Prof. Huai-Qiang Ju is an Associate Professor of Department of Experiment Research. He was graduated from Sun Yat-sen University with Ph.D. degree in molecular medicine (2014), and recruited to Sun Yat-sen University Cancer Center as Associate Professor via the “One Hundred Talents Project of Sun Yat-sen University” (2017). Also, he was awarded as The Young Zhujiang Scholars from Ministry of Education of Guangdong (2018), and the Distinguished Young Scholar Professor of Guangdong province (2018). He mainly focus on investigation the mechanisms of tumor microenvironment remodeling in gastrointestinal cancer.

Investigate the molecular mechanisms of tumor microenvironment remodeling in gastrointestinal cancer, and develop novel diagnostic and therapeutic strategies for GI cancer.

2013/01-2014/12, Exchange student, MD Anderson Cancer Center, Houston, Texas; Advisor: Paul J. Chiao

2011/09-2013/01, Ph.D. of Molecular Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Advisor: Prof. Peng Huang

2008/09-2011/06, Master of Genetics, Jinan University, Guangzhou, China; Advisor: Prof. Yi-Fei Wang

2004/09-2008/06, Bachelor of Bioscience, Qingdao Agriculture University, Qingdao, China

1. Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming, J. Liu#, Z.X. Liu#, Q.N. Wu#, Y.X. Lu, C.W. Wong, L. Miao, Y. Wang, Z. Wang, Y. Jin, M.M. He, C. Ren, D.S. Wang, D.L. Chen, H.Y. Pu, L. Feng, B. Li, D. Xie, M.S. Zeng, P. Huang, A. Lin, D. Lin, R.H. Xu, H.Q. Ju*, Nat Commun 11(1) (2020) 1507.

2. Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers, Y. Wang#, J.H. Lu#, F. Wang#, Y.N. Wang, M.M. He, Q.N. Wu, Y.X. Lu, H.E. Yu, Z.H. Chen, Q. Zhao, J. Liu, Y.X. Chen, D.S. Wang, H. Sheng, Z.X. Liu, Z.L. Zeng, R.H. Xu, H.Q. Ju*, Cancer Lett 473 (2020) 74-89.

3. LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Y. Wang#, J.H. Lu#, Q.N Wu#, Y. Jing, D.S. Wang, Y.X Chen, J. Liu, X.J. Luo, Q. Meng, H.Y. Pu, Y.N. Wang, P.S. Hu, Z.X. Liu, Z.L. Zeng, Q. Zhao, R. Deng, X.F. Zhu, H.Q. Ju*, R.H. Xu*, Mol Cancer 18(1) (2019), 174

4. A circRNA signature predicts postoperative recurrence in stage II/III colon cancer, H.Q. Ju#, Q. Zhao#, F. Wang#, P. Lan, Z. Wang, Z.X. Zuo, Q.N. Wu, X.J. Fan, H.Y. Mo, L. Chen, T. Li, C. Ren, X.B. Wan, G. Chen, Y.H. Li, W.H. Jia, R.H. Xu*, EMBO Mol Med (2019) e10168.

5. METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma, T. Li#, P.S. Hu#, Z. Zuo#, J.F. Lin, X. Li, Q.N. Wu, Z.H. Chen, Z.L. Zeng, F. Wang, J. Zheng, D. Chen, B. Li, T.B. Kang, D. Xie, D. Lin, H.Q. Ju*, R.H. Xu*, Mol Cancer 18(1) (2019) 112.

6. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications, H.Q. Ju#, Y.X. Lu#, D.L. Chen#, Z.X. Zuo, Z.X. Liu, Q.N. Wu, H.Y. Mo, Z.X. Wang, D.S. Wang, H.Y. Pu, Z.L. Zeng, B. Li, D. Xie, P. Huang, M.C. Hung, P.J. Chiao, R.H. Xu*,J Natl Cancer Inst 111(6) (2019). 584-597

7. LncRNA CamK-A Regulates Ca(2+)-Signaling-Mediated Tumor Microenvironment Remodeling, L.J. Sang#, H.Q. Ju#, G.P. Liu, T. Tian, G.L. Ma, Y.X. Lu, Z.X. Liu, R.L. Pan, R.H. Li, H.L. Piao, J.R. Marks, L.J. Yang, Q. Yan, W. Wang, J. Shao, Y. Zhou, T. Zhou, A. Lin*, Mol Cell 72(1) (2018，Cover Article) 71-83 e7.

8. Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer, S. Li#, Z. Zhuang#, T. Wu#, J.C. Lin, Z.X. Liu, L.F. Zhou, T. Dai, L. Lu, H.Q. Ju*, Redox Biol 18 (2018) 246-255.

9. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma, H.Q. Ju, H. Ying, T. Tian, J. Ling, J. Fu, Y. Lu, M. Wu, L. Yang, A. Achreja, G. Chen, Z. Zhuang, H. Wang, D. Nagrath, J. Yao, M.C. Hung, R.A. DePinho, P. Huang, R.H. Xu, P.J. Chiao*, Nat Commun 8 (2017) 14437.

10. ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition, H.Q. Ju#, G. Zhan#, A. Huang, Y. Sun, S. Wen, J. Yang, W.H. Lu, R.H. Xu, J. Li, Y. Li, G. Garcia-Manero, P. Huang, Y. Hu*, Leukemia 31(10) (2017) 2143-2150.

Updated by International Office, Sun Yat-sen University Cancer Center