About Us

Zeng Musheng MD, PhD

Title: Professor and Vice-President

Prof. Zeng administrates Office of Research Management, Office of International Administration, and Experimental Research Department.


Department: Experimental Research


Prof. Mu-Sheng Zeng is a vice director and professor of Sun Yat-sen University Cancer Center. He gained his Ph.D. degree at Sun Yat-sen University in 1998 and had his Post-doc training in Tennessee State University and New England Medical Center, Tufts University from 1999 to 2003. Prof. Mu-Sheng Zeng moved back to China to start his lab in 2003. In 2014, he was awarded as The Yangtze River Scholar Distinguished Professor from Ministry of Education of China. In 2016, he was awarded as Distinguished Scholar Professor of Guangdong province.

Email zengmsh@sysucc.org.cn


Research Interests:  

Zeng’s laboratory majorly engages in the pathogenesis, diagnosis and intervention of Nasopharyngeal Carcinoma (NPC), especially the mechanism of EBV infection and transformation of nasopharyngeal epithelial cells as well as development of EBV vaccine. In endemic regions, NPC presents as a complex disease caused by an interaction of Epstein-Barr virus (EBV) chronic infection, environmental, and genetic factors, in a multistep carcinogenic process. They completed the first full-length genomic sequence analysis of an NPC-derived EBV strain (termed GD1, Guangdong strain 1). His group established the first cellular proto-oncogene immortalized nasopharyngeal epithelial cell line and found the functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN and P16 in the development and progression of cancer. Most importantly, they established highly infective efficiency in vitro epithelial cell model for EBV infection, and identified that NMHC-IIA, EphA2 and NRP1 as key cellular receptors to mediate EBV infection of nasopharyngeal epithelial cells.


Selected publications:

1)   Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD, Li SB, Du Y, Xiong D, He JY, Li MZ, Liu YM, Zhou AJ, Zhong Q, Zeng YX, Kieff E, Zhang ZQ, Gewurz BE, Zhao B*, Zeng MS*, Ephrin receptor A2 is an epithelial cell receptor for EBV entry. Nat Microbiol, 2018 Feb;3(2):164-171

2)   Zhong Q, Liu Z, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X*, Zeng MS*, The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma. Clin Cancer Res, 2018 Feb 1, 24(3):659-673.

3)   Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS*, Zhang Z*, TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun, 2017. Oct 16, 8(1): p. 945

4)   Chen XX, Zhong Q, Liu Y, Yan SM, Chen ZH, Jin SZ, Xia TL, Li RY, Zhou AJ, Su Z, Huang YH, Huang QT, Huang LY, Zhang X, Zhao YN, Yun JP, Wu QL, Lin DX, Bai F*, Zeng MS*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing. Nat Commun, 2017. 8(1): p. 524.

5)   Tang LQ, Zhang H, Li Y, Zhang A, Chen ML, Li SB, Mai HQ, Zeng MS*, A Sponsored Supplement to SciencePrecision medicine in ChinaChapter 2 Precision medicine for nasopharyngeal carcinoma Science, 2016.12.23, 24~27

6)   Hua WF, Zhong Q, Xia TL, Chen Q, Zhang MY, Zhou AJ, Tu ZW, Qu C, Li MZ, Xia YF, Wang HY, Xie D, Claret FX, Song EW, Zeng MS*, RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma. Cell Death Dis, 2016. 7(9): p. e2352

7)   Hu LJ, Lin ZR, Wu YH, Dong JQ, Zhao B, Cheng YB, Huang PY, Xu LH, Xia TL, Xiong D, Wang HB, Li MZ, Guo L, Kieff E, Zeng YX, Zhong Q*, Zeng MS*, Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing. Front Med, 2016. 10(1): p. 61-75.

8)   Li RC, Du Y, Zeng QY, Tang LQ, Zhang H, Li Y, Liu WL, Zhong Q, Zeng MS*, Huang XM*, Antibodies Against Epstein-Barr Virus Glycoprotein gp42 for the Diagnosis of Nasopharyngeal Carcinoma. Clin Lab, 2016. 62(4): p. 553-61.

9)   Tang LQ, Li CF, Li J, Chen WH, Chen QY, Yuan LX, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Zhang L, Guo SS, Liu LT, Guo L, Wu YS, Luo DH, Huang PY, Mo HY, Xiang YQ, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Cao KJ, Qian CN, Guo X, Zeng YX, Mai HQ*, Zeng MS*, Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma. J Natl Cancer Inst, 2016. 108(1).

