Research
    Zhou Fangjian
    Title Professor, Chairman of Department of Urology
    Profile

    Modified radical cystectomy
    Our group has made several modifications to the traditional radical cystectomy. The first is a modified technique to prevent complications related to stoma and ileoureteral anastomosis in patients undergoing ileal conduit diversion. The second is a modified technique for neourethral anastomosis in orthotopic neobladder reconstruction. Both of the two modifications have been widely accepted by peers.

    Nephron sparing operation
    Our group pays a lot of attention to nephron sparing operation. As more and more small renal mass being detected accidentally by body exam, and the prolonged  life span, preserving the kidney is more and more important. Our group made some modification to the traditional nephron sparing operation, which significantly reduced the postoperative complication.

    The mechanisms of Bladder cancer metastasis
    Metastasis is the main reason of failure in cancer treatment. Bladder cancer with metastasis is incurable. Hence exploring the mechanisms of Bladder cancer metastasis can provide new idea in the treatment of bladder cancer. Our group demonstrated that up-regulation of Nkx2.8 inhibited epithelial-mesenchymal transition (EMT), an early key event in cancer metastasis, in bladder cancer cells. The research is supported by the grants from the Natural Science Foundation of China (No. 81272810) and the Natural Science Foundation of Guangdong Province, China(No. S2012010009466).

    1995, The first award for“The series studies of renal stone and renal function” Hunan Province Science and Technology Association

    Email zhoufj@sysucc.org.cn
    Phone
    Research Interest(s)

     

    Education

    Obtained Medical Bachelor in 1984, Medical Master in 1987 and Medical Doctor in 1992  from Hunan Medical University

    Publications

    1. Zhang Z, Li J, Zheng H, Yu C, Chen J, Liu Z, Li M, Zeng M, Zhou F, Song L. Expression and cytoplasmic      localization of SAM68 Is a significant and independent prognostic marker for renal cell carcinoma. Cancer Epidemiol  Biomarkers Prev. 2009,18:2685-93

    2. Guo-Liang Hou , Yong-Hong Li , Zhi-Ling Zhang , Yong-Hong Xiong , Xiao-Feng Chen , Kai Yao, Zhuo-Wei Liu , Hui Han , Zi-Ke Qin , Fang-Jian Zhou. A modified technique for neo-urethral anastomosis in orthotopic neobladder reconstruction. Urology. 2009,74:1145-1149

    3. Kai Yao, Guo-Liang Hou., Zhuo-Wei Liu , Shao-Long Yu, Yong-Hong Li, Fang-jian Zhou. Upper urinary tract dilation due to conglutination of intraluminal distal ureters after orthotopic neobladder with split-cuff nipple ureteral reimplants: Early results of 8 cases. Urologic Oncology: Seminars and Original Investigations,2009, 27: 611–616

    4. Zhou J, Weng D, Zhou F, Pan K, Song H, Wang Q, Wang H, Wang H, Li Y, Huang L, Zhang H, Huang W, Xia J. Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses. Cancer Immunol Immunother. 2009, 58(10):1587-97. (IF: 3.804)

    5. Zi-Ke Qin, Jian-An Yang, Yun-lin Ye, Xing Zhang, Li-Hua Xu, Fang-Jian Zhou, Hui Han, Zuo-Wei Liu, Li-Bing Song and Mu-Sheng Zeng. Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer 2009, 9:61

    6. Fang J. Zhou, Shao L. Yu, Yong H.Li, Zhuo W. Liu, Yong H. Xiong, Pei H. Wu, Hui Han, Zi K.Qin. Intra-arterial chemotherapy with gecitabine and cisplatin for patients with recurrence of transitional cell carcinoma confined to the pelvis. J Chemo, 2009, 21(1):91-97 

    7. Wei Chen, Jun-hang Luo, Wen-feng Hua, Fang-jian Zhou, Marie C. Lin, Hsiang-fu Kung, Yi-xin Zeng, Xin-yuan Guan, Dan Xie. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial cancer of the bladder treated with radical cystectomy. Cancer Epidemiol Biomakers Prev 2009,18(2):400-4008

    8. Dong P, Flores J, Pelton K, Solomon KR. Prohibitin is a cholesterol-sensitive regulator of cell cycle transit.J Cell Biochem. 2010,111(5):1367-74.

