Modified radical cystectomy
Our group has made several modifications to the traditional radical cystectomy. The first is a modified technique to prevent complications related to stoma and ileoureteral anastomosis in patients undergoing ileal conduit diversion. The second is a modified technique for neourethral anastomosis in orthotopic neobladder reconstruction. Both of the two modifications have been widely accepted by peers.

Nephron sparing operation
Our group pays a lot of attention to nephron sparing operation. As more and more small renal mass being detected accidentally by body exam, and the prolonged  life span, preserving the kidney is more and more important. Our group made some modification to the traditional nephron sparing operation, which significantly reduced the postoperative complication.

The mechanisms of Bladder cancer metastasis
Metastasis is the main reason of failure in cancer treatment. Bladder cancer with metastasis is incurable. Hence exploring the mechanisms of Bladder cancer metastasis can provide new idea in the treatment of bladder cancer. Our group demonstrated that up-regulation of Nkx2.8 inhibited epithelial-mesenchymal transition (EMT), an early key event in cancer metastasis, in bladder cancer cells. The research is supported by the grants from the Natural Science Foundation of China (No. 81272810) and the Natural Science Foundation of Guangdong Province, China(No. S2012010009466).

1995, The first award for“The series studies of renal stone and renal function” Hunan Province Science and Technology Association

 

Obtained Medical Bachelor in 1984, Medical Master in 1987 and Medical Doctor in 1992  from Hunan Medical University

1. Zhang Z, Li J, Zheng H, Yu C, Chen J, Liu Z, Li M, Zeng M, Zhou F, Song L. Expression and cytoplasmic      localization of SAM68 Is a significant and independent prognostic marker for renal cell carcinoma. Cancer Epidemiol  Biomarkers Prev. 2009，18:2685-93

2. Guo-Liang Hou , Yong-Hong Li , Zhi-Ling Zhang , Yong-Hong Xiong , Xiao-Feng Chen , Kai Yao, Zhuo-Wei Liu , Hui Han , Zi-Ke Qin , Fang-Jian Zhou. A modified technique for neo-urethral anastomosis in orthotopic neobladder reconstruction. Urology. 2009,74:1145-1149

3. Kai Yao, Guo-Liang Hou., Zhuo-Wei Liu , Shao-Long Yu, Yong-Hong Li, Fang-jian Zhou. Upper urinary tract dilation due to conglutination of intraluminal distal ureters after orthotopic neobladder with split-cuff nipple ureteral reimplants: Early results of 8 cases. Urologic Oncology: Seminars and Original Investigations,2009, 27: 611–616

4. Zhou J, Weng D, Zhou F, Pan K, Song H, Wang Q, Wang H, Wang H, Li Y, Huang L, Zhang H, Huang W, Xia J. Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses. Cancer Immunol Immunother. 2009, 58(10):1587-97. (IF: 3.804)

5. Zi-Ke Qin, Jian-An Yang, Yun-lin Ye, Xing Zhang, Li-Hua Xu, Fang-Jian Zhou, Hui Han, Zuo-Wei Liu, Li-Bing Song and Mu-Sheng Zeng. Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer 2009, 9:61

6. Fang J. Zhou, Shao L. Yu, Yong H.Li, Zhuo W. Liu, Yong H. Xiong, Pei H. Wu, Hui Han, Zi K.Qin. Intra-arterial chemotherapy with gecitabine and cisplatin for patients with recurrence of transitional cell carcinoma confined to the pelvis. J Chemo, 2009, 21(1):91-97 

7. Wei Chen, Jun-hang Luo, Wen-feng Hua, Fang-jian Zhou, Marie C. Lin, Hsiang-fu Kung, Yi-xin Zeng, Xin-yuan Guan, Dan Xie. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial cancer of the bladder treated with radical cystectomy. Cancer Epidemiol Biomakers Prev 2009,18(2):400-4008

8. Dong P, Flores J, Pelton K, Solomon KR. Prohibitin is a cholesterol-sensitive regulator of cell cycle transit.J Cell Biochem. 2010,111(5):1367-74.

9. Kai Yao, Hua Tu, Yong-Hong Li, Zi-Ke Qin, Zhuo-Wei Liu, Fang-Jian Zhou, Hui Han. Modified technique of radical inguinal lymphadenectomy for penile carcinoma: morbidity and outcome.J Urol. 2010, 184:546-552

10. Yong-Hong Xiong, Zhi-Ling Zhang, Yong-Hong Li,Zhuo-Wei Liu, Guo-Liang Hou,Qing Liu,Jing-Ping Yun, Xue-Qi Zhang and Fang-Jian Zhou. Benign pathological findings in 303 Chinese patients undergoing surgery for presumed localized renal cell carcinoma. Int J Urol, 2010,17:517-521

