Prof. Lanjun Zhang obtained his M.D. in 1984 and his Master in Cardio-Thoracic Surgery in 1990 from The Fourth Military Medical University. From 2001 to 2004, he conducted his research in the field of artificial bio-materials esophagus in Sun Yat-sen University Cancer Center and he obtained his Ph.D in Clinical Oncology. He completed his medical residency in The First Affiliate Hospital of Fourth Military Medical University in China. After attending physician in cardio-thoracic surgery and oncology in Xian and Guangzhou, he has spent his entire training in thoracic oncology at SYSUCC, Sun Yat-sen University, Guangzhou. He was appointed the Director of Thoracic surgery Department in 2010. Under his leadership, the department has been honored The State Key Department by Ministry of Health in 2011.  Professor Zhang is also vice chairman of Lung Cancer Union of Western China and Vice chairman of Trauma Professional Committee in Thoracic Surgery of Chinese medical doctor Association, and member of Tumor Reconstruction Committee of Plastic Surgery Branch of Chinese Medical Association as well.

Professor Zhang focuses his study either on clinical or basic research, including lung cancer, esophageal cancer, tumor biomarkers investigation, Prognostic factors and treatment stratification, and target therapy. He is also an expert in the reconstruction with artificial bio-materials organs. The patent of his artificial esophagus was awarded in 2001. He is also involved in numerous review committees of journals, funds and diverse expertise in China and internationally.

He has published over 35 articles during the last ten years in peer-reviewed scientific journals, including J Clin Oncol, Eur J Cardiothorac Surg , BMC Cancer, Ann Oncol, Cancer Genet Cytogenet.

1. Surgical treatment for thoracic tumor

2. Innovation diagnosis for early stage lung cancer

3. Screening of molecular biomarker in individual treatment for lung cancer

4. Clinical application of artificial organs

5. Reconstruction for artificial chest wall following wide tumor resection

6. Application for surgical reconstruction with artificial esophagus

7. Management for tumor bank and tumor information plate

1984: Graduated from the Fourth Military Medical University and was conferred upon the degree of Bachelor of Medicine;

1986: Studied cardiac surgery at Royal Children's Hospital of Melbourne;

1991: Graduated from the Fourth Military Medical University and was conferred upon the degree of Master of Medicine;

2004: Graduated from Sun Yat-sen University and was conferred upon the degree of Doctor of Medicine.

1. Cai L, Zhu JF, Zhang XW, Lin SX, Su XD, Lin P, Chen K, Zhang LJ. A comparative analysis of EGFR mutation status in association with the efficacy of TKI in combination with WBRT/SRS/surgery plus chemotherapy in brain metastasis from non-small cell lung cancer. J Neurooncol. 2014 Nov;120(2):423-30.

2. Wen YS；Cai L；Zhang XW；Zhu JF；Zhang ZC；Shao JY；Zhang LJ. Concurrent oncogene mutation profile in chinese patients with stage ib lung adenocarcinoma. Medicine _ Volume 00, Number 00, Month 2014

3. Mahmut Ozsahin, René-Olivier Mirimanoff, Juliette Thariat, Xu Shan Sun, Banu Atalar, Yasmin Lassen-Ramshad, Gamze Ugurluer, Sunil Krishnan, Christopher Hallemeier, Paul Van Houtte, Marco Krengli, Lan Jun Zhang, Kenneth Chang, Ryan Funk, Jessica Rooney, Robert C. Miller. The Rare Cancer Network: Ongoing Studies and Future Strategy. Rare Tumors. 2014 July 30; 6(3): 5465.

4.  Zhu JF, Feng XY, Zhang XW, Wen YS, Lin P, Rong TH, Cai L, Zhang LJ.Time-varying pattern of postoperative recurrence risk of early-stage (T1a-T2bN0M0) non-small cell lung cancer (NSCLC): results of a single-center study of 994 Chinese patients. PLoS One. 2014 Sep 9;9(9):e106668.

5. Jianfei Zhu, Ling Cai, Haoxian Yang, Yinsheng Wen, Junye Wang, Tiehua Rong, Jianyong Shao , Lanjun Zhang. Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation coexisting in Chinese patients with lung adenocarcinoma. Thoracic Cancer 5 (2014) 411–416.

6. Jian-Fei Zhu, Ling Cai, Xue-Wen Zhang, Yin-Sheng Wen, Xiao-Dong Su, Tie-Hua Rong, Lan-Jun Zhang. High plasma fibrinogen concentration and platelet count unfavorably impact survival in non-small cell lung cancer patients with brain metastases. Chin J Cancer; 2014; Vol. 33 Issue 2: 96-104.