    9. Kai Yao, Hua Tu, Yong-Hong Li, Zi-Ke Qin, Zhuo-Wei Liu, Fang-Jian Zhou, Hui Han. Modified technique of radical inguinal lymphadenectomy for penile carcinoma: morbidity and outcome.J Urol. 2010, 184:546-552

    10. Yong-Hong Xiong, Zhi-Ling Zhang, Yong-Hong Li,Zhuo-Wei Liu, Guo-Liang Hou,Qing Liu,Jing-Ping Yun, Xue-Qi Zhang and Fang-Jian Zhou. Benign pathological findings in 303 Chinese patients undergoing surgery for presumed localized renal cell carcinoma. Int J Urol, 2010,17:517-521

    11. Zhi Ling Zhang, Zhuo Wei Liu, Fang Jian Zhou, Yong Hong Li, Yong Hong Xiong, Kai Rao, Guo Liang Hou, Hui Han, Zi Ke Qin, Shao Long Yu, Xiao Feng Chen. Modified technique to prevent complications related to stoma and ileoureteral anastomosis in patients undergoing ileal conduit diversion.Urology,2010,76(4): 996-1000

    12. Jun-Hang Luo, Fang-Jian Zhou, Dan Xie, Zhi-Ling Zhang, Bing Liao, Hong-Wei Zhao, Yu-Ping Dai, Ling-Wu Chen, Wei Chen. Analysis of long-term survival in patients with localized renal cell carcinoma: laparoscopic versus open radical nephrectomy. World J Urol, 2010,28: 289

    13. Zhang Zhi-ling, Xiong Yong-hong, Li Yong-hong, Hou Guo-liang, Liu Zhuo-wei, Han Hui, Qin Ze-ke,Yun Jing-ping, Zhou Fang-jian. Reassessment of the predictive role of perivesical fat invasion in invasive bladder cancer prognosis in 151 chinese patients. Chinese Medical J, 2011:124(18):2915-2919

    14. Song Wu, Yong Wang, Liang Sun, Zhiling Zhang, Zhimao Jiang, Zike Qin, Hui Han, Zhuowei Liu, Xianxin Li, Aifa Tang, Yaoting Gui, Zhiming Cai and Fangjian Zhou.  Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma. BMC Cancer, 2011, 11:413

    15. Liu ZW, Zhang XQ, Hou GL, Zhang ZL, Qin ZK, Han H, Zhou FJ. Primary adult intratesticular rhabdomyosarcoma: Results of the treatment of six cases. Int J Urol. 2011,18(2):171-4.

    16. Yun-Lin Ye, Xiang-Zhou Sun, Fu-Fu Zheng, Jun Bian, Yan-Ping Huang, Xue-Qi Zhang, Zhi-Xun Li, Ying Nie, Zi-Ke Qin, and Yu-Ping Dai. Clinical Analysis of Management of Pediatric Testicular Germ Cell Tumors. Urology.2012,56(1):112-118

    17. Kai Yao,Hyewon Youn,Xiaoyan Gao,Bijun Huang,Fangjian Zhou, Benyi Li, and Hui Han*.Casein Kinase 2 Inhibition Attenuates Androgen Receptor Function and Cell Proliferation in PC Cells. The Prostate,2012. Published online

    18. Zhuo-Wei Liu,Ephrem O.Olweny,Gang Yin,Stephen Faddegon,Yung K.Tan, Woong  Kyu Han,Jeffrey A. Cadeddu. Prediction of perioperative outcomes following minimally invasive partial nephrectomy: role of the R.E.N.A.L nephrometry score. World J Urol,2012,DOI:10.1007/s00345-012-0876-3O

    19. Chen Ming-Kun,YE Yun-lin,ZHOU Fang-jian,LIU Jian-ye,LU Ke-shi,HAN Hui,LIU Zhuo-wei,XU Zhen-zhou and QIN Zi-ke. Clipping Extremity of Ureter Is Effective for Preventing Bladder Recurrence after Upper Urinary Tract Urothelial Carcinoma,Chinese Medical Journal. 2012.125(21):3821-3825

    20. Chen Ming-Kun,YE Yun-lin, ZHOU Fang-jian,LIU Jian-ye,LU Ke-shi,HAN Hui,LIU Zhuo-wei,XU Zhen-zhou and QIN Zi-ke. Clipping Extremity of Ureter Is Effective for Preventing Bladder Recurrence after Upper Urinary Tract Urothelial Carcinoma,Chinese Medical Journal. 2012,125(21):3821-3825

    21. Liu JY, Li YH, Lin HX, Liao YJ,Mai SJ, Liu ZW, Zhang ZL, Jiang LJ, Zhang JX, Kung HF, Zeng YX, Zhou FJ (Xie D  Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder. BMC Cancer. Epub 2013 Jul 19.

