Our Experts

Name: Yan Li
Title: Professor
Email: liyan@sysucc.org.cn

Dr. Yan Li obtained her M.D. degree at Hubei University of Medicine and Ph.D degree at Sun Yat-sen Medical University in 1995 and 2001, respectively. She had post-doctoral training in School of Medicine, Yale University from 2004-2005. Dr. Yan Li has acquired many funds from NSFC (82072604, 81871903, 81672357, 81472255, 81172338 and 30700820) and Guangdong Province. She was awarded as Outstanding Young Medical Talents in Guangdong Province in 2018. She has published more than 70 peer-reviewed papers, including Gastroenterology, Cancer Research and Oncogene.


Dr. Yan Li is interested in molecular mechanism of tumorigenesis, metastasis and interactions between microenvironment and tumor cell. She has identified some tumor suppressors, oncogenes and non-coding RNAs in ESCC and HCC. She also found a novel mechanism of genomic instability in esophageal cancers.


M.D. School of Medicine, Hubei University of Medicine, China 1990-1995

Ph.D. Sun Yat-sen Medical University, China 1996-2001


1. Suo D, Wang Z, Li L, Chen Q, Zeng T, Liu R, Yun J, Guan XY*, Li Y*. HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis. Oncogene  2020

2. Suo D#, Wang L#, Zeng T, Zhang H, Li L, Liu J, Yun J, Guan XY*, Li Y*. NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2. Oncogenesis 2020 

3. Zeng T#, Tang Z#, Liang L, Suo D, Li L, Li J, Yuan Y, Guan XY*, Li Y*. PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF-κB. Mol Oncol 2020 

4. Zhan YT#, Li L#, Zeng TT, Zhou NN, Guan XY*, Li Y*. SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma. Aging (Albany NY)  2020 

5. Zheng YL#, Li L#, Jia YX, Zhang BZ, Li JC, Zhu YH, Li MQ, He JZ, Zeng TT, Ban XJ, Yuan YF, Li Y*, Guan XY*. LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway. Theranostics 2019 

6. Li M, Wang L, Zhan Y, Zeng T, Zhang X, Guan XY*, Li Y*. Membrane Metalloendopeptidase (MME) Suppresses Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) by Inhibiting FAK-RhoA Signaling Axis. Am J Pathol 2019 

7. Li Y*, Lin S, Li L, Tang Z, Hu Y, Ban X, Zeng T, Zhou Y, Zhu YH, Gao S, Deng W, Zhang X, Xie D, Yuan Y, Huang P, Li J, Cai Z, Guan XY*. PDSS2 deficiency induces hepatocarcinogenesis by decreasing mitochondrial respiration and reprogramming glucose metabolism. Cancer Res 2018 

8. Zhang B, Zhang Z, Li L, Qin YR, Liu H, Jiang C, Zeng TT, Li MQ, Xie D, Li Y*, Guan XY*, Zhu YH*. TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling. Nat Commun 2018  

9. Zhou Y, Wang L, Ban X, Zeng T, Zhu Y, Li M, Guan XY*, Li Y*. DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma. Oncogene 2018

10. Wang L, Li M, Zhan Y, Ban X, Zeng T, Zhu Y, Yun J, Guan XY*, Li Y*. Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients. Mol Carcinog 2018 

11. Huang PY, Zeng TT, Ban X, Li MQ, Zhang BZ, Zhu YH, Hua WF, Mai HQ, Zhang L, Guan XY*, Li Y*. Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy. BMC Cancer 2016 

12. Yang H, Li XD, Zhou Y, Ban X, Zeng TT, Li L, Zhang BZ, Yun J, Xie D, Guan XY, Li Y*. Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma. Oncotarget 2015 

13. Li H, Zhang J, Chen SW, Liu LL, Li L, Gao F, Zhuang SM, Wang LP, Li Y*, Song M*. Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer. J Transl Med 2015

14. Huang PY, Zeng TT, Li MQ, Ban X, Zhu YH, Zhang BZ, Mai HQ, Zhang L, Guan XY*, Li Y*. Proteomic analysis of a nasopharyngeal carcinoma cell line and a nasopharyngeal epithelial cell line. Tumori 2015 

15. Huang PY#, Li Y#, Luo DH, Hou X, Zeng TT, Li MQ, Mai HQ, Zhang L. Expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma. Strahlenther Onkol 2015 

16. Li Y*, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased Expression of EIF5A2, via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma. Gastroenterology 2014 

17. Song Y, Li J, Zhu Y, Dai Y, Zeng T, Liu L, Li J, Wang H, Qin Y, Zeng M, Guan XY*, Li Y*. MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. Oncotarget 2014 

18. Li Y*, Zhu CL, Nie CJ, Li JC, Zeng TT, Zhou J, Chen J, Chen K, Fu L, Liu H, Qin Y, Guan XY*.  Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma. PLoS One 2013

19. Chen K, Li Y*, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY*. Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma. PLoS One 2013 

20. Huang PY#, Li Y#, Mai HQ, Luo RZ, Cai YC, Zhang L. Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy. Oral Oncol 2012 

21. Li Y, Chen L, Nie CJ, Zeng TT, Liu H, Mao X, Qin Y, Zhu YH, Fu L, Guan XY. Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma. Cancer Res 2011   

22. Li Y, Nie CJ, Hu L, Qin YR, Liu HB, Zeng TT, Chen LL, Fu L, Deng W, Chen SP, Jia WH, Zhang CY, Xie D, Guan XY.  Characterization of a novel mechanism of genomic instability involving SEI1/SET/NM23H1 pathway in esophageal cancers.  Cancer Res  2010 

23. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS, Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates. Hum Gene Ther 2008 

24. Xue G#, Liu RY#, Li Y#, Cheng Y, Liang ZH, Wu JX, Zeng MS, Tian FZ, Huang W. Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. Cancer Immunol Immunother 2007 

Updated March 2021

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