo C, Yang Q, Xu P,Deng M,Jiang T, Cai L et al. Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas: A Randomized Clinical Trial. JAMA Netw Open. 2023;6(1):e2253285.

    7. Lun Liang, Zhenning Wang, Hao Duan, Zhenqiang He, Jie Lu, Xiaobing Jiang, Hongrong Hu,Chang Li, Chengwei Yu, Sheng Zhong, Run Cui, Xiaoyu Guo, Meiling Deng, Yuanyuan Chen, Xiaojing Du, Shaoxiong Wu, Likun Chen, Yonggao Mou.Survival Benefits of Radiotherapy and Surgery in Lung Cancer Brain Metastases with Poor Prognosis Factors.Current Oncology. 2023 Feb 13;30(2):2227-2236

    8. Lun Liang, Liangbao Wen,Shixing Qin, Zhenqiang He, Jie Lu, Run Cui, Xiaobing Jiang, Hongrong Hu, Sheng Zhong, Chang Li, Chengwei Yu, Yuang Xie, Zhenning Wang,  Hao Duan, Yonggao Mou.Poor Karnofsky performance status is not a contraindication for neurosurgical resection in patients with lung cancer brain metastases: a multicenter, retrospective PSM-IPTW cohort study.Journal of neuro-oncology.Journal of neuro-oncology. 2023;162(2):327-335

    9. Lu J, Wang Z, He Z, Hu Y, Duan H, Liu Z, Li D, Zhong S, Ren J, Zhao G, Mou Y, Yao M. Oligomer-Aβ42 suppress glioma progression via potentiating phagocytosis of microglia. CNS Neurosci Ther. 2024 Jan;30(1):e14495. doi: 10.1111/cns.14495. Epub 2023 Oct 17. PMID: 37849438; PMCID: PMC10805446.

    10. Zhong S, Ren JX, Yu ZP, Peng YD, Yu CW, Deng D, Xie Y, He ZQ, Duan H, Wu B, Li H, Yang WZ, Bai Y, Sai K, Chen YS, Guo CC, Li DP, Cheng Y, Zhang XH, Mou YG. Predicting glioblastoma molecular subtypes and prognosis with a multimodal model integrating convolutional neural network, radiomics, and semantics. J Neurosurg. 2022 Dec 2;139(2):305-314. doi: 10.3171/2022.10.JNS22801. PMID: 36461822.


    Ke Sai
    Title Deputy Director and Associate Professor
    Profile
    Ke Sai, M.D., Ph. D. is Associated Professor in the Department of Neurosurgery/Neuro-oncology at Sun Yat-sen University Cancer Center, Guangzhou, China. Dr. Sai received his medical degree from Sun Yat-sen University School of Medicine. He completed a residency and fellowship in neurosurgical oncology at Sun Yat-sen University Cancer Center, Guangzhou. Dr. Sai trained as a post-doctor supervised by Professor Alfred Yung and Professor Howard Colman from 2007 – 2009 at MD Anderson Cancer Center, Houston, where he was a recipient of MD Anderson Cancer Center Trainee Excellence Award (2009). Dr. Sai’s clinical interests are in the use of multimodality intraoperative monitoring techniques for the resection of brain tumors. He is also a NSFC-funded translational researcher who has published extensively on targeted therapies for glioma stem cells. He is a board member of the Chinese Society of Neuro-oncology (CSNO) and serves as an executive editor of the Glioma, which is the official journal of CSNO. Dr. Sai has published more than 30 peer-reviewed articles and book chapters. 
    Email saike@sysucc.org.cn
    Phone
    Research Interest(s)

    Multimodality intraoperative monitoring techniques for the resection of brain tumors, and translational research on targeted therapy against malignant gliomas.
    Education

    2009 Ph.D. Sun Yat-sen University, Medical School, P.R.China. Clinical Oncology

    2004 M.S. Sun Yat-sen University, Medical School, P.R.China. Clinical Medicine

    2002 M.D. Sun Yat-sen University, Medical School, P.R.China. Clinical Medicine

    Postgraduate Training 

    5/2007-4/2009 Postdoctoral fellowship, Department of Neuro-Oncology, UT MD Anderson Cancer Center, TX, U.S.A.

