Dr. Yu-chen Cai is an associate professor of oncology in the Experiment Research Department of Sun Yat-sen University Cancer Center (SYSUCC). She obtained her Ph.D. degree in oncology at Sun Yat-sen University in 2009. She has been a research assistant at Li Ka Shing Faculty of Medicine of the University of Hong Kong from 2012 to 2014. She has been a visiting associate professor at Karolinska Institutet from 2018 to 2019.  Dr Cai has published more than 30 peer-reviewed papers.

Biology and mechanism of the proliferation and metastasis in triple-negative breast cancer.

2005-2009
Ph.D. in Oncology, Sun Yat-sen University

1999-2002  
Master Degree in Oncology, Sun Yat-sen University

1995-1999
Bachelor Degree in Biology, Sun Yat-sen University

1. Yu-Chen Cai#, Hang Yang#, Ke-Feng Wang, Tan-Huan Chen, Wen-Qi Jiang*, Yan-Xia Shi*. ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer. BMC Cancer. 2020 Sep 14;20(1):878

2. Yang L#, Cai Y#, Zhang D, Sun J, Xu C, Zhao W, Jiang W*, Pan C*. miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer. J Breast Cancer. 2018 Dec;21(4):371-381

3. Wang D*, Lee MMS, Shan G, Kwok RTK, Lam JWY, Su H*, Cai Y*, Tang BZ*. Highly Efficient Photosensitizers with Far-Red/Near-Infrared Aggregation-Induced Emission for In Vitro and In Vivo Cancer Theranostics. Adv Mater. 2018 Sep;30(39): e1802105

4. Fengshou Wu#, Huifang Su#, Yuchen Cai#, Wai-Kwok Wong, Wenqi Jiang*, Xunjin Zhu*. Porphyrin-Implanted Carbon Nanodots for Photoacoustic Imaging and in Vivo Breast Cancer Ablation. ACS Applied Bio Materials. 2018, 1: 110-117

5. Yang H#, Cai YC#, Cao Y, Song M, An X, Xia Y, Wei J, Jiang WQ, Shi YX*. The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study. Cancer Communication. 2015, 34: 51.

6. Xia Q#, Cai YC#, Peng R,Wu G, Shi Y*, Jiang W*. The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition. Int J Oncol. 2014 Mar;44(3): 735-744

7. Cai YC#, Xia Q#, Su QG, Luo RZ, Sun YL, Shi YX*, Jiang WQ*. mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death in human nasopharyngeal carcinoma cells. Int J Mol Med. 2013 Apr; 31(4): 904-912.

8. Cai YC, Zou Y, Ye YL, Sun HY, Su QG, Wang ZX, Zeng ZL, Xian LJ*. Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium(M410). Invest New Drugs. 2011 Apr; 29(2): 300-311.

9. Wang KF#, Yang H#, Jiang WQ, Li S*, Cai YC*. Puquitinib mesylate (XC-302) induces autophagy via the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells. Int J Mol Med. 2015, 36: 1556-1562



Updated June 2022 by International Office, Sun Yat-sen University Cancer Center