Lingling Shu is Associate professor of Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, She received M.D. from The University of Hong Kong at 2016 and finished postdoctoral training during 2017-2019. Her main focus on targeted therapy and immune therapy in Hematology Oncology. Dr.Shu published many papers in renowned journals such as Nature Communications, Advanced Science. 

Plasma cell myeloma, Lymphoma andAcute Myeloid Leukemia pathophysiology mechanism and novel targeted therapy.

PhD The University of Hong Kong   2012-2016

Bachelor  Southern Medical University 2007-2012

1. Zhongsheng You, Zihao Hu, Chongxian Hou, Chengcheng Ma, Xiangdong Xu 1, Yaofeng Zheng, Xinlin Sun, Yiquan Ke, Jianli Liang, Zijing Xie, Lingling Shu*, Yang Liu*. FABP4 facilitates epithelial-mesenchymal transition via elevating CD36 expression in glioma cells. Neoplasia 2024 Nov:57:101050. doi: 10.1016/j.neo.2024.101050. Epub 2024 Sep 6.

2. Xiaoping Wu, Laiyee Cheong, Lufengzi Yuan, Leigang Jin, Zixuan Zhang,Yang Xiao, Zhiguang Zhou, Aimin Xu ,Ruby Laichong Hoo*, Lingling Shu*. Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis. Adv Sci (Weinh). 2024 Jun 17:e2308461. doi: 10.1002/advs.202308461. Epub ahead of print. PMID: 38884133 . 

3. Zhangsheng Xiong, Xiangdong Xu, Yuxuan Zhang, Chengcheng Ma, Chongxian Hou, Zhongsheng You,Lingling Shu*,Yiquan Ke* ,Yang Liu*.IFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway. Cell Death Dis. 2024 Jan 13;15(1):45. doi: 10.1038/s41419-023-06416-5. PMID: 38218875; PMCID: PMC10787840. 

4. Hanying Huang; Yang Li; Ziang Zhu; Yang Liu; Weida Wang; Shuzhao Chen; Xiaoping Wu; Yun Wang; Yanzhou Chen; Huanxin Lin; Yang Liang; Lingling Shu*; A new autophagy-related nomogram and mechanism in multiple myeloma, Genes & Diseases, 2023.101120,ISSN 2352-3042,https://doi.org/10.1016/j.gendis.2023.101120.

5. Yang Li, Hanying Huang, Ziang Zhu, Shuzhao Chen, Yang Liang, Lingling Shu*. TSC22D3 as an immune-related prognostic biomarker for acute myeloid leukemia. iScience. 2023 Jul 22;26(8):107451. doi: 10.1016/j.isci.2023.107451.(中科院2区，IF=4.6, 共同通讯倒数第一）

6. Leigang Jin#; Leiluo Geng#; Lei Ying; Lingling Shu; Kelvin Ye; Ranyao Yang; Yan Liu; Yao Wang; Yin Cai; Xue Jiang; Qin Wang; Xingqun Yan; Boya Liao; Jie Liu; Fuyu Duan; Gary Sweeney; Connie Wai Hong Woo; Yu Wang; Zhenyuan Xia; Qizhou Lian; Aimin Xu ; FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity, Circulation, 2022, 2022(146): 1537-1557 .

7. Yang Liu; Xiangdong Xu; Yuxuan Zhang; Yunzhao Mo; Xinlin Sun*; Lingling Shu*; Yiquan Ke*. Paradoxical role of β8 integrin on angiogenesis and vasculogenic mimicry in glioblastoma. Cell Death Dis. 2022 Jun 8;13(6):536, 2022, 134(6).

8. Xiao Y#, Shu LL#, Wu XP, Liu Y, Cheong LY, Liao BY, Xiao XY, Hoo LC, Zhiguang Zhou GC, Xu A. (2021). Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages. JCI Insight, 2021(6(7).

9. Shu LL#, Zhong L#, Xiao Y, Wu XP, Liu Y, Jiang X, Tang T, Hoo LC, Zhou ZG, Xu A (2020). Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice. Clinical Science, 2020(134): 1679–1696.

10.  Shu L#, Hoo RL#*, Wu X, Pan Y, Lee IP, Cheong L, Bornstein SR, Rong X, Guo J, Xu A*. Adipocyte fatty acid binding protein mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.Nature communications 8.1 (2017): 1-16