Associate Professor and Master's Supervisor in the Colorectal Department at Sun Yat-sen University Cancer Center. His research focuses on epigenetics in colorectal cancer liver metastasis and mechanisms of systemic therapy resistance. He has published over 30 SCI papers as first/corresponding author in journals including Autophagy and Molecular Cancer, with 5 papers having an impact factor >10. Dr. Peng leads multiple national and provincial grants and has received awards such as the "35under35" Outstanding Young Oncologist.

Focused on systematic research of epigenetics in mechanisms of colorectal cancer liver metastasis and systemic therapy resistance.

2008-09 to 2013-06, Wuhan University, Clinical Medicine, Bachelor

2013-09 to 2018-06, Sun Yat-sen University, Oncology, PhD

Work Experience:

2018-07 to 2019-12, Sun Yat-sen University Cancer Center, Resident Physician

2020-01 to 2022-12, Sun Yat-sen University Cancer Center, Attending Physician

2023-01 to Present, Sun Yat-sen University Cancer Center, Associate Chief Physician

1. Jiahua He, Weihao Li, ... Jianhong Peng; “Cancer associated fibroblasts-derived lactate induces oxaliplatin treatment resistance by promoting cancer stemness via ANTXR1 lactylation in

colorectal cancer” Cancer Letters, 2025; 631: 217917.

2. Weifeng Wang,Yuxiang Deng,... Jianhong Peng;“Feedback regulation between histone H3 lysine 18 lactylation and TROP2-mediated glycolysis drives metastatic progression of colorectal cancer” Clinical and Translational Medicine,2026;16(1):e70562.

3. Weili Zhang, Hui Sun, ... Jianhong Peng; “Neoadjuvant rectal-tumor regression grade combined score as surrogate endpoint for disease-free survival in locally advanced rectal cancer patients after neoadjuvant chemoradiotherapy” The Oncologist, 2025; 30(6): oyaf124.

4. Rongxin Zhang, Xiaojun Wu, ... Jianhong Peng, Zhizhong Pan; “Long-term outcomes of intraoperative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection (IOCCRC): a randomized, multicenter, prospective, phase III trial” International Journal of Surgery, 2024; 110(10): 6622-6631.

5. Kaixuan Zeng, Jianhong Peng, ... Junzhong Lin; “A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis” Molecular Cancer, 2023; 22(1): 202.

6. Weihao Li, Chi Zhou, ... Jianhong Peng, Junzhong Lin; “Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer” Autophagy, 2024; 20(1): 114-130.