Nasopharygeal carcinoma: 1) Mechanism of Metastasis and Prognostic Factors; 2) Combinded treatment for advanced NPC

09/1984 - 07/1989  Undergraduate study in Norman Bethune University of Medical Science, Changchun City, JiLin Province, obtained MDdegree.

07/1989 - 10/1994  Resident doctor, Training as Radiotherapistat Guangdong Provincial People’s Hospital,Guangzhou City,GuangdongProvince.

11/1994 - 10/1997 Attending doctor, RadiotherapyDepartment, GuangDong Provincial People’s Hospital, Guangzhou City, Guangdong Province.

11/1997 – 06/2000  Training as Specialist ofRadiotherapy-Oncology in Paris, France: Department of Radiotherapy-Oncology：

－Henri-Mondor Hospital, XIIth University of Paris;

－Tenon Hospital, VIth  University of Paris;

－and EORTC Chronotherapy Center, Department of ClinicalOncology, Paul Brousse Hospital, XIth  University of Paris.

07/2000 – 01/2001  Attending doctor and Radiotherapist atRadiotherapy Department, Guangdong Provincial People’s Hospital, Guangzhou city, Guangdong Province.

02/ 2001 – 11/2014  Associate Professor,Department of Nasopharygeal Cancer, Cancer

Center, Sun Yat-sen University, Guang Zhou City, Guangdong Province.

12/ 2014 – 11/2014  Professor,Department of Nasopharygeal Cancer, Cancer

Center, Sun Yat-sen University, Guang Zhou City, Guangdong Province.

1.      Huan-Xin Lin,  Rui Sun, Min Xu ,…LingGuo，Clinical Study of Inductionchemotherapy with docetaxel, cisplatin and 5-FU followed by radiotherapy andconcurrent cisplatin in local advanced nasopharyngeal carcinoma. Cancer Research and Clinic. 2010,8 (22):515-8

2.      Xu Min,Guo Ling,Liao Jiahua, et al. Retrospective analysis of efficacy on radiotherapyalone or concurrent chemoradiotherapy for patients with stage T3N0-1M0nasopharyngeal cancer. Cancer Research and Clinic. 2010,8(22):526-9

3.      MinXu,Huan-Xin Lin, Rui Sun,…Ling Guo,Value of predicting metastasis by1992 staging system and 2008 staging system in nasopharyngeal carcinomapatients. CHIN J CANCER PREV TREAT. 2010,8(17):1293-97

4.     Guo L,Lin HX, Xu M, et al. Phase Istudy of TPF neoadjuvant chemotherapy followed by radical radiotherapy inadvanced nasopharyngeal carcinoma.Chinese journal of cancer. 2010 Feb; 29(2):136-9.

5.     Guo Ling,Lin Huanxin. Cancer Chronotherapy –From Basic Research To Clinical Application.Chin J of Clin Oncol, 2004, 31(1): 56-59.

6.     Guo Ling,Lin Huanxin, Li Fengyan, et al. Phase Istudy of capcitabine with concurrent radiotherapy in early-stage nasopharyngealcarcinoma. Chin J Oncol, April 2004, Vol 26, No 4: 250-253.

7.     Guo Ling,Lin Huanxin, Qiu Fang, et al. FeasabilityStudy of Chronomodulated Chemotherapy with 5-Fu ± LV and DDPin the Treatment of Advanced Nasopharyngeal Cancer. Chin J of Clin Oncol, 2004,31(13): 721-724.

8.     Guo Ling,Lin Huanxin, Qiu Fang, et al. ConcurrentChemoradiotherapy Using Oral Capecitabine and Carboplatin in The Treatment ofElderly Patients with Advanced Nasopharyngeal Carcinoma. Cancer Research onPrevention and Treatment. 2006, 33(5): 368-370.

9.     Guo Ling,Lin Huanxin, Xian Li-jian. Chronotherapywith 5-Fu / LV and L-OHP in the Treatment of Advanced Colorectal CancerPatients Failed by the Same Regimen I Conventional Injection- 5 cases report.Guangzhou Med J. 2001, 32(suppl): 15-19.

