Dr. Pei-Rong Ding is currently a Professor and Chief Surgeon in the Department of Colorectal Cancer at Sun Yat-sen University Cancer Center (SYSUCC). He has extensive experience and expertise in developing treatment for colorectal cancer, gastrointestinal stromal tumor and gastrointestinal neuroendocrine tumor. He is skilled at treating primary, metastatic, and recurrent colorectal cancer. His expertise in minimally invasive surgery enables him to remove tumors without causing significant trauma to the patient. He is skilled in nerve-sparing surgical techniques that preserve sphincter, bladder, and sexual function in rectal surgery. Dr. Ding’s primary research interests include the screening and management of hereditary colorectal cancer and early-onset colorectal cancer, and optimization of neoadjuvant therapy for locally advanced rectal cancer. He is now leading several clinical trials to explore a better treatment models for rectal cancer and Lynch Syndrome. He has published more than 30 papers in some celebrated journal such as JNCI, Ann Surg, Eur J Can, theranostics, and Oncoimmunology.

Screening and management of hereditary colorectal cancer and early-onset colorectal cancer; optimization of neoadjuvant therapy for locally advanced rectal cancer; impact of microenvironment on immunotherapy of colorectal cancer.

2005/9-2010/7, Sun Yat-Sen University, Oncology, PhD, Supervisor: Pan Zhizhong

1997/9-2002/7, Sun Yat-Sen University, Clinical Medicine, Bachelor

1. Liu D. X., Li D. D., He W., Ke C. F., Jiang W., Tang J. H., Kong L. H., Li Y., Sui Q. Q., Xiao B. Y., Li W. R., Hong Z. G., Xu R. H., Pan Z. Z., Zhang X. S., Ding P. R. PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer. Oncoimmunology 9:1711650, 2020

2. Sui Q., Zheng J., Liu D., Peng J., Ou Q., Tang J., Li Y., Kong L., Jiang W., Xiao B., Chao X., Pan Z., Zhang H., Ding P. R. Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study. BMC Cancer 19:1210, 2019

3. Sui Q. Q., Jiang W., Wu X. D., Ling Y. H., Pan Z. Z., Ding P. R. A frameshift mutation in exon 19 of MLH1 in a Chinese Lynch syndrome family: a pedigree study. J Zhejiang Univ Sci B 20:105-108, 2019

4. Jiang W., Cai M. Y., Li S. Y., Bei J. X., Wang F., Hampel H., Ling Y. H., Frayling I. M., Sinicrope F. A., Rodriguez-Bigas M. A., Dignam J. J., Kerr D. J., Rosell R., Mao M., Li J. B., Guo Y. M., Wu X. Y., Kong L. H., Tang J. H., Wu X. D., Li C. F., Chen J. R., Ou Q. J., Ye M. Z., Guo F. M., Han P., Wang Q. W., Wan D. S., Li L., Xu R. H., Pan Z. Z., Ding P. R., Written on behalf of A. M. E. Colorectal Cancer Cooperative Group Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features. Int J Cancer, 2018

5. Tang J., Jiang W., Liu D., Luo J., Wu X., Pan Z., Ding P., Li Y. The comprehensive molecular landscape of the immunologic co-stimulator B7 and TNFR ligand receptor families in colorectal cancer: immunotherapeutic implications with microsatellite instability. Oncoimmunology 7:e1488566, 2018

6. Mai D., Ding P., Tan L., Zhang J., Pan Z., Bai R., Li C., Li M., Zhou Y., Tan W., Zhou Z., Li Y., Zhou A., Ye Y., Pan L., Zheng Y., Su J., Zuo Z., Liu Z., Zhao Q., Li X., Huang X., Li W., Wu S., Jia W., Zou S., Wu C., Xu R. H., Zheng J., Lin D. PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma. Theranostics 8:5213-5230, 2018

7. Liu G. C., Liu R. Y., Yan J. P., An X., Jiang W., Ling Y. H., Chen J. W., Bei J. X., Zuo X. Y., Cai M. Y., Liu Z. X., Zuo Z. X., Liu J. H., Pan Z. Z., Ding P. R. The Heterogeneity Between Lynch-Associated and Sporadic MMR Deficiency in Colorectal Cancers. J Natl Cancer Inst, 2018

