About Us

Zeng Musheng, MD, PhD

Title: Professor and Vice-President

Prof. Zeng administrates the Department of General Affairs and the construction of the new campus in Knowledge City, Luogang.

Department: Experimental Research

Prof. Musheng Zeng is a vice director and professor of Sun Yat-sen University Cancer Center. He gained his Ph.D. degree at Sun Yat-sen University in 1998 and had his Post-doc training in Tennessee State University and New England Medical Center, Tufts University from 1999 to 2003. Prof. Musheng Zeng moved back to China to start his lab since 2003. In 2014, he was awarded as Changjiang Scholar Professor from Ministry of Education of China.

Zeng's laboratory majorly engages in the pathogenesis and etiology of Nasopharyngeal Carcinoma (NPC), especially the mechanism of EBV infection and transformation in nasopharyngeal epithelial cells. In endemic regions, NPC presents as a complex disease caused by an interaction of Epstein-Barr virus (EBV) chronic infection, environmental, and genetic factors, in a multistep carcinogenic process.
Email zengmsh@sysucc.org.cn
Phone 020-87343191

Research Interests:
Prof. Zeng has previously deeply studied the variation of EBV and completed the first full-length genomic sequence analysis of an NPC-derived EBV strain (termed GD1, Guangdong strain 1).

He has already established the first cellular proto-oncogene immortalized nasopharyngeal epithelial cell line and preliminarily illuminated the mechanisms involved in the tumorigenesis of NPC, and found the functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer. Most importantly, he recently established highly infective efficiency and stable in vitro epithelial cell model for EBV infection. Moreover, he discovered that EBV encoded LMP2A could induce epithelial mesenchymal transition (EMT) and increases side population of stem-like cancer cells in NPC, suggesting a novel mechanism by which EBV induces the initiation, metastasis and recurrence of NPC.

Recently, he has identified that NRP1 interacts with gB and mediates EBV infection of nasopharyngeal epithelial cells, putting forward the novel mechanism of EBV infecting epithelial cells.

Selected publications:
1)   Wang HB, Zhang H, Zhang JP, Li Y, Zhao B, Feng GK, Du Y, Xiong D, Zhong Q, Liu WL, Du H, Li MZ, Huang WL, Tsao SW, Hutt-Fletcher L, Zeng YX, Kieff E, Zeng MS*. Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells. Nat Commun. 2015 Feb 11;6:6240. doi: 10.1038/ncomms7240.

2)   Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li MF, Band V, Band H, Shi QH, Zeng YX, Zeng MS*. The Polycomb Group Protein Bmi-1 Represses Tumor Suppressor PTEN and Induces Epithelial-mesenchymal Transition in Nasopharyngeal Epithelial Cells. J Clin Invest. 2009 Dec;119(12):3626-36. doi: 10.1172/JCI39374. Epub 2009 Nov 2.

3)   Xu FH, Xiong D, Xu YF, Cao SM, Xue WQ, Qin HD, Liu WS, Cao JY, Zhang Y, Feng QS, Chen LZ, Li MZ, Liu ZW, Liu Q, Hong MH, Shugart YY, Zeng YX, Zeng MS*, Jia WH*. An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation. J Natl Cancer Inst. 2012 Sep 19;104(18):1396-410. Epub 2012 Sep 12.

4)   Kong QL, Hu LJ, Cao JY, Huang YJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ, Shao JY, Qian CN, Xia YF, Song LB, Zeng YX, Zeng MS*. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog. 2010 Jun 3;6(6):e1000940

5)   Feng GK, Liu RB, Zhang MQ, Ye XX, Zhong Q, Xia YF, Li MZ, Wang J, Song EW, Zhang X, Wu ZZ, Zeng MS*. SPECT and near-infrared fluorescence imaging of breast cancer with a neuropilin-1-targeting peptide. J Control Release. 2014 Oct 28;192:236-42.

6)   Tang LQ, Li CF, Chen QY, Zhang L, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Chen WH, Liu H, Guo SS, Liu LT, Li J, Zhang JP, Guo L, Zhao C, Cao KJ, Qian CN, Zeng YX, Guo X, Mai HQ, Zeng MS*. High-sensitivity C-reactive protein complements plasma epstein-barr virus deoxyribonucleic Acid prognostication in nasopharyngeal carcinoma: a large-scale retrospective and prospective cohort study. Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):325-36.