10. Guo Ling,Lin Huanxin, Pan Qiong, et al. Radiotherapy in the Treatment of CutaneousClassic Kaposi’s Sarcoma. QiLu Zhongliu Zazhi. 1999, 6(1): 23-24.

11. Guo Ling,LinHuanxin, Pan Qiong, et al. Epidemic Kaposi’s Sarcoma in Genital Organs- 71Cases Report. Chinese Journal of Cancer, 1999,18(suppl): 461-466.

12.  JiangYong, Hong Ming-huang, Deng Man-quan,Guo Ling, et al. Phase I Clinical Trial Evaluation of Capcitabine inConcurrent Combination of Radiotherapy in nasopharyngeal carcinoma. ChineseJournal of Cancer, 2004, 23（4）：461-466.

13.  QiuFang, Hua Yi-Jun,Guo Ling,et al.Mucoepidermoid Carcinoma of Nasopharyx: a Report of 12 Cases. Chinese Journalof Cancer, 2005, 24（3）：850-854.

14.  LuoDong-hua, Hong Ming-huang,Guo Ling,et al. Analysis of Oral MucositisRisk Factors During Radiotherapy fornasopharyngeal carcinoma patients and Establishment of a Discriminant Model.Chinese Journal of Cancer, 2005, 24（7）：850-854.

15.  Zeng ZL, Sun J,Guo L,et al. Circadian rhythm in dihydropyrimidine dehydrogenaseactivity and reduced glutathione content in peripheral blood of nasopharyngealcarcinoma patients. Chronobiol Int. 2005; 22(4):741-54.

16.  Tang Ya-mei, Li Yi, Zhang Yin-yin,Guo Ling,et al. Clinical Analysis and Study on theLife Quality of Patients with Radiation Encephalopathy After Radiotherapy ofNasopharyngeal Cancer inGuangdongProvince. Chin J RadiolMed Prot. August 2005, 25(4): 336-339.

17.  Qiu Fang, Deng Man-quan,Guo Ling,et al. Clinical Observation of CapsulePing-Xiao concurrent with Radiotherapy in the Treatment of NasopharyngealCarcinoma. J of Mordern Oncol. 2006，3，14（3）：336－337.

18.  HuaYi-jun, Hong Ming-huang,Guo Ling,et al. The Application of Atificial Neural Network to Prediction of 5-yearSurvival in Nasopharyngeal Carcinoma. J of Oncol, 2006, 12(4): 300-304

19.  ChenMY, Guo X, Wen WP, Hua YJ,Guo L,etal. Salvage surgical operation viaendoscopic transnasal approach for local persistent or recurrent nasopharyngealcarcinoma.Ai Zheng. 2007 Jul;26(7):673-8

20.  WuMingwei, Zeng Zhaolei, Sun Jian,GuoLing,et al. Circadian Rhythm of the Peripheral Blood Cell Counts inHealthy Volunteers and Nasopharyngeal Carcinoma Parients. Chin J BloodTransfusion. 2008, 21(1): 21-24

21.  Wu Mingwei, Zeng Zhaolei, Li Su,Guo Ling,et al. Circadian Variation of PlasmaCortisol and Whole Blood Reduced Glutathione Levels in Nasopharyngeal CarcinomaParients. Ai Zheng, 2008 Mar;27(3):237-42

22.  Yi-Jun Hua, Ming-Yuan Chen, Ming-Huang Hong, Chong Zhao,Ling Guo, Fei Han, Wei Luo, Rui Sun, Yuan-YuanChen and Hui Liu. Short-term efficacy of endoscopy-guided debridement onradiation-related nasopharyngeal necrosis in 20 nasopharyngeal carcinomapatients after radiotherapy. Chinese Journal of Cancer, 2008, 27:7: 52-56