10)  Liu ZH, Hu JL, Liang JZ, Zhou AJ, Li MZ, Yan SM, Zhang X, Gao S, Chen L, Zhong Q*, Zeng MS*, Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression. Cell Death Dis, 2015. 6: p. e1920.

11) Xiong D, Du Y, Wang HB, Zhao B, Zhang H, Li Y, Hu LJ, Cao JY, Zhong Q, Liu WL, Li MZ, Zhu XF, Tsao SW, Hutt-Fletcher LM, Song E, Zeng YX, Kieff E*, Zeng MS*, Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells. Proc Natl Acad Sci U S A, 2015. 112(35): p. 11036-41.

12) Wang HB, Zhang H, Zhang JP, Li Y, Zhao B, Feng GK, Du Y, Xiong D, Zhong Q, Liu WL, Du H, Li MZ, Huang WL, Tsao SW, Hutt-Fletcher L, Zeng YX, Kieff E, Zeng MS*, Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells. Nat Commun, 2015. 6: p. 6240.

13)  Tang LQ, Hu DP, Chen QY, Zhang L, Lai XP, He Y, Xu YX, Wen SH, Peng YT, Chen WH, Guo SS, Liu LT, Qian CN, Guo X, Zeng MS*, Mai HQ*, Elevated high-sensitivity C-reactive protein levels predict decreased survival for nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era. PLoS One, 2015. 10(4): p. e0122965.

14)  Ni C, Chen Y, Zeng M (co-first author), Pei R, Du Y, Tang L, Wang M, Hu Y, Zhu H, He M, Wei X, Wang S, Ning X, Wang M, Wang J, Ma L, Chen X, Sun Q, Tang H, Wang Y, Wang X*, In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures. Cell Res, 2015. 25(7): p. 785-800.

15) Zong D, Yin L, Zhong Q, Guo WJ, Xu JH, Jiang N, Lin ZR, Li MZ, Han P, Xu L, He X*, Zeng MS*. ZNF 488 Enhances the Invasion and Tumorigenesis in Nasopharyngeal Carcinoma via the Wnt Signaling Pathway Involving Epithelial Mesenchymal Transition. Cancer Res Treat. 2015 Mar 12. doi: 10.4143/crt.2014.311.

16)  Han P, Lin ZR, Xu LH, Zhong Q, Zhu XF, Liang FY, Cai Q, Huang XM*, Zeng MS*, Ribonucleotide reductase M2 subunit expression and prognostic value in nasopharyngeal carcinoma. Mol Med Rep, 2015. 12(1): p. 401-9.

17)  Tang LQ, Li CF, Chen QY, Zhang L, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Chen WH, Liu H, Guo SS, Liu LT, Li J, Zhang JP, Guo L, Zhao C, Cao KJ, Qian CN, Zeng YX, Guo X, Mai HQ*, Zeng MS*, High-sensitivity C-reactive protein complements plasma Epstein-Barr virus deoxyribonucleic acid prognostication in nasopharyngeal carcinoma: a large-scale retrospective and prospective cohort study. Int J Radiat Oncol Biol Phys, 2015. 91(2): p. 325-36.

18) Feng GK, Liu RB, Zhang MQ, Ye XX, Zhong Q, Xia YF, Li MZ, Wang J, Song EW, Zhang X*, Wu ZZ*, Zeng MS*, SPECT and near-infrared fluorescence imaging of breast cancer with a neuropilin-1-targeting peptide. J Control Release, 2014. 192: p. 236-42.

19)  Yuan L, Liu ZH, Lin ZR, Xu LH, Zhong Q*, Zeng MS*, Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma. Cancer Biol Ther, 2014. 15(12): p. 1613-21.

20) Zhang JP, Zhang H, Wang HB, Li YX, Liu GH, Xing S, Li MZ, Zeng MS*, Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma. J Transl Med, 2014. 12: p. 222

21)            Zou QF, Du JK, Zhang H, Wang HB, Hu ZD, Chen SP, Du Y, Li MZ, Xie D, Zou J, Sun HD, Pu JX, Zeng MS* Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma. J Transl Med, 2013. 11: p. 200

22)            Wang HB, Liu GH, Zhang H, Xing S, Hu LJ, Zhao WF, Xie B, Li MZ, Zeng BH, Li Y, Zeng MS*, Sp1 and c-Myc regulate transcription of BMI1 in nasopharyngeal carcinoma. FEBS J, 2013. 280(12): p. 2929-44.

