Pathogenesis and etiology of NPC
Zeng Musheng's Laboratory
Prof. Musheng Zeng is a vice director and professor of Sun Yat-sen University Cancer Center. He gained his Ph.D. degree at Sun Yat-sen University in 1998 and had his Post-doc training in TennesseeState University and New England Medical Center, Tufts University from 1999 to2003. Prof. Musheng Zeng moved back to China to start his lab since 2003.
Zeng's laboratory majorly engage in the pathogenesis and etiology ofNasopharyngeal Carcinoma (NPC), especially the mechanism of EBV infection and transformation in nasopharyngeal epithelial cells. In endemic regions, NPC presents as a complex disease caused by an interaction of Epstein-Barr virus (EBV) chronic infection, environmental, and genetic factors, in a multistep carcinogenic process.
Prof. Zeng has previously deeply studied on the genetically determined susceptibility of NPC patients and the variation of EBV, furthermore, completed the first full-length sequence analysis of an NPC-derived EBV strain.
He has already established the first cellular proto-oncogene immortalized nasopharyngeal epithelial cell line and preliminarily illuminated the mechanisms involved in the tumorigenesis of NPC, and found the functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer.
Most importantly, he recently established highly infective efficiency and stable in vitro epithelial cell model for EBV infection.
Moreover, he discovered that LMP2A induces EMT and stem-like cell self-renewal in NPC, suggesting a novel mechanism by which Epstein-Barr virus induces the initiation, metastasis and recurrence of NPC.
Professor of Experimental Research
Sun Yat-sen University
651 Dong Feng Road, East Guangzhou, China 510060