23.  HuaYi-jun, ....Guo Linget al.Application of Support Vector Machine to Predict 5-year Survival Status ofPatients with Nasopharyngeal Carcinoma after Treatment. The Chinese-GermanJournal of Clinical Oncology. 2006, Feb, 5(1): 8-12

24. Liang WJ, Qiu F, Hong MH,Guo L, et al. Differentially expressed genes between upward anddownward progressing types of nasopharyngeal carcinoma.Ai Zheng. 2008 May;27(5):460-5

25.  Tang Y, Zhang Y,Guo L,Peng Y,Luo Q,Xing Y. Relationship between individual radiosensitivity and radiationencephalopathy of nasopharyngeal carcinoma after radiotherapy.StrahlentherOnkol.2008 Oct;184(10):510-4. Epub 2008Oct 1.

26. Hua YJ, Chen MY, Qian CN, Hong MH, Zhao C,Guo L,Guo X, Cao KJ. Postradiationnasopharyngeal necrosis in the patients with nasopharyngeal carcinoma.Head Neck.2009Jun;31(6):807-12

27. LONG Zhen, XIEMing-qiang, ZHANG Tao, SHEN Hui, XU Xue-qing,GUO Ling.Effect of targeted therapy withcisplatin-loaded magnetic nanoparticles combined with radiotherapy for nasopharyngealcarcinoma in nude mice.JSouth Med Univ,2009;（29）9:1827-30

28. ZHANGHongzheng, XIE Minqiang, LI Zhonghan,GUOLin. Expression of folate receptor inthe tissues and cells of nasopharyngeal carcinoma. China Journal of ModernMedicine, 2009，19（6）：833－840

29.  Pei-Yu Huang，Hai-Qiang Mai Dong-Hua Luo， FangQiu，Ning-Wei Li，Yan-Qun Xiang，Qiu-YanChen，Li Zhang，Rui Sun，Ka-Jia Cao，Ling Guo，Man-Quan Deng，Hao-YuanMo, Xiang Guo，Feng Zhang，Su-Mei Cao，Min-Yuan Chen， Ying Guo，Yu-Ying Fan， Wen-Hu，Yi-Jun Hua，Guo-Feng Xie, and Ming-Huang Hong. Induction-concurrent chemoradiotherapy versus inductionchemotherapy and radiotherapy for locoregionally advancednasopharyngeal carcinoma. Chinese Journal of Cancer， 2009, 28（10）: 1033－1042

30.  Analysisof Respiration Induced Motion on the Accuracy of Three-Dimensional ConformalRadiotherapy Planning in Lung Cancer. Int.J.Radiation Oncology Bio.Phys；2000, 46(3): 745

31.  Radiotherapiedes Lymphomes Cutanes. (Francais). Cancer-Radiotherapy；1999,  3(2): 105-111.

32.  ConformalRadiotherapy (CRT) Planning for Lung Cancer Analysis of Intrathoracic OrganMotion During Extreme Phases of Breathing. Int. J. Radiation Oncology Biol.Phys. 2001,51(4): 1081-1092.

33.  Associationradiochirurgicale conservatrice des cancers du seins de petit volume :intérêt des clips chirurgicaux dans le lit de tumorectomie (Breast-conservingsurgery and irradiation for early breast cancers : value of surgical clipswithin the excision cavity). Cancer-Radiotherapie, 2001, l5(3);255-261.(Francais)

34.  Ge N, Lin HX, Xiao XS,Guo L,et al. Prognostic significance of Oct4 and Sox2 expression in hypopharyngealsquamous cellcarcinoma. Journal of Translational Medicine 2010 oct 12, 8: 94

35.   Xiang-Bo Wan,1,2,†Xin-Juan Fan,3,†Ming-Yuan Chen,1,2,†… Ling Guo,1,2，et, al . Elevated beclin 1 expression is correlatedwithHIF-1α in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 6:3,1-10; April 1, 2010;

36.   Wen-TingLiao,Ling Guo, Yi Zhong, Yan-Heng Wu, Jun Liand Li-Bing Song. Astrocyte elevatedgene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma.J Transl Med. 2011 Dec 1; 9:205.  (co-author.IF＝3.51)

37. Lv X, Xiang YQ, Cao SM, Qian CN, Li NW,Guo L,…Guo X. Prospective validation of the prognostic value of elevatedserum vascular endothelial growth factor in patients with nasopharyngealcarcinoma: more distant metastases and shorter overall survivalaftertreatment.Head Neck. 2011 Jun;33(6):780-5.