7. Dong-Rong Situ, Philippe Dartevelle, Thierry Le Chevalier, Lan-Jun Zhang. The Sino-French 2012 Conference in Thoracic Oncology: an international academic platform for in-depth exchange on comprehensive research. Chin J Cancer. 2013 February; 32(2): 53-58

8. Yu-Zhen Zheng, Shu-Qin Dai, Wei Li, Xun Cao, Xin Wang, Jian-Hua Fu, Peng Lin, Lan-Jun Zhang, Bin Lu, Jun-Ye Wang. Comparison between different reconstruction routes in esophageal squamous cell carcinoma. World J Gastroenterol. 2012 October 21; 18(39): 5616–5621. Published online 2012 October 21. doi: 10.3748/wjg.v18.i39.5616.

9. Zhang LJ, Cai L, Li Z, Wang WP, Guo K, Shao JY, Wang JY, Yu H, Rong TH. Relationship between epidermal gowth factor receptor gene mutation and gene copy number in Chinese patients with non-small cell lung cancer. Chin J Cancer. 2012 October; 31(10): 491–499

10. Guo K, Cai L, Zhang Y, Zhu JF, Rong TH, Lin P, Hao CL, Wang WP, Li Z, Zhang LJ. The predictive value of histological tumor regression grading (TRG) for therapeutic evaluation in locally advanced esophageal carcinoma treated with neoadjuvant chemotherapy. Chin J Cancer. 2012 Aug;31(8):399-408. doi: 10.5732/cjc.011.10406. Epub 2012 May 8.

11. Zheng YZ, Dai SQ, Shan HB, Gao XY, Zhang LJ, Cao X, Zhu JF, Wang JY Managing esophageal leaks by endoscopic transluminal drainage in esophageal cancer patients with superior mediastinal sepsis after esophagectomy. Chin J Cancer. . 2012 Oct 11. 

12.  Zhang LJ, Cai L, Li Z, Wang WP, Guo K, Shao JY, Wang JY, Yu H, Rong TH.Relationship between epidermal growth factor receptor gene mutation and copy number in Chinese patients with non-small cell lung cancer. Chin J Cancer. 2012 Oct;31(10):491-9

13. Guo K, Cai L, Zhang Y, Zhu JF, Rong TH, Lin P, Hao CL, Wang WP, Li Z, Zhang LJ. The predictive value of histological tumor regression grading (TRG) for therapeutic evaluation in locally advanced esophageal carcinoma treated with neoadjuvant chemotherapy. Chin J Cancer, 2012 Aug;31(8):399-408.

14. Jianfei Zhu, Ling Cai, Haoxian Yang, Yinsheng Wen,Junye Wang, Tiehua Rong, Lanjun Zhang. Plasma fibrinogen levels are associated with epidermal growth factor receptor gene mutation in Chinese patients with non-small cell lung cancer. The Chinese-German Journal of Clinical Oncology. 2013, May 12:203-209.

15. Zhang LJ, Wang WP, Li WY, et al. A new alternative for bony chest wall reconstruction using biomaterial artificial ribs and pleura: animal experiment and clinical application. Eur J Cardiothorac Surg. 2010, OCT; 40(4):939-947.

16. Dai Y, Long H, Lin P, Fu JH, Zhang LJ, Zhu ZH, Zhang X, Rong TH, Su XD. Impact of the number of resected and involved lymph nodes on the outcome in patients with stage II non-small cell lung cancer. Zhonghua Zhong liu Za Zhi. 2010 jun; 32(6):436-440.

17. Liu WL, Guo XZ, Zhang LJ, Wang JY, Zhang G, Guan S, Chen YM, Kong QL, Xu LH, Liu MZ, Song LB, Zeng MS. Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma. BMC cancer. 2010 Sep; 10:467.

18. Dai Y, Su XD, Long H, Lin P, Fu JH, Zhang LJ, Wang X, Wen ZS, Zhu ZH, Zhang X, Rong TH. Survival analysis of 220 patients with completely resected stage II non-small cell lung cancer. Chin J Cancer. 2010 May; 29(5):538-544.

19. Xie MR, Zhang X, Lin P, Lin YB, Rong TH, Zhang LJ, Wen ZS, Li XD. Short and lon-term outcomes of neoadjuvant chemotherapy for local advanced esophageal carcinoma. Zhonghua Yi Xue Za Zhi. 2009 Nov; 89(41):2906-2909.

