Research
    Qian Chao-Nan
    Title Vice-President & Professor
    Profile
    Dr. Chao-Nan Qian is the professor of nasopharyngeal carcinoma and vice president of Sun Yat-sen University Cancer Center. Dr. Qian obtained his Bachelor in Medicine (equivalent to MD in the US) and PhD at Sun Yat-sen University of Medical Sciences, P. R. China in 1992 and 1999, respectively. His post doctoral training at University of Texas MD Anderson Cancer Center and Van Andel Research Institute in Michigan provided him with great opportunities to explore the fields of tumorigenesis, tumor angiogenesis, tumor metastasis, and drug resistance of tumor cells. He was appointed as Research Scientist at Van Andel Research Institute in 2004 and Deputy Director of the Laboratory of Translational Cancer Research at National Cancer Center Singapore in May 2007. He then rejoined the Department of Nasopharyngeal Carcinoma at Sun Yat-sen University Cancer Center (SYSUCC) as a Professor in June 2007, Assistant to The President of SYSUCC in January 2008, and Vice President of SYSUCC in November 2013. In 2010-2012, Dr. Qian has also been leading a small research team at Van Andel Research Institute. Dr. Qian has published more than 90 research papers.
    Email qianchn@sysucc.org.cn
    Phone +86-20-87343457
    Research Interest(s)
    His qualification as a principal investigator at SYSUCC is based on his extensive experience in the areas of cancer biology and clinical management of nasopharyngeal carcinoma (NPC), with specific interest in the mechanisms underlying cancer metastasis, carcinogenesis, and tumor angiogenesis. NPC has the highest metastatic rate among head and neck cancers. Metastasis is a predominant aggressive behavior causing most of the cancer-related death. Hypoxia is a common microenvironment condition that frequently triggers the signaling for cancer aggressiveness in vivo. 
    Education

    Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China

    M.D.

    1992

    Medicine

    The First Affiliated Hospital and The Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China

    Residency Training

    1992-1994

    Medicine

    Sun Yat-sen University of Medical Sciences, Guangzhou, P.R. China

    Ph.D.

    1999

    Oncology

    University of Texas MD Anderson Cancer Center,  Houston, Texas, USA

    Post-Doctoral Training

    2000

    Oncology

    Van Andel Research Institute, Grand Rapids, Michigan, USA

    Post-Doctoral Training

    2000-2003

    Oncology

    Publications

    1.                  Bao YN, Cao X, Luo DH, Sun R, Peng LX, Wang L, Yan YP, Zheng LS, Xie P,Cao Y, Liang YY, Zheng FJ, Huang BJ, Xiang YQ, Lv X, Chen QY, Chen MY, HuangPY, Guo L, Mai HQ, Guo X, Zeng YX, QianCN*.  Urokinase-type plasminogenactivator receptor signaling is critical in nasopharyngeal carcinoma cellgrowth and metastasis. Cell Cycle 2014; 13(12):1958-69.

    2.                  Liang YY, Zheng LS, Wu YZ, Peng LX, Cao Y, Cao X, Xie P, Huang BJ, Qian CN*. RASSF6 promotesp21Cip1/Waf1-dependent cell cycle arrest and apoptosis through activation ofthe JNK/SAPK pathway in clear cell renal cell carcinoma. Cell Cycle 2014; 13(9):1440-9.

    3.                  Yang CF, Peng LX, Huang TJ, Yang GD, Chu QQ, Liang YY, Cao X, Xie P,Zheng LS, Huang HB, Cai MD, Huang JL, Liu RY, Zhu ZY, Qian CN*, Huang BJ*.  Cancer stem-like cell characteristics inducedby EB virus-encoded LMP1 contribute to radioresistance in nasopharyngealcarcinoma by suppressing the p53-mediated apoptosis pathway. Cancer Lett 2014; 344(2):260-71.

    4.                  Chen ZY, He WZ, Peng LX, JiaWH, Guo RP, Xia LP*, Qian CN*.A prognostic classifier consisting of 17 circulating cytokines is a novelpredictor of overall survival for metastatic colorectal cancer patients. Int J Cancer 2014Jun 11. [Epub ahead of print].