38.  ChenQY, Wen YF,Guo L,Liu H, Huang PY,Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, Hua YJ, Guo X,Cao KJ, Hong MH, Qian CN, Mai HQ.Concurrent Chemoradiotherapy vs RadiotherapyAlone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial.J Natl Cancer Inst. 2011 Dec7;103(23):1761-70. doi: 10.1093/jnci/djr432. Epub 2011 Nov 4. 

39.  Liao Jiahua, Lin Huanxin, Sun Jian, Sun Rui,Guo Ling.Chrono-chemotherapy of Docetaxel in Nude Mice Bearing Human NasopharyngealCarcinoma.Cancer Research onPrevention and Treatment.2012, 39（1）: 18-22

40.  RUISUN, QING ZHANG,LING GUOMING YUANCHEN, YING SUN, BRIAN CAO, JIAN SUN. HGF stimulates proliferation through theHGF/c-Met pathway in nasopharyngeal carcinoma cells.Oncol Lett.2012 May; 3(5): 1124-1128. Epub 2012 Feb 20. PMID: 22783404 [PubMed]

41.  Huan Li,Ling Guo,Shu-Wei Chen, Xiao-HuiZhao, Shi-Min Zhuang,Li-Ping Wang, Li-Bing Song, and Ming Song. GOLPH3overexpression correlates with tumor progression and poor prognosis in patientswith clinically N0 oral tongue cancer. J Transl Med. 2012; 10: 168.

42.  Huang PY, Cao KJ, Guo X, Mo HY,Guo L, Xiang YQ, Deng MQ, Qiu F, Cao SM, Guo Y, Zhang L, Li NW, SunR, Chen QY, Luo DH, Hua YJ, Mai HQ, Hong MH.A randomized trial of inductionchemotherapy plus concurrent chemoradiotherapy versus induction chemotherapyplus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. OralOncol. 2012 Oct;48(10):1038-44. doi: 10.1016/j.oraloncology.2012.04.006. Epub2012 May 14.PMID: 22591726 PubMed - in process]

43.  ChenMY, Hua YJ, Wan XB, Sun R, Huang PY, Xiang YQ,Guo L, Mo HY, Yang Y, Hong MH. Aposteriorly pedicled middle turbinate mucoperiosteal flap resurfacing nasopharynxafter endoscopic nasopharyngectomy for recurrent nasopharyngealcarcinoma.Otolaryngol Head Neck Surg. 2012 Mar;146(3):409-11. doi:10.1177/0194599811430918. Epub 2012 Jan 6. No abstract available. PMID:22228599 [PubMed - indexed for MEDLINE]

44.  ZHUYu-liang，MAI Hai-qiang，GUO Xiang，et al. PRELIMINARY REVEALS ON CORRELATION OF EIF3，EIF5AAND NASOPHARYNGEAL CARCINOMA WITH PROTEOMICS. Modern Preventive Medicine， 2012, Vol.39, NO.3: 667-669

45. QIU,Fang, GUOLing,MOHaoyuan, DENG Manquan. Clinical observation of combination of taxotere andnedaplatin in the treatment of PF regimen resistant metastatic and recurrentnasopharyngeal carcinoma. CHIN J CANCER PREV TREAT, Feb,2012,vol.19, No. 3:217-219

46. Huai Liu,Qiu-Yan Chen,Ling Guo, Lin-QuanTang, Hao-Yuan Mo, Zong-Liang Zhong, Pei-Yu Huang, Dong-Hua Luo, Rui Sun, XiangGuo, Ka-Jia Cao, Ming-Huang Hong and Hai-Qiang Mai. Feasibility and efficacy ofchemoradiotherapy for elderly patients with locoregionally advanced nasopharyngealcarcinoma: results from a matched cohort analysis. Radiation Oncology 2013,8:70(第二作者，IF=2.11)