23)            Xu FH, Xiong D, Xu YF, Cao SM, Xue WQ, Qin HD, Liu WS, Cao JY, Zhang Y, Feng QS, Chen LZ, Li MZ, Liu ZW, Liu Q, Hong MH, Shugart YY, Zeng YX, Zeng MS*, Jia WH*, An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation. J Natl Cancer Inst, 2012. 104(18): p. 1396-410.

24) Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB, Zeng MS*, Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer, 2011. 10(1): p. 10.

25) Kong QL, Hu LJ, Cao JY, Huang YJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ, Shao JY, Qian CN, Xia YF, Song LB, Zeng YX, Zeng MS*, Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog, 2010. 6(6): p. e1000940.

26) Cao JY, Liu L, Chen SP, Zhang X, Mi YJ, Liu ZG, Li MZ, Zhang H, Qian CN, Shao JY, Fu LW, Xia YF*, Zeng MS*, Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Mol Cancer, 2010. 9: p. 237.

27)  Dong J, Zeng BH, Xu LH, Wang JY, Li MZ, Zeng MS*, Liu WL *, Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma. J Transl Med, 2010. 8: p. 81.

28)  Liu WL, Guo XZ, Zhang LJ, Wang JY, Zhang G, Guan S, Chen YM, Kong QL, Xu LH, Li MZ, Song LB, Zeng MS*, Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma. BMC Cancer, 2010. 10: p. 467.

29)  Guo BH, Zhang X, Zhang HZ, Lin HL, Feng Y, Shao JY, Huang WL, Kung HF, Zeng MS*, Low expression of Mel-18 predicts poor prognosis in patients with breast cancer. Ann Oncol, 2010. 21(12): p. 2361-9.

30)  Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX, Zeng MS*, The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest, 2009. 119(12): p. 3626-36.

31) Qin ZK, Yang JA, Ye YL, Zhang X, Xu LH, Zhou FJ, Han H, Liu ZW, Song LB, Zeng MS*, Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer, 2009. 9: p. 61.

32) Liu WL, Zhang G, Wang JY, Cao JY, Guo XZ, Xu LH, Li MZ, Song LB, Huang WL, Zeng MS*, Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma. Biochem Biophys Res Commun, 2008. 375(3): p. 440-5.

33) Guo XZ, Zhang G, Wang JY, Liu WL, Wang F, Dong JQ, Xu LH, Cao JY, Song LB, Zeng MS*, Prognostic relevance of Centromere protein H expression in esophageal carcinoma. BMC Cancer, 2008. 8: p. 233.

34)            Liu JH, Song LB, Zhang X, Guo BH, Feng Y, Li XX, Liao WT, Zeng MS*, Huang KH*, Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol, 2008. 97(3): p. 267-72

35) Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS*, Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res, 2007. 13(2 Pt 1): p. 508-14.

36)Song LB, Zeng MS*, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF, Fu LW, Huang WL, Dimri GP, Band V, Zeng YX, Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res, 2006. 66(12): p. 6225-32.

37) Song LB, Liao WT, Mai HQ, Zhang HZ, Zhang L, Li MZ, Hou JH, Fu LW, Huang WL, Zeng YX, Zeng MS*, The clinical significance of twist expression in nasopharyngeal carcinoma. Cancer Lett, 2006. 242(2): p. 258-65.

38) Jiang RC, Qin HD, Zeng MS(co-first author), Huang W, Feng BJ, Zhang F, Chen HK, Jia WH, Chen LZ, Feng QS, Zhang RH, Yu XJ, Zheng MZ, Zeng YX*, A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma. Cancer Res, 2006. 66(2): p. 693-700.

39)  Zeng M, Zhang Y, Bhat I, Wazer DE, Band H, Band V*, The human kallikrein 10 promoter contains a functional retinoid response element. Biol Chem, 2006. 387(6): p. 741-7.

40)  Zeng MS, Li DJ, Liu QL, Song LB, Li MZ, Zhang RH, Yu XJ, Wang HM, Ernberg I, Zeng YX*, Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J Virol, 2005. 79(24): p. 15323-30.

41) Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V*, Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem, 2002. 277(47): p. 45611-8.

Last updated: March, 2019

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