Prof. Guo Xiang was born in December 1963. In June 1988, he graduated from Department of Clinical Medicine of former Sun Yat-sen University of Medical Sciences and received the Doctoral Degree in Clinical Oncology. From September 1997 to January 1998, he further studied in Radiation Oncology of Shanghai Medical College of Fudan University; from June 2000 to June 2002, he received post-doctoral training in Van Andel Research Institute (VARI) in America, primarily engaging himself in the research on the application of gene chips in cancer; from 2002 in April to June 2002, he served as a visiting scholar and studied in William Beaumont Hospital’s Cancer Institute in the United States. Currently, he works as the Chief Physician, doctoral advisor and Associate Chief for Department of Nasopharyngeal Carcinoma, member and secretary of Chinese Society of Nasopharyngeal Carcinoma, Chinese Anti-cancer Association, editorial board member of Chinese Journal of Cancer and expert reviewer to Chinese Journal of Clinical Oncology.
 
After graduating from the undergraduate program, he worked in school and entered the Head and Neck at the Sun Yat-sen University Cancer Center (SYSUCC), engaging himself in medical treatment, teaching and scientific research. He masters solid theoretical basis for oncology and surgical basic skills and accumulates abundant experience in clinical practice. Since 1995, he has specialized in nasopharynx carcinoma’s clinical diagnosis and treatment, scientific research and teaching. Type of Work: clinical diagnosis, combination therapy, and research on the biological features of nasopharynx carcinoma; surgical treatment of recurrent nasopharynx carcinoma (including minimally invasive surgery of recurrent or residual nasopharyngeal carcinoma, surgical treatment of recurrent or residual cervical lymph nodes and surgical treatment of complications caused by radiotherapy); research on the biological features of nasopharynx carcinoma. He served as editor-in-chief in compilation of one monograph, co-wrote five monographs and published over 20 papers.

1. Diagnosis and combination therapy of nasopharynx carcinoma
2. Rescue surgical treatment of nasopharynx carcinoma
3. Surgical treatment of complications and sequelae after radiotherapy of nasopharynx carcinoma
4. Study on the biological characteristics of nasopharynx carcinoma

09/1982 – 06/1988: Department of Clinical Medicine of former Sun Yat-sen University of Medical Sciences

09/1994 – 06/1997: Studied to obtain the Doctoral Degree in Clinical Oncology in former Sun Yat-sen University of Medical Sciences and received the Doctoral Degree

09/1997 - 01/1998: Further studied in the Radiation Oncology at the Shanghai Medical College of Fudan University

06/2000 – 06/2002: Studied to obtain the Postdoctoral Degree from Van Andel Research Institute (USA)

04/2002 – 06/2002: Studied as a visiting scholar at the William Beaumont Hospital’s Cancer Institute in the United States

Main Publications (* Corresponding author):
1. Wang FL, Guo X*, Yuan ZT, Cao SM, Rao HL, Hong JH, Shao Q, Li NW, Hong MH. Expression and clinical significance of Wnt-1 andβ-catenin in nasopharyngeal carcinoma. Chinese Journal of Cancer, 2009; 28 (1): 91-95.

2. Mo HY, Deng MQ, Mai HQ, Qi B, Li NW, Guo X, Hong MH. The influences and treatment of deafness in nasopharyngeal carcinoma patients after radiotherapy. Modern Oncology, 17 (10): 1856-58. 

3. Hua YJ, Chen MY, Qian CN, Hong MH, Zhao C, Guo L, Guo X, Cao KJ. Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma. Head Neck. 2009 Jun;31(6):807-12.

4. Mai HQ, Mo HY, Deng JF, Deng MQ, Mai WY, Huang XM, Guo X, Hong MH. Endoscopic microwave coagulation therapy for early recurrent T1 nasopharyngeal carcinoma. Eur J Cancer. 2009 May;45(7):1107-10.

5. Chen MY, Wen WP, Guo X, Yang AK, Qian CN, Hua YJ, Wan XB, Guo ZM, Li TY, Hong MH.  Endoscopic nasopharyngectomy for locally recurrent nasopharyngeal carcinoma. Laryngoscope. 2009 Mar;119(3):516-22. 

6. Liu TR, Yang AK, Guo X, Li QL, Song M, He JH, Wang YH, Guo ZM, Zhang Q, Chen WQ, Chen FJ. Adenoid cystic carcinoma of the nasopharynx: 27-year experience. Laryngoscope. 2008 Nov;118(11):1981-8.

