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Name: Shi-Juan Mai
Title: Associate Professor
Email: maishj@sysucc.org.cn

Dr. Shi-Juan Mai is an associate professor of Oncology in the Experimental Research Department of Sun Yat-sen University Cancer Center (SYSUCC). She obtained her Ph.D. degree at Sun Yat-sen University and then was recruited by SYSUCC as research assistant in 2001. She received her postdoctoral training in the Laboratoire de Virologie Moléculaire of Université Lyon-1 in France from 2005 to 2006. Dr. Mai has gained 4 research grants from National Natural Science Foundation of China and published more than 30 SCI research papers.


Study on the nonsense-mediated mRNA decay pathway in cancer.
Study on the prognostic value and biological function of non-coding RNAs in cancer.


1990-1995   Bachelor of Medicine, Henan medical university.

1995-1998   Master of medicine in Pathology, Sun Yat-sen University.

1998-2001   Doctor of medicine in Pathology, Sun Yat-sen University.

2005-2006   Postdoctoral fellow in Virology, Université Lyon-1.


1. Mai S, Xiao R, Shi L, Zhou X, Yang T, Zhang M, Weng N, Zhao X, Wang R, Liu J, Sun R, Qin H, Wang H. MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma. Cell Death Dis. 2019 Oct 28;10(11):819.

2. Wen W, Mai SJ, Lin HX, Zhang MY, Huang JL, Hua X, Lin C, Long ZQ, Lu ZJ, Sun XQ, Liu SL, Yang Q, Zhu Q, Wang HY, Guo L. Identification of two microRNA signatures in whole blood as novel biomarkers for diagnosis of nasopharyngeal carcinoma. J Transl Med. 2019 Jun 3;17(1):186.

3. Xiao RW, Shi L, Yang T, Zhang MY, Wang HY, Mai SJ. Identification of RRAS gene related to nasopharyngeal carcinoma based on pathway and network-based analyses. Transl Cancer Res. 2019 Apr;8(2):664-675 

4. Shi L, Xiao R, Wang M, Zhang M, Weng N, Zhao X, Zheng XFS, Wang H, Mai S. MicroRNA-342-3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.Oncol Rep. 2018 Nov;40(5):2750-2757.

5. Wang MH, Sun R, Zhou XM, Zhang MY, Lu JB, Yang Y, Zeng LS, Yang XZ, Shi L, Xiao RW, Wang HY, Mai SJ. Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway. Cell Death Dis. 2018 Jan 5;9(1):2.

6. Wang MH, Zhou XM, Zhang MY, Shi L, Xiao RW, Zeng LS, Yang XZ, Zheng XFS, Wang HY, Mai SJ. BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway. Aging (Albany NY). 2017 Apr;9(4):1326-1340.

7. Zhang JX, Mai SJ, Huang XX, Wang FW, Liao YJ, Lin MC, Kung HF, Zeng YX, Xie D. MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling. Ann Oncol. 2014 Nov;25(11):2196-204.

8. Zhang JX, Qian D, Wang FW, Liao DZ, Wei JH, Tong ZT, Fu J, Huang XX, Liao YJ, Deng HX, Zeng YX, Xie D, Mai SJ. MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy. Cancer Lett. 2013 Feb 1;329(1):91-8.

9. Zhang JX, Huang XX, Cai MB, Tong ZT, Chen JW, Qian D, Liao YJ, Deng HX, Liao DZ, Huang MY, Zeng YX, Xie D, Mai SJ. Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis. J Transl Med. 2012 Dec 5;10:242.

10. Wang FW, Wu XR, Liu WJ, Liao YJ, Lin S, Zong YS, Zeng MS, Zeng YX, Mai SJ, Xie D. Heat shock factor 1 upregulates transcription of Epstein-Barr Virus nuclear antigen 1 by binding to a heat shock element within the BamHI-Q promoter. Virology. 2011 Dec 20;421(2):184-91.

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