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Name: Zhu Xiaofeng
Title: Director and Professor
Email: zhuxfeng@mail.sysu.edu.cn
Phone:
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Zhu Xiaofeng is the deputy director of the Experimental Research Department and a professor in the State Key Laboratory of Oncology in South China. He is also the Director of the Committee of Cancer pharmacology in Guangdong Pharmacological Society, a Standing member of the Committee of Cancer pharmacology in Chinese Pharmacological Society, aStanding member of the Committee of anticancer drug in Chinese association for cancer research, Editorial board member for Chinese Journal of Cancer; Editorial board member for Frontier in Pharmacology and an Advisory board member for Advances in Therapy. His main research interest is Signal transduction in cancer and targeted anticancer drugs.


He also is at the origin of 8 patents and products such as Shikonin derivatives and their antitumor effect or Houttuyninum compositions and methods for inhibiting the activity of erbB-2 based thereon and was awarded with numerous grants and honours, for example for Targeted therapy for cancer stem cells., 973 program, 4,500,000yuan RMB, from 2012 to 2016.

 

Interests

Signal transduction in cancer and targeted anticancer drugs

 

Patents and Products
1) Shikonin derivatives and their antitumor effect. ZL02114973.9
2) Houttuyninum compositions and methods for inhibiting the activity of erbB-2 based thereon. PCT/US01/43123。
3) Quinoline derivatives substituted by aliphatic amino groups, the preparation and the pharmaceutical use thereof. ZL200310112457.3;PCT/CN2004/000175.
4) HER2 tyrosine kinase inhibitors. 200410052496.3
5) A novel Chalconeomixe and its function. ZL200510101717.6
6)Preparation and antitumor effect of Hirsutanols A. Patent application number: 200910037541.0
7) 5-thiazole compounds and their biological function. Patent application number:2010102651155
8) Anonin injection for cancer therapy transfered to Sanjin Pharmaceutical Company for development.

For information on Professor Zhu's laboratory, click here and select: Signal transduction and targeted drugs in cancer, cancer stem cells and autophagy in nasopharyngeal carcinoma and ovarian cancer.
Education

2000,1----2000,9   Visiting scholar, Structure biology and anticancer drug discovery program, Georgetown University Lombardi Cancer Center
1997,9----2000,12  Ph.D. in Oncology, Cancer center, Sun Yat-sen University of Medical Sciences
1993,9----1996,7  Master Degree in Oncology, Cancer center, Sun Yat-sen University of Medical Sciences
1988,9----1993,7   M.D, Clinical medicine, Wannan Medical College

Publications

1. Ting Sun, Xuan Li, Peng Zhang, Wen-Dan Chen, Hai-Liang Zhang, Dan-Dan Li, Rong Deng, Xiao-Jun Qian, Lin Jiao, Jiao Ji, Yuan-Tian Li, Rui-Yan Wu, Yan Yu, Gong-Kan Feng, Xiao-Feng Zhu*. Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat Commun. 2015; 6: 7215.

2. Jing-Hong Chen, Peng Zhang, Wen-Dan Chen, Dan-Dan Li, Rong Deng, Xuan Li, Jiao Ji, Gong-Kan Feng, Yi-Xin Zeng, Jian-Wei Jiang*, Xiao-Feng Zhu*. ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to topotecan in cancer cells. Autophagy, 2015; 11(2): 239-52

3. Yun-Tian Li, Xiao-Jun Qian, Yan Yu, Zhen-Hua Li, Rui-Yan Wu, Jiao Ji, Lin Jiao, Xuan Li, Peng-Fei Kong, Wen-Dan Chen, Gong-Kan Feng, Rong Deng, Xiao-Feng Zhu*. EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy. Oncotarget. 2015 Apr 29. [Epub ahead of print]

4. Xiao-jun Qian, Yun-tian Li, Yan Yu, Yang Fen, Rong Deng, Jiao Ji, Lin Jiao, Xuan Li, Rui-Yan Wu, Wen-Dan Chen, Gong-Kan Feng, Xiao-Feng Zhu*. Inhibition of DNA Methyltransferase as a Novel Therapeutic Strategy to Overcome Acquired Resistance to Dual PI3K/mTOR Inhibitors. Oncotarget. 2015; 6(7): 5134-46

5. Juan Qin, Jiao Ji, Rong Deng, Jun Tang, Fen Yang, Gong-Kan Feng, Wen-Dan Chen, Xiao-Qi Wu, Xiao-Jun Qian, Shao-Hua Chang, Ke Ding, Xiao-Feng Zhu*. DC120, a novel AKT inhibitor, preferentially inhibits nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2 expression. Oncotarget. 2015; 6(9):6944-58

6. Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF*. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer. Cell Death Dis. 2014 Mar 13;5:e1114.