    8/2004 The Australia and Asia Pacific Clinical Oncology Research Development Workshop. Sponsord by MOGA, AACR and ASCO

    7/2004-12/2006 Clinical Residency, Sun Yat-sen University Cancer Center, Guangzhou, P.R.China
    Publications

    1. Hu WM, Wang F, Xi SY, Zhang X, Lai JP, Wu HY, Liu LL, Sai K#, Zeng J#. Practice of the New Integrated Molecular Diagnostics in Gliomas: Experiences and New Findings in a Single Chinese Center. J Cancer. 2020.

    2. Ding Y, He C, Lu S, Wang X, Wang C, Wang L, Zhang J, Piao M, Chi G, Luo Y, Sai K#, Ge P#. MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis. Cancer Lett. 2019.

    3. Xi S*, Sai K*, Hu W, Wang F, Chen Y, Wang J, Zeng J, Chen Z. Clinical significance of the histological and molecular characteristics of ependymal tumors: a single institution case series from China. BMC Cancer. 2019.

    4. Sun S, Xue D, Chen Z, Ou-Yang Y, Zhang J, Mai J, Gu J, Lu W, Liu X, Liu W, Sheng L, Lu B, Lin Y, Xing F, Chen Z, Mou Y, Yan G, Zhu W, Sai K#. R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells. Cell Death Dis. 2019.

    5. Hu WM, Zhang J, Sun SX, Xi SY, Chen ZJ, Jiang XB, Lin FH, Chen ZH, Chen YS, Wang J, Yang QY, Guo CC, Mou YG, Chen ZP, Zeng J, Sai K#. Identification of P4HA1 as a prognostic biomarker for high-grade gliomas. Pathol Res Pract. 2017.

    6. Sai K, Zhong MG, Wang J, Chen YS, Mou YG, Ke C, Zhang XH, Yang QY, Lin FH, Guo CC, Chen ZH, Zeng J, Lv YC, Li X, Gao WC, Chen ZP. Safety evaluation of high-dose BCNU-loaded biodegradable implants in Chinese patients with recurrent malignant gliomas. J Neurol Sci. 2014.

    7. Sai K, Li WY, Chen YS, Wang J, Guan S, Yang QY, Guo CC, Mou YG, Li WP, Chen ZP. Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells. Am J Chin Med. 2014.

    8. Sai K, Mou YG, Zeng J, Lv YC, Xi SY, Guan S, Zhang XH, Wang J, Ke C, Guo JG, Chen YS, Chen ZP. Neurosurgical interventions for patients with nasopharyngeal carcinoma: a single institution experience. World J Surg Oncol. 2013.

    9. Sai K, Yang QY, Shen D, Chen ZP. Chemotherapy for gliomas in mainland China: An overview. Oncol Lett. 2013.

    10. Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S, Chen Z, Alfred Yung WK, Priebe W, Colman H. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J Neurooncol. 2012.



    Updated November  2021 by International Office, Sun Yat-sen University Cancer Center
    Chen Zhong-ping
    Title Professor and Founder Chairman of the Department of Neurosurgery/Neuro-oncology
    Profile

    Dr. Chen is a Professor and Founder Chairman in the Department of Neurosurgery/Neuro-oncology of Sun Yat-sen University Cancer Center. Dr. Chen is Founder president of Chinese Society of Neuro-Oncology(CSNO). Dr. Chen’s clinical interests include microsurgery and multimodality treatment for primary and metastatic tumors in central nervous system, particularly gliomas. Chemotherapy and immunotherapy are important adjuvant treatments in his clinical practice. 

    Dr. Chen has received many awards including Francis McNaughton Memorial Prize in 1998(Canadian Neurological Society), WHO Prize for Chinese Young Professional in Mental Health & Neuroscience in 1993, and Wang Chong-cheng Academic Award for Chinese Neurosurgeon in 2006.

