Dr. Shuai Chen is professor of Molecular Medicine in SYSUCC. Dr. Chen obtained his bachelor degree in biotechnology at Xiamen University in 2002 and Ph.D. degree in Genetics at Fudan University in 2007. From 2007 to 2011, Dr. Chen worked as a postdoc fellow at Masonic Cancer Center, University of Minnesota. Dr. Chen came back to China in 2011 and worked as associate professor at Institute of Microbiology, Chinese Academy of Sciences. Since April 2014, Dr. Chen was recruited to State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center.

1. Innate immune recognition of pathogens and cancer.

2. The regulation of innate immune signal pathways.

3. Innate immunotherapy of cancer and infectious diseases.

2007.12-2011.2   Postdoc fellow in Experimental Medicine
Masonic Cancer Center, University of Minnesota, USA

2002.9-2007.6 Ph.D. in Genetics
School of life sciences, Fudan University, Shanghai, China

1998.9-2002.6  Bachelor degree in Biotechnology
School of life sciences, Xiamen University, Xiamen, China

1) Sheng C#, Wang Z#, Yao C#, Chen HM, Kan G, Wang D, Chen H*, Chen S*. CALML6 Controls TAK1 Ubiquitination and Confers Protection Against Acute Inflammation. J Immunol. 2020 Apr 17;ji1901042.

2) Wang Z#, Sheng C#, Yao C#, Chen H, Wang D, Chen S*. The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Cell Rep. 2019 Jan 29;26(5):1273-1285.

3) Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, Huang H, Huang W, Chen S*. Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Nat Commun. 2018 Oct 22;9(1):4381.

4) Geng R, Tan X, Wu J, Pan Z, Yi M, Shi W, Liu R, Yao C, Wang G, Lin J, Qiu L, Huang W*, Chen S*. RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis. Cell Death Dis. 2017 Aug 10;8(8):e2994.

5) Geng R, Tan X, Zuo Z, Wu J, Pan Z, Shi W, Liu R, Yao C, Wang G, Lin J, Qiu L, Huang W*, Chen S*. Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells. Chin J Cancer. 2017 Jul 31;36(1):63.

6) Chen S, Sheng C, Liu D, Yao C, Gao S, Song L, Jiang W, Li J, Huang W*. Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses. J Immunol. 2013 Sep 1;191(5):2614-23.

7) Chen S, Bohrer L, Rai A, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H*. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat Cell Biol 2010 Nov; 12(11):1108-14. (selected by Faculty of 1000)