Our Experts

Name: Xia Yunfei
Title: Professor,Chief Physician
Email: xiayf@sysucc.org.cn

Professor Xia has practiced medicine for more than 30 years, mainly engaged in radiotherapy for nasopharyngeal carcinoma (NPC), glioma and lymphoma. With an emphasis on individualized treatment of nasopharyngeal carcinoma, Prof. Xia has proposed four radiotherapy-related types of NPC, including: Type I (no primary and regional recurrence and no distant metastasis), Ⅱ (primary or regional and no distant metastasis), Ⅲ (no primary and regional recurrence, and distant metastasis), Ⅳ (primary or regional recurrence, and distant metastasis). He has also developed a new clinical stage for NPC based on clinical biological behavior and efficacy, including: stage I: non-metastatic, namely lesion limited in nasopharynx, no regional lymph node metastasis, no distant metastasis, EBV-DNA:(-); stage II: tendency to metastasize, namely lesion not limited in nasopharynx, with regional lymph nodes metastasis, 0<EBV-DNA<1.0*105; stage III metastatic, namely distant metastasis, EBV-DNA≥1.0*105. On this basis, Prof. Xia has carried out a large number of basic and clinical research on the radiobiology of NPC, individualized treatment, and treatment of local-regional recurrence and distant metastatic refractory NPC. He has completed 1 National 863 Program, 1 Guangzhou Key Fund grant research and 5 National Natural Science Foundation of China (NSFC) grant researches, and is currently chairing 1 Guangzhou Key Fund grant research and 1 NSFC grant research. He has published more than 200 papers in both English and Chinese, and edited two monographs on nasopharyngeal carcinoma.


Radiation treatment for nasopharyngeal carcinoma, brain tumor and lymphoma.

For information on Professor Xia's laboratory, click here and select: Screening and validating tumor radiobiological markers and clinical prognostic indicators.

1991.9-1994.7 Master of Medicine in Radiation Oncology, Sun Yat-sen University of Medical Sciences.

1980.9-1985.7 Suzhou Medical College, Department of Radiation Medicine, Bachelor of Medicine.


1. The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis. Zi‑Lu Huang ,Shan Liu, Guan‑Nan Wang, Shuo‑Han Zheng, Shi‑Rong Ding, Ya‑lan Tao, Chen Chen, Song‑Ran Liu, Xin Yang, Hui Chang, Xiao‑Hui Wang and Yun‑Fei Xia. Cancer Cell Int 2019

2. O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area. Guan-Nan Wang, Shu Zhou, Chen Chen, Hui Chang, Yalan Tao, Shan Liu, Xiao-Hui Wang, Wen-Wen Zhang, Yang Liu,Song-Ran Liu, Shi-Rong Ding, Xin Yang, Zheng-Qian Ye, Yi-Feng Gao, Yun-Fei Xia. J Cancer  2019

3. Target delineation and dose prescription of adaptive replanning intensity-modulated radiotherapy for nasopharyngeal carcinoma. Xie D, Cheng W, Lv S, Zhong R, Wang L, Hu J, Wang M, Huang S, Su Y, Xia YF. Cancer Commun (Lond) 2019

4. Effectiveness and safety of different amifostine regimens: Preliminary results of a phase II multicenter randomized controlled trial. Chang H, Yi W, Wang X, Tao Y, Yang X, Chen C, Zhang W, Zhou S, Liu S, Li X, Ding S, Li J, Li G, Shao X, Liu Y, Song W, Xia Y. Chin J Cancer Res 2018

5. Surrogate endpoints shortening the therapeutic evaluation duration for different subgroups of patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy: A retrospective analysis of 830 patients stratified by the 8th edition of the UICC/AJCC staging system and plasma Epstein-Barr viral. Shu Zhou, Chen Chen, Song-ran Liu, Ya-lan Tao, Hui Chang, Xiao-hui Wang, Xin Yang, Wen-Wen Zhang, Shan Liu, Shi-rong Ding, Guan-nan Wang, Yun-fei Xia. J Cancer 2018

6. A Prognostic Score for Nasopharyngeal Carcinoma with Bone Metastasis: Development and Validation from Multicenter. Chen Chen, Jing-Bo Wu, Hao Jiang, Jin Gao, Jia-Xin Chen, Chang-Chuan Pan, Lu-Jun Shen, YuChen, Hui Chang, Ya-Lan Tao, Xiao-Hui Li, Pei-Hong Wu, Yun-Fei Xia. J Cancer 2018

7. RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma. Chen Qu, Yiying Zhao, Guokai Feng , Chen Chen ,Yalan Tao,  Shu Zhou,  Songran Liu , Hui Chang , Musheng Zeng, Yunfei Xia. Journal of Cellular & Molecular Medicine 2017

