Screening and validating tumor radiobiological markers and clinical prognostic indicators
Xia Yunfei's Laboratory
The laboratory of Prof. Yunfei Xia, is within the Sun Yat-sen University Cancer Center. The team of Prof. Xia is mainly engaged in screening and validating tumor radiobiological markers and clinical prognostic indicators.In basic research, Xia lab established spectroscopic techniques and parameters to detect the radio sensitivity of nasopharyngeal carcinoma based on free radicals, light biology, molecular biology and proteomics; revealed mechanisms of NPC radio-resistance such as p53-p21, DNA-PK / ATM-DNA repair pathways, cell cycle and apoptosis; screened predictive and prognostic indicators for nasopharyngeal carcinoma diagnosis by MALDI-TOF MS-based technologies. From Clinical scale, Xia lab divided NPC into four radiotherapy-related types as follows, Type I: radiosensitive and non-metastasis-prone, Type II: radioresistant and non-metastasis-prone, Type III: radiosensitive and metastasis-prone, and Type IV: radioresistant and metastasis-prone; found prognosis indicators of NPC from routine blood and biochemical examinations and therefore established the prognosis model. Moreover, Xia lab proposed improved glioma postoperative radiation therapy biological target.
1. Tumor radiobiological behavior related clinical and molecular typing research .
2. Study of nasopharyngeal carcinoma individualized treatment based on badiobiological behavior.
Yunfei Xia, prof.
Radiation Oncology Department of Sun Yat-sen university cancer center
Address: No. 651, Room 926 , Building 2, Sun Yat-sen university Cancer Center,Dongfeng East Road, Yuexiu District, Guangzhou.