Our Experts

Name: Qian Chao-Nan
Title: Professor
Email: qianchn@sysucc.org.cn

Dr. Chao-Nan Qian is the professor of Department of Nasopharyngeal Carcinoma, SYSUCC and president of Guangzhou Concord Cancer Center. Dr. Qian obtained his Bachelor in Medicine (equivalent to MD in the US) and PhD at Sun Yat-sen University of Medical Sciences, P. R. China in 1992 and 1999, respectively. His post doctoral training at University of Texas MD Anderson Cancer Center and Van Andel Research Institute in Michigan provided him with great opportunities to explore the fields of tumorigenesis, tumor angiogenesis, tumor metastasis, and drug resistance of tumor cells. He was appointed as Research Scientist at Van Andel Research Institute in 2004 and Deputy Director of the Laboratory of Translational Cancer Research at National Cancer Center Singapore in May 2007. He then rejoined the Department of Nasopharyngeal Carcinoma at Sun Yat-sen University Cancer Center (SYSUCC) as a Professor in June 2007, Assistant to The President of SYSUCC in January 2008, and Vice President of SYSUCC in November 2013. In 2019, Dr. Qian was appointed as President of Guangzhou Concord Cancer Center. Dr. Qian has published over 180 articles in reputable journals, and been supported by 1 state key grant and 4 general grants from the National Natural Science Foundation of China. He has been the associate/senior associate editor of Chinese Journal of Cancer / Cancer Communications since 2009.

His qualification as a principal investigator at SYSUCC is based on his extensive experience in the areas of cancer biology and clinical management of nasopharyngeal carcinoma (NPC), with specific interest in the mechanisms underlying cancer metastasis, carcinogenesis, and tumor angiogenesis. NPC has the highest metastatic rate among head and neck cancers. Metastasis is a predominant aggressive behavior causing most of the cancer-related death. Among several research interests of Dr. Qian, the molecular mechanisms of cancer metastasis have been focused and anti-metastasis new drugs development is ongoing.
For information on Professor Qian's laboratory, click here and select: Cellular and Molecular Mechanisms of Cancer Metastasis.

M.D. 1992, Medicine
Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China

Residency Training 1992-1994, Medicine
The First Affiliated Hospital and The Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China

Ph.D. 1999, Oncology
Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China

Post-Doctoral Training  2000, Oncology
University of Texas MD Anderson Cancer Center,  Houston, Texas, USA

Post-Doctoral Training 2000-2003, Oncology
Van Andel Research Institute, Grand Rapids, Michigan, USA


(Selected publications from over 180 papers)
1. Xu L, Hu H, Zheng LS, Wang MY, Mei Y, Peng LX, Qiang YY, Li CZ, Meng DF, Wang MD, Liu ZJ, Li XJ, Huang BJ, Qian CN. ETV4 is a theranostic target in clear cell renal cell carcinoma that promotes metastasis by activating the pro-metastatic gene FOSL1 in a PI3K-AKT dependent manner. Cancer Lett 2020; 482:74-89.

2. Yuan TZ, Zhan ZJ, Qian CN.  New frontiers in proton therapy: applications in cancers.  Cancer Commun (Lond) 2019; 39(1):61.

3. You R, Liu YP, Lin DC, Li Q, Yu T, Zou X, Lin M, Zhang XL, He GP, Yang Q, Zhang YN, Xie YL, Jiang R, Wu CY, Zhang C, Cui C, Wang JQ, Wang Y, Zhuang AH, Guo GF, Hua YJ, Sun R, Yun JP, Zuo ZX, Liu ZX, Zhu XF, Kang TB, Qian CN, Mai HQ, Sun Y, Zeng MS, Feng L, Zeng YX, Chen MY. Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma.  Cancer Res 2019; 79(23):5930-5943.

4. Yang Q, Cao SM, Guo L, Hua YJ, Huang PY, Zhang XL, Lin M, You R, Zou X, Liu YP, Xie YL, Wang ZQ, Mai HQ, Chen QY, Tang LQ, Mo HY, Cao KJ, Qian CN, Zhao C, Xiang YQ, Zhang XP, Lin ZX, Li WX, Liu Q, Li JB, Ling L, Guo X, Hong MH, Chen MY.  Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: long-term results of a phase III multicentre randomised controlled trial.  Eur J Cancer 2019; 119:87-96.