    5.                  Liang YY, Chen MY, Hua YJ, ChenS, Zheng LS, Cao X, Peng LX, Xie P, Huang BJ, Sun R, Wang L, Xiang YQ, Guo X, Qian CN*. Downregulation of Ras AssociationDomain Family Member 6 (RASSF6) Underlies the Treatment Resistance of HighlyMetastatic Nasopharyngeal Carcinoma Cells. PLoS One 2014; 9(7):e100843.

    6.                  Chen ZY, Wei W, Guo ZX, Peng LX, Shi M, Li SH, Xiao CZ, Zhong C, Qian CN*, Guo RP*. Usingmultiple cytokines to predict hepatocellular carcinoma recurrence in twopatient cohorts. Br J Cancer 2014; 110(3):733-40.

    7.                  Qian CN*. Hijacking the vasculature in ccRCC-co-option, remodelling andangiogenesis. Nature Reviews Urology 2013; 10(5):300-304.

    8.                  Liu RY, Dong Z, Liu J, Zhou L, Huang W, Khoo SK, Zhang Z, Petillo D, TehBT, Qian CN*, Zhang JT *. Over-expression ofasparagine synthetase and matrix metalloproteinase 19 confers cisplatinsensitivity in nasopharyngeal carcinoma cells. Molecular Cancer Therapeutics 2013; 12(10):2157-2166.

    9.                  Poon SL, Pang ST, McPherson JR, Yu W, Huang KK, Guan P, Weng WH, SiewEY, Liu Y, Heng HL, Chong SC, Gan A, Tay ST, Lim WK, Cutcutache I, Huang D, LerLD, Nairismägi ML, Lee MH, Chang YH, Yu KJ, Chan-On W, Li BK, Yuan YF, QianCN, Ng KF,Wu CF, Hsu CL, Bunte RM, Stratton MR, Futreal PA, Sung WK, Chuang CK, Ong CK,Rozen SG, Tan P, Teh BT. Genome-wide mutational signatures of aristolochic acidand its application as a screening tool. ScienceTranslational Medicine 2013; 5(197):197ra101.

    10.              Chen ZY, Shi M, Peng LX, Wei W, Li XJ, Guo ZX, Li SH, Zhong C, Qian CN*, Guo RP*.   Dovitinibpreferentially targets endothelial cells rather than cancer cells for theinhibition of hepatocellular carcinoma growth and metastasis.  Journal of Translational Medicine 2012;10(1):245.

    11.              Zheng FJ, Ye HB, Wu MS, LianYF, Qian CN*,Zeng YX*. Repressing malic enzyme 1 redirects glucose metabolism, unbalancesthe redox state, and attenuates migratory and invasive abilities innasopharyngeal carcinoma cell lines. Chinese Journal of Cancer 2012; 31(11):519-31.

    12.              Li J*, Mo HY, Xiong G, Zhang L, He J, Huang ZF, Liu ZW, Chen QY, Du ZM,Zheng LM, Qian CN*,Zeng YX.  Tumor microenvironment MIFdirects the accumulation of IL-17-producing tumor-infiltrating lymphocytes andpredicts favorable survival in nasopharyngeal carcinoma patients. Journal of Biological Chemistry 2012; 287(42): 35484-95.

    13.              Li XJ, Peng LX, Shao JY, Lu WH,Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, Zeng MS, Kang TB, ZengYX, Teh BT, Qian CN*. As anindependent unfavorable prognostic factor, IL-8 promotes metastasis ofnasopharyngeal carcinoma through induction of epithelial-mesenchymal transitionand activation of AKT signaling.  Carcinogenesis 2012; 33(7):1302-1309.

    14.              Ong CK, Subimerb C, PairojkulC, Wongkham S, Cutcutache I, Yu W, McPherson JR, Allen GE, Ng CC, Wong BH,Myint SS, Rajasegaran V, Heng HL, Gan A, Zang ZJ, Wu Y, Wu J, Lee MH, Huang D,Ong P, Chan-On W, Cao Y, Qian CN, Lim KH, Ooi A, Dykema K, FurgeK, Kukongviriyapan V, Sripa B, Wongkham C, Yongvanit P, Futreal PA,Bhudhisawasdi V, Rozen S, Tan P, Teh BT. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nature Genetics 2012; 44(6):690-693.