8. An inflammatory biomarker-based nomogram to predict prognosis of patients with nasopharyngeal carcinoma: an analysis of a prospective study. Xiaohui Li, Hui Chang, Bingqing Xu, Yalan Tao, Jin Gao, Chen Chen, Chen Qu, Shu Zhou, Songran Li, Xiaohui Wang, Wenwen Zhang, Xin Yang, Silang Zhou, Yunfei Xia. Cancer Med 2017

9. Vicious circle of acute radiation toxicities and weight loss predicts poor prognosis for nasopharyngeal carcinoma patients receiving intensity modulated radiotherapy. Guo Li, Xiong-ying Jiang, Bo Qiu, Lu-Jun Shen, Chen Chen, Yun-Fei Xia. J.Cancer 2017

10. New suggestion for clinical downstaging of nasopharyngeal carcinoma in the era of intensity-modulated radiotherapy.  Gao Jin, Chen chen, Tao Yalan, Wang Xiaohui, Chang Hui, Li Xiaohui ,Han Fei, Su Yong, Xia Yunfei. Chin J Radiat Oncol 2017.

11. Alcohol drinking as an unfavorable prognostic factor for male patients with nasopharyngeal carcinoma. Chen YP, Zhao BC, Chen C, Lei XX, Shen LJ, Chen G, Yan F, Wang GN, Chen H, Jiang YQ, Xia YF. Sci Rep 2016

12. Forty-six cases of nasopharyngeal carcinoma treated with 50Gy radiotherapy plus hematoporphyrin derivative: 20 years of follow-up and outcomes from the sun yat-sen university cancer center. Xu BQ, Tu ZW, Tao YL, Liu ZG, Li XH, Yi W, Jiang CB, Xia YF. Chinese journal of cancer 2016

13. Revalidation of a prognostic score model based on complete blood count for nasopharyngeal carcinoma through a prospective study. Xiaohui Li, Hui Chang, Yalan Tao, Xiaohui Wang, Jin Gao, Wenwen Zhang, Chen Chen, Yunfei Xia. Chin J Cancer Res 2016

14. CFTR is a potential marker for nasopharyngeal carcinoma prognosis and metastasis. Ziwei Tu, Chen Qu, Jie Ting Zhang, Xiaohua Jiang, Yunfei Xia, Hsiao Chang Chan. Oncotarget 2016

15. CT-diagnosed severe skull base bone destruction predicts distant bone metastasis in early N-stage nasopharyngeal carcinoma. Yi W, Liu ZG, Li X, Tang J, Jiang CB, Hu JY, Tu ZW, Wang H, Niu DL, Xia YF. Onco Targets and therapy 2016

16. Brcc3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro. Ziwei Tu, Bingqing Xu, Chen Qu, Yalan Tao, Chen Chen, Wenfeng Hua, Guokai Feng, Hui Chang, Zhigang Liu, Guo Li, Changbin Jiang, Wei Yi, Musheng Zeng and Yunfei Xia. Radiation Oncology 2015

17. Pretreatment platelet count improves the prognostic performance of the tnm staging system and aids in planning therapeutic regimens for nasopharyngeal carcinoma: A single-institutional study of 2,626 patients.Yu-Pei Chen, Bing-Cheng Zhao, Chen Chen, Lu-Jun Shen, Jin Gao, Zhuo-Yao Mai,Meng-Kun Chen, Gang Chen, Fang Yan, Su Liu and Yun-Fei Xia. Chinese journal of cancer 2015

18. Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients. YU‑PEI CHEN, CHEN CHEN, ZHUO‑YAO MAI, JIN GAO, LU-JUN SHEN, BING‑CHENG ZHAO,MENG-KUN CHEN, GANG CHEN, FANG YAN, TONG‑YI HUANG,and YUN‑FEI XIA. Oncol Lett 2015

19. Smoking is a poor prognostic factor for male nasopharyngeal carcinoma treated with radiotherapy. Chen Chen, Shen Lu-Jun, Li Bo-Fei, Gao Jin, Xia Yun-Fei. Radiotherapy and Oncology 2014

20. Influence of pretreatment ideal body weight percentile and albumin on prognosis of nasopharyngeal carcinoma: Long-term outcomes of 512 patients from a single institution. Li Guo, Gao Jin, Liu Zhi-Gang, Tao Ya-Lan, Xu Bing-Qing, Tu Zi-Wei, Zhang Xiu-Ping, Zeng Mu-Sheng, Xia Yun-Fei. Head Neck 2014

21. Haemoglobin,Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction of the TNMStaging System in Nasopharyngeal Carcinoma: Development and Validation in 3237 Patients from a Single Institution. Chang H, Gao J, Xu BQ, Guo SP, Lu RB, Li G, Huang SM, Han F, Liu ZG, Tao YL, Tu ZW, Chen C, Li XH, Xia YF. Clin Oncol 2013