    More than 100 peer-reviewed papers have been published in leading scientific journals including Cancer Research, Clinical Cancer Research, Journal of National Cancer Institute, Neurosurgery, Journal of Neurosurgery, Journal of Neuro-oncology, and Neuro-oncology. 
    Email chenzhp@sysucc.org.cn
    Phone
    Research Interest(s)

    Dr. Chen’s research interests including: Genetic alterations leading to resistance of human brain tumors to chemotherapy, and has found that ERCC2, one of the important components in nucleotide excision repair (NER) system related to alkylating agent resistance in human tumor cell lines. MGMT associated drug resistance in glioma has also been investigated and applied in his clinical practice. He also, for the first time, has found that vasculogenic mimicry (VM), a new circulation exists in malignant gliomas. And, immunotherapy for glioma, such as CIK cell local therapy and DC-glioma fusion cells (FC), is also his investigating field. Last 20 years, Dr. Chen has also participated more than 20 clinical trials for glioma treatment as PI, Co-PI or investigator.

    For information on Professor Chen's laboratory, click here and select: Brain cancer genetic resistance/drug resistance in glioma/vasculogenic mimicry (VM) in glioma
    Education

    MD (1982) Suzhou Medical College, Suzhou, China.


    Ph.D. (1993) Suzhou Medical College, China

    1982 –1987 Residency training for Neurosurgery, Suzhou Medical College, China.

    1993-1999 Postdoctoral research fellow/research Associate, Neurosurgery/Oncology, McGill University, Montreal, Canada.
    Publications

    Selected Publications

    1. Shaoyan Xi, haiping cai, Jiabin Lu, Yu Zhang, yanjiao Yu, Furong Chen, Qitao Huang, and Fang Wang, Zhongping Chen. The pseudogene PRELID1P6 promotes glioma progression via the hnHNPH1-Akt/mTOR axis. Oncogene, published on line:09 June 2021. 

    2. Xin Mei, Yin-Sheng Chen, Qing-Ping Zhang, Fu-Rong Chen, Shao-Yan Xi, Ya-Kang Long, Ji Zhang, Hai-Ping Cai, Chao Ke, Jing Wang, Zhong-Ping Chen. Association between glioblastoma cell-derived vessels and poor prognosis of the patients. Cancer Communications. 2020;40:211–221.

    3. Xiang-Rong Ni, Yi-Ying Zhao, Hai-Ping Cai, Zhi-Hui Yu, Jing Wang, Fu-Rong Chen, Yan-Jiao Yu, Guo-Kai Feng, Zhong-Ping Chen. Transferrin Receptor 1 Targeted Optical Imaging for Identifying Glioma Margin in Mouse Models. J Neurooncol. 2020，148：245–258.

    4. Haiping Cai， Yanjiao Yu，Xiangrong Ni, Cong Li，Yuanjun Hu, Jing Wang, Furong Chen, Shaoyan Xi and Zhongping Chen. LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis. Cell Death and Disease (2020) 11:1032.

    5. Hai-ping Cai, Jing Wang, Shao-yan Xi, Xiang-rong Ni, Yin-sheng Chen, Yan-jiao Yu, Zi-wen Cen, Zhi-hui Yu, Fu-rong Chen, Cheng-cheng Guo, Ji Zhang, Chao Ke, Jian Wang and Zhong-ping Chen. Tenascin-cmediated vasculogenic mimicry formation via regulation of MMP2/MMP9 in glioma. Cell Death Dis. 2019 Dec; 10(12): 879.IF5.959

    6. Mei X, Chen YS, Chen FR, Xi SY, Chen ZP. Glioblastoma stem cell differentiation into endothelial cells evidenced through live cell imaging Running title: Live cell imaging of GSCs CD34 expression. Neuro Oncol. 2017 Mar 8. doi: 10.1093/neuonc/nox016. [Epub ahead of print], Neuro Oncol. 2017 Aug 1;19(8):1109-1118

    7. Fu J, Yang QY, Sai K, Chen FR, Pang JC, Ng HK, Kwan AL, Chen ZP.TGM2 inhibition attenuates ID1 expression in CD44-high glioma-initiating cells. Neuro-oncology, 2013,15（10）：1353-1365

    8. Liu XM,Zhang QP,Mu YG,Zhang XH,Sai K,Pang JC,Ng HK,Chen ZP.Clinical significance of vasculogenic mimicry in human gliomas. J Neurooncol,2011,(105 ):173-179.

