Pathogenesis of Myeloid Malignancies; Immune Model and Immune Treatment for Hematological Cancer.

2011-2016: Yale University School of Medicine (Post-doctoral Training)

2004-2007: Shanghai Jiao-Tong University School of Medicine (PhD)

1993-1998: Tianjin Medical University (MBBS)

1. Huan Li, Chongxiang Chen, Fang Hu, Jiaojiao Wang, Qingyu Zhao, Robert Peter Gale, Yang Liang. Impact of corticosteroid therapy on outcomes of persons with SARS-CoV2, SARS-CoV or MERS-CoV infection: a systematic review and meta-analysis. Leukemia (2020 in Press)

2. Yang Liang, Toma Tebaldi, Kai Rejeski, Poorval Joshi, Giovanni Stefani, Ashley Taylor,  Yuanbin Song, Radovan Vasic, Jamie Maziarz, Kunthavai Balasubramanian, Anastasia Ardasheva, Alicia Ding, Alessandro Quattrone, Stephanie Halene. SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Leukemia 2018 Dec;32(12):2659-2671. doi: 10.1038/s41375-018-0152-7. Epub 2018 Jun 1.

3. Eunhee Kim, Janine O. Ilagan, Yang Liang, Gerrit M. Daubner, Stanley Lee, Aravind Ramakrishnan, Yue Li, Young Rock Chung, Jean-Baptiste Micol, Michele Murphy, Hana Cho, Min-Kyung Kim, Ahmad S. Zebari, Silvia Buonamic, Peter Smith, H. Joachim Deeg, Camille Lobry, Iannis Aifantis, Yorgo Modis, Frederic H.-T. Allain, Stephanie Halene, Robert K. Bradley, Omar Abdel-Wahab. SRSF2 mutations impair hematopoiesis and alter exon recognition. Cancer Cell 2015 May 11; 27(5):617-30. doi: 10.1016/j.ccell.2015.04.006.

4. Yang Liang, Lin-Hai Yang, Hui Jiang, Xiao-Jun Yuan, Li-Rong Sun, Jing-Yan Tang, Ning-Ling Wang. Treatment outcome of young age children with acute lymphoblastic leukemia: achievements and directions implied from Shanghai Children’s Medical Center based SCMC-ALL-2005 protocol. Br J Haematol 2015 Apr; 169(2):267-77. doi: 10.1111/bjh.13288.

5. Tao Zhen, Chuan-Feng Wu, Ping Liu, Hai-Yan Wu, Guang-Biao Zhou, Ying Lu, Jian-Xiang Liu, Yang Liang, Keqin Kathy Li, Yue-Ying Wang, Yin-Yin Xie, Miao-Miao He, Huang-Ming Cao, Wei-Na Zhang, Li-Min Chen, Kevin Petrie, Sai-Juan Chen, Zhu Chen. Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor–Like Protein. Sci Transl Med 2012 Mar 28;4(127):127ra38. doi: 10.1126/scitranslmed.3003562.

6. Yue-Ying Wang, Li-Juan Zhao, Chuan-Feng Wu, Ping Liu, Lin Shi, Yang Liang, Shu-Min Xiong, Jian-Qing Mia, Zhu Chen, Ruibao Ren, Sai-Juan Chen, C-KIT mutation cooperates with full length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci USA 2011 Feb 8; 108(6):2450-5. doi: 10.1073/pnas.1019625108.

7. Jiao, Chuan-Feng Wu, Yang Liang, Hai-Min Chen, Shu-Min Xiong, Bing Chen, Jing-Yi Shi, Yue-Ying Wang, Jing-Han Wang, Yu Chen, Jun-Min Li, Long-Jun Gu, Jing-Yan Tang, Zhi-Xiang Shen, Bai-Wei Gu, Wei-Li Zhao, Zhu Chen and Sai-Juan Chen. AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2. Leukemia 2009 Sep;23(9):1598-604. doi: 10.1038/leu.2009.104.

8. Lan Wang, Guang-Biao Zhou, Ping Liu, Jun-Hong Song, Yang Liang, Xiao-Jing Yan, Fang Xu, Bing-Shun Wang, Jian-Hua Mao, Zhi-Xiang Shen, Sai-Juan Chen, and Zhu Chen. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci USA 2008 Mar 25; 105(12):4826-31. doi: 10.1073/pnas.0712365105.

Updated May 2020 by International Office, Sun Yat-sen University Cancer Center