    15.              Qin L, Bromberg-White JL, QianCN*.  Opportunities and challenges in tumorangiogenesis research: back and forth between bench and bed.  Advances in Cancer Research 2012; 113:191-239.

    16.              Chen QY, Wen YF, Guo L, Liu H,Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, HuaYJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ.  Concurrent chemoradiotherapy vs radiotherapyalone in stage II nasopharyngeal carcinoma: Phase III randomized trial. Journal of National Cancer Institute 2011; 103(23):1761-1770.

    17.              Li GP, Wang H, Lai YK, Chen SC,Lin MC, Lu G, Zhang JF, He XG, Qian CN*, Kung HF*. Proteomic profiling between CNE-2 and its strongly metastaticsubclone S-18 and functional characterization of HSP27 in metastasis ofnasopharyngeal carcinoma.  Proteomics 2011;11(14): 2911-20.

    18.              Wang HY, Sun BY, Zhu ZH, ChangET, To KF, Hwang JS, Jiang H, Kam MK, Chen G, Cheah SL, Lee M, Liu ZW, Chen J,Zhang JX, Zhang HZ, He JH, Chen FL, Zhu XD, Huang MY, Liao DZ, Fu J, Shao Q,Cai MB, Du ZM, Yan LX, Hu CF, Ng HK, Wee JT, Qian CN, Liu Q,Ernberg I, Ye W, Adami HO, Chan AT, Zeng YX, Shao JY.  Eight-signature classifier for prediction ofnasopharnyngeal carcinoma survival. Journal of Clinical Oncology 2011; 29(34):4516-4525.

    19.              Li XJ, Ong CK, Cao Y, Xiang Y,Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ,Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN*. Serglycin is a theranostic target in nasopharyngeal carcinoma thatpromotes metastasis. CancerRes 2011; 71(8): 3162-3172.

    20.              Qian CN*.Exploration of the postponing mechanismthat delays carcinoma onset. Cancer Cell International 2010; 10: 38.

    21.              Kong QL, Hu LJ, Cao JY, HuangYJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ,Shao JY, Qian CN, Xia YF,Song LB, Zeng YX, Zeng MS.  Epstein-Barr virus-encoded LMP2A induces anepithelial-mesenchymal transition and increases the number of side populationstem-like cancer cells in nasopharyngeal carcinoma.  PLoSPathogen 2010; 6(6): e1000940.

    22.              Huang D,Ding Y, Li Y, Luo WM, Zhang ZF, Snider J, Vandenbeldt K, Qian CN, Teh BT. Sunitinib acts primarily on tumorendothelium rather than tumor cells to inhibit the growth of renal cell carcinoma.  CancerResearch 2010; 70(3):1053-62.

    23.              Huang D,Ding Y, Zhou M, Rini BI, Petillo D, QianCN, Kahnoski R, Futreal PA, Furge KA, Teh BT.  Interleukin-8 mediates resistance toantiangiogenic agent sunitinib in renal cell carcinoma.  CancerResearch 2010; 70(3):1063-71.

    24.              Qian CN*, Furge K, Knol J, Huang D, Chen J, Dykema KJ, Kort EJ, Massie A, Khoo SK, VandenBeldt K, Resau JH,Anema J, Kahnoski RJ, Morreau H, Camparo P, Comperat E, Sibony M, Denoux Y, Molinie V, Vieillefond A, Eng C, Williams BO, Teh BT*.  Activation of thePI3K/AKT pathway induces transitional cell carcinoma of the renal pelvis:  Identification in human tumors andconfirmation in animal models. Cancer Research 2009;69(21): 8256-8264.

    25.              Tang LQ, Chen QY, Guo SS, ChenWH, Li CF, Zhang L, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Liu H, Liu LT,Yan SM, Guo L, Zhao C, Cao KJ, Liu Q, QianCN, Ma J, Guo X, Zeng MS, Mai HQ. The impact of plasma epstein-barrvirus DNA and fibrinogen on nasopharyngeal carcinoma prognosis: anobservational study.  Br J Cancer. 2014 Jul 22. [Epub ahead ofprint].

