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Name: Dongxin Lin
Title: Academician of the Chinese Academy of Engineering, Professor

Prof. Lin obtained his medical Master degree at Beijing Medical University in 1986 and received post-doc training on chemical carcinogenesis and molecular epidemiology at WHO International Agency for Cancer Research (Lyon, France) and FDA National Center for Toxicological Research (Arkansas, USA) from 1989 to 1994. He started to serve as associate professor from 1995 and full professor from 1997 in the Department of Etiology & Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College. He was elected as academician of the Chinese Academy of Engineering in 2013. Prof. Lin have been serving as joint Professor at Sun Yat-sen University Cancer Center since 2015. 

His has been working on cancer genetics and genomics, especially on esophageal cancer and pancreatic cancer with more than 260 publications in peer-reviewed journals including Nature, Nature Genetics, Gastroenterology, J Clin Invest, Nature communications, Cancer Research, etc. He has been honored with awards for his research work including the National Natural Science Award in 2006, the National Prize for Progress in Science and Technology in 2008, the National Natural Science Award in 2013, the National Prize for Progress in Science and Technology in 2013, etc.
Molecular mechanism of tumorigenesis and genetic susceptibility of cancer; gene-environment interaction in cancer; the effect of genomic alterations on cancer treatment.
1977-1980: Medical Student, Shanghai Medical University, Shanghai, China
1983-1986: Medical Graduate Student, Beijing Medical University, Beijing, China
1. Pan L, Huang X, Liu ZX, Ye Y, Li R, Zhang J, Wu G, Bai R, Zhuang L, Wei L, Li M, Zheng Y, Su J, Deng J, Deng S, Zeng L, Zhang S, Wu C, Che X, Wang C, Chen R, Lin D*, Zheng J*. Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression. J Clin Invest. 2021 Nov 15;131(22):e148130. 
2. Huang X, Pan L, Zuo Z, Li M, Zeng L, Li R, Ye Y, Zhang J, Wu G, Bai R, Zhuang L, Wei L, Zheng Y, Su J, Deng J, Deng S, Zhang S, Zhu S, Che X, Wang C, Wu C, Chen R, Lin D*, Zheng J*. LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling. Nat Commun. 2021 Jun 22;12(1):3830. 
3. Deng J, Zhang J, Ye Y, Liu K, Zeng L, Huang J, Pan L, Li M, Bai R, Zhuang L, Huang X, Wu G, Wei L, Zheng Y, Su J, Zhang S, Chen R, Lin D*, Zheng J*. N6-methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression. Cancer Res. 2021 Oct 15;81(20):5268-5283.
4. Ye Y, Feng W, Zhang J, Zhu K, Huang X, Pan L, Su J, Zheng Y, Li R, Deng S, Bai R, Zhuang L, Wei L, Deng J, Li M, Chen R, Lin D*, Zuo Z*, Zheng J*. Genome-wide identification and characterization of circular RNA m6A modification in pancreatic cancer. Genome Med. 2021 Nov 19;13(1):183.
5. Li R, Di L, Li J, Fan W, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*. A body map of somatic mutagenesis in morphologically normal human tissues. Nature. 2021 Sep;597(7876):398-403. 
6. Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, Pan L, Zheng Y, Su J, Ye Y, Fu Z, Zheng S, Zuo Z, Liu Z, Zhao Q, Che X, Xie D, Jia W, Zeng MS, Tan W, Chen R*, Xu RH*, Zheng J*, Lin D*. Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nat Commun. 2019 Apr 23;10(1):1858. 
7. Chang J, Zhong R, Tian J, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Zhu Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Wu T, Wu C*, Miao X*, Lin D. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018 Mar;50(3):338-343. 
8. Zheng J, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, Zhou Y, Miao X, Jiang G, Yu X, Yang X, Cao G, Zuo C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H, Wu C*, Lin D*. Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat Genet. 2016 Jul;48(7):747-57.

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