Ke Sai | Neurosurger | Sun Yat-sen University Cancer Center-Sun Yat-sen University Cancer Center

Name: Ke Sai

Title: Deputy Director and Associate Professor

Email: saike@sysucc.org.cn

Phone:

Profile

Ke Sai, M.D., Ph. D. is Associated Professor in the Department of Neurosurgery/Neuro-oncology at Sun Yat-sen University Cancer Center, Guangzhou, China. Dr. Sai received his medical degree from Sun Yat-sen University School of Medicine. He completed a residency and fellowship in neurosurgical oncology at Sun Yat-sen University Cancer Center, Guangzhou. Dr. Sai trained as a post-doctor supervised by Professor Alfred Yung and Professor Howard Colman from 2007 – 2009 at MD Anderson Cancer Center, Houston, where he was a recipient of MD Anderson Cancer Center Trainee Excellence Award (2009). Dr. Sai’s clinical interests are in the use of multimodality intraoperative monitoring techniques for the resection of brain tumors. He is also a NSFC-funded translational researcher who has published extensively on targeted therapies for glioma stem cells. He is a board member of the Chinese Society of Neuro-oncology (CSNO) and serves as an executive editor of the Glioma, which is the official journal of CSNO. Dr. Sai has published more than 30 peer-reviewed articles and book chapters.

Interests

Multimodality intraoperative monitoring techniques for the resection of brain tumors, and translational research on targeted therapy against malignant gliomas.

Education

2009 Ph.D. Sun Yat-sen University, Medical School, P.R.China. Clinical Oncology

2004 M.S. Sun Yat-sen University, Medical School, P.R.China. Clinical Medicine

2002 M.D. Sun Yat-sen University, Medical School, P.R.China. Clinical Medicine

Postgraduate Training

5/2007-4/2009 Postdoctoral fellowship, Department of Neuro-Oncology, UT MD Anderson Cancer Center, TX, U.S.A.

8/2004 The Australia and Asia Pacific Clinical Oncology Research Development Workshop. Sponsord by MOGA, AACR and ASCO

7/2004-12/2006 Clinical Residency, Sun Yat-sen University Cancer Center, Guangzhou, P.R.China

Publications

1. Hu WM, Wang F, Xi SY, Zhang X, Lai JP, Wu HY, Liu LL, Sai K#, Zeng J#. Practice of the New Integrated Molecular Diagnostics in Gliomas: Experiences and New Findings in a Single Chinese Center. J Cancer. 2020.

2. Ding Y, He C, Lu S, Wang X, Wang C, Wang L, Zhang J, Piao M, Chi G, Luo Y, Sai K#, Ge P#. MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis. Cancer Lett. 2019.

3. Xi S*, Sai K*, Hu W, Wang F, Chen Y, Wang J, Zeng J, Chen Z. Clinical significance of the histological and molecular characteristics of ependymal tumors: a single institution case series from China. BMC Cancer. 2019.

4. Sun S, Xue D, Chen Z, Ou-Yang Y, Zhang J, Mai J, Gu J, Lu W, Liu X, Liu W, Sheng L, Lu B, Lin Y, Xing F, Chen Z, Mou Y, Yan G, Zhu W, Sai K#. R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells. Cell Death Dis. 2019.

5. Hu WM, Zhang J, Sun SX, Xi SY, Chen ZJ, Jiang XB, Lin FH, Chen ZH, Chen YS, Wang J, Yang QY, Guo CC, Mou YG, Chen ZP, Zeng J, Sai K#. Identification of P4HA1 as a prognostic biomarker for high-grade gliomas. Pathol Res Pract. 2017.

6. Sai K, Zhong MG, Wang J, Chen YS, Mou YG, Ke C, Zhang XH, Yang QY, Lin FH, Guo CC, Chen ZH, Zeng J, Lv YC, Li X, Gao WC, Chen ZP. Safety evaluation of high-dose BCNU-loaded biodegradable implants in Chinese patients with recurrent malignant gliomas. J Neurol Sci. 2014.

7. Sai K, Li WY, Chen YS, Wang J, Guan S, Yang QY, Guo CC, Mou YG, Li WP, Chen ZP. Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells. Am J Chin Med. 2014.

8. Sai K, Mou YG, Zeng J, Lv YC, Xi SY, Guan S, Zhang XH, Wang J, Ke C, Guo JG, Chen YS, Chen ZP. Neurosurgical interventions for patients with nasopharyngeal carcinoma: a single institution experience. World J Surg Oncol. 2013.

9. Sai K, Yang QY, Shen D, Chen ZP. Chemotherapy for gliomas in mainland China: An overview. Oncol Lett. 2013.

10. Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S, Chen Z, Alfred Yung WK, Priebe W, Colman H. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J Neurooncol. 2012.

Updated November 2021 by International Office, Sun Yat-sen University Cancer Center

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