Dr Xie is a Professor and Vice Director of the Department of Pathology, Sun Yat-Sen University Cancer Center. He is a Principle Investigator of the State Key laboratory of Oncology in South China, and the Vice Chairman of Young committee members in Cancer Metastasis Association of Chinese Anticancer Association. He is one of the Distinguished Young Scholars (National Nature Science Fund of China) and Outstanding Scholars in New Era (the Ministry of Education of China). Dr Xie’s research focuses on the genetic mechanisms and/or prediction biomarkers of cancer metastasis in several types of human carcinomas including colorectal, hepatoceullar, oesophageal and lung cancers. 

He has been granted by National Fund for Outstanding Young Scientists of China, the National Basic Research Program (973 Program) and the Nature Science Foundation of China. He has got over 130 papers been published in the peer-reviewed English journals, such as Lancet Oncol, Gut, Hepatology, Cancer Res, Oncogene, Clin Cancer Res, Ann Oncol and others.

Basic and translational studies on cancer metastasis and anticancer drugs.

For information on Professor Xie's laboratory, click here and select: Genetic mechanisms and/or prediction biomarkers of cancer metastasis.

 

Sept. 1986-July 1991 Bachelor Degree of Medicine, Central South University, Changshai, China

Sept. 1993-July19 96 Master Degree of Medicine, Sun Yat-Sen University, Guangzhou, China

Sept.20 00-July20 04 Ph.D., Clinical Oncology, The University of Hongkong, Hongkong, China

1. Zhang JX, Song W, Chen ZH, Wei JH, Liao YJ, Lei J, Hu M, Chen GZ, Liao B, Lu J, Zhao HW, Chen W, He YL, Wang HY, Xie D* , Luo JH*. Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. Lancet Oncol. 2013 ;14(13):1295-306. 

2. Qian D, Zhang B, He LR, Cai MY, Mai SJ, Liao YJ, Liu YH, Lin MC, Bian XW, Zeng YX, Huang JJ, Kung HF, Xie D*. The Telomere/Telomerase Binding Factor PinX1 is a New Target to Improve the Radiotherapy Effect of Esophageal Squamous Cell Carcinomas. J Pathol. 2013 ;229(5):765-74.

3. Xu C, Xie D (co-first author), Yu S, Yang X, He, Yang J, Ping Y, Wang B, Yang L, Xu S, Cui W, Wang Q, Fu W, Liu Q, Qian C, Cui Y, Rich JN, Kung HF, Zhang X*, Bian XW*. A novel complex of β-catenin/POU5F1/SOX2 is responsive and dependent on IGF-1R signaling for prediction of poor prognosis in lung adenocarcinoma. Cancer Res. 2013;73(10):3181-9.

4. Zhu W, Cai MY, Tong ZT, Dong SS, Mai SJ, Liao YJ, Bian XW, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D*. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through c-myc to induce epithelial-mesenchymal transition. Gut. 2012;61(4):562-75.

5. Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D*. The putative tumor suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut. 2012;61(2):278-89.

6. Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D*. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. 2012;31(5):583-94.

7. Zhang B, Qian D, Ma HH, Jin R, Yang PX, Cai MY, Liu YH, Liao YJ, Deng HX, Mai SH, Zhang H, Zeng YX, Lin MC, Kung HF*, Xie D*, Huang JJ*. Anthyracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitinization and degradation. Oncogene. 2012;31(1):1-12.

8. Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D*. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut. 2011;60(7):967-76.

9. He LR, Zhao HY, Li BK, Zhang LJ, Liu MZ, Kung HF, Guan XY, Bian XW, Zeng YX, Xie D*. Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients. Ann Oncol. 2010;21(8):1675-81. 

10. Rao ZY, Cai MY, Yang GF, He LR, Mai SJ, Hua WF, Liao YJ, Deng HX, Chen YC, Guan XY, Zeng YX, Kung HF, Xie D*. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-{beta}1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis. 2010;31(9):1576-83.

Updated by International Office, Sun Yat-sen University Cancer Center