22. High weight loss during radiation treatment changes the prognosis in under- rmal weight nasopharyngeal carcinoma patients for the worse: a retrospective analysis of 2433 cases. Shen LJ, Chen C, Li BF,Gao J, Xia YF. PLos One 2013

23. Increased platelet count is an indicator of metastasis in patients with nasopharyngeal carcinoma. Gao J, Zhang HY, Xia YF. Tumour Biology 2013

24. First-line combination of gemcitabine, oxaliplatin, and Lasparaginase (GELOX) followed by involvedfield radiation therapy for patients with stage IE/IIE extranodal natural killer/Tcell lymphoma. Wang Liang, Wang Zhi-hui, Chen Xiao-qin, Li Ya-jun, Wang Ke-feng, Xia Yun-fei, Xia Zhong-jun. Cancer, 2013

25. Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell lines in vitro. Shao Cui-jie, Wu Ming-wei, Chen Fu-rong, Li Cong, Xia Yun-fei, Chen Zhong-ping. Chinese Medical Journal 2012

26. Aurora-A is an efficient marker for predicting poor prognosis in human nasopharyngeal carcinoma with aggressive local invasion: 208 cases with a 10-year follow-up from a single institution. ZHI-GANG LIU, WEI YI, YA-LANG TAO, HSXIAO-CHANG CHAN, MU-SHENG ZENG, YUN-FEI XIA. Oncology Letters 2012

27. Comparative serumproteomic analysis involving liver organ-specific metastasis-associatedproteins of nasopharyngeal carcinoma. Changchuan Pan, Yalan Tao, Ni He, Ming Zhao, Wang Li, Zilin Huang, Jing Gao, Yunfei Xia, Peihong Wu. Experimental and Therapeutic Medicine 2012

28. Bmi-1 induces radioresistance in MCF-7 mammary carcinoma cells. Liu ZG, Liu L, Xu LH, Yi W, Tao YL, Tu ZW, Li MZ, Zeng MS, Xia YF. Oncology Reports 2012

29. Involvement of Difference in Decrease of HemoglobinLevel in Poor Prognosis ofInvolvement of Difference in Decrease of HemoglobinLevel in Poor Prognosis of Stage I and II Nasopharyngeal Carcinoma: Implicationin Outcome of Radiotherapy.  Gao J, Tao YL, Li G, Yi W, Xia YF. International Journal of Radiation Oncology, Biology, Physics 2012

30. Identifying FGA Peptides as Nasopharyngeal Carcinoma-Associated Biomarkers by Magnetic Beads. Tao YL, Li Y, Gao J, Liu ZG, Tu ZW, Li G, Xu BQ, Niu DL, Jiang CB, Yi W, Li ZQ, Li J, Wang YM, Cheng ZB, Liu QD, Bai L, Zhang C, Zhang JY, Zeng MS, Xia YF. Journal of Cellular Biochemistry 2012

31. Subdividing the M1 stage of liver metastasis for nasopharyngeal carcinoma to better predict metastatic survival. Pan C, He N, Zhao M, Gu Y, Huang Z, Li W, Xia Y, Wu P. Medical Oncology 2011

32. Preparation of anti-NYD-SP8 rabbit polyclonal antibody and its application in the analysis of NYD-SP8 expression in nasopharyngeal carcinoma cell lines and clinical tissues. Yang LL, Wu JB, Liu ZG, U L, Zeng MS, Yan SS, Chan HC, Xia YF. Tumori 2011

33. Prognosticsignificance and therapeutic implications of nasopharyngeal carcinoma. Cao JY, Liu L, Chen SP, Zhang X, Mi YJ, Liu ZG, Li MZ, Zhang H, Qian CN, Shao JY, Fu LW, Xia YF. Zeng MS. Molecular Cancer 2010

34. Relationship between Traditional Chinese Medicine Typing and Imaging Characteristic to Radiosenitivity of Nasopharyngeal Carcinoma. Hong Bao, Jing Gao, Tao Huang, ZI-Ming Zhou, Bei Zhang, Yun-Fei Xia. Chinese Journal of Cancer 2010

35. Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Cao JY, Liu L, Chen SP, Zhang X, Mi YJ, Liu ZG, Li MZ, Zhang H, Qian CN, Shao JY, Fu LW, Xia YF, Zeng MS. Molecular Cancer 2010

36. Continuous fall in hemoglobin level is a poor prognostic factor in patients with nasopharyngeal carcinoma treated with radiotherapy. Jin Gao, Jing-Ye Hu, Yun-Fei Xia, Wei Yi, Ya-Lan Tao, Guo Li. Chinese Journal of Cancer 2010