    26.              Liang YY, Chen MY, Hua YJ, ChenS, Zheng LS, Cao X, Peng LX, Xie P, Huang BJ, Sun R, Wang L, Xiang YQ, Guo X, Qian CN*. Downregulation of Ras AssociationDomain Family Member 6 (RASSF6) Underlies the Treatment Resistance of HighlyMetastatic Nasopharyngeal Carcinoma Cells. PLoS One 2014; 9(7):e100843.

    27.              Jiang R, Yang ZH, Luo DH, GuoL, Sun R, Chen QY, Huang PY, Qiu F, Zou X, Cao KJ, Mai HQ, Guo X, Qian CN, Hong MH, Chen MY.  Elevated apolipoprotein A-I levels areassociated with favorable prognosis in metastatic nasopharyngeal carcinoma. Med Oncol 2014; 31(8):80.

    28.              Chia CS, Ong WS, Li XJ, SoongYL, Chong FT, Tan HK, Soo KC, Qian CN,Teh BT, Iyer NG.  Serglycin expression:An independent marker of distant metastases in nasopharyngeal carcinoma. Head Neck 2014 Jul 3. [Epub ahead ofprint]

    29.              Chen ZY, He WZ, Peng LX, JiaWH, Guo RP, Xia LP*, Qian CN*.A prognostic classifier consisting of 17 circulating cytokines is a novelpredictor of overall survival for metastatic colorectal cancer patients. Int J Cancer 2014Jun 11. [Epub ahead of print].

    30.              Bao YN, Cao X, Luo DH, Sun R, Peng LX, Wang L, Yan YP, Zheng LS, Xie P,Cao Y, Liang YY, Zheng FJ, Huang BJ, Xiang YQ, Lv X, Chen QY, Chen MY, HuangPY, Guo L, Mai HQ, Guo X, Zeng YX, QianCN*.  Urokinase-type plasminogenactivator receptor signaling is critical in nasopharyngeal carcinoma cellgrowth and metastasis. Cell Cycle 2014; 13(12):1958-69.

    31.              Liang YY, Zheng LS, Wu YZ, Peng LX, Cao Y, Cao X, Xie P, Huang BJ, Qian CN*. RASSF6 promotesp21Cip1/Waf1-dependent cell cycle arrest and apoptosis through activation ofthe JNK/SAPK pathway in clear cell renal cell carcinoma. Cell Cycle 2014; 13(9):1440-9.

    32.              Chen ZY, Wei W, Guo ZX, Peng LX, Shi M, Li SH, Xiao CZ, Zhong C, Qian CN*, Guo RP*. Usingmultiple cytokines to predict hepatocellular carcinoma recurrence in twopatient cohorts. Br J Cancer 2014; 110(3):733-40.

    33.              Akervall J, Nandalur S, Zhang J, QianCN, Goldstein N, Gyllerup P, Gardinger Y, Alm J, Lorenc K, Nilsson K,Resau J, Wilson G, Teh B.  A novel panelof biomarkers predicts radioresistance in patients with squamous cell carcinomaof the head and neck.  Eur J Cancer 2014; 50(3):570-81.

    34.              Yang CF, Peng LX, Huang TJ, Yang GD, Chu QQ, Liang YY, Cao X, Xie P,Zheng LS, Huang HB, Cai MD, Huang JL, Liu RY, Zhu ZY, Qian CN*, Huang BJ*.  Cancer stem-like cell characteristics inducedby EB virus-encoded LMP1 contribute to radioresistance in nasopharyngealcarcinoma by suppressing the p53-mediated apoptosis pathway. Cancer Lett 2014; 344(2):260-71.

    35.              Liu H, Qi B, Guo X, Tang LQ, Chen QY, Zhang L, Guo L, Luo DH, Huang PY,Mo HY, Xiang YQ, Qiu F, Sun R, Zhang Y, Chen MY, Hua YJ, Lv X, Wang L, Zhao C,Cao KJ, Qian CN, Hong MH, MaiHQ.  Genetic variations in radiation and chemotherapydrug action pathways and survival in locoregionally advanced nasopharyngeal carcinomatreated with chemoradiotherapy. PLoS One 2013;8(12):e82750.

    36.              Yang HJ, Huang TJ, Yang CF, Peng LX, Liu RY, Yang GD, Chu QQ, Huang JL,Liu N, Huang HB, Zhu ZY, Qian CN*, Huang BJ*. Comprehensive profiling of Epstein-Barrvirus-encoded miRNA species associated with specific latency types in tumorcells. Virol J 2013; 10(1): 314.