5. Liu YP, Li H, You R, Li JB, Liu XK, Yang AK, Guo X, Song M, Zhang Q, Guo ZM, Chen WK, Liu WW, Zou X, Hua YJ, Yang Q, Zhang YN, Sun R, Mo HY, Guo L, Lin AH, Mai HQ, Qian CN, Chen MY.  Surgery for isolated regional failure in nasopharyngeal carcinoma after radiation: Selective or comprehensive neck dissection.  Laryngoscope 2019; 129(2):387-395.

6. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z.  Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Mol Cell 2018;72(4):650-660.e8.

7. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell 2017; 66(5):684-697.

8. Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, Chen MY, Mai HQ, Guo L, Guo X, Shao JY, Huang BJ, Zhang W, Qian CN. SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. Cancer Res 2017; 77(2):579-589.

9. Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol 2016; 18(5):561-71.

10. Yang CF, Yang GD, Huang TJ, Li R, Chu QQ, Xu L, Wang MS, Cai MD, Zhong L, Wei HJ, Huang HB, Huang JL, Qian CN, Huang BJ. EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loop. Oncogene 2016; 35(26):3419-31.

11. Tang LQ, Li CF, Li J, Chen WH, Chen QY, Yuan LX, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Zhang L, Guo SS, Liu LT, Guo L, Wu YS, Luo DH, Huang PY, Mo HY, Xiang YQ, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Cao KJ, Qian CN, Guo X, Zeng YX, Mai HQ, Zeng MS. Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma. J Natl Cancer Inst 2015; 108(1).

12. Qian CN. Hijacking the vasculature in ccRCC-co-option, remodelling and angiogenesis. Nat Rev Urol 2013; 10(5):300-304.

13. Li J, Mo HY, Xiong G, Zhang L, He J, Huang ZF, Liu ZW, Chen QY, Du ZM, Zheng LM, Qian CN, Zeng YX. Tumor microenvironment MIF directs the accumulation of IL-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. J Biol Chem 2012; 287(42): 35484-95.

14. Li XJ, Peng LX, Shao JY, Lu WH,Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, Zeng MS, Kang TB, ZengYX, Teh BT, Qian CN*. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis 2012; 33(7):1302-1309.

15. Chen QY, Wen YF, Guo L, Liu H,Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, HuaYJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ. Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: Phase III randomized trial. J Nat Cancer Inst 2011; 103(23):1761-1770.

16. Li GP, Wang H, Lai YK, Chen SC,Lin MC, Lu G, Zhang JF, He XG, Qian CN*, Kung HF*. Proteomic profiling between CNE-2 and its strongly metastaticsubclone S-18 and functional characterization of HSP27 in metastasis ofnasopharyngeal carcinoma. Proteomics 2011;11(14): 2911-20.

17. Wang HY, Sun BY, Zhu ZH, Chang ET, To KF, Hwang JS, Jiang H, Kam MK, Chen G, Cheah SL, Lee M, Liu ZW, Chen J, Zhang JX, Zhang HZ, He JH, Chen FL, Zhu XD, Huang MY, Liao DZ, Fu J, Shao Q, Cai MB, Du ZM, Yan LX, Hu CF, Ng HK, Wee JT, Qian CN, Liu Q, Ernberg I, Ye W, Adami HO, Chan AT, Zeng YX, Shao JY. Eight-signature classifier for prediction of nasopharnyngeal carcinoma survival. J Clin Oncol 2011; 29(34):4516-4525.

18. Li XJ, Ong CK, Cao Y, Xiang Y, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ,Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res 2011; 71(8): 3162-3172.

19. Qian CN, Furge K, Knol J, Huang D, Chen J, Dykema KJ, Kort EJ, Massie A, Khoo SK, VandenBeldt K, Resau JH, Anema J, Kahnoski RJ, Morreau H, Camparo P, Comperat E, Sibony M, Denoux Y, Molinie V, Vieillefond A, Eng C, Williams BO, Teh BT. Activation of thePI3K/AKT pathway induces transitional cell carcinoma of the renal pelvis: Identification in human tumors and confirmation in animal models. Cancer Res 2009;69(21): 8256-8264.

20. Qian CN, Berghuis B, Tsarfaty G, Bruch M, Kort EJ, Ditlev J, Tsarfaty I, Hudson E, Jackson DG, Petillo D, Chen J, Resau JH, Teh BT. Preparing the "soil": The primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res 2006;66(21):10365-10376.

Updated May 2020 by International Office, Sun Yat-sen University Cancer Center

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