    22. Liu JY, Zhang Q, Ye YL, Li J, Chen W, Li YH, Zhang ZL, Yao K, Jiang LJ, Han H, Liu ZW, Qin ZK, Zhou FJ. Prognostic significance of tumor location and superficial urothelial bladder carcinoma history in patients with ureteral urothelial carcinoma treated with radical nephroureterectomy. 2013,45(2):395-404

    23. Kai Yao, Zai-Shang Li, Fang-Jian Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li and Hui Han*. Anatomical retroperitoneoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumours: initial operative experience. Asian  J  Andrology, 2013,11

    24. Pei Dong,Zhou wei Liu,Xiang Dong Li,Yong Hong Li,Kai Yao,Song Wu,Zi Ke Qin,Hui Han,Fang jian Zhou. Risk factors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors. Med Oncol,2013,30:494.

    Han Hui
    Title Professor
    Profile

    Prof. Han is specialized in treating patients with genitourinary system cancers, including bladder, kidney, prostate,adrenal gland, ureter, urethra, testis, epididymis, spermatic cord, and penis and so on. He is good at various kinds of urological operations, especially retroperitoneal lymph node dissection and inguinal lymphadenectomy.

    Prof. Han perform laparscopic and open procedures to treat these cancers, often in a multi-disciplinary team approach with the integration of expertise by medical oncology and/or radiation oncology. He also pursued technical innovations which have transformed the management of these cancers including open inguinal lymphadenectomy, laparoscopic retroperitoneal lymph node dissection, open/ laparoscopic radical nephrectomy and laparoscopic radical prostatectomy.

    Annually, Prof. Han perform approximately 100 partial/radical nephrectomy procedures for kidney cancer, 20 prostatectomy procedures for prostate cancer, 20 cystectomy procedures for bladder cancer, 20 lymph node dissections for penile cancer, and 15 retroperitoneal lymph node dissections for testis cancer. He also has unique expertise in managing rare urologic cancers and salvage procedures for recurrent cancers of the bladder and prostate that have failed initial therapy with surgery or other treatments.

    Email hanhui@sysucc.org.cn
    Phone
    Research Interest(s)
    Education

    Prof. Han trained in the Tong Ji University School of Medicine. He acquired M.D in Tong Ji University School of Medicine  and completed his Residency training in Tong Ji hospital.

    Publications

    1.Kai Yao, Hyewon Youn, Xiaoyan Gao,Bijun Huang,Fangjian Zhou, Benyi Li and Hui Han*. Casein Kinase 2 Inhibition Attenuates Androgen Receptor Function and Cell Proliferation in PC Cells. The Prostate, 72 (4):1423-1430,  2012   (IF 4.14)

    2.Kai Yao, Zai-Shang Li, Fang-Jian Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Hui Han*. Anatomical retroperitoneoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumors: initial operative experience, Asian Journal of Andrology ,16 (1):136-139,  2014   (IF 2.140)

    3.Kai Yao, Peng Chen, Zi-jun Zou, Zi-Ke Qin, Zhuo-Wei Liu , Yong-Hong Li, Fang-Jian Zhou, Hui Han*. Disease specific survival after radical lymphadenectomy for penile cancer: prediction by lymph node count and density. Urologic Oncology: Seminars and Original Investigations, 2013, Dec 30. [Epub ahead of print] (IF 3.647)

    4. Kai Yao, Zi-jun Zou, Zai-shang Li, Fang-Jian Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Hui Han*. Fascia lata preservation during inguinal lymphadenectomy for penile cancer:rationale and outcome, Urology , 82 (8):642-647,  2013   (IF 2.424)

    5.Kai Yao,  Hua Tu, Yong-Hong Li, Fang-Jian1 Zhou and Hui Han*. Modified Technique of Radical Inguinal Lymphadenectomy for Penile Carcinoma: Morbidity and Outcome, Journal of Urology, 184(8):546-552, 2011   (IF 3.696)

    6.Han H*, Yao K, Zhou FJ. Modified Technique of radical inguinal lymphadenectomy to reduce the complication of skin necrosis for penile carcinoma, European Urology Supplements, 10(2): 339-340, 2011   (IF 2.162) 

    7.Han H*, Youn YH, Yao K, Zhou FJ, Huang HB, Li BY. CK2-selective CK2 inhibitor: effect on AR receptor and cell cycle in castrationresistant prostate cancer cell line, European Urology Supplements, 10 (2): 292-293, 2011    (IF 2.162) 

    8.Han H*, Yao K, Zhou FJ. Extroperitoneal lymph node dissection ( report of 7 cases). J of endourology .2008:22(supl 1):A286

    Qin Zike
    Title Professor, Chief Physician
    Profile Bladder cancer, kidney cancer, prostate cancer, testicular cancer, and other comprehensive treatment.
    Email qinzk@sysucc.org.cn
    Phone
    Research Interest(s) Principles of bladder cancer. In recent years, we investigated the role of  Bmi-1 in progression and metastasis of bladder cancer and found that Bmi-1 was related to recurrence and progression of  bladder cancer.
    Education 1984—1989  Guangxi Medical university, Bachelor Degree

    1993--1996  Cancer Center of Sun Yat-sen University, Master Degree

    1996--1999  First Affiliated Hospital of Sun Yat-sen University, Doctor Degree

    Publications 1. Intra-arterial Chemotherapy Is Reliable in Preventing High-risk Superficial Bladder Cancer from Recurrence and Progression. Journal of Chemotherapy. 2009,21(6): 681-686 .