    37.              Yang GD, Huang TJ, Peng LX, Yang CF, Liu RY, Huang HB, Chu QQ, Yang HJ,Huang JL, Zhu ZY, Qian CN*,Huang BJ *. Epstein-Barr Virus_Encoded LMP1 Upregulates MicroRNA-21 to Promotethe Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Apoptosisby Suppressing PDCD4 and Fas-L. PLoS One 2013; 8(10):e78355.

    38.              Chen MY, Jiang R, Guo L, Zou X, Liu Q, Sun R, Qiu F, Xia ZJ, Huang HQ,Zhang L, Hong MH, Mai HQ, Qian CN. Locoregional radiotherapy inpatients with distant metastases of nasopharyngeal carcinoma at diagnosis. Chin J Cancer 2013; 32(11):604-13

    39.              Qian CN*. Hijacking the vasculature in ccRCC-co-option, remodelling andangiogenesis. Nature Reviews Urology 2013; 10(5):300-304.

    40.              Liu RY, Dong Z, Liu J, Zhou L, Huang W, Khoo SK, Zhang Z, Petillo D, TehBT, Qian CN*, Zhang JT *. Over-expression ofasparagine synthetase and matrix metalloproteinase 19 confers cisplatinsensitivity in nasopharyngeal carcinoma cells. Molecular Cancer Therapeutics 2013; 12(10):2157-2166.

    41.              Liu H, Huang PY, Tang LQ, Chen QY, Zhang Y, Zhang L, Guo L, Luo DH, MoHY, Xiang YQ, Qiu F, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, CaoKJ, Qian CN, Hong MH, Mai HQ. Functional polymorphismsof matrix metalloproteinase-9 and survival in patients with locoregionallyadvanced nasopharyngeal carcinoma treated with chemoradiotherapy. Medical Oncology 2013 Dec; 30(4):685.doi: 10.1007/s12032-013-0685-6.

    42.              Poon SL, Pang ST, McPherson JR, Yu W, Huang KK, Guan P, Weng WH, SiewEY, Liu Y, Heng HL, Chong SC, Gan A, Tay ST, Lim WK, Cutcutache I, Huang D, LerLD, Nairismägi ML, Lee MH, Chang YH, Yu KJ, Chan-On W, Li BK, Yuan YF, QianCN, Ng KF,Wu CF, Hsu CL, Bunte RM, Stratton MR, Futreal PA, Sung WK, Chuang CK, Ong CK,Rozen SG, Tan P, Teh BT. Genome-wide mutational signatures of aristolochic acidand its application as a screening tool. ScienceTranslational Medicine 2013; 5(197):197ra101.

    43.              Tang LQ, Chen QY, Fan W, Liu H, Zhang L, Guo L, Luo DH, Huang PY, ZhangX, Lin XP, Mo YX, Liu LZ, Mo HY, Li J, Zou RH, Cao Y, Xiang YQ, Qiu F, Sun R,Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, Cao KJ, QianCN, Zeng MS,Mai HQ. Prospective study of tailoring wholebody dual-modality [18F]fluorodeoxyglucosepositron emission tomography/computed tomography with plasma Epstein-Barr virusDNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initialstaging. Journal of Clinical Oncology 2013; 31(23): 2861-2869.

    44.              Cao Y, Zhang ZL, Zhou M, ElsonP, Rini B, Aydin H, Feenstra K, Tan MH, Berghuis B, Tabbey R, Resau JH, ZhouFJ, Teh BT, Qian CN*. Pericyte coverage of differentiated vessels inside tumor vasculatureis an independent unfavorable prognostic factor for patients with clear cellrenal cell carcinomaCancer 2013; 119(2):313-24.

    45.              XiaWX, Zhang HB, Shi JL, Lu X, Wang L, Ye YF, Cao KJ, Qian CN, Guo X, Xiang YQ. A prognostic model predicts the risk of distantmetastasis and death for patients with nasopharyngeal carcinoma based onpre-treatment serum C-reactive protein and N-classification. European Journal of Cancer 2013 Apr 6. [Epub ahead of print]

    46.              ChenY, Wang K, Qian CN, Leach R.  DNA methylation isassociated with transcription of Snail and Slug genes.  Biochem Biophys Res Commun 2013; 430(3): 1083-1090.