47. Lin HX, Hua YJ, Chen QY, Luo DH,Sun R, Qiu F, Mo HY, Mai HQ, Guo X, Xian LJ, Hong MH,Guo L. Randomized study ofsinusoidal chronomodulated versus flat intermittent induction chemotherapy withcisplatin and 5-fluorouracil followed by traditional radiotherapy forlocoregionally advanced nasopharyngeal carcinoma.Chin JCancer. 2013 32(9): 502-511

48.  WangX, Yang Q,Guo L, Li XH, Zhao XH,Song LB, Lin HX. Flotillin-2 is associated with breast cancer progression andpoor survival outcomes.J Transl Med. 2013 Aug15;11(1):190. [Epub ahead of print]

49.  San-gangWu, Zhen-yu He, Juan Zhou, Jia-yuan Sun, Feng-yan Li, Qin Lin, Ling Guo,Huan-xin Lin. Serum levels of CEA and CA15-3 in different molecular subtypesand prognostic value in Chinese breast cancer. The Breast, 23 (2014) 88-93. ISSN: 0960-9776

2015
1. Jiang R, Cai XY, Yang ZH, Yan Y, Zou X, Guo L, Sun R, Luo DH, Chen QY, Huang PY, Xiang YQ, Lu X, Wang L, Xia WX, Mai HQ, Chen MY. Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma. Chin J Cancer. 2015 Jun 10;34(1):23. doi: 10.1186/s40880-015-0025-7.
2. Zou X, Han F, Ma WJ, Deng MQ, Jiang R, Guo L, Liu Q, Mai HQ, Hong MH, Chen MY. Salvage endoscopic nasopharyngectomy and intensity-modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma. Head Neck. 2015 Aug; 37(8):1108-15.
3. Huang PY, Zeng Q, Cao KJ, Guo X, Guo L, Mo HY, Wu PH, Qian CN, Mai HQ, Hong MH. Ten-year outcomes of a randomised trial for locoregionally advanced nasopharyngeal carcinoma: A single-institution experience from an endemic area. Eur J Cancer. 2015 Sep;51(13):1760-70.
4. You R, Zou X, Wang SL, Jiang R, Tang LQ, Zhang WD, Li L, Zhang MX, Shen GP, Guo L, Qian CN, Mai HQ, Ma J, Hong MH, Chen MY. New surgical staging system for patients with recurrent nasopharyngeal carcinoma based on the AJCC/UICC rTNM classification system. Eur J Cancer. 2015 Sep;51(13):1771-9.
5. Qi Yang , Huanxin Lin , Shu Wu, Fangyong Lei, Xi Zhu, Libing Song,   Minghuang Hong, Ling Guo. Prostate Tumor Overexpressed 1(PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal CarcinomaProgression and Poor Survival Outcomes. PLoS One. 2015 Aug 25; 10 (8): e0136448  (通讯，IF=3.234）
6. Jiang R, Zou X, Hu W, Fan YY, Yan Y, Zhang MX, You R, Sun R, Luo DH, Chen QY, Huang PY, Hua YJ, Guo L, Chen MY. The elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients. Tumour Biol. 2015 Sep;36(10):7775-87. doi: 10.1007/s 13277-015-3505-0. Epub 2015 May 6.
7. Guo SS, Tang LQ, Chen QY, Zhang L, Liu LT, Huang PY, Cao KJ, Guo L, Mo HY, Guo X, Hong MH, Zeng MS, Qian CN, Mai HQ.Is Hemoglobin Level in Patients with Nasopharyngeal Carcinoma Still a Significant Prognostic Factor in the Era of Intensity-Modulated Radiotherapy Technology? PLoS One. 2015Aug 27;10(8) : e0136033. doi: 10.1371/ journal. pone.0136033. e Collection 2015.
8. Tang LQ, Li CF, Li J, Chen WH, Chen QY, Yuan LX, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Zhang L, Guo SS, Liu LT, Guo L, Wu YS, Luo DH, Huang PY, Mo HY, Xiang YQ, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Cao KJ, Qian CN, Guo X, Zeng YX, Mai HQ, Zeng MS. Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma. J Natl Cancer Inst. 2015 Oct 14;108(1). pii: djv291. doi: 10. 1093/ jnci/djv291. Print 2016 Jan
9. Chen WH, Tang LQ, Zhang L, Chen QY, Guo SS, Liu LT, Fan W, Zhang X, Guo L, Zhao C, Cao KJ, Qian CN, Guo X, Xie D, Zeng MS, Mai HQ. Combining plasma Epstein-Barr virus DNA and nodal maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography improved prognostic stratification to predict distant metastasis for locoregionally advanced nasopharyngeal carcinoma. Oncotarget. 2015 Nov 10; 6(35): 38296 - 307. doi: 10.18632/oncotarget.5699.
10. Liu LT, Tang LQ, Chen QY, Zhang L, Guo SS, Guo L, Mo HY, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Bei JX, Hong MH, Shao JY, Sun Y, Ma J, Mai HQ. The Prognostic Value of Plasma Epstein-Barr Viral DNA and Tumor Response to Neoadjuvant Chemotherapy in Advanced-Stage Nasopharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):862-9. doi: 10.1016/j.ijrobp.2015.08.003. Epub 2015 Aug 7.
11. Guo SS, Tang LQ, Zhang L, Chen QY, Liu LT, Guo L, Mo HY, Luo DH, Huang PY, Xiang YQ, Sun R, Chen MY, Wang L, Lv X, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Bei JX, Hong MH, Shao JY, Sun Y, Ma J, Mai HQ. The impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy. BMC Cancer. 2015 Dec 16; 15: 977. doi: 10.1186/s12885-015-1964-8.