7. He JH, Liao XL, Wang W, Li DD, Chen WD, Deng R, Yang D, Han ZP, Jiang JW, Zhu XF*. Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy. Int J Oncol, 2014:45(3): 1099-108.

8. Yang F, Qian XJ, Qin W, Deng R, Wu XQ, Qin J, Feng GK, Zhu XF*. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal carcinoma.  PLoS One. 2013;8(3):e59879

9. Xiao-Yue Zhang, Xiao-Qi Wu, Rong Deng, Ting Sun, Gong-Kan Feng, Xiao-Feng Zhu*. Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells. Cell Signal. 2013 Jan;25(1):150-8

10. Rong Deng, Fen Yang, Shao-Hua Chang, Jun Tang, Juan Qin, Gong-Kan Feng, Ke Ding, Xiao-Feng Zhu*. DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth. Mol Pharmacol, 2012, 82(2):189-98

11. Jun Tang, Rong Deng, Rong-Zhen Luo, Guo-Ping Shen, Mo-Yan Cai, Zi-Ming Du, Shang Jiang, Ming-Tian Yang, Jian-Hua Fu, Xiao-Feng Zhu*. Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients. Breast Cancer Res Treat, 2012, 134(2):549-60

12. Dan-Dan Li, Ting Sun, Xiao-Qi Wu, Shu-Peng Chen, Rong Deng, Shan Jiang, Gong-Kan Feng, Jin-Xuan Pan, Xiao-shi Zhang, Yi-Xin Zeng, Xiao-Feng Zhu*. The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment. PLoS ONE*, 2012, 7(9): e45058. doi:10.1371/journal.pone.0045058

13. Rong Deng, Jun Tang, Jian-Guo Ma, Shu-Peng Chen, Liang-Ping Xia, Wen-Jun Zhou, Dan-Dan Li, Gong-Kan Feng, Yi-Xin Zeng, Xiao-Feng Zhu*. PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. Oncogene, 2011, 30: 944-55

14. Dan-Dan Li, Jin-Feng Guo, Jia-Jia Huang, Lin-Lin Wang, Rong Deng, Jian-Nan Liu, Gong-Kan Feng, Ding-Jun Xiao, Song-Zhi Deng, Xiao-Shi Zhang, Xiao-Feng Zhu*. Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells. PLos One, 2010, 5(8):e12176

15. Rong Deng, Jun Tang, Bin-Fen Xie, Gong-Kan Feng, Yue-Han Huang, Zong-Chao Liu, Xiao-Feng Zhu*. SYUNZ-16, a new synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway. Int J Cancer, 2010, 127(1):220-9

16. Wen-Jun Zhou, Rong Deng, Xiao-Yue Zhang, Gong-Kan Feng, Lian-Quan Gu, Xiao-Feng Zhu*. G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells. Mol Cancer Ther, 2009, 8:3203-3213

17. Dan-Dan Li, Lin-Lin Wang, Rong Deng, Jun Tang, Yang Shen, Jin-Feng Guo, Yao Wang, Liang-Ping Xia, Gong-Kan Feng, Quentin Q Liu, Wen-Lin Huang, Yi-Xin Zeng, Xiao-Feng Zhu*. The pivotal role of c-Jun-NH2-terminal kinase-mediated Beclin-1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene, 2009, 28, 886-898.

18. Rong Deng, Jun Tang, Liang-Ping Xia, Dan-Dan Li, Lin-Lin Wang, Gong-Kan Feng, Yi-Xin Zeng, Xiao-Feng Zhu*. ExcisaninA induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther, 2009, 8(4): 873-882.