7)   Yuan L, Liu ZH, Lin ZR, Xu LH, Zhong Q, Zeng MS*. Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma. Cancer Biol Ther. 2014;15(12):1613-21

8)   Zhang JP, Zhang H, Wang HB, Li YX, Liu GH, Xing S, Li MZ, Zeng MS*. Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma. J Transl Med. 2014 Aug 7;12:222. doi: 10.1186/s12967-014-0222-1

9)   Zou QF, Du JK, Zhang H, Wang HB, Hu ZD, Chen SP, Du Y, Li MZ, Xie D, Zou J, Sun HD, Pu JX, Zeng MS*. Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma. J Transl Med. 2013 Aug 28;11:200. doi: 10.1186/1479-5876-11-200

10)  Wang HB, Liu GH, Zhang H, Xing S, Hu LJ, Zhao WF, Xie B, Li MZ, Zeng BH, Li Y, Zeng MS*. Sp1 and c-Myc regulate transcription of BMI1 in nasopharyngeal carcinoma. FEBS J. 2013 Jun;280(12):2929-44.

11)  Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB, Zeng MS*. Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer. 2011 Jan 28;10(1):10. doi: 10.1186/1476-4598-10-10.

12)  Cao JY, Liu L, Chen SP, Zhang X, Mi YJ, Liu ZG, Li MZ, Zhang H, Qian CN, Shao JY, Fu LW, Xia YF *, Zeng MS*. Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Mol Cancer. 2010 Sep 9;9:237

13)  Dong J, Zeng BH, Xu LH, Wang JY, Li MZ, Zeng MS*, Liu WL *.Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma. J Transl Med. 2010 Sep 3;8:81

14)  Liu WL, Guo XZ, Zhang LJ, Wang JY, Zhang G, Guan S, Chen YM, Kong QL, Xu LH, Li MZ, Song LB, Zeng MS*. Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma. BMC Cancer. 2010 Sep 1;10:467

15)  Guo BH, Zhang X, Zhang HZ, Lin HL, Feng Y, Shao JY, Huang WL, Kung HF, Zeng MS*. Low expression of Mel-18 predicts poor prognosis in patients with breast cancer. Ann Oncol. 2010 May 5.

16)  Song LB, Zeng MS*, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF,  Fu LW, Huang WL, Dimri G, Band V and Zeng YX. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res. 2006;66 (12):6225 .

17)  Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS*.  CENP-H is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival. Clin Cancer Res. 2007,13(2):508-14.

18)  Zeng MS, Li DJ, Liu QL, Song LB, Li MZ, Zhang RH, Yu XJ, Wang HM, Ernberg I, Zeng YX. Genomic sequence analysis of an Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J Virol (IF 5.31) 2005, 79 (24):15323-15330.

19)  Qin ZK, Yang JA, Ye YL, Zhang X, Xu LH, Zhou FJ, Han H, Liu ZW, Song LB, Zeng MS*. Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer. 2009 Feb 19;9:61. PubMed PMID: 19228380; PubMed Central PMCID: PMC2652492.

20)  Liu WL, Zhang G, Wang JY, Cao JY, Guo XZ, Xu LH, Li MZ, Song LB, Huang WL, Zeng MS*. Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2008 Oct 24;375(3):440-5. Epub 2008 Aug 21. PubMed PMID: 18722351.

21)  Guo XZ, Zhang G, Wang JY, Liu WL, Wang F, Dong JQ, Xu LH, Cao JY, Song LB, Zeng MS*. Prognostic relevance of Centromere protein H expression in esophageal carcinoma. BMC Cancer. 2008 Aug 13;8:233. PubMed PMID: 18700042; PubMed Central PMCID: PMC2535782.

22)  Song LB, Liao WT, Mai HQ, Zhang HZ, Zhang L, Li MZ, Hou JH, Fu LW, Huang WL, Zeng YX, Zeng MS*. The Clinical Significance of Twist Expression in Nasopharyngeal Carcinoma. Cancer Letters. 2006,242(2):257.

23)  Jiang RC, Qin HD, Zeng MS(the first three mentionned authors contributed equally to the article), Huang W, Feng BJ, Zhang F, Chen HK, Jia WH, Chen LZ, Feng QS, Zhang RH, Yu XJ, Zheng MZ, Zeng YX. A functional variant in the transcriptional regulatory region of gene LOC344967 co-segregates with disease phenotype in familial nasopharyngeal carcinoma. Cancer Res. 2006, 66(2): 693-700.

24)  Liu JH, Song LB, Zhang X, Guo BH, Feng Y, Li XX, Liao WT, Zeng MS*(corresponding author), Huang KH. Bmi-1*(corresponding author) expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol. 2008;97(3):267

25)  Zeng MS , Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V. Human papilloma virus 16 E6 oncoprotein inhibits RXR-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem. 2002; 277(47): 45611-45618.

26)  Zeng M, Zhang Y, Bhat I, Wazer D and Band V. The human kallikrein 10 promoter contains a functional retinoid acid response element. Biol Chem..2006, 387(6):741

Last updated: March, 2015

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