    9. Fu J,Shao CJ,Chen FR,NG HK,Chen ZP.Autophagy Induced by Valproic Acid is Associated with Oxidative Stress in Glioma Cell Lines.Neuro-oncology,2010,12(4):328-340.

    10. Chen HY,Shao CJ,Chen FR,Kwan AL,Chen ZP.Role of ERCC1 Promoter Hypermethylation in drug resistance to cisplatin in human gliomas. Int J Cancer,2010,126(8):1255-1259.

    11. Yue WY,Yu SH, Zhao SG,Chen ZP. Molecular markers relating to malignant progression in grade II astrocytoma. J Neurosurgery,2009,110(4):709-14.

    12. Shao CJ,Fu J,Shi HL,Mu YG,Chen ZP.Activities of DNA-PK and Ku86, but not Ku70, may predictsensitivity to cisplatin in human gliomas.J Neurooncol,2008,89(1):27-35.

    13. Chen HY,Shao CJ,Shi HL,Mu YG,Sai K,Chen ZP.Single nucleotide polymorphisms and expression of ERCC1 and ERCC2 vis-à-vis chemotherapy drug cytotoxicity in human gliomas.J Neuro-oncology,2007,82:257-262.

    14. Yue WY,Chen ZP.Does vasculogenic mimicry exist in astrocytoma? J Histochem Cytochem.2005, 53(8):997-1002.

    15. Chen ZP,Pan J,Huang Q,Sun ZF,Zhou LY,Wang AD.Antitumor efficacy of SarCNU in a Human Glioma Xenograft Model expressing both MGMT and Extraneuronal Monoamine Transporter.J Neuro-Oncology,2001,51:19-24.

    16. Chen ZP,Carter CA,Alley MC,Mohr G,Panasci LC.Both Extraneuronal Monoamine Transporter and O6-methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of SarCNU in Human Tumor Xenografts.J Pharmacol Exp Ther,2001,296(3):712-715.

    17. Wang ZM,Chen ZP,Xu ZY,Christodoulopoulos G,Bello V,Mohr G,Aloyz R,Panasci LC.In vitro evidence for homologous recombinational repair in resistance to melphalan.J Natl Cancer Inst,2001,93(19):1473-1478.

    18. Chen ZP,Wang G,Huang Q,Sun ZF,Zhou LY,Wang AD,Panasci LC.Enhanced antitumor activity of SarCNU in comparison to BCNU in an extraneuronal monoamine transporter positive human glioma xenograft model. J Neuro-Oncology,1999,44:7-14.

    19. Chen ZP,Remack J,Brent TP,Mohr G,Panasci LC.Extraneuronal Monoamine Transporter Expression vis-à-vis SauCNU Cytotoxicity in Human Tumor Cell Lines.Clinical Cancer Research, 1999,5:4186-4190.

    20. Chen ZP,McQuillan A,Mohr G,Panasci LC.Excision repair cross-complementing rodent repair dificiency gene2 expression and chloroethylnitrosourea  resistance in human glioma cell lines. Neurosurgery,1998,42(5)1112-1119.

    21. Chen ZP,Malapetsa A,McQuillan A,Marcantonia D,Bello V,Mohr G,Remack J,Brent TP,Panasci LC.Evidence for nucleotide excision repair as a modifying factor of MGMT mediated innate chloroethylnitrosourea resistance in human tumor cell lines. Molecular Pharmacology,1997,52: 815-820. 

    22. Chen ZP,Malapetsa A,Marcantonio D,Mohr G,Brien S,Panasci LC.Correlation of chloroethylnitrosourea resistance with ERCC-2 expression in human tumor cell lines as determined by quantitative competitive polymerase chain reaction. Cancer Research ,1996,56: 2475-2478.

    23. Chen ZP,Malapetsa A,Brien S,Mohr G,Panasci LC.Quantitation of ERCC-2 expression by reverse-transcription polymerase chain reaction comparison to Northern blot analysis. Anal Biochem,1997,244: 50-54.