19. Dan-Dan Li, Xiao-Qi Wu, Ju Tang, Xiao-Yi Wei, Xiao-Feng Zhu*. ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. Cancer Biology & Therapy, 2009; 8(8):739-43

20. Hu ZY, Zhu XF(co-first author), Zhong ZD, Sun J, Wang J, Yang D, Zeng YX. ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts. Int J Cancer, 2008, 123(10):2418-29

21. Yuan XW, Zhu XF*, Liang SG, Fan Q, Chen ZX, Huang XF, Sheng PY, He AS, Yang ZB, Deng R, Feng GK, Liao WM. Interferonalpha enhances etoposide-induced apoptosis in human osteosarcoma U2OS cells by a p53-dependent pathway. Life Sci, 2008, 82(7-8): 393-401

22. Guo JF, Zhou JM, Zhang Y, Deng R, Liu JN, Feng GK, Liu ZC, Xiao DJ, Deng SZ, Zhu XF*. Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Cell Biol Int. 2008, 32(1):48-54

23. Xiang-Wei Yuan, Xiao-Feng Zhu*, Wei-Ming Liao. p14ARF sensitizes human osteosar- coma cells to cisplatin-induced apoptosis in a p53-independent manner. Cancer Biology & Therapy, 2007, 6(7): 1074 -1080

24. Guan Z, Wang XR, Zhu XF (co-first author), Huang XF, Xu J, Wang LH, Wan XB, Long ZJ, Liu JN, Feng GK, Huang W, Zeng YX, Chen FJ, Liu Q. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res, 2007;67(21):10436-44

25. Xiang-Wei Yuan, Xiao-Feng Zhu*, Huang XF, Sheng PY, He AS, Yang ZB, Deng R, Feng GK, Liao WM. Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis1. Acta Pharmacol Sin, 2007, 28(11):1835-41.

26. Yu-Ping Mei, Jun-Min Zhou, Yi Wang, He Huang, Rong Deng, Gong-Kan Feng, Yi-Xin Zeng, Xiao-Feng Zhu*. Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cells. Cell Cycle, 2007, 6(11): 1379-1385.

27. Jian-nan Liu, Rong Deng, Jin-Feng Guo, Jun-Min Zhou, Gong-Kan Feng, Zhi-Shu Huang, Lian-Quan Gu, Yi-Xin Zeng, Xiao-Feng Zhu*.  Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells. Leukemia, 2007, 21(6), 1300-1302

28. Zhi-Yi Cheng, Wen-Jie Li, Feng He, Jun-Min Zhou and Xiao-Feng Zhu*. Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem, 2007, 15(3): 1533-1538

29. Rong Deng, Wenming Li, Zhong Guan, Jun-Min Zhou, Yi Wang, Yu-Ping Mei, Ming-Tao Li, Gong-Kan Feng, Wenlin Huang, Zong-Chao Liu, Yifan Han, Yi-Xin Zeng and Xiao-Feng Zhu*. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis.  Oncogene, 2006, 25(53):7070-7

30. Jun-Min Zhou, Xiao-Feng Zhu*, Yu-Jin Lu, Rong Deng, Zhi-Shu Huang, Yu-Ping Mei, Yi Wang, Wenlin Huang, Zong-Chao Liu, Lian-Quan Gu and Yin-Xin Zeng. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503-511

31. Xiao-Feng Zhu*, Jing-Song Wang, Li-Ling Cai, Yi-Xin Zeng and Dajun Yang. SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G phase in breast cancer cells. Cancer Science, 2006, 97(1): 84-89

32. Yu-Ping Mei, Xiao-Feng Zhu*, Jun-Min Zhou, He Huang, Rong Deng, Yi-Xin Zeng. siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression. Cancer Letters, 2006, 232, 189-198

33. Jin-Jun Zhu, Fu-Bo Li, Xiao-Feng Zhu*, Wei-Ming Liao. The p33(ING1b) tumor suppressor cooperates with p53 to induce apoptosis in response to etoposide in human osteosarcoma cells. Life Sciences, 2006, 78(13):1469-77

34. Xiao-Feng Zhu, Bin-Fen Xie, Jun-Min Zhou, Gong-Kan Feng, Zong-Chao Liu, Xiao-Yi Wei, Feng-Xian Zhang, Mei-Fang Liu and Yi-Xin Zeng. Blockade of VEGF receptor signal pathway and antitumor activity of ON-III, a component from Chinese herbal medicine. Mol Pharmacol, 2005, 67(5):1444-1450.