    47.              Lu X, Wang FL, Guo X, Wang L,Zhang HB, Xia WX, Li SW, Li NW, Qian CN, Xiang YQ.  Favorable survival of female patients withnasopharyngeal carcinoma.  Chinese Journal of Cancer 2013; 32(5):283-288.

    48.              Chen ZY, Shi M, Peng LX, Wei W, Li XJ, Guo ZX, Li SH, Zhong C, Qian CN*, Guo RP*.   Dovitinibpreferentially targets endothelial cells rather than cancer cells for theinhibition of hepatocellular carcinoma growth and metastasis.  Journal of Translational Medicine 2012;10(1):245.

    49.              Gu AD, Zeng MS, Qian CN*. The criteria to confirm the role of Epstein-Barr virus in nasopharyngealcarcinoma initiation.  International Journal of Molecular Science 2012; 13(10): 13737-47.

    50.              Chen S, Zhao BW, Li YF, FengXY, Sun XW, Li W, Zhou ZW, Zhan YQ, Qian CN, Chen YB.  The prognostic value of harvested lymph nodesand the metastatic lymph node ratio for gastric cancer patients: results of astudy of 1,101 patients.  PLoS One 2012;7(11): e49424.

    51.              Zheng FJ, Ye HB, Wu MS, LianYF, Qian CN*,Zeng YX*. Repressing malic enzyme 1 redirects glucose metabolism, unbalancesthe redox state, and attenuates migratory and invasive abilities innasopharyngeal carcinoma cell lines. Chinese Journal of Cancer 2012; 31(11):519-31.

    52.              Wee J, NeiWL, Yeoh KW, Yeo RM, Loong SL, Qian CNWhy are East Asians more susceptible toseveral infection-associated cancers (carcinomas of the nasopharynx, stomach,liver, adenocarcinoma of the lung, nasal NK/T-cell lymphomas)?  Medical Hypotheses 2012; 79(6):833-42.

    53.              Li J*, Mo HY, Xiong G, Zhang L, He J, Huang ZF, Liu ZW, Chen QY, Du ZM,Zheng LM, Qian CN*,Zeng YX.  Tumor microenvironment MIFdirects the accumulation of IL-17-producing tumor-infiltrating lymphocytes andpredicts favorable survival in nasopharyngeal carcinoma patients. Journal of Biological Chemistry 2012; 287(42): 35484-95.

    54.              Chen S, Chen YB, Li YF, FengXY, Zhou ZW, Yuan XH, Qian CN*Normal carcinoembryonic antigen indicatesbenefit from perioperative chemotherapy to gastric carcinoma patients.  World Journal of Gastroenterology 2012; 18(29): 3910-3916

    55.              Liu X, Lv XB, Wang XP, Sang Y,Xu S, Hu K, Wu M, Liang Y, Liu P, Tang J, Lu WH, Feng QS, Chen LZ, QianCN, Bei JX, Kang T, Zeng YXMiR-138suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting theCCND1 oncogene.  CellCycle 2012; 11(13):2495-506.

    56.              Li XJ, Peng LX, Shao JY, Lu WH,Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, Zeng MS, Kang TB, ZengYX, Teh BT, Qian CN*. As anindependent unfavorable prognostic factor, IL-8 promotes metastasis ofnasopharyngeal carcinoma through induction of epithelial-mesenchymal transitionand activation of AKT signaling.  Carcinogenesis 2012; 33(7):1302-1309.

    57.              Ong CK, Subimerb C, PairojkulC, Wongkham S, Cutcutache I, Yu W, McPherson JR, Allen GE, Ng CC, Wong BH,Myint SS, Rajasegaran V, Heng HL, Gan A, Zang ZJ, Wu Y, Wu J, Lee MH, Huang D,Ong P, Chan-On W, Cao Y, Qian CN, Lim KH, Ooi A, Dykema K, FurgeK, Kukongviriyapan V, Sripa B, Wongkham C, Yongvanit P, Futreal PA,Bhudhisawasdi V, Rozen S, Tan P, Teh BT. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nature Genetics 2012; 44(6):690-693.