    2. Expression of Bmi-1 is a Prognostic Marker in Bladder Cancer. BMC Cancer,2009, 9: 61-68 .

    3. Clipping the extremity of ureter prior to nephroureterectomy is effective for preventing subsequent bladder recurrence after upper urinary tract urothelial carcinoma. Chin Med J (Engl).125(21):3821-6,2012.

    4. Clinical Analysis of Management of Pediatric Testicular Germ Cell Tumors Urology.2012, 79(4): 892-7 .

    5. The risk factors for the presence of pelvic lymph node metastasis in penile squamous cell carcinoma patients with inguinal lymph node dissection. World J Urol.  2013,(6):1519-24.

    6. Intra-arterial chemotherapy with gemcitabine and cisplatin in locally advanced or recurrent squamous cell carcinoma of penis. Chinese Journal of Cancer.  2013,(11):619-23.

    Zhuo-wei Liu
    Title Associate Professor
    Profile

    Dr. Liu specializes in diagnosis and treatment of genitourinary cancers, including surgery and combination therapy (neoadjuvant chemotherapy, adjuvant chemotherapy, targeted therapy and etc.)
    He is also a recognized expert in laparoscopic surgery, do a lot of complex, challenging laparoscopic operations, such as laparoscopic radical cystectomy, laparoscopic retroperitoneal lymph node dissection for testicular tumors, laparoscopic partial nephrectomy and laparoscopic radical prostatectomy.

    Dr. Liu‘s research interests include Bladder Cancer and Testicular Cancer, those keep Dr. Liu at the forefront of his field.

    Professional Training
    Residency
    Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China,1998 -2000
    Department of Urology, Cancer Center, Sun Yat-sen University, Guangzhou, China, 2000-2002
    Attending doctor:
    Department of Urology, Cancer Center, SunYat-sen University, Guangzhou, China, 2002-2007

    Visiting scholar
    Department of Urology, Hokkaido University, Sapporo, Japan, 2004-2005(Training for laparoscopic surgery)
    Department of Urology, UT Southwestern Medical Center, Dallas, United States,visiting assistant professor. 2011-2012

    Associate professor
    Department of Urology, Cancer Center, Sun Yat-sen University, Guangzhou, China, 2008-present

    Honors and Awards
    2009 Outstanding Younger Doctor of The Cancer Center of Sun Yat-sen University
    2008“Excellent Papers for Youth” The Fifth Chinese Conference on Oncology

    Email liuzhw@sysucc.org.cn
    Phone
    Research Interest(s)

    Minimally invasive surgery for Urological oncology.

    Multidisciplinary management for bladder cancer and testicular cancer

    Education
    Publications

    1.Pei Dong,Zhou-wei Liu,Xiang Dong Li, et al. Risk factors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors. Med Oncol. 2013;30(1):494-5. (corresponding author)

    2. Pei Dong, Lijuan Jiang,..Zhuowei Liu.Inductiong ofpalitaxel  resistance by ERamediated Prohibitin Mitochondrial-Nuclear Shuttling. PLOS ONE. 2013;8(12).e83519 .(corresponding author)

    3. Zhuo-Wei Liu, EphremO,Olweny, Gang Yin, et al. Prediction of perioperative outcomes following minimally invasive partial nephrectomy: role of the R.E.N.A.L nephrometry score. World J Urol(2013)31:1183-1189.

    4. Zhuo-Wei Liu, Stephen Faddegon, EphremO,Olweny, et al. Renal oxygenation during partial nephrectomy: a comparison between artery-only occlusion versus artery and vein occlusion. Journal of Endourology 2013,27(4):470-474.

    5. Lv ZJ, Wu S, Dong P, Yao K, He YY, Gui YT, Zhou FJ, Liu ZW, Cai ZM. Clinical outcomes in patients with stage I non-seminomatous germ cell cancer.Asian J Androl.2013;15,58-563.(corresponding author)

    6. LiuZhuo-wei,Zhang xue-qi, HouGuo-liang et al.Primary adultintratesticularrhabdomyosarcoma: results of the treatment of six cases. International Journal of Urology. 2011,18:171-4.