    Updated November 2021 by International Office, Sun Yat-sen University Cancer Center
    Wang Jian
    Title Associate chief physician
    Profile
    Prof. Wang Jian graduated from Guangzhou Medical University in 1993 and after that worked in the Department of Neurosurgery at the Second Affiliated Hospital of Guangzhou Medical University. He has accumulated rich clinical experience in the diagnosis and treatment of diseases such as nervous system tumors, brain trauma and cerebrovascular disease. He was a student of Liu Yunsheng, a famous Chinese expert in neurosurgery and Professor of Xiangya School of Medicine, Central South University, and was awarded a master's degree and a doctoral degree in neurosurgery in 1997 and 2003 respectively. He had been engaged in postdoctoral research in the Department of Neurosurgery at the University of Florida and conducted sphenoid sinus and temporal bone microdissection studies at Rhoton microdissection laboratory from August 2007 to September 2009.

    Currently he serves as the Associate Chief Physician of the Department of Neurosurgery at Sun Yat-sen University Cancer Center and is engaged in clinical work and scientific research. He has carried out in-depth studies on the diagnosis and microsurgery treatment of skull base tumor and pediatric neural tumor. He is also a youth member of the Chinese Society of Neuro-oncology, Chinese Anti-cancer Association, a member of the Society of Pediatric Oncology, Guangdong Anti-cancer Association, and Editorial Board Member of the Chinese Journal of Neuro-oncology.

    He has published over 20 papers on professional journals in and outside China and participated in the compilation and translation of three books on neurosurgery, namely Practical Microsurgery of Skull Base, Endoscopic Skull Base and Brain Surgery: Tips and Pearls, and Rhoton Cranial Microanatomy and Surgical Approaches. He was awarded the First Class of Scientific and Technological Progress Award at provincial level.
    Email
    Phone
    Research Interest(s)
    Education
    Publications

    Updated by International Office, Sun Yat-sen University Cancer Center
    Yang Qunying
    Title Associate chief physician and specialist in neuro-oncology chemotherapy
    Profile
    Prof. Yang is a specialist in neurosurgery and neuro-oncology chemotherapy as well as a member in the glioma single disease expert group at Sun Yat-sen University Cancer Center. In 2012, she studied clinical neuro-oncology at the University of Texas MD Anderson Cancer Center which ranks first in tumor combination therapy in America. In 2013, she served as a visiting scholar at the Neurosurgery and Brain Tumor Center of Prince of Wales Hospital, the Chinese University of Hong Kong and was engaged in the clinical work on neuro-oncology. She has been engaged in clinical chemotherapy and combination therapy of various malignant tumors for over ten years. Through diagnosis and treatment on quite a number of brain metastasis and primary brain tumor patients, she has carried out a series of studies and exploration on nervous system tumors. She is one of the first batch of specialists in neuro-oncology chemotherapy in China. She has rich experience in chemotherapy of primary central nervous system tumor, brain metastasis and children and teenager malignant tumors. She is skilled in chemotherapy and individualized combination therapy for brain glioma, brain germ cell tumor, medulloblastoma, primitive neuroectodermal tumor, neuroblastoma, primary central nervous system lymphoma, malignant meningioma, ependymoma and brain metastasis, etc. She has been in charge of holding six "National Neuro-oncology Chemotherapy and Molecularly Targeted Drug Therapy Study Group" (national level continuing medical education program) since 2007.
     
    She has participated in a number of multi-centric clinical trials of anti-tumor new drug (cytotoxic drug and molecularly targeted therapy drug) in and outside China. She has received a number of scientific research funds from National Natural Science Foundation of China, project of Development Center for Medical Science and Technology, Ministry of Health, P.R.China, project of Guangdong Provincial Department of Science and Technology, scientific research project of Health Department of Guangdong Province, project funded by Guangdong Provincial Association for Science and Technology (fund for young and middle-aged scientists and technicians to go abroad to participate in international academic conferences), and fund for scientific research on single diseases of Sun Yat-sen University Cancer Center. She is the Chief Editor of Handbook of Nervous System Tumor Chemotherapy. She also participated in the compilation of books such as Nervous System Tumors, and Clinical Practice Guidelines for Central Nervous System Tumors. And she has published over 30 papers in SCI journals and Chinese core journals.
    Email
    Phone
    Research Interest(s)

    Chemotherapy, molecularly targeted therapy and combination therapy for nervous system tumors.
    Education
    Publications
    1. Fu J, Yang QY（共同第一作者）, Sai K, Chen FR, Pang JC, Ng HK, Kwan AL, Chen ZP. TGM2 inhibition attenuates ID1 expression in CD44-high glioma -initiating cells.Neuro Oncol, 2013,15（10）：1353-1365. （SCI-IF:6.18分)

    2. KE SAI,QUN-YING YANG,DONG SHEN,ZHONG-PING CHEN.Chemotherapy for gliomas in mainland China:An overview.ONCOLOGY LETTERS,2013,5:1448-1452.