35. Jin-Jun Zhu, Fu-Bo Li, Jun-Min Zhou, Zong-Chao Liu, Xiao-Feng Zhu*, Wei-Ming Liao. The Tumor Suppressor p33(ING1b) Enhances Taxol-induced Apoptosis by p53-Dependent Pathway in Human Osteosarcoma U2OS Cells. Cancer Biol Ther, 2005, 4(1):39-47.

36. Zong-Wei Wang, Jun-Min Zhou, Zhi-Shu Huang, Ai-Ping Yang, Zong-Chao Liu, Yun-Fei Xia, Yi-Xin Zeng, Xiao-Feng Zhu*. Aloe polysaccharides mediated radioprotective effect through the inhibition of apoptosis. J Radiat Res, 2004, 45 (3): 447-454.

37. Xiao-Feng Zhu, Zong-Chao Liu, Bin-Fen Xie, Yi-Xin Zeng. Ceramide induces cell cycle arrest and upregulates p27kip in nasopharyngeal carcinoma cells. Cancer Letters, 2003, 193(2):149-155.

38. Xiao-Feng Zhu, Zong-Chao Liu, Bin-Fen Xie, Zhi-Min Li, Gong-Kan Feng, Hai-Hiu Xie, Shu-Jun Wu, Ren-Zhou Yang, Xiao-Yi Wei, Yi-Xin Zeng. Involvement of Caspase-3 Activation in Squamocin-induced Apoptosis in Leukemia Cell line HL-60. Life Sciences, 2002, 70(11):1259-1269.

39. Xiao-Feng Zhu, Zong-Chao Liu, Bin-Fen Xie, Zhi-Min Li, Gong-Kan Feng, Dajun Yang, Yi-Xin Zeng. EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cell line CNE2.  Cancer Letters, 2001, 169 (1): 27-32.

40. Xiao-Feng Zhu, Xiao-Shi Zhang, Zhi-Min Li, Yu-Qi Yao, Bin-Fen Xie, Zong-Chao Liu, Yi-Xin Zeng. Apoptosis induced by ceramide in hepatocellular carcinoma Bel7402 cells. Acta Pharmacol Sin, 2000, 21(3):225-8

41. Huang JJ, Li HR, Huang Y, Jiang WQ, Xu RH, Huang HQ, Lv Y, Xia ZJ, Zhu XF, Li ZM. Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy, 2010, 6: 777-83

42. Chen J, Hu CF, Hou JH, Shao Q, Yan LX, Zhu XF, Zeng YX, Shao JY. Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma. J Transl Med, 2010, 8: 30

43. Du ZM, Hu CF, Shao Q, Huang MY, Kou CW, Zhu XF, Zeng YX, Shao JY. Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients. Int J Cancer, 2009, 125(8):1832-41.

44. Hu ZY, Sun J, Zhu XF, Yang D, Zeng YX. ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway.  J Transl Med, 2009; 7:74.

45. Li JJ, Ding Y, Li DD, Peng RQ, Feng GK, Zeng YX, Zhu XF, Zhang XSThe overexpression of ERCC-1 is involved in the resistance of lung cancer cells to cetuximab combined with DDP. Cancer Biol Ther, 2009, 8: 1914-21

46. Jia HY, Wu JX, Zhu XF, Chen JM, Yang SP, Yan HJ, Tan L, Zeng YX, Huang W. ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leuk Res, 2009, 33(11):1512-9

47. Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, Zhu XF, Zhang XS. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy, 2009, 5(3):303-6

48. Li HL, Li S, Shao JY, Lin XB, Cao Y, Jiang WQ, Liu RY, Zhao P, Zhu XF, Zeng MS, Guan ZZ, Huang W. Pharmacokinetic and pharmacodynamic study of intratumoral injection of an adenovirus encoding endostatin in patients with advanced tumors. Gene Ther, 2008,15(4):247-56

49. Wan XB, Long ZJ, Yan M, Xu J, Xia LP, Liu L, Zhao Y, Huang XF, Wang XR, Zhu XF, Hong MH, Liu Q. Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis, 2008, 29(10):1930-7

50. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates. Hum Gene Ther, 2008,19(8):827-39

