Prof. Lv is a Chief Physicianof the Nasopharyngeal Carcinoma Department, with a focus on personalized comprehensive treatment strategies fornasopharyngeal carcinoma. His research centred on optimizing treatment protocols, utilizing advanced technologies such as deep learning for prognostic prediction, and exploring novel therapeutic combinations to improve patient outcomes. Professor Lv has led and participated in numerous clinical trials and translational research projects, resulting in several high-impact publications in top-tier journals such as The Lancet Oncology, Journal of the National Cancer Institute, and Nature Communications.

Personalized Comprehensive Treatment for Nasopharyngeal Carcinoma

Ph.D.of Oncology, Sun Yat-sen University Cancer Center

1. Xing Lv#; Xun Cao#; Wei-Xiong Xia#; Kui-Yuan Liu; Meng-Yun Qiang; Ling Guo; Chao-Nan Qian; Ka-Jia Cao; Hao-Yuan Mo; Xian-Ming Li; Zi-Huang Li; Fei Han; Yu-Xiang He; Yu-Meng Liu; Shao-Xiong Wu; Yong-Rui Bai; Liang-Ru Ke; Wen-Ze Qiu; Hu Liang; Guo-Ying Liu; Jing-Jing Miao; Wang-Zhong Li; Shu-Hui Lv; Xi Chen; Chong Zhao*; Yan-Qun Xiang*; Xiang Guo*; Induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and 2 fluorouracil followed by chemoradiotherapy in patients with stage III-IVB 3 nasopharyngeal carcinoma: an open-label, non-inferiority, randomised phase 3 trial, Lancet Oncol. 2021 May;22(5):716-726；

2. Qiang, Mengyun#; Li, Chaofeng#; Sun, Yuyao#; Sun, Ying; Ke, Liangru;Xie, Chuanmiao; Zhang, Tao; Zou, Yujian; Qiu, Wenze; Li, Yingxue; Li, Xiang;  Liu, Kuiyuan;Chen, Qiuyan; Mai, Haiqiang;Xie,Guotong*; Guo, Xiang*; Lv, Xing*; A Prognostic Predictive System Based on Deep Learning for Locoregionally Advanced Nasopharyngeal Carcinoma, J Natl Cancer Inst. 2021 May 4;113(5):606-615.

3. Cao X, Huang HY, Liang CX, Lin ZC, Zhou JY, Chen X, Huang YY, Zhan ZJ, Ke LR, Han LJ, Xia WX, Tang LQ, Guo SS, Liang H, Guo X, Lv X*. Toripalimab plus capecitabine in the treatment of patients with residual nasopharyngeal carcinoma: a single-arm phase 2 trial. Nat Commun. 2024 Jan 31;15(1):949.

4. Chaofeng Li#, Bingzhong Jing#, Liangru Ke, Bin Li, Weixiong Xia, Caisheng He, Chaonan Qian, Chong Zhao, Haiqiang Mai, Mingyuan Chen, Kajia Cao, Haoyuan Mo, Ling Guo, Qiuyan Chen, Linquan Tang, Wenze Qiu, Yahui Yu, Hu Liang, Xinjun Huang, Guoying Liu, Wangzhong Li, Lin Wang, Rui Sun, Xiong Zou, Shanshan Guo, Peiyu Huang, Donghua Luo, Fang Qiu, Yishan Wu, Yijun Hua, Kuiyuan Liu, Shuhui Lv, Jingjing Miao, Yanqun Xiang, Ying Sun, Xiang Guo*, Xing Lv*; Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies; Cancer Commun (Lond). 2018 Sep 25;38(1):59. 