20. He LR, Zhao HY, Li BK, Zhang LJ, Liu MZ, Kung HF, Bian XW, Zeng YX, Xie D. Overexpression of AIB1 negatively affects survival of surgical resected non-small cell lung cancer patients. Ann Oncol. 2010 Aug; 21(8): 1675-1681.

21. Yu H, Zhang SY, Wang X, Xie ZM, Wang JY, Li Y, Xie X, Zhou JL, Zhang LJ, Fu JH. Evaluation of scalene lymph node or contralateral mediastinum biopsy during mediastinoscopy for non-small cell lung cancer. Zhonghua Zhong Liu Za Zhi. 2009 Oct; 31(10):780-782.

22. He LR, Liu MZ, Li BK, Jia WH, Zhang Y, Liao YJ, Chen YC, Zhang LJ, Guan XY, Zeng YX, Kung HF, Xie D. High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int J Cancer. 2010 Jul 1; 127(1):138-147.

23. Zhang DK, Su XD, Lin P, Long H, Fu JH, Zhang LJ, Ma GW, Rong TH. Clinical analysis of 22 cases of esophageal adenosquamous carcinoma. Zhonghua Zhong Liu Za Zhi. 2009 Apr; 31(4):302-304.

24. Zhu ZH, Sun BY, Ma Y, Shao JY, Long H, Zhang X, Fu JH, Zhang LJ, Su XD, Wu QL, Ling P, Chen M, Xie ZM, Hu Y, Rong TH, Three immunomarker support vector machines-based prognostic classifiers for stage IB non-small cell lung cancer. J Clin Oncol. 2009 Mar 1; 27(7): 1091-1099.

25. Zhang DK, Su XD, Long H, Lin P, Fu JH, Zhang LJ, Ma GW, Zhu ZH, Dai Y, Rong TH. Surgical treatment and prognosis in patients with squamous cell carcinoma of the thoracic esophagus. Zhonghua Wai Ke Za Zhi. 2008 Sep; 46(17):1333-1336.

26. Su XD, Long H, Wang X, Fu JH, He JH, Lin P, Zhang LJ, Ma GW. Impact of visceral pleural invasion on the prognosis of stage Ib non-small cell lung cancer. Zhonghua Zhong Liu Za Zhi. 2008 May; 30(5):368-371.

27. Su XD, Wang X, Rong TH, Long H, Fu JH, Lin P, Zhang LJ, Wang SY, Wen ZS, Ma GW. Prognostic effect of mediastinal lymph node dissection in patients with stage I non-small cell lung cancer. Zhonghua Wai Ke Za Zhi. 2007 Nov 15; 45(22):1543-1545.

28. Deng YJ, Rong TH, Zhang LJ, Su XD, Lin ZC, Situ DR. Influence of unexpected simultaneous splenectomy on postoperative complications and prognosis of patients undergoing radical esophagectomy for esophageal carcinoma. Ai Zheng. 2007 Sep; 26(9): 983-986.

29. Li BJ, Wang JY, Huang XP, Zhang LJ, Long H, Yang MT, Rong TH. Clinical significance of hMAM mRNA detection in bone marrow of breast carcinoma patient. Zhonghua Zhong Liu Za Zhi. 2006 Oct; 28(10):766-769.

30. Lin ZC, Long H, Rong TH, Yang MT, Huang ZF, Lin P, Zhang LJ, Li XD. Surgical treatment efficacy of bronchioloalveolar carcinoma: a retrospective analysis of 130 patients. Ai Zheng. 2006 Sep: 25(9):1123-1126.

31. Zhang LJ, Rong TH, Xu GL, Su XD, Zhi FC, Guo XM, Zhang PY. Experimental study of preventing postoperative stenosis by modifying artificial esophagus in dogs. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Jun; 28(3):325-328.

32. Zhang LJ, Rong TH, Wu QL, Su XD, Long H, Zhao JM, Zhang PY, Li XD. Histological regeneration process of “neo-esophagus”. Ai Zheng. 2006 Jun; 25(6): 689-695.

33. Zhang PY, Li BJ, Su XD, Wen ZS, Zhao JM, Zhang LJ, Long H, Rong TH. In vitro killing effects of STI571 on esophageal carcinoma cell lines CE-48T and CE-81T. Ai Zheng. 2006 Apr; 25(4): 456-60.

34. Huang XP,Rong TH, Wang JY, Tang YQ, Li BJ, Xu DR, Zhao MQ, Zhang LJ, Fang Y, Su XD, Liang QW. Negative implication of C-MYC as an amplification target in esophageal cancer. Cancer Genet Cytogenet. 2006 Feb; 165(1): 20-24.

Last Updated on: February 2016 by International Office, Sun Yat-sen University Cancer Center