    7. Li Xiangdong,LiuZhuo-wei, et al. Intra-arterial chemotherapy for pelvic recurrence after radical cystectomy for bladder urothelial cancer. Chinese Medical journal. 2012. (corresponding author)

    8. Zhang ZL, LiuZhuo-wei, Zhou FJet al. Modified Technique to Prevent Complications Related to Stoma and Ileoureteral Anastomosis in Patients Undergoing Ileal Conduit Diversion. Urology. 2010, 76:996-1000.

    9. Bagrodia A, Harrow B, Liu ZW, et al.Evaluation of anatomic and morphologic nomogram to predict malignant and high-grade disease in a cohort of patients with small renal masses. UrolOncol. 2014,32(1):37.e17-23.

    10.Liu JY, Li YH, Liu ZW,et al.Influence of body mass index on oncological outcomes in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy. Int J Urol. 2013 Aug 12. doi: 10.1111/iju.12208.

    11.Kai Yao, Guo-Liang Hou, Zhuo-Wei Liu,etal.Upper urinary tract dilation due to conglutination of intraluminal distalureters after orthotopicneobladder with split-cuff nipple ureteralreimplants: Early results of 8 cases. Urologic Oncology: Seminars and Original Investigations. 2009, 27: 611–616


    Last Updated on: March 2015

    Yao Kai
    Title Associate Professor
    Profile

    Doctor Yao is specialized in treating patients with genitourinary system cancers, including bladder, kidney, prostate, adrenal gland, ureter, urethra, testis, epididymis, spermatic cord, and penis and so on. He is good at various kinds of urological operations, especially radical inguinal lymphadenectomy. Doctor Yao perform laparscopic and open procedures to treat these cancers, often in a multi-disciplinary team approach with the integration of expertise by medical oncology and/or radiation oncology. He also pursued technical innovations which have transformed the management of these cancers including open inguinal lymphadenectomy, laparoscopic retroperitoneal lymph node dissection, open/ laparoscopic radical nephrectomy and laparoscopic radical prostatectomy. He also has unique expertise in managing rare urologic cancers and salvage procedures for recurrent cancers of the penis and kidney that have failed initial therapy with surgery or other treatments.

    Email yaokai@sysucc.org.cn
    Phone
    Research Interest(s)

     

    Education

    Doctor Yao trained in the ShangHai JiaoTong University School of Medicine. He acquired M.D in ShangHai JiaoTong University School of Medicine  and completed his Residency training in Rui Jin hospital.

    Publications

    1. Kai Yao, Hyewon Youn, Xiaoyan Gao,Bijun Huang,Fangjian Zhou, Benyi Li and Hui Han*. Casein Kinase 2 Inhibition Attenuates Androgen Receptor Function and Cell Proliferation in PC Cells. The Prostate, 72 (4):1423-1430,  2012   (IF 4.14)

    2. Kai Yao, Zai-Shang Li, Fang-Jian Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Hui Han*. Anatomical retroperitoneoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumors: initial operative experience, Asian Journal of Andrology ,16 (1):136-139,  2014   (IF 2.140)

    3. Kai Yao, Peng Chen, Zi-jun Zou, Zi-Ke Qin, Zhuo-Wei Liu , Yong-Hong Li, Fang-Jian Zhou, Hui Han*. Disease specific survival after radical lymphadenectomy for penile cancer: prediction by lymph node count and density. Urologic Oncology: Seminars and Original Investigations, 2013, Dec 30. [Epub ahead of print] (IF 3.647)

    4. Kai Yao, Zi-jun Zou, Zai-shang Li, Fang-Jian Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Hui Han*. Fascia lata preservation during inguinal lymphadenectomy for penile cancer:rationale and outcome, Urology , 82 (8):642-647,  2013   (IF 2.424)

    5. Kai Yao,  Hua Tu, Yong-Hong Li, Fang-Jian1 Zhou and Hui Han*. Modified Technique of Radical Inguinal Lymphadenectomy for Penile Carcinoma: Morbidity and Outcome, Journal of Urology, 184(8):546-552, 2011   (IF 3.696)

    6. Han H, Yao K, Zhou FJ. Modified Technique of radical inguinal lymphadenectomy to reduce the complication of skin necrosis for penile carcinoma, European Urology Supplements, 10(2): 339-340, 2011   (IF 2.162) 

    7. Han H, Youn YH, Yao K, Zhou FJ, Huang HB, Li BY. CK2-selective CK2 inhibitor: effect on AR receptor and cell cycle in castrationresistant prostate cancer cell line, European Urology Supplements, 10 (2): 292-293, 2011    (IF 2.162) 

    8. Han H, Yao K, Zhou FJ. Extroperitoneal lymph node dissection ( report of 7 cases). J of endourology .2008:22(supl 1):A286

    9.Kai Yao, Guo-Liang Hou, Yong-Hong Li,Han H and Fang-jian Zhou. Upper urinary tract dilation due to conglutination of intraluminal distal ureters after orthotopic neobladder with split-cuff nipple ureteral reimplants: Early results of 8 cases. Urologic Oncology: Seminars and Original Investigations, 27(10):611-616, 2010, (IF 3.647).