8. Yu X., Wang Q. X., Xiao W. W., Chang H., Zeng Z. F., Lu Z. H., Wu X. J., Chen G., Pan Z. Z., Wan D. S., Ding P. R., Gao Y. H. Neoadjuvant oxaliplatin and capecitabine combined with bevacizumab plus radiotherapy for locally advanced rectal cancer: results of a single-institute phase II study. Cancer Commun (Lond) 38:24, 2018

9. Fan W. H., Xiao J., An X., Jiang W., Li L. R., Gao Y. H., Chen G., Kong L. H., Lin J. Z., Wang J. P., Pan Z. Z., Ding P. R. Patterns of recurrence in patients achieving pathologic complete response after neoadjuvant chemoradiotherapy for rectal cancer. J Cancer Res Clin Oncol 143:1461-1467, 2017

10. Tang J., Wu X., Bai Y., Gao Y., Jiang W., Kong L., Lin J., Wan D., Pan Z., Ding P. Long-Term Outcome of Oxaliplatin and Capecitabine (XELOX) Concomitant with Neoadjuvant Radiotherapy and Extended to the Resting Period in High Risk Locally Advanced Rectal Cancer. J Cancer 9:1365-1370, 2018

11. Qiu B., Ding P. R., Cai L., Xiao W. W., Zeng Z. F., Chen G., Lu Z. H., Li L. R., Wu X. J., Mirimanoff R. O., Pan Z. Z., Xu R. H., Gao Y. H. Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer. Chin J Cancer 35:65, 2016

12. Liu G. C., Yan J. P., He Q., An X., Pan Z. Z., Ding P. R. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterol Res Pract 2016:1798285, 2016

13. Lin J., Peng J., Qdaisat A., Li L., Chen G., Lu Z., Wu X., Gao Y., Zeng Z., Ding P., Pan Z. Severe weight loss during preoperative chemoradiotherapy compromises survival outcome for patients with locally advanced rectal cancer. J Cancer Res Clin Oncol 142:2551-2560, 2016

14. Wang Q. X., Li S. H., Zhang X., Xie L., Cai P. Q., An X., Pan Z. Z., Ding P. R. Identification of locally advanced rectal cancer with low risk of local recurrence. PLoS One 10:e0117141, 2015

15. Tang J. H., An X., Lin X., Gao Y. H., Liu G. C., Kong L. H., Pan Z. Z., Ding P. R. The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Oncotarget 6:33919-25, 2015

16. Liu G. C., Zhang X., Xie E., An X., Cai P. Q., Zhu Y., Tang J. H., Kong L. H., Lin J. Z., Pan Z. Z., Ding P. R. The Value of Restaging With Chest and Abdominal CT/MRI Scan After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. Medicine (Baltimore) 94:e2074, 2015

17. Gao Y. H., Lin J. Z., An X., Luo J. L., Cai M. Y., Cai P. Q., Kong L. H., Liu G. C., Tang J. H., Chen G., Pan Z. Z., Ding P. R. Neoadjuvant sandwich treatment with oxaliplatin and capecitabine administered prior to, concurrently with, and following radiation therapy in locally advanced rectal cancer: a prospective phase 2 trial. Int J Radiat Oncol Biol Phys 90:1153-60, 2014

18. Gao Y. H., Zhang X., An X., Cai M. Y., Zeng Z. F., Chen G., Kong L. H., Lin J. Z., Wan D. S., Pan Z. Z., Ding P. R. Oxaliplatin and capecitabine concomitant with neoadjuvant radiotherapy and extended to the resting period in high risk locally advanced rectal cancer. Strahlenther Onkol 190:158-64, 2014

19. You K. Y., Huang R., Ding P. R., Qiu B., Zhou G. Q., Chang H., Xiao W. W., Zeng Z. F., Pan Z. Z., Gao Y. H. Selective use of adjuvant chemotherapy for rectal cancer patients with ypN0. Int J Colorectal Dis, 2014