51. Wang LH, Yan M, Xu DZ, Cao JX, Zhu XF, Zeng YX, Liu Q. Requirement of aurora-A kinase in astral microtubule polymerization and spindle microtubule flux. Cell Cycle. 2008, 7(8):1104-11

52. Zhang NH, Song LB, Wu XJ, Li RP, Zeng MS, Zhu XF, Wan DS, Liu Q, Zeng YX, Zhang XS.Proteasome inhibitor MG-132 modifies coxsackie and adenovirus receptor expression in colon cancer cell line lovo. Cell Cycle, 2008, 7(7):925-33

53. Li ZM, Jiang WQ, Zhu ZY, Zhu XF, Zhou JM, Liu ZC, Yang DJ, Guan ZZ. Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells. Cancer Biol Ther, 2007, 8;7(1): 56-60

54. Xiao X, Wu J, Zhu X, Zhao P, Zhou J, Liu QQ, Zheng L, Zeng M, Liu R, Huang W. Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase. Int J Cancer, 2007, 121(9):2095-104.

55. Jiangxue Wu, Xia Xiao, Peng Zhao, Gang Xue, Yinghui Zhu, Xiaofeng Zhu, Limin Zheng, Yixin Zeng and Wenlin Huang. Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma. Clin Cancer Res, 2006, 12(15):4702-13.

56. Jin-Lin Zhou, Yu-Jing Lu, Tian-Miao Ou, Jun-Min Zhou, Zhi-Shu Huang, Xiao-Feng Zhu, Cui-Juan Du, Xian-Zhang Bu, Lin Ma, Lian-Quan Gu, Yue-Ming Li, and Albert Sun-Chi Chan. Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. J Med Chem, 2005, 48(23):7315-21.

57. Wenzhe Ma, Yicun Huang, LiDong Lin, Xiaofeng Zhu, Yizhu Chen, Hanhong Xu and Xiaoyi Wei. Two new biologically  active illudane  sesquiterpenes from the  mycelial  cultures of Panaeolus retirugis. J Antibiot, 2004, 57(11):721-5.

58. Ning-Ning Zhou, Xiao-Feng Zhu, Jun-Min Zhou, Zhi-Min Li, Xiao-Shi Zhang, Peng Huang, Wen-Qi Jiang. 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells. Acta Pharmacol Sin, 2004, 25(11):1515-20

59. Jun-Min Zhou, Xiao-Feng Zhu, Qi-Chao Pan, Duan-Fang Liao, Zhi-Min Li, Zong-Chao Liu. Manumycin inhibits cell proliferation and Ras signal transduction pathway in human heptocellular carcinoma cells. Int J Mol Med, 2003, 11(6):767:71

60. Jun-Min Zhou, Xiao-Feng Zhu, Qi-Chao Pan, Duan-Fang Liao, Zhi-Min Li, Zong-Chao Liu. Manumycin induced apoptosis in human heptocellular carcinoma cells. Int J Mol Med, 2003, 12(6):955-9.

61. Xiao-Shi Zhang, Xiao-Feng Zhu, Jin-Song Gao, Yan-li Ye, Qi-Sheng Feng, Zong-Chao Liu, Yi-Xin Zeng. Variable sensitivity of endothelial cells to epirubicin in xenografts of human nasopharyngeal carcinoma CNE2 cells. Cancer Biol Ther, 2002, 1(3): 263-265

62. Istvan J. Enyedy, Yan Ling, Kassoum Nacro, York Tomita, Xihan Wu, Yeyu Cao, Ribo Guo, Bihua Li, Xiaofeng Zhu, Ying Huang, Ya-Qiu Long, Peter P. Roller, Dajun Yang and Shaomeng Wang. Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem, 2001, 44(25):4313-24.

63. Terrence R. Burke Jr., Zhu-Jun Yao, Yang Gao, Jane X. Wu, Xiaofeng Zhu, Juliet H. Luo, Ribo Guo and Dajun Yang. N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding. Bioorg Med Chem, 2001, 9(6): 1439-1445

64. Xiao-Shi Zhang, Xiao-Feng Zhu, Jin-Song Gao, Chao-Nan Qian, Zhu-Ji Kuang, Zong-Chao Liu, Yi-Xin Zeng. Multiple drug resistance phenotype of human endothelial cells induced by vascular endothelial growth factor 165. Acta Pharmacol Sin, 2001, 22 (8): 731-736

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