7. Qi Z, Guo X *, Li NW, Xiang YQ, Cao SM, Hong MH. Clinical Characteristics and Prognosis of Aged Nasopharyngeal Carcinoma Patients: A Report of 313 Cases. Chinese Journal of Cancer, 2008; 27 (3): 289-294.

8. Yuan TZ, Guo X *, Zheng L, Cao SM, Li NW, Xiang YQ. Occurrence and Influencing Factors of Paranasal Sinusitis in Nasopharyngeal Carcinoma Patients after Radiotherapy. Chinese Journal of Cancer, 2008; 27 (8): 866-869.

9. Yuan TZ, Li XX, Cao Y, Qian CN, Zeng MS, Guo X *. Correlation of Epidermal Growth Factor Receptor Activation to Metastasis-free Survival of Nasopharyngeal Carcinoma Patients. Chinese Journal of Cancer, 2008; 27 (5): 449-454.

10. Yuan TZ, Li NW, Cao SM, Qi Z, Guo X *. Peripheral nerve sheath tumors at the epithelioid cell type of nasopharyngeal skull base: A report of one case and literature review. Chin J Cancer Prev Treat, 2008 April; 15 (8):639-640.

11. Mr TQ, Mai HQ, Mai WY, Mo HY, Huang XM, Guo X, Hong MH. Endoscopic Microwave Coagulation Therapy for Locally Recurrent Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2008; 27 (7): 734-737.

12. Cao SM, Guo X *, Chen FuJ, Yang AK, Chen WK, Li NW. Serum Diagnosis of Head and Neck Squamous Cell Carcinoma Using Surface-enhanced Desorption Ionization Mass Spectrometry and Artificial Neural Network Analyses. Chinese Journal of Cancer, 2007; 26 (7): 767-770.

13. Chen MY, Guo X, Wen WP, Hua YJ, Guo L, Li NW, Chen QY, Sun R, Hong MH. Salvage Surgical Operation via Endoscopic Transnasal Approach for Local Persistent or Recurrent Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2007; 26 (7): 673-678.

14. Mo HY, Mai HQ, Li NW, Li J, Huang WJ, Guo X, Hong MH. Study of secretory otitis media after radiotherapy in nasopharyngeal carcinoma and inquisition of prevention and treatment. Chin J Cancer Prev Treat, 2007 July; 14 (13) 1005-1007.

15. Mai HQ, Zeng ZY, Feng KT, Ye YL, Zhang CQ, Liang WJ, Guo X, Mo HY, Hong MH. Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma.Cancer Sci. 2006 Dec; 97(12):1388-95. Epub 2006 Oct 9.

16. Mai HQ, Zeng ZY, Zhang CQ, Feng KT, Guo X, Mo HY, Deng MQ, Min HQ, Hong MH.  Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma. Cancer. 2006 Apr 1; 106(7):1548-53.

17. Cao SM, Guo X *, Li NW, Xiang YQ, Hong MH, Min HQ. Clinical analysis of 1142 Hospitalized Cantonese Patients with Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2006 Feb; 25 (2):204-208.

18. Xiang YQ, Yao HR, Wang SS, Hong MH, He JH, Cao SM, Min HQ, Song EW, Guo X*. Prognostic Value of Survivin and Livin in Nasopharyngeal Carcinoma. Laryngoscope, 2006 Jan; 116(1):126-130.

19. Guo X*, Cao SM, Yu JK, Hong MH, Zhang CQ, Li NW, Xiang YQ, Qian CN, Hu X, Min HQ, Zeng YX. Distinct serumal proteomic patterns between ascending and descending types of loco-regionally advanced nasopharyngeal carcinoma assessed by surface enhanced laser desorption ionization and artificial neural network analyses. Chin Med J (Engl), 2005 Nov; 118(22):1912-1917.

20. Xiang YQ, Yao RH, Guo X *, Hong MH, Cao SM, Min HQ. Expression of survival in nasopharyngeal carcinoma and its prognostic significance. Chin J Cancer Prev Treat, 2006 Jan; 13 (2):120-123.

21. Cao SM, Guo X, Li NW, Hong MH, Min HQ. The Family Clustering Study of Nasopharyngeal Carcinoma Patients in Guangdong. Cancer Research on Prevention and Treatment, 2006 Apr; 33 (4):283-285.

22. Sun ZY, Mai HQ, Xie CM, Zhao ZJ, Qi B, Hong MH, Guo X, Mo HY.  Prognostic influence of parapharyngeal space involvement in nasopharyngeal carcinoma. Chin J Cancer Prev Treat, 2006; 13 (10): 756-759.