    Last Updated on: March 2015

    Li Yonghong
    Title Associate Professor
    Profile

    Dr. Li specializes in diagnosis and treatment of genitourinary cancers. He focus on prostate cancer, including early diagnosis of prostate cancer with elevated PSA, open or robotic-assisted radical prostatectomy, prostate cryoablation, and comprehensive treatment of prostate cancer. He is a recognized expert in prostate cryoablation.

     
    Last Updated on: February 2016
    Email
    Phone
    Research Interest(s)


    Diagnosis of prostate cancer

    Treatment of prostate cancer with cryoablation or surgery

    Education

    2011 - Present Ph.D., Medical college, Sun Yat-sen University

    2003 - 2006  Master, Medical college, Sun Yat-sen University

    1996 – 2001 M.D., Medical college of University of South China

    Publications

    1. Li YH, Elshafei A, Agarwal G, Ruckle H, Powsang J, Jones JS. Salvage focal prostate cryoablation for locally recurrent prostate cancer after radiotherapy: initial results from the cryo on-line data registry. Prostate. 2015 Jan;75(1):1-7. (IF=3.566)

    2. Li YH, Elshafei A, Li J, Gong M, Susan L, Fareed K, Jones JS. Transrectal Saturation Technique May Improve Cancer Detection as an Initial Prostate Biopsy Strategy in Men with Prostate-specific Antigen <10 ng/ml. Eur Urol. 2014 Jun;65(6):1178-83.(IF=12.48)

    3. Li YH, Elshafei A, Li J, Hatem A, Zippe CD, Fareed K, Jones JS. Potential Benefit for Transrectal Saturation Prostate Biopsy as an Initial Biopsy Strategy: Decreased Likelihood of Finding Significant Cancer on Future Biopsy. Urology. 2014 Apr;83(4):714-8. (IF = 2.132)

    4. Elshafei A, Li YH(Co-Frist author), Hatem A, Moussa AS, Ethan V, Krishnan N, Li J, Jones JS. The utility of PSA velocity in prediction of prostate cancer and high grade cancer after an initially negative prostate biopsy. Prostate. 2013 Dec;73(16):1796-802.(IF=3.566)

    5. Liu JY, Li YH(Co-Frist author), Lin HX, Liao YJ, Mai SJ, Liu ZW, Zhang ZL, Jiang LJ, Zhang JX, Kung HF, Zeng YX, Zhou FJ, Xie D. Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder. BMC Cancer. 2013 Jul 19;13:349. doi: 10.1186/1471-2407-13-349. (IF=3.319)

    6. Liu J, Li Y(Co-Frist author), Liao Y, Mai S, Zhang Z, Liu Z, Jiang L, Zeng Y, Zhou F, Xie D. High expression of H3K27me3 is an independent predictor of worse outcome in patients with urothelial carcinoma of bladder treated with radical cystectomy. Biomed Res Int. 2013;2013: 390482. doi: 10.1155/2013/390482. (IF=2.706)

    7. Zhang ZL, Li YH(Co-Frist author), Luo JH, Liu ZW, Yao K, Dong P, Han H, Qin ZK, Chen W, Zhou FJ. Complications of radical nephrectomy for renal cell carcinoma: a retrospective study comparing transperitoneal and retroperitoneal approaches using a standardized reporting methodology in two Chinese centers. Chin J Cancer. 2013 Aug;32(8):461-8.

    8. Zhang ZL, Li YH, Xiong YH, Hou GL, Yao K, Dong P, Liu ZW, Han H, Qin ZK, Zhou FJ. Oncological outcome of surgical treatment in 336 patients with renal cell carcinoma. Chin J Cancer. 2010 Dec;29(12):995-9.

    9. Liu JY, Qian D, He LR, Li YH(Co-Frist author), Liao YJ, Mai SJ, Tian XP, Liu YH, Zhang JX, Kung HF, Zeng YX, Zhou FJ, Xie D. PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway. Mol Cancer. 2013 Nov 23;12(1):148. doi: 10.1186/1476-4598-12-148.(IF=5.397)

    10. Liu JY, Li YH, Liu ZW, Zhang ZL, Ye YL, Yao K, Han H, Qin ZK, Zhou FJ. Intraarterial chemotherapy with gemcitabine and cisplatin in locally advanced or recurrent penile squamous cell carcinoma. Chin J Cancer. 2013 Nov;32(11):619-23.

