Our Experts

Name: Zhao-Lei Zeng
Title: Associate Professor
Email: zengzhl@sysucc.org.cn

Dr. Zhao-lei Zeng is an Associate Professor of the Department of Experiment Research. She obtained her M.D. degree at Sun Yat-sen University of Medical Sciences in 2000 and Ph.D. degree in Oncology at Sun Yat-sen University in 2009. She had been a visiting associate professor at MD Anderson Cancer Center from 2014 to 2015. She was awarded as Tip-top Scientific and Technical Innovative Youth Talents of Guangdong special support program in 2016.  Dr. Zeng has published more than 70 peer-reviewed papers, including some papers in renowned journals such as Hepatology, Clinical Cancer Research, and Oncogene.


Dr. Zhao-lei Zeng is interested in the molecular mechanisms of individualized treatment for gastrointestinal (GI) cancer and the study of developing prognostic and predictive markers in patients with GI cancer.


Ph.D. in Oncology, Sun Yat-Sen University, China, 2005-2009.

Master Degree in Oncology, Sun Yat-Sen University, China, 2000-2003.

M.D. Sun Yat-Sen University of Medical Sciences, China, 1995-2000.


Selected publications

1. Yang DD#, Chen ZH#, Yu K#, Lu JH, Wu QN, Wang Y, Ju HQ, Xu RH, Liu ZX, Zeng ZL*. METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway. Front Oncol. 2020 Feb 26;10:115.

2. Yang DD, Chen ZH, Wang DS, Yu HE, Lu JH, Xu RH, Zeng ZL*. Prognostic value of the serum apolipoprotein B to apolipoprotein A-I ratio in metastatic colorectal cancer patients. J Cancer 2020 Jan 1;11(5):1063-1074.

3. Lu JH#, Zuo ZX#, Wang W#, Zhao Q, Qiu MZ, Luo HY, Chen ZH, Mo HY, Wang F, Yang DD, Wang Y, Wei XL, Wu QN, Ju HQ, Xu RH, Zeng ZL*. A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients. Cell Death Discov. 2018 Dec 18;4:116.

4. Wang YN#, Zeng ZL#, Lu J#, Wang Y, Liu ZX, He MM, Zhao Q, Wang ZX, Li T, Lu YX, Wu QN, Yu K, Wang F, Pu HY, Li B, Jia WH, Shi M, Xie D, Kang TB, Huang P, Ju HQ, Xu RH. CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis. Oncogene. 2018 Nov;37(46):6025-6040.

5. Chen DL#, Wang ZQ#, Zeng ZL#, Wu WJ, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Ren C, Wang FH, Chiao LJ, Pelicano H, Huang P, Li YH, Xu RH. Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. Hepatology. 2014 Aug; 60(2):598-609.

6. Zeng ZL#, Luo HY#, Yang J#, Wu WJ, Chen DL, Huang P, Xu RH. Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer. Clin Cancer Res. 2014 Feb 15;20(4):1042-52.

7. Chen DL#, Zeng ZL#, Yang J#, Ren C, Wang DS, Wu WJ, Xu RH. L1cam promotes tumor progression and metastasis and is an independent unfavorable prognostic factor in gastric cancer. J Hematol Oncol. 2013 Jun 27;6:43.

8. Wu WJ#, Zhang Y#, Zeng ZL#, Li XB, Hu KS, Luo HY, Yang J, Huang P, Xu RH. Beta-phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotype. Biochem Pharmacol. 2013 Feb 15;85(4):486-96.

9. Zeng ZL#, Wu WJ#, Yang J#, Tang ZJ, Chen DL, Qiu MZ, Luo HY, Wang ZQ, Jin Y, Wang DS, Xu RH. Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma. J Transl Med. 2012 Aug 31;10:181.

10. Zeng Z#, Lin H#, Zhao X#, Liu G, Wang X, Xu R, Chen K, Li J, Song L. Overexpression of GOLPH3 promotes proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor. Clin Cancer Res. 2012 Aug 1;18(15):4059-69.

Updated May 2020 by International Office, Sun Yat-sen University Cancer Center

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