    3. Jiang XB,Yang QY,Sai K,Zhang XH,Chen ZP,Mou YG.Brain metastases from colorectal carcinoma: a description of 60 cases in a single Chinese cancer center.Tumour Biol,2011,32(6):1249-1256.

    4. Chen LK,Liang Y,Yang QY, Xu F,Zhou NN,Xu GC,Liu GZ,Wei WD.Triplet platinum -based combination sequential chemotherapy improves survival outcome and quality of life of advanced non-small cell lung cancer patients. Asian Pac J Cancer Prev,2012;13(5):1863-1867.

    5. Zhang GH,Jiang XB,Zhang XH,Sai K,Yang QY,Chen ZP,Mou YG.Correlation between TGF-β1 expression and Treg cell infiltration in glioma.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi,2011,27(6):680-682.

    6. Mou YG, Sai K, Wang ZN, Zhang XH, Lu YC, Wei DN, Yang QY, Chen ZP. Surgical management of radiation-induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: Report of 14 cases.Head Neck,2011,33(10):1493-500.

    7. Zhen-ye Li, Xiang-heng zhang，Yu Chen，Jian-gui Guo，Ke Sai，Qun-ying Yang， Zhong-ping Chen，Yong-gao Mou, .Clinical significance of B7-H4 expression in matched non-small cell lung cancer brain metastases and primary tumors. OncoTargets and Therapy, 2013:6 869–875.( SCI-IF:2.073)




    Updated by International Office, Sun Yat-sen University Cancer Center
    Jiang Xiao-bing
    Title Professor
    Profile

    Dr Xiao-Bing Jiang is currently an Professor in the Department of Neurosurgical Oncology at Sun Yat-Sen University (SYSU) Cancer Center, Guangzhou, China. He graduated from Sun Yat-sen University with a doctor degree. He was admitted to Harvard Medical School and Massachusetts General Hospital twice as a visiting scholar. He is the member of CHINA PITUITARY ADENOMAS SPECIALIST COUNCIL, andGUANGDONG MEDICALN DOCTOR ASSOCIATION. In recent years, he published more than 20 papers in international professional journals including Molecular Cancer, Oncogene, Research, and J Clin Endocrinol Metab as the first author or corresponding author. He has presided over a number of research projects including national Natural Science Foundation of China and provincial Natural Science Foundation of China.

    Email jiangxiaob1@sysucc.org.cn
    Phone
    Research Interest(s)

    He specializes in performing trans-nasal endoscopic surgery to resect sellar tumors, including pituitary adenoma, craniopharyngioma, chordoma and osteochondroma. Research focus in application of artificial intelligence in diagnosis and treatment of pituitary tumor, relationship between epigenetic regulation and incidence of pituitary tumor. 

    Education 2001.09 - 2006.06 Southwest Medical University, Bachelor
    2006.09 - 2009.06 Sun Yat-sen University, Master
    2011.09 - 2014.06 Sun Yat-sen University, Ph.D
    2013.02 - 2014.02 Neurosurgery/Neuroendocrinology Laboratory, Massachusetts General Hospital, Ph.D
    Publications

    1. Yunzhi Zou, Xiaoqiong Bao, Depei Li, Zhen Ye, Rong Xiang, Yuanzhong Yang, Zhe Zhu, Ziming Chen, Lingxing Zeng, Chunling Xue, Hongzhe Zhao, Boyuan Yao, Qilin Zhang, Zeming Yan, Zekun Deng, Jintong Cheng, Guanghao Yue, Wanming Hu, Jixiang Zhao, Ruihong Bai, Zhenhua Zhang, Aiqun Liu, Jialiang Zhang, Zhixiang Zuo,Xiaobing Jiang. FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors. Mol Cancer,2024 Sep 20;23(1):205. doi: 10.1186/s12943-024-02117-5.