2016
12. San-Gang Wu , Zhen-Yu He , Hong-Yue Ren , Li-Chao Yang , Jia-Yuan Sun , Feng-Yan Li , Ling Guo，Huan-Xin Lin. Use of CEA and CA15-3 to Predict Axillary Lymph Node Metastasis in Patients with Breast Cancer. Journal of Cancer  2016 Jan 1;7(1):37-41. doi: 10.7150/jca.13090. (共同通讯，IF=3.271）
13. Qian Zhu, Su-Mei Cao, Huan-Xin Lin, Qi Yang, Sai-Lan Liu, Ling Guo. Overexpression of acylglycerol kinase is associatedwith poorer prognosis and lymph node metastasisin nasopharyngeal carcinoma. Tumor Biol. (2016) mar; 37:3349–3357(通讯，IF=2.926）
14. Ye L, Guo L, He Z, Wang X, Lin C, Zhang X, Wu S, Bao Y, Yang Q, Song L, Lin H. Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition. Oncotarget. 2016 Apr 26; 7(17):23757-71. doi: 10.18632 /oncotarget.8121. (共同第一作者IF=5.008）
15. Jiang R, You R, Pei XQ, Zou X, Zhang MX, Wang TM, Sun R, Luo DH, Huang PY, Chen QY, Hua YJ, Tang LQ, Guo L, Mo HY, Qian CN, Mai HQ, Hong MH, Cai HM, Chen MY.Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients' survival. Oncotarget. 2016 Jan 19;7(3):3645-57. doi: 10.18632/oncotarget.6436.
16. Zhang L, Tang LQ, Chen QY, Liu H, Guo SS, Liu LT, Guo L, Mo HY, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Shao JY, Sun Y, Ma J, Hong MH, Mai HQ. Plasma Epstein-Barr viral DNA complements TNM classification of nasopharyngeal carcinoma in the era of intensity-modulated radiotherapy. Oncotarget. 2016 Feb 2;7(5):6221-30. doi: 10.18632/oncotarget.6754.
17. Hu L, Lin Z, Wu Y, Dong J, Zhao B, Cheng Y, Huang P, Xu L, Xia T, Xiong D, Wang H, Li M, Guo L, Kieff E, Zeng Y, Zhong Q, Zeng M. Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing. Front Med. 2016 Mar;10(1):61-75. doi: 10.1007/s11684-016-0436-0. Epub 2016 Mar 11.
18. Zhang L, Liu H, Tang LQ, Chen QY, Guo SS, Liu LT, Guo L, Mo HY, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Shao JY, Sun Y, Ma J, Hong MH, Mai HQ. Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis. Oncotarget. 2016 Apr 19;7(16):21913-21. doi: 10.18632/oncotarget.8008.
19. Guo SS, Tang LQ, Chen QY, Zhang L, Liu LT, Guo L, Mo HY, Luo DH, Huang PY, Xiang YQ, Sun R, Chen MY, Wang L, Lv X, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Bei JX, Hong MH, Shao JY, Sun Y, Ma J, Mai HQ. Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in stage III-IVb nasopharyngeal carcinoma patients with Epstein-Barr virus DNA ≥4000 copies/ml: a matched study. Oncotarget. 2016 Apr 18. doi: 10.18632/oncotarget.8828. [Epub ahead of print]
20. Liu LT, Chen QY, Tang LQ, Zhang L, Guo SS, Xie CM, Liu XW, Guo L, Mo HY, Chen MY, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Bei JX, Hong MH, Shao JY, Sun Y, Ma J, Mai HQ. Advanced-Stage Nasopharyngeal Carcinoma: Restaging System after Neoadjuvant Chemotherapy on the Basis of MR Imaging Determines Survival. Radiology. 2016 Aug 1:152540. [Epub ahead of print]
21. Zhu Q, Zou X, You R, Jiang R, Zhang MX, Liu YP, Qian CN, Mai HQ, Hong MH, Guo L, Chen MY. Establishment of an innovative staging system for extramedullary plasmacytoma.BMC Cancer. 2016 Oct 8;16(1):777. (共同通讯，IF=3.265）