    58.              Lee SY, Qian CN,Ooi AS, Chen P, Tan VK, Chia CS, Hwang JS, Teh BT, Soo KC.  2011 Young surgeon's award winner: Highendothelial venules: A novel prognostic marker in cancer metastasis and themissing link?  Annals Academy of Medicine Singapore 2012; 41(1):21-8.

    59.              Qin L, Bromberg-White JL, QianCN*.  Opportunities and challenges in tumorangiogenesis research: back and forth between bench and bed.  Advances in Cancer Research 2012; 113:191-239.

    60.              Chen MY, Wang SL, Zhu YL, ShenGP, Qiu F, Luo DH, Chen QY, Jiang R, Cao KJ, Qian CN, HongMH.  Use of a posterior pedicle nasalseptum and floor mucoperiosteum flap to resurface the nasopharynx afterendoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma.  Head & Neck 2012; 34(10):1383-8.

    61.              Chen QY, Wen YF, Guo L, Liu H,Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, HuaYJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ.  Concurrent chemoradiotherapy vs radiotherapyalone in stage II nasopharyngeal carcinoma: Phase III randomized trial. Journal of National Cancer Institute 2011; 103(23):1761-1770.

    62.              Li J, Huang ZF, Xiong G, Mo HY,Qiu F, Mai HQ, Chen QY, He J, Chen SP, Zheng LM, Qian CN, ZengYX.  Distribution, characterization, andinduction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells innasopharyngeal carcinoma.  Journal of Translational Medicine 2011; 9:189.

    63.              Wang HY, Sun BY, Zhu ZH, ChangET, To KF, Hwang JS, Jiang H, Kam MK, Chen G, Cheah SL, Lee M, Liu ZW, Chen J,Zhang JX, Zhang HZ, He JH, Chen FL, Zhu XD, Huang MY, Liao DZ, Fu J, Shao Q,Cai MB, Du ZM, Yan LX, Hu CF, Ng HK, Wee JT, Qian CN, Liu Q,Ernberg I, Ye W, Adami HO, Chan AT, Zeng YX, Shao JY.  Eight-signature classifier for prediction ofnasopharnyngeal carcinoma survival. Journal of Clinical Oncology 2011; 29(34):4516-4525.

    64.              Zhao YY, Xue C, Jiang W, Zhao HY,Huang Y, Feenstra K, Resau JH, Qian CN, Zhang L.  Predictive Value of IntratumoralMicrovascular Density in Patients with Advanced Non-small Cell Lung CancerReceiving Chemotherapy Plus Bevacizumab.  Journal of Thoracic Oncology 2011; 7(1): 71-75

    65.              Li XJ, Qian CN*.  Serglycinin human cancers.  ChineseJournal of Cancer 2011; 30(9):585-589.

    66.              Li GP, Wang H, Lai YK, Chen SC,Lin MC, Lu G, Zhang JF, He XG, Qian CN*, Kung HF*. Proteomic profiling between CNE-2 and its strongly metastaticsubclone S-18 and functional characterization of HSP27 in metastasis ofnasopharyngeal carcinoma.  Proteomics 2011;11(14): 2911-20.

    67.              Liu RY, Dong Z, Liu J, Yin JY,Zhou L, Wu X, Yang Y, Mo W, Huang W, Khoo SK, Chen J, Petillo D, Teh BT, Qian CN, Zhang JT.  Role of eIF3a in regulating cisplatinsensitivity and in translational control of nucleotide excision repair ofnasopharyngeal carcinoma.  Oncogene 2011;  30(48):4814-23.

    68.              Ding T, Xu J, Zhang Y, Guo RP,Wu WC, Zhang SD, Qian CN,Zheng L.  Endothelium-coated tumorclusters are associated with poor prognosis and micrometastasis ofhepatocellular carcinoma after resection.  Cancer 2011; 117(21):4878-4889.

    69.              Li XJ, Ong CK, Cao Y, Xiang Y,Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ,Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN*. Serglycin is a theranostic target in nasopharyngeal carcinoma thatpromotes metastasis. CancerRes 2011; 71(8): 3162-3172.

    70.              Cao SM, Simons MJ, Qian CN.  The prevalence and prevention ofnasopharyngeal carcinoma inChina.  Chin J Cancer 2011; 30(2):114-9.