20. Cai P. Q., Wu Y. P., An X., Qiu X., Kong L. H., Liu G. C., Xie C. M., Pan Z. Z., Wu P. H., Ding P. R. Simple measurements on diffusion-weighted MR imaging for assessment of complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Eur Radiol 24:2962-70, 2014

21. Liu G. C., Tang J. H., Wen S. J., Cao H. X., An X., Cai P. Q., Kong L. H., Lin J. Z., Li L. R., Pan Z. Z., Ding P. R. Is early surveillance with CT scan necessary in patients with stage II/III colorectal cancer: A retrospective study. J Surg Oncol, 2013

22. Gao Y. H., An X., Sun W. J., Cai J., Cai M. Y., Kong L. H., Lin J. Z., Liu G. C., Tang J. H., Wu X. J., Chen G., Pan Z. Z., Ding P. R. Evaluation of capecitabine and oxaliplatin administered prior to and then concomitant to radiotherapy in high risk locally advanced rectal cancer. J Surg Oncol, 2013

23. An X., Lin X., Wang F. H., Goodman K., Cai P. Q., Kong L. H., Fang Y. J., Gao Y. H., Lin J. Z., Wan D. S., Pan Z. Z., Ding P. R. Short term results of neoadjuvant chemoradiotherapy with fluoropyrimidine alone or in combination with oxaliplatin in locally advanced rectal cancer: a meta analysis. Eur J Cancer 49:843-51, 2013

24. Ding P., Liska D., Tang P., Shia J., Saltz L., Goodman K., Downey R. J., Nash G. M., Temple L. K., Paty P. B., Guillem J. G., Wong W. D., Weiser M. R. Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective study. Ann Surg 256:111-6, 2012

25. Ding P. R., Tiwari A. K., Ohnuma S., Lee J. W., An X., Dai C. L., Lu Q. S., Singh S., Yang D. H., Talele T. T., Ambudkar S. V., Chen Z. S. The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. PLoS One 6:e19329, 2011

26. Ding P. R., An X., Cao Y., Wu X. J., Li L. R., Chen G., Lu Z. H., Fang Y. J., Wan D. S., Pan Z. Z. Depth of tumor invasion independently predicts lymph node metastasis in T2 rectal cancer. J Gastrointest Surg 15:130-6, 2011

27. An X., Wang F. H., Ding P. R., Deng L., Jiang W. Q., Zhang L., Shao J. Y., Li Y. H. Plasma Epstein-Barr virus DNA level strongly predicts survival in metastatic/recurrent nasopharyngeal carcinoma treated with palliative chemotherapy. Cancer 117:3750-7, 2011

28. An X., Ding P. R., Wang F. H., Jiang W. Q., Li Y. H. Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma. Tumour Biol 32:317-24, 2011

29. Ding P. R., An X., Zhang R. X., Fang Y. J., Li L. R., Chen G., Wu X. J., Lu Z. H., Lin J. Z., Kong L. H., Wan D. S., Pan Z. Z. Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer. Int J Colorectal Dis 25:1427-33, 2010

30. Ding P. R. , Liska D. , Goodman K. A. , Saltz L. , Guillem J. G. , Paty P. , Temple L. K. F. , Nash G. M. , Wong W. D. , Weiser M. R. : Predictors of site-specific recurrence following combined modality therapy for locally advanced rectal cancer. (Abstract), Journal of Clinical Oncology, 2010 ASCO Annual Meeting. Chicago, 2010, pp 3642

31. An X., Tiwari A. K., Sun Y., Ding P. R., Ashby C. R., Jr., Chen Z. S. BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review. Leuk Res 34:1255-68, 2010

32. An X., Ding P. R., Xiang X. J., Wang Z. Q., Wang F. H., Feng F., Jiang W. Q., He Y. J., Xu R. H., Li Y. H. Carcinoembryonic antigen surge in metastatic colorectal cancer patients responding to irinotecan combination chemotherapy. Biomarkers 15:243-8, 2010

33. An X., Ding P. R., Li Y. H., Wang F. H., Shi Y. X., Wang Z. Q., He Y. J., Xu R. H., Jiang W. Q. Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer. Biomarkers 15:516-22, 2010

Updated May 2020