Yuanbin Song is Associate professor of Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, he received M.D. from Southern Medical University at 2012 and finished postdoctoral training at Section of Hematology/Department of Internal Medicine and Yale Cancer Center Yale University School of Medicine during 2013-2020. His main focus on Novel Humanized Mice Model for myelodysplastic syndromes and Acute Myeloid Leukemia pathophysiology mechanism, also interesting in targeted therapy in Hematology Oncology. Yuanbin published many papers in renowned journals such as Science, Nature Communications, Immunity.

Myelodysplastic syndromes and Acute Myeloid Leukemia pathophysiology mechanism and novel targeted therapy.

1. Yuanbin Song, Liang Shan, Rana Gbyli, Wei Liu, Till Strowig, Amisha Patel, Xiaoying Fu, Xiaman Wang, Mina Xu, Yimeng Gao, Ashley Qin, Emanuela M Bruscia, Toma Tebaldi, Giulia Biancon, Padmavathi Mamillapalli, David Urbonas, Elizabeth Eynon, David Gonzales, Jie Chen, Diane S. Krause, Jonathan Alderman, Stephanie Halene, Richard Flavell. Combined liver-cytokine humanization comes to the rescue of circulating human RBC. Science, 2021 Mar 5; 371(6533):1019-1025.

2. Yuanbin Song, Anthony Rongvaux, Ashley Taylor, Tingting Jiang, Toma Tebaldi, Kunthavai Balasubramanian, Arun Bagale, Yunus Terzi, Rana Gbyli, Xiaman Wang, Xiaoying Fu, Yimeng Gao, Jun Zhao, Nikolai A. Podoltsev, Mina Xu, Natalia Neparidze, Ellice Wong, Richard Torres, Emanuela M Bruscia, Yuval Kluger, Markus G Manz, Richard Flavell, Stephanie Halene. A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies. Nature Comm, 2019, 10 (1): 366. 

3. Yimeng Gao, Radovan Vasic, Yuanbin Song（Co first author）, Rhea Teng, Rana Gbyli, Giulia Biancon, Raman Nelakanti, Anastasia Ardasheva, Xiaoying Fu, Xiaman Wang, Burak Dura, Veronica Lee, Gabriella Viero, Rong Fan, Andrew Xiao, Richard A. Flavell, Hua-Bing Li, Toma Tebaldi, Stephanie Halene. Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Antiviral Innate Immune Response and Hematopoietic Failure. Immunity. 2020, Jun 16;52(6):1007-1021. 

4. Yuanbin Song, Rana Gbyli, Xiaoying Fu, Stephanie Halene. Functional Analysis of Human Hematopoietic Stem Cells In Vivo in Humanized Mice. Methods Mol Biol. 2020; 2097: 273-289. 

5. Liu, Haiyan, Ziping Li, Fei Qiu, Chunjie Li, Xiaojing Lin, Yingyi He, Maoxiang Qian, Yuanbin Song (Corresponding author), Hui Zhang. Association between Nr3c1 Mutations and Glucocorticoid Resistance in Children with Acute Lymphoblastic Leukemia. Frontiers in Pharmacology 2021, 12(562).

6. Rana Gbyli, Yuanbin Song（Co first author）, Stephanie Halene. Humanized mice as preclinical models for myeloid malignancies. Biochemical Pharmacology. 2020; Apr; 174:113794.

7. Saito Y, Ellegast JM, Rafiei A, Song Yuanbin, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG: Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice. Blood. 2016 Aug 19; 2016 Aug 19. PMID: 27543436

8. Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Yuanbin, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS: 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1. PMID: 28148839

9. Yang Liang, Toma Tebaldi, Kai Rejeski, Poorval Joshi, Giovanni Stefani, Ashley Taylor, Yuanbin Song, Radovan Vasic, Jamie Maziarz, Kunthavai Balasubramanian, Anastasia Ardasheva,1 Alicia Ding, Alessandro Quattrone, Stephanie Halene. SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Leukemia. 2018;32(12):2659-71.

10. Yongdeng Zhang, Lena Schroeder, Mark Lessard, Phylicia Kidd, Jeeyun Chung, Yuanbin Song, Lorena Benedetti, Yiming Li, Jonas Ries, Pietro DeCamilli, James Rothman, David Baddeley, Jonathan Grimm, Luke Lavis, Joerg Bewersdorf. Nanoscale subcellular architecture revealed by multicolor 3D salvaged fluorescence imaging. Nature Methods. 2020, Feb;17(2):225-231.

Updated November 2021 by International Office, Sun Yat-sen University Cancer Center