23. Guo L, Lin HX, Qiu F, Luo HD, Sun R, Guo X, Hong MH. Concurrent Chemoradiotherapy Using Oral Capecitabine and Carboplatin in the Treatment of Elderly Patients with Advanced Nasopharyngeal Carcinoma. Cancer Research on Prevention and Treatment, 2006; 33 (5): 368-370.

24. Xiang YQ, Zhao HR, Guo X *, Hong MH, Cao SM, Min HQ. Apoptosis of Nasopharyngeal Carcinoma SUNE-1 Cell Lines Induced by inhibitors of Topoismerase II. Chinese Journal of Clinical Oncology, 2005 Dec; 32 (24): 406-1409.

25. Xiang YQ, Zhao HR, Guo X *, Hong MH, Cao SM, Min HQ. Apoptosis of Nasopharyngeal Carcinoma CNE-2 Cell Lines Induced by Topoismerase II, ADM and THP. Journal of Sun Yat-sen University (Medical Sciences), 2005; 26 (3S): 70-72. 

26. Akervall J, Guo X (Co-first author), Qian CN, Schoumans J, Leeser B, Kort E, Cole A, Resau J, Bradford C, Carey T, Wennerberg J, Anderson H, Tennvall J, Teh BT. Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. Clinical Cancer Research, 2004 Dec; 10(24): 8204-8013. 

27. Guo X, Cao SM, Hong MH, Zhang CQ, Han AJ, Xiang YQ, Hou JH, Min HQ. Clinical Value of Vascular Endothelial Growth Factor Detection in Forecasting Distant Metastasis Risk of Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2004; 23 (10): 1171-75.

28. Xiang YQ, Min HQ, Hong MH, Cao SM, He JH, Hou JH, Guo X*. Expression of Topoisomerase IIα in Nasopharyngeal Carcinoma and Its Clinical Significance. Chinese Journal of Cancer, 2004; 23 (3): 322-325. 

29. Guo X, Lui WO, Qian CN, Chen JD, Gray SG, Rhodes D, Haab B, Stanbridge E, Wang H, Hong MH, Min HQ, Larsson C, Teh BT.  Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses.  Int J Oncol., 2002 Dec; 21(6):1197-1204.

30. Hong MH, Min QH, Guo X *, Ma J, Mai HQ, Zhang WT, Zhang F, Zhang JM. To prove the rationality of ’92 staging with results of nasopharyngeal carcinoma treated by stratified multitherapies. Chinese Journal of Cancer, 2000; 19 (5): 460-2.

31. Guo X *, Min HQ, Huang XM, Zhang JM, Chen FJ. The maxillary swing approach for resection of nasopharyngeal carcinoma. Chinese Journal of Cancer, 1999; 18 (2): 187-189.

32. Guo X*, Min HQ, Zeng MS, Qian CN, Huang XM, Shao JY, Hou JH. nm23-H1 expression in nasopharyngeal carcinoma: correlation with clinical outcome.  Int J Cancer. 1998 Dec; 18; 79 (6):596-600.

33. Guo X*, Min Huaqing, Shao Jianyong, Hou Jinhui. Expression of Nm23-H1 Gene Product in Nasophartngeal Carcinoma and Its Clinical Significance. Chinese Journal of Cancer Research, 1998; 10(1): 49-53.

34. Guo X *, Min HQ, Huang XM, Zhang JM, Chen FJ, Qian CN. Exploration of new approach to salvage surgical operation of nasopharyngeal carcinoma -- the inverted maxillary approach for resection. Chinese Journal of Cancer, 1998; 17 (4): 271-273. 

35. Guo X *, Min HQ, Zhao JY, Hou JH. Expression and clinical significance of gene products of Nm23-H in the human nasopharyngeal carcinoma. Chinese Journal of Cancer, 1997; 16 (2): 119-122. 

36. Guo X *, Min QH. Salvage surgical operation of nasopharyngeal carcinoma (Review). China Cancer, 1997; 6 (7): 18-20. 

37. Guo X *, Min HQ, Zeng ZY, Chen FJ. Esthesioneuroblastoma (clinical analysis of 23 cases). Chinese Journal of Trauma and Distablity Medicine, 1996; 4 (3): 30-31. 