11. Zhi Ling Zhang, Zhuo Wei Liu, Fang Jian Zhou, Yong Hong Li, Yong Hong Xiong, Kai Rao, Guo Liang Hou, Hui Han, Zi Ke Qin, Shao Long Yu, Xiao Feng Chen. Modified technique to prevent complications related to stoma and ileoureteral anastomosis in patients undergoing ileal conduit diversion.Urology,2010,76(4): 996-1000

12. Jun-Hang Luo, Fang-Jian Zhou, Dan Xie, Zhi-Ling Zhang, Bing Liao, Hong-Wei Zhao, Yu-Ping Dai, Ling-Wu Chen, Wei Chen. Analysis of long-term survival in patients with localized renal cell carcinoma: laparoscopic versus open radical nephrectomy. World J Urol, 2010,28: 289

13. Zhang Zhi-ling, Xiong Yong-hong, Li Yong-hong, Hou Guo-liang, Liu Zhuo-wei, Han Hui, Qin Ze-ke,Yun Jing-ping, Zhou Fang-jian. Reassessment of the predictive role of perivesical fat invasion in invasive bladder cancer prognosis in 151 chinese patients. Chinese Medical J, 2011:124(18):2915-2919

14. Song Wu, Yong Wang, Liang Sun, Zhiling Zhang, Zhimao Jiang, Zike Qin, Hui Han, Zhuowei Liu, Xianxin Li, Aifa Tang, Yaoting Gui, Zhiming Cai and Fangjian Zhou.  Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma. BMC Cancer, 2011, 11:413

15. Liu ZW, Zhang XQ, Hou GL, Zhang ZL, Qin ZK, Han H, Zhou FJ. Primary adult intratesticular rhabdomyosarcoma: Results of the treatment of six cases. Int J Urol. 2011,18(2):171-4.

16. Yun-Lin Ye, Xiang-Zhou Sun, Fu-Fu Zheng, Jun Bian, Yan-Ping Huang, Xue-Qi Zhang, Zhi-Xun Li, Ying Nie, Zi-Ke Qin, and Yu-Ping Dai. Clinical Analysis of Management of Pediatric Testicular Germ Cell Tumors. Urology.2012,56(1):112-118

17. Kai Yao,Hyewon Youn,Xiaoyan Gao,Bijun Huang,Fangjian Zhou, Benyi Li, and Hui Han*.Casein Kinase 2 Inhibition Attenuates Androgen Receptor Function and Cell Proliferation in PC Cells. The Prostate,2012. Published online

18. Zhuo-Wei Liu，Ephrem O.Olweny,Gang Yin,Stephen Faddegon,Yung K.Tan, Woong  Kyu Han,Jeffrey A. Cadeddu. Prediction of perioperative outcomes following minimally invasive partial nephrectomy: role of the R.E.N.A.L nephrometry score. World J Urol,2012,DOI:10.1007/s00345-012-0876-3O

19. Chen Ming-Kun,YE Yun-lin,ZHOU Fang-jian,LIU Jian-ye,LU Ke-shi,HAN Hui,LIU Zhuo-wei,XU Zhen-zhou and QIN Zi-ke. Clipping Extremity of Ureter Is Effective for Preventing Bladder Recurrence after Upper Urinary Tract Urothelial Carcinoma，Chinese Medical Journal. 2012.125（21）：3821-3825

20. Chen Ming-Kun,YE Yun-lin, ZHOU Fang-jian,LIU Jian-ye,LU Ke-shi,HAN Hui,LIU Zhuo-wei,XU Zhen-zhou and QIN Zi-ke. Clipping Extremity of Ureter Is Effective for Preventing Bladder Recurrence after Upper Urinary Tract Urothelial Carcinoma，Chinese Medical Journal. 2012,125（21）：3821-3825

21. Liu JY, Li YH, Lin HX, Liao YJ,Mai SJ, Liu ZW, Zhang ZL, Jiang LJ, Zhang JX, Kung HF, Zeng YX, Zhou FJ (Xie D  Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder. BMC Cancer. Epub 2013 Jul 19.

22. Liu JY, Zhang Q, Ye YL, Li J, Chen W, Li YH, Zhang ZL, Yao K, Jiang LJ, Han H, Liu ZW, Qin ZK, Zhou FJ. Prognostic significance of tumor location and superficial urothelial bladder carcinoma history in patients with ureteral urothelial carcinoma treated with radical nephroureterectomy. 2013,45(2):395-404

23. Kai Yao, Zai-Shang Li, Fang-Jian Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li and Hui Han*. Anatomical retroperitoneoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumours: initial operative experience. Asian  J  Andrology, 2013,11

24. Pei Dong,Zhou wei Liu,Xiang Dong Li,Yong Hong Li,Kai Yao,Song Wu,Zi Ke Qin,Hui Han,Fang jian Zhou. Risk factors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors. Med Oncol,2013,30:494.

Updated by International Office, Sun Yat-sen University Cancer Center