    2. Yunzhi Zou, Hao Duan, Zekun Deng, Rong Xiang, Jixiang Zhao, Zhenhua Zhang, Wanming Hu, Yuanzhong Yang, Zeming Yan, Shujuan Wen, Zexian Liu, Gao Zhang, Yonggao Mou, Depei Li,Xiaobing Jiang.Single-cell atlas profiling revealed cellular characteristics and dynamic changes after PD-1 blockade therapy of brain metastases from laryngeal squamous cell carcinoma.Mol Cell Biochem. 2024 Aug 1. doi: 10.1007/s11010-024-05064-3. 

    3. Weikang Chen,Xiaobing Jiang, Wei Liang, Haojie Bai, Mingze Xu, Zhe Liu, Lina Yi, Yanming Liu, Yanxia Huang, Yongxin Zhang, Lixia Xu, Baoshu Xie, Nu Zhang, Jun Yu, Jing Lu, Haipeng Xiao, and Xiaoxing Li.SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids. Research,2024; 13:7:0376. doi: 10.34133/research.0376. eCollection 2024.

    4. Jiayu Gu, Xiaoqun Chen, Xiaoman Cheng, Yunzhi Zou, Zekun Deng, Depei Li , Zhihuan Zhou,Xiaobing Jiang.Headache alleviation with nasal irrigation following endoscopic endonasal surgery for pituitary adenomas.BMC Endocr Disord.2024 Apr 15;24(1):45.

    5. Run Cui, Hao Duan, Wanming Hu, Chang Li , Sheng Zhong, Lun Liang, Siyu Chen, Hongrong Hu, Zhenqiang He, Zhenning Wang, Xiaoyu Guo, Zexin Chen, Cong Xu, Yu Zhu, Yinsheng Chen, Ke Sai, Qunying Yang, Chengcheng Guo, Yonggao Mou,Xiaobing Jiang.Establishment of human pituitary neuroendocrine tumor derived organoid and its pilot application for drug screening.J Clin Endocrinol Metab, 2024 Apr 24:dgae228. doi: 10.1210/ clinem/dgae228.

    6. Zhen-Ning Wang,Xiao-Bing Jiang, Jie Lu, Xiao-Yu Guo, Zhen-Qiang He, Hao Duan, Lun Liang, Run Cu, Hong-Rong Hu, Xiang-Heng Zhang, Sheng Zhong, Chang Li, Cheng-Wei Yu, Cheng-Cheng Guo, Yong-Gao Mou. Survival Benefit from Surgical Resection in Lung Cancer Patients with Brain Metastases: A Single-Center, Propensity-Matched Analysis Cohort Study. Ann Surg Oncol. 2022 Feb 18. doi: 10.1245/s10434-022-11365-y.

    7. Guanzhi Ding, Xiushun Zhao, Cai Peng , Li Li, Jing Guo, Deperi Li, Xiaobing Jiang. Anchor-Free Feature Aggregation Network for Instrument Detection in Endoscopic Surgery. IEEE Access, 2023 (11),29464-473. 

    8. Weiyu Zhang, Siyu Chen, Qiu Du, Piaopiao Bian, Yutong Chen, Zexian Liu, Jian Zheng, Ke Sai, Yonggao Mou, Zhongping Chen, Xiang Fan,Xiaobing Jiang. CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1. Oncogene, 2022 Mar;41(11):1550-1562. 

    9. Yunzhi Zou, Depei Li, Jiayu Gu, Siyu Chen, Xia Wen, Jiajun Dong,Xiaobing Jiang. The recurrence of prolactinoma after withdrawal of dopamine agonist: a systematic review and meta-analysis. BMC Endocr Disord, 2021 Nov 13;21(1):225. 

    10. Hongyu Li, Qi Zhao, Yihua Zhang, Ke Sai, Lunshan Xu, Yonggao Mou, Yubin Xie, Jian Ren,Xiaobing Jiang. Image-driven classification of functioning and nonfunctioning pituitary adenoma by deep convolutional neural networks. Computational and Structural Biotechnology Journal 19 (2021) 3077-3086. 

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