38. Xial LP, Zeng ZY, Chen ZH, Guo ZM, Guo X, Zhang Q. Surgery for the recurrent and persistent lymph node of nasopharyngeal carcinoma after radiotherapy. Chin J Otorhinolaryngol Head Neck Surg, 2005; 140 (2): 95-99. 

39. Mai, HQ, Mo HY, Hong MH, Guo X, Deng MQ, Zhang F, Min HQ. Impact of Pre-radiotherapy Hemoglobin Level on Local Control of Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2005; 24 (6): 727-730.

40. Lindvall C, Furge K, Bjorkholm M, Guo X, Haab B, Blennow E, Nordenskjold M, Teh BT. Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes. Haematologica, 2004 Sep; 89(9):1072-81.

41. Gray SG, Qian CN, Furge K, Guo X, Teh BT. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int J Oncol, 2004 Apr; 24(4):773-95.

42. Fuh-Mei Duh, Matthew Fivash, Michele Moody, Maria Li Lung, Xiang Guo, Eric Stanbridge, Michael Dean, Michael Voevoda, Li-Fu Hu, Vladimir Kashuba, Eugene R. Zabarovsky, Chao-Nan Qian, Sharad Godbole, Bin Tean Teh and Michael I. Lerman. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. Molecular and Cellular Probes, 2004; 18(1):39-44.

43. Cao SM, Min HQ, Gao JS, Hong MH, Xiao XB, Zhang CQ, Liu XD, Zhang AL, Guo X. Significance of Cell-free Epstein-Barr Virus DNA in Monitoring Prognosis of Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2003; 22 (3): 302-6.

44. Qian CN, Guo X, Cao B, Kort EJ, Lee CC, Chen J, Wang LM, Mai WY, Min HQ, Hong MH, Vande Woude GF, Resau JH, Teh BT. Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma.  Cancer Res., 2002 Jan 15; 62(2):589-96.

45. Xiang YQ, Guo X, Hong MH. Progress in studying molecule markers of nasopharyngeal carcinoma. Journal of Practical Oncology, 2004; 19 (4): 273-275.

46. Tao JP, Li MZ, Wang HM, Guo X, Hong MH. Study on the Tumorigenicity of Nasopharyngeal Carcinoma Cells Transfected with Haman IL-18 cDNA in Hu-PBL-SCID Mice. Current Immunology (Shanghai Journal of Immunology), 2002; 22 (6): 408-410.

47. Gray SG, Guo X, Kedra D, Teh BT, Guo X, Min HQ.  Correspondence re: P. P. Claudio et al., Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Res., 60: 8-12, 2000. Cancer Res. 2001 Aug 1; 61(15):5950-5953.

48. Mai HQ, Huang XM, Zhang F, Deng MQ, Guo X, Min HQ. Clinical Analysis on Osteoradionecrosis of Skull Base in Patients with Nasopharyngeal Carcinoma after Radiotherapy. China Journal of Cancer, 2001; 20 (1): 69-71.

49. Qian CN, Zhang CQ, Guo X, Hong MH, Cao SM, Mai WY, Min HQ, Zeng YX.  Elevation of serum vascular endothelial growth factor in male patients with metastatic nasopharyngeal carcinoma.  Cancer, 2000 Jan 15; 88(2): 255-261.

50. Min HQ, Guo X. Retrospect and prospect of study on nasopharyngeal carcinoma. Foreign Medical Sciences (Cancer Section), 2000; 27 (1): 11-14.

51. Yang AK, Guo X. Clinical analysis of mucosal malignant melanoma of head and neck. Cancer Research on Prevention and Treatment, 2000; 27 (4): 309-310. 

52. Min HQ, Hong MH, Guo X, Qian XN. Progress in study of nasopharyngeal carcinoma. China Cancer, 1999; 8 (12): 558-561.

53. Yang SC, Li SN, Liu F, Mai WY, Guo X. Changes in the Th1 cells in peripheral blood of patients with nasopharyngeal carcinoma and its relation to the course. Chinese Journal of Immunology, 1998; 14 (3): 220-223.

54. ang SC, Li SN, Liu F, Mai WY, Guo X. Transfection of B7-1 gene nasopharyngeal carcinoma cell lines and the cellular immune responses induced by transfection. Chinese Journal of Immunology, 1998; 14 (3): 172-175.

55. Guo X, Min HQ. Status of surgical operation in the treatment of nasopharyngeal carcinoma (Review). China Journal of Cancer, 1998; 17 (5): 394-396. 