37. Influence of level-Ib lymphadenopathy on prognosis of nasopharyngeal carcinoma. Wei Yi, Xiao-Mao Liu, Yun-Fei Xia, Qing Liu, Jing-Tian, Li. Chinese Journal of Cancer 2010

38. Impact of pretherapy body mass index on prognosis of nasopharyngeal carcinoma. Jing-Ye Hu, Wei Yi, Yun-Fei Xia, Jin Gao, Zhi-Gang Liu, and Ya-Lan Tao. Chinese Journal of Cancer 2009

39. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L,Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li MF, Band V, Shi QH, Zeng YX, and Zeng MS. The Journal of Clinical Investigation 2009

40. Studies on Pentoxifylline and Tocopherol combination for Radiation-induced Heart Disease in Rats. Hui Liu, Mai Xiong, Yun-fei Xia, Die-Hua Yong. International Journal of Radiation Oncology Biology Physics 2009.

41. Relationship between Methylation Status of ERCC1 Promoter and Radio-sensitivity in Glioma Cell Lines. Zhi‐Gang Liu, Hua‐Yun Chen,  Jing‐Jian Cheng,  Zhong‐Ping Chen, Xiao‐Nan Li ,Yun‐fei Xia. Cell Biology International 2008

42. Mitochondrial DNA somatic mutations are frequent in nasopharyngeal carcinoma. Pang LJ, Shao JY, Liang XM, Xia YF, Zeng YX. Cancer Biology & Therapy 2008

43. Cell viscoelastic characterization using photoacoustic measuremen. Jianghua Li, Zhilie Tang, Yunfei Xia, Yanfei Luo, Guanghua Li. Journal of Applied Physics 2008

44. Yong Wu, Yun-Fei Xia, Wei-Han Hu. Quality of life of nasopharyngeal carcinoma survivors in Mainland China. Quality of life research 2007

45. DNA-dependent protein kinase activity and radiosensitivity of nasopharyngeal carcinoma cell lines CNE1/CNE2.Yu-Xiang He, Ping-Ping Zhong, Yun-Fei Xia. Acta Physiologica Sinica 2007

46. Radiotherapy -related typing in 842 patients in canton with nasopharyngeal carcinoma. Zhi-qiang Li, Qin Liu, Xiu-fang Liu, Yun-Fei Xia. International Journal of Radiation Oncology Biology Physics 2006

47. Bmi-1 Is a Novel Molecular Marker of Nasopharyngeal Carcinoma Progression and Immortalizes Primary Human Nasopharyngeal Epithelial Cells. Li-Bin Song, Yun-Fei Xia, Mu-Sheng Zeng. Cancer Research 2006

48. The effect of p21 antisense oligodeoxynucleotides on the radiosensitivity of nasopharyngeal carcinoma cells with normal p53 function.Xiu-fang Liu, Man-zhi Li, Yun-fei Xia. Cell Biology International 2006

49. Radiotherapy for pediatric brain stem glioma. Xia Yunfei. Guangdong Medical Journal 2005

50. Radiobiological characteristics of the nasopharyngeal carcinoma cell lines in different p53 function status.Liu Xiufang, Xia Yunfei, Li Manzhi, He Yuxiang, Zheng Meilian, Jiang Changbin. Chinese Journal of Radiation Oncology 2005

51. Comparison of Ku protein expression in the CNE1 and CNE2 nasopharyngeal carcinoma cell lines. He Yuxiang, Xia Yunfei, Liu Xiufang, et al. Chinese Journal of Radiation Oncology 2005

52. Value of survival fraction at two gray (SF2) in evaluating radiation effect on nasopharyngeal bioptic tumor tissue. Jiang Hao, Xia Yunfei, Liu Xiufang, Qian Jianyang, Liang Rongju. Chinese Journal of Radiological Medicine and Protection 2004

53. Practical Radiotherapy for Nasopharyngeal Carcinoma. Xia Yunfei, Qian Jianyang, Zhang Enpi.ed. Peking University Medical Press 2003

54. Advance on Radiotherapy for Metastatic Encephaloma. Xia Yunfei. Guangdong Medical Journal 2002

55. Cellular Radiobiological Characteristics of 14 Human Nasopharyngeal Carcinoma Cell Lines. Xia Yunfei, Li Mangzhi, Huang Bing, Chen Jianjin, Li zhiqiang, and Willian A. Brock. Radiotherapy and Oncology 2001

56. Radiation biology and dosimetry of modified moving strip technique. Xia Yunfei, Qian Jianyang, Zhen Zuoshen. Chinese Journal of Cancer 2000

Updated September 2020 by International Office, Sun Yat-sen University Cancer Center

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