5. Wang-Zhong Li#; Xing Lv#; Dan Hu#; Shu-Hui Lv#; Guo-Ying Liu#; Hu Liang#; Yan-Fang Ye#;Wen Yang#; Han-Xiong Zhang#; Tai-Ze Yuan; De-ShenWang; Nian Lu; Liang-Ru Ke;Wu-Bing Tang; Li-Hua Tong; Zhi-Jie Chen; Ting Liu; Ka-Jia Cao; Hao-Yuan Mo; Ling Guo; Chong Zhao; Ming-Yuan Chen; Qiu-Yan Chen; Pei-Yu Huang; Rui Sun; Fang Qiu; Dong-Hua Luo; LinWang; Yi-Jun Hua; Lin-Quan Tang; Chao-Nan Qian; Hai-Qiang Mai*; Xiang Guo*; Yan-Qun Xiang*; Wei-Xiong Xia*, Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial. JAMA Oncol. 2022 May 1;8(5):706-714. 

6. Wei-Xiong Xia#; Xing Lv#; Hu Liang#; Guo-Ying Liu#; Rui Sun#; Qi Zeng; Si-Wei Li; Hao-Yuan Mo; Fei Han; Dong-Hua Luo; Qing Liu; Meng-Yun Shi; Yan-Fang Ye; Jing Yang; Liang-Ru Ke; Meng-Yun Qiang; Wen-Ze Qiu; Ya-Hui Yu; Kui-Yuan Liu; Xin-Jun Huang; Wang-Zhong Li; Shu-Hui Lv; Zhuo-Chen Cai; Jing-Jing Miao; Ling Guo; Ming-Yuan Chen; Ka-Jia Cao; Lin Wang; Chong Zhao; Pei-Yu Huang; Qiu-Yan Chen; Yi-Jun Hua; Lin-Quan Tang; Chao-Nan Qian; Hai-Qiang Mai; Xiang Guo; Yan-Qun Xiang；A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer. Clin Cancer Res. 2021 Aug 1;27(15):4186-4194.  

7. Qiu, Wen Ze#; Zhang, Hai Bo#; Xia, Wei Xiong; Ke, Liang Ru; Yang, Jing; Yu, Ya Hui; Liang, Hu; Huang, Xin Jun; Liu, Guo Ying; Li, Wang Zhong; Xiang, Yan Qun; Kang, Tie Bang*; Guo, Xiang*; Lv, Xing*; The CXCL5/CXCR2 axis contributes to the epithelial-mesenchymal transition of nasopharyngeal carcinoma cells by activating ERK/GSK-3beta/snail signalling, J Exp Clin Cancer Res, 2018,37(1):85. 

8. Cao X, Chen X, Lin ZC, Liang CX, Huang YY, Cai ZC, Li JP, Gao MY, Mai HQ, Li CF, Guo X, Lyu X*. Add-on individualizing prediction of nasopharyngeal carcinoma using deep-learning based on MRI: A multicentre, validation study. iScience. 2022 Aug 3;25(9):104841.

9. Zhan ZJ, Huang HY, Xiao YH, Zhao YP, Cao X, Cai ZC, Huang YY, Chen X, Deng Y, Zhou JY, Zhang LL, Luo ZY, Qiu WZ, Yuan TZ, Hu W, Fan YY, Mai HQ, Yang Y, Guo X, Lv X*. Anxiety and depression in nasopharyngeal carcinoma patients and network analysis to identify central symptoms: A cross-sectional study from a high-incidence area. Radiother Oncol. 2024 Aug;197:110324. doi: 10.1016/j.radonc.2024.110324. Epub 2024 May 10. PMID: 38735537.

10. Guo-Ying Liu#, Xing Lv# , Yi-Shan Wu  , Min-Jie Mao  , Yan-Fang Ye , Ya-Hui Yu  , Hu Liang  , Jing Yang, Liang-Ru Ke  , Wen-Ze Qiu  , Xin-Jun Huang  , Wang-Zhong Li  , Xiang Guo  , Yan-Qun Xiang*, Wei-Xiong Xia*；Effect of induction chemotherapy with cisplatin, fluorouracil, with or without taxane on locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis. Cancer Commun (Lond). 2018 May 10;38(1):21.