    11. Hou GL, Li YH, Zhang ZL, Xiong YH, Chen XF, Yao K, Liu ZW, Han H, Qin ZK, Zhou FJ. A modified technique for neourethral anastomosis in orthotopic neobladder reconstruction. Urology. 2009 Nov;74(5):1145-9. (IF=2.132) 

    12. Elshafei A, Kartha G, Li Y, S Moussa A, Hatem A, Gao T, Jones JS. Low risk patients benefit from extreme anterior apical sampling on initial biopsy for prostate cancer diagnosis. Prostate. 2014 Sep;74(12):1183-8. (IF=3.566)

    13. Cai MY, Luo RZ, Li YH, Dong P, Zhang ZL, Zhou FJ, Chen JW, Yun JP, Zhang CZ, Cao Y. High-expression of ZBP-89 correlates with distal metastasis and poor prognosis of patients in clear cell renal cell carcinoma. Biochem Biophys Res Commun. 2012 Oct 5;426(4): 636-42. (IF=2.281)

    14. Zhang ZL, Dong P, Li YH, Liu ZW, Yao K, Han H, Qin ZK, Zhou FJ. Radical cystectomy for bladder cancer: oncologic outcome in 271 Chinese patients. Chin J Cancer. 2014 Mar 5;33(3):165-71. 

    15. Zhang ZL, Xiong YH, Li YH, Hou GL, Liu ZW, Han H, Qin ZK, Yun JP, Zhou FJ. Reassessment of the predictive role of perivesical fat invasion in invasive bladder cancer prognosis in 151 Chinese patients. Chin Med J (Engl). 2011 Sep;124(18):2915-9. (IF=1.016) 

    16. Zhang ZL, Chen W, Li YH, Liu ZW, Luo JH, Lau W, Tan MH, Zhou FJ. Stage T1N0M0 renal cell carcinoma: the prognosis in Asian patients. Chin J Cancer. 2011 Nov;30(11):772-8.

    17. Yao K, Tu H, Li YH, Qin ZK, Liu ZW, Zhou FJ, Han H. Modified technique of radical inguinal lymphadenectomy for penile carcinoma: morbidity and outcome. J Urol. 2010 Aug;184(2):546-52.(IF=3.753)

    18. Xiong YH, Zhang ZL, Li YH, Liu ZW, Hou GL, Liu Q, Yun JP, Zhang XQ, Zhou FJ. Benign pathological findings in 303 Chinese patients undergoing surgery for presumed localized renal cell carcinoma. Int J Urol. 2010 Jun;17(6):517-21. (IF=1.798)

    19. Dong P, Liu ZW, Li XD, Li YH, Yao K, Wu S, Qin ZK, Han H, Zhou FJ. Risk factors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors. Med Oncol. 2013 Mar;30(1):494. (IF=2.058) 

    20. Zhang ZL, Liu ZW, Zhou FJ, Li YH, Xiong YH, Rao K, Hou GL, Han H, Qin ZK, Yu SL, Chen XF. Modified technique to prevent complications related to stoma and ileoureteral anastomosis in patients undergoing ileal conduit diversion. Urology. 2010 Oct;76(4):996-1000. (IF = 2.132) 

    21. Jiang L, Zhang Z, Dong P, Li Y, Yao K, Liu Z, Han H, Qin Z, Yao M, Zhou F. Efficacy of radical cystectomy plus adjuvant intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced bladder cancer.  Chin Med J (Engl). 2014;127(7):1249-54. (IF=1.016)

    22. Zhang SQ, Wu S, Yao K, Dong P, Li YH, Zhang ZL, Li XX, Zhou FJ. Retroperitoneal schwannoma mimicking metastatic seminoma: case report and literature review. Chin J Cancer. 2013 Mar;32(3):149-52. 

