Dr. Ping Zhou is an associate professor in Sun Yat-sen University Cancer Center (SYSUCC). He obtained his Ph.D. degree in Huazhong Agricultural University in 2011. From 2012 to 2020, he worked as a postdoc in Feng Shao’s lab at the National Institute of Biological Sciences (NIBS), Beijing, China. During his postdoctoral research, Dr. Zhou focused on bacterial infection and host innate immune response and discovered that intracellular alpha-kinase 1 (ALPK1) functions as a novel pattern recognition receptor which senses bacterial metabolite ADP-heptose leading to inflammatory response.

The mechanism and transformation prospect of innate immune signaling pathway in pathogen infection and non-infectious diseases.

2012.03-2020.08 Postdoctoral fellow, National Institute of Biological Sciences (NIBS), Beijing, China

1. A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy. Yue Xu, Ping Zhou, Sen Cheng, Qiuhe Lu, Kathrin Nowak, Ann-Katrin Hopp, Lin Li, Xuyan Shi, Zhiwei Zhou, Wenqing Gao, Da Li, Huabin He, Xiaoyun Liu, Jingjin Ding, Michael O. Hottiger, Feng Shao*. Cell, 2019

2. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Ping Zhou#, Yang She#, Na Dong, Peng Li, Huabin He, Alessio Borio, Qingcui Wu, Shan Lu, Xiaojun Ding, Yong Cao, Yue Xu, Wenqing Gao, Mengqiu Dong, Jingjin Ding, Da-Cheng Wang, Alla Zamyatina, Feng Shao*. Nature, 2018 (#Equal contribution)

3. N(epsilon)-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. Wang Liu#, Yan Zhou#, Tao Peng#, Ping Zhou, Xiaojun Ding, Zilin Li, Haoyu Zhong, Yue Xu, She Chen, Howard C. Hang*, Feng Shao*. Nature Microbiology, 2018. (#Equal contribution)

4. A hybridization-chain-reaction-based method for amplifying immunosignals. Rui Lin, Qiru Feng, Peng Li, Ping Zhou, Ruiyu Wang, Zhe Liu, Zhiqiang Wang, Xiangbing Qi, Nan Tang, Feng Shao, Minmin Luo*. Nature Methods, 2018.

5. Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Peng Li, Wei Jiang, Qin Yu, Wang Liu, Ping Zhou, Jun Li, Junjie Xu, Bo Xu, Fengchao Wang, Feng Shao*. Nature, 2017.