Brain cancer genetic resistance/drug resistance in glioma/vasculogenic mimicry (VM) in glioma
Chen Zhong-ping's Laboratory

Summary
The laboratory of Neurosurgery/Neuro-oncology is one of the labs in Department of Experimental Research of Sun Yat-sen University Cancer Center (SYSUCC). The head of the lab is Dr. Zhong-ping Chen, who is also the chairman of Department of Neurosurgery/Neuro-oncology of SYSUCC. The lab’s directions are the following:
1) Genetic alterations leading to resistance of human brain tumors to chemotherapy, and has found that ERCC2, one of the important components in nucleotide excision repair (NER) system related to alkylating agent resistance in human tumor cell lines;

2) MGMT associated drug resistance in glioma has also been investigated and applied in his clinical practice;

3) Vasculogenic mimicry (VM) in glioma were first reported by us, which is anew circulation pattern exists in malignant gliomas.

As a successful surgeon, Dr. Chen also interests in microsurgery and multimodality treatment for primary and metastatic tumors in central nervous system, particularly gliomas. Dr Chen has been awarded Francis Mc Naughton Memorial Prize in 1998 (Canadian Neurological Society), WHO Prize for Chinese Young Professional in Mental Health & Neuroscience in 1993,and Wang Chong-cheng Academic Award for Chinese Neurosurgeon in 2006. More than200 papers have been published in leading scientific journals by our lab members,  including Cancer Research, Clinical Cancer Research, Journal of National Cancer Institute, Neurosurgery, Journal of Neurosurgery, Journal of Neuro-oncology, and Neuro-oncology.

Current Research
1. Study of molecular mechanisms of VEGF regulating the transition from vasculogenic mimicry to tumor-derived vessels in glioma

2. The study of molecular typing and biomarker in gioma in Chinese population

3. The anticancer effect of combination therapy with temozolomide and levetiracetam inglioma

4. The mechanism of the DLL4-Notch1 regulated vasculogenic mimicry transition inglioma

5. The prognostic biomarkers study in glioblastoma multiforme

6. The role of delta-PI3K in the metastasis process of glioblastoma multiforme

Contact Information
Zhong-ping Chen, M.D., Ph.D.
Professor & Chairman
Department of Neurosurgery/Neuro-oncology
Sun Yat-sen University Cancer Center

Address
Sun Yat-sen University Cancer Center, Building 2, Room 926
651 Dongfeng Road East, Guangzhou,Guangdong, China, 510060
Tel & Fax: 86-20-87343169
Email: Chenzhp@sysucc.org.cn