2017
22. Liu SL, Lin HX, Qiu F, Zhang WJ, Niu CH, Wen W, Sun XQ, Ye LP, Wu  
XQ, Lin CY, Song LB, Guo L. Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients. PLoS One. 2017 Jan 12;12(1):e0169280. doi: 10.1371/journal.pone.0169280. eCollection 2017. (通讯，IF= 3.057）
23. Cao SM, Yang Q, Guo L, Mai HQ, Mo HY, Cao KJ, Qian CN, Zhao C, Xiang YQ, Zhang XP, Lin ZX, Li WX, Liu Q, Qiu F, Sun R, Chen QY, Huang PY, Luo DH, Hua YJ, Wu YS, Lv X, Wang L, Xia WX, Tang LQ, Ye YF, Chen MY, Guo X, Hong MH. Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase III multicentre randomised controlled trial. Eur J Cancer. 2017 Apr;75:14-23. doi: 10.1016/j.ejca.2016.12.039. Epub 2017 Feb 16（共同第一作者，IF：6.029）
24. Liu SL, Lin HX, Lin CY, Sun XQ, Ye LP, Qiu F, Wen W, Hua X, Wu XQ, Li J, Song LB, Guo L. TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition. Cancer Lett. 2017 Jun 3;402:117-130. doi: 10.1016/j.can let.2017.05.022. [Epub ahead of print](通讯，IF=6.375）
25. Zhu Q, Cai MY, Chen CL, Hu H, Lin HX, Li M, Weng DS, Zhao JJ, Guo L, Xia JC. Tumor cells PD-L1 expression as a favorableprognosis factor in nasopharyngeal carcinomapatients with pre-existing intratumor-infiltrating lymphocytes. Oncoimmunology. 2017 Apr 27; 6(5): e1312240. （共同通讯作者：IF=7.719）

Updated by International Office, Sun Yat-sen University Cancer Center