Identify and Map the Susceptibility Genes Contributing to NPC
Zeng Yixin's Laboratory
The pathogenesis of nasopharyngeal carcinoma (NPC) is highly related to genetic, Epstein-Barr Virus (EBV) infection and environmental risk factors. Under the supervision of Dr. Zeng, our lab aims to identify and map the susceptibility genes contributing to the NPC through next generation sequencing technology. We also lay an emphasis on elucidating the underlying molecular mechanism between those susceptibility genes and tumorigenesis. On the other hand, we are trying to find out if there will be NPC-associated EBV subtypes of high pathogenecity, as EBV infection is a well-known risk factor and commonly observed in NPC. Our lab employs multidisciplinary approaches and techniques, including genome wide association study (GWAS), cell culture system, molecular biology study and bioinformatics analysis.
1. Identification and functional characterization of nasopharyngeal (NPC) susceptibility genes
2. Identification and functional characterization of NPC associated Epstein-Barr Virus (EBV) subtypes
3. Gene, EBV and environment interactions in the pathogenesis of NPC
4. Cancer biotherapy and intervene of EBV in the early stage of NPC pathogenesis
Yi-Xin Zeng, M.D., Ph.D.
Department of Laboratory Research
Sun Yat-sen University Cancer Center
651 Dongfeng Road East,
Guangdong Province, China