    23. Yao K, Hou GL, Liu ZW, Yu SL, Li YH, Zhou FJ. Upper urinary tract dilation due to conglutination of intraluminal distal ureters after orthotopic neobladder with split-cuff nipple ureteral reimplants: early results of 8 cases. Urol Oncol. 2009 Nov-Dec;27(6):611-6. (IF=3.363) 


    Last Updated on: February 2016

    Zhang Zhiling
    Title Attending physician
    Profile

    Dr. Zhang Zhiling is proficient in the diagnosis and treatment of a variety of urologic neoplasms, including renal cell carcinoma, adrenal tumor, bladder cancer, prostatic cancer and testicular cancer. He specializes in partial nephrectomy, cryoablation and enucleation for small renal cell carcinoma, which can maximize the preservation of renal function. He also has great interests in combination therapy for advanced renal carcinoma as well as minimally invasive treatment for renal carcinoma, bladder cancer and adrenal tumor. He acted as a visiting scholar in Cleveland Clinic in 2014 and focused on the research and practice of renal cancer. He has been to the United States, South Korea, Hong Kong and Macau for academic exchange and repeatedly attended domestic and foreign academic conferences to introduce the abundant experience in diagnosis and treatment for urologic neoplasms of Department of Urology, Sun Yat-sen University Cancer Center. He has published several peer reviewed articles on renal cancer.

    Email
    Phone
    Research Interest(s)

    Pathogenesis and pathogeny of urologic neoplasms. Zhang Zhiling takes tremendous interest in the kidney-sparing surgery for early renal carcinoma and the targeted therapy for advanced renal carcinoma. He has presided over a multitude of international multi-center clinical trials in relation to renal carcinoma targeted therapy and accumulated rich experience in the combination therapy for renal carcinoma.


    Education

    2001-2006: Undergraduate studies in Clinical Medicine at Guangzhou Medical University;

    2006-2009: Master’s degree student at Sun Yat-sen University Cancer Center;

    2009-2012: Ph.D. student at Sun Yat-sen University Cancer Center; physician for oncology specialty training.

    Publications

    1. Zhang Z , Li J, Zheng H, Yu C, Chen J, Liu Z, Li M, Zeng M, Zhou F, Song L. Expression and Cytoplasmic Localization of SAM68 Is a Significant and Independent Prognostic Marker for Renal Cell Carcinoma. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2685-93.

    2. Cao Y, Zhang ZL, Zhou M, Elson P, Rini B, Aydin H, Feenstra K, Tan MH, Berghuis B, Tabbey R, Resau JH, Zhou FJ, Teh BT, Qian CN. Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma. Cancer. 2013 Jan 15;119(2):313-24.

    3. Yu C, Zhang Z, Liao W, Zhao X, Liu L, Wu Y, et al. The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. Carcinogenesis. 2012 Mar;33(3):678-86.

    4. Zhang ZL, Xiong YH, Li YH, Hou GL, Liu ZW, Han H, Qin ZK, Yun JP, Zhou FJ. Reassessment of the predictive role of perivesical fat invasion in invasive bladder cancer prognosis in 151 Chinese patients. Chin Med J (Engl). 2011 Sep;124(18):2915-9.

    5. Zhang ZL, Liu ZW, Zhou FJ, Li YH, Xiong YH, Rao K, Hou GL, Han H, Qin ZK, Yu SL, Chen XF. Modified Technique to Prevent Complications Related to Stoma and Ileoureteral Anastomosis in Patients Undergoing Ileal Conduit Diversion. Urology. 2010 Oct; 76(4):996-1000; discussion 1001. Epub 2010 Jan 29.

    6. Xiong YH, Zhang ZL, Li YH, Liu ZW, Hou GL, Liu Q, Yun JP, Zhang XQ, Zhou FJ.Benign pathological findings at surgery for presumed localized renal cell carcinoma in 303 Chinese Patients. Int J Urol. 2010 Jun; 17(6):517-21.

    7. Zhang ZL, Li YH, Xiong YH, Hou GL, Yao K, Dong P, Liu ZW, Han H, Qin ZK, Zhou FJ. Oncological outcome of surgical treatment in 336 patients with renal cell carcinoma. Chin J Cancer. 2010 Dec;29(12):995-9.

    8. Zhang ZL, Chen W, Li YH, Liu ZW, Luo JH, Lau W, Tan MH, Zhou FJ. Stage T1N0M0 renal cell carcinoma: Analysis of the prognosis in Asian patients. Chin J Cancer. 2011 Nov;30(11):772-8.

    9. Zhang ZL, Li YH, Luo JH, Liu ZW, Yao K, Dong P, Han H, Qin ZK, Chen W, Zhou FJ. Complications of radical nephrectomy for renal cell carcinoma: a retrospective study comparing transperitoneal and retroperitoneal approaches using a standardized reporting methodology in two Chinese centers. Chin J Cancer. 2013 Jan 9. [Epub ahead of print]

    10. Zhang ZL, Dong P, Li YH, Liu ZW, Yao K, Han H, Qin ZK, Zhou FJ. Radical cystectomy for treating bladder cancer: oncological outcome in 271 Chinese patients. Chin J Cancer. 2013 Aug 6. [Epub ahead of print]

     
    Last Updated on: March 2015

     

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