56. Zeng MS, Guo X, Wang HM, Li MZ, Song LB, Yun JP, Guo HY. Expression of nm23-H1 mRNA and protein in nasopharyngeal carcinoma. Journal of Sun Yat-sen University, 1998; 19 (1): 7-10.

Major Monographs:
1. Hong MH, Guo X. Editor. Nasopharyngeal Carcinoma. China Medical Science Press, 2003. 

2. Guo X. Research on Screening and Early Diagnosis and Treatment for Nasopharyngeal Carcinoma. Edited by Dong ZW. Progress in China Research on Cancer (VIII). Peking University Medical Press, 2007; Pp401-417.

3. Guo X. Surgical Treatment for Nasopharyngeal Carcinoma. Edited by Zeng YX, Rong TH, Seminars on Nasopharyngeal Carcinoma. Zhengzhou University Press, 2006; Pp41-45. 

4. Guo X, Lu TX. Nasopharyngeal Carcinoma. Edited by Wan DS, Clinical Oncology (Second Edition). Science Press, 1999; pp: 217-229.

5. Guo X. Surgical Treatment. Edited by Hong MH and Guo X, Nasopharyngeal Carcinoma. China Medical Science Press, 2003; pp: 279-296. 

6. Guo X. Emergency Treatment. Edited by Hong MH and Guo X, Nasopharyngeal Carcinoma. China Medical Science Press, 2003; pp:346-351.   

7. Al-Sarraf, M., and Guo X. Head and Neck Cancers. In Cancer Chemotherapy and Biological Response Modifiers. Annual 21, G. Giaccone, R. Schilsky, and P. Sondel, 2003 Elsevier B.V., pp 430-443. 

8. Min HQ, Guo X. Nasopharyngeal Carcinoma. Edited by Li SL, New Head and Neck Oncology. Scientific and Technical Documentation Press, 2002; pp: 496-545. 

9. Guo X. Surgical Treatment of Nasopharyngeal Carcinoma. Edited by Min HQ, New Treatment Specifications of Common Cancers (Nasopharyngeal Carcinoma section). Peking Union Medical College Press,

10. Guo X. Surgical Treatment of Nasopharyngeal Carcinoma. Edited by Min HQ, Study on Nasopharyngeal Carcinoma. Guangdong Science & Technology Press, 1998: 265-280.

11. Guo X, Min HQ. Nasopharyngeal Carcinoma. Edited by Wang DS, Clinical Oncology. Science Press, 1998; pp: 122-32.
 

Research Projects:
1. Study on screening nasopharyngeal carcinoma metastasis-related genes with the technology of cDNA microarray (an international cooperation project of Guangdong Provincial Department of Science and Technology, undertaker)

2. Study on screening early nasopharyngeal carcinoma-specific serum protein with protein microarray (Guangdong Provincial Department of Science and Technology, undertaker) 

3. Study on screening nasopharyngeal carcinoma metastasis-related genes and predicting prognosis with the technology of cDNA microarray (Project 985, undertaker)

3. Role of IAP family proteins in prognosis of nasopharyngeal carcinoma (Hospital’s fund, undertaker).5. Application of protein microarray technology to screen marker nasopharyngeal carcinoma-specific serum protein markers (Hospital’s fund, undertaker).

1. Molecular biological characteristics of nasopharyngeal carcinoma in multi-stages of occurrence and development (Project 973, participant).

2. Research on screening nasopharyngeal carcinoma risk indicators of high-risk group(Health Department of Guangdong Province, participant).

 
Awards and Honors: 
1. Series research on prevention and treatment of nasopharyngeal carcinoma (the Second Class Award of State Science and Technology Advancement Award, 2000, No. 6, )

2. Research on ’92 staging and treatment of nasopharyngeal carcinoma (the First Class Award of Sci-Tech Advancement of Guangdong Province, 1999, No. 3)

3. Research on ’92 staging and treatment of nasopharyngeal carcinoma (the First Class Award of Health Department of Guangdong Province, 1999, No. 3)

4. Second-class Prize of “Mr. Deng Anticancer Science Award” (Sun Yat-sen University Cancer Center, 2006, Jan.)

5. Star of Technology, “Tianheng Cup” Award of Clinical Oncology Research Results (Sun Yat-sen University Cancer Center, 1999) 

6. Application of transnasal endoscopic surgery in the diagnosis and treatment of nasopharyngeal carcinoma, Third-class Prize in the Medical Achievement Award of Zhongshan School of Medicine (No. 041, Rank No. 2)

Updated by International Office, Sun Yat-sen University Cancer Center