    71.              Lv X, Xiang YQ, Cao SM, Qian CN, Li NW, Guo L, Mai HQ,Chen QY, Huang PY, Luo D, Cao KJ, Hong MH, Guo X.  Prospectivevalidation of the prognostic value of elevated serum vascular endothelialgrowth factor in patients with nasopharyngeal carcinoma: More distantmetastases and shorter overall survival after treatment. Head and Neck 2011; 33(6): 780-785.

    72.              Lu X, Qian CN, Mu YG, Li NW, Li S, Zhang HB, Li SW, Wang FL, GuoX, Xiang YQ. Serum CCL2 and serum TNF-α- Two new biomarkers predict bone invasion, post-treatment distant metastasisand poor overall survival in nasopharyngeal carcinoma. European Journal of Cancer 2011; 47(3):339-346.

    73.              Chen JA, Shi M, Li JQ, Qian CN*. Angiogenesis: multiple masks in hepatocellularcarcinoma and liver regenerationHepatology International  2010; 4(3): 537–547.

    74.              Qian CN*.Exploration of the postponing mechanismthat delays carcinoma onset. Cancer Cell International 2010; 10: 38.

    75.              Cao JY, LiuL, Chen SP, Zhang X, Mi YJ, Liu ZG, Li MZ, Zhang H, Qian CN, Shao JY, Fu LW, Xia YF, Zeng MS.  Prognosticsignificance and therapeutic implications of centromere protein F expression inhuman nasopharyngeal carcinoma.  Molecular Cancer 2010; 9(1): 237.

    76.              Cao SM, Yu JK, Chen QY, Li NW,Xiang YQ, Qian CN, Hu X,Zhang CQ, Xie D, Guo X.  Detection of nasopharyngeal carcinoma usingsurface-enhanced laser desorption and ionization mass spectrometry profiles ofthe serum proteome.  Chinese Journal of Cancer 2010; 29(8):721-8.

    77.              Li Y, Zhang ZF, Chen J, HuangD, Ding Y, Tan MH, Qian CN,Resau JH, Kim H, Teh BT.  VX680/MK-0457, a potent and selectiveAurorakinase inhibitor,targets both tumor and endothelial cells in clear cell renal cell carcinoma. American Journal of TranslationalResearch 2010; 2(3):296-308.

    78.              Kong QL, Hu LJ, Cao JY, HuangYJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ,Shao JY, Qian CN, Xia YF,Song LB, Zeng YX, Zeng MS.  Epstein-Barr virus-encoded LMP2A induces anepithelial-mesenchymal transition and increases the number of side populationstem-like cancer cells in nasopharyngeal carcinoma.  PLoSPathogen 2010; 6(6): e1000940.

    79.              Wee JT, Ha TC, Loong SL, Qian CN. Is nasopharyngealcancer really a "Cantonese cancer"? Chinese Journal of Cancer 2010; 29(5):517-26.

    80.              Huang D,Ding Y, Li Y, Luo WM, Zhang ZF, Snider J, Vandenbeldt K, Qian CN, Teh BT. Sunitinib acts primarily on tumorendothelium rather than tumor cells to inhibit the growth of renal cellcarcinoma.  Cancer Research 2010; 70(3):1053-62.

    81.              Huang D,Ding Y, Zhou M, Rini BI, Petillo D, QianCN, Kahnoski R, Futreal PA, Furge KA, Teh BT.  Interleukin-8 mediates resistance toantiangiogenic agent sunitinib in renal cell carcinoma.  CancerResearch 2010; 70(3):1063-71.

    82.              Zhang YL, Li J, MoHY, Qiu F, Zheng LM, Qian CN,Zeng YX.  Different subsets oftumor infiltrating lymphocytes correlate with NPC progression in differentways.  Molecular Cancer 2010; 9(1):4.

    83.              Li HS, Cao Y, Qian CN. Kazal-type Serine Protease Inhibitors and HumanDiseases.  Basic and Clinic Medicine 2010; 30(5): 550-553 (Chinese).

    84.              Wee JT, Anderson BO,  Corry J, D’Cruz A, Soo KC, Qian CN, Chua DT, Hicks RJ, GohHK, Khoo JB, Ong SC, Forastiere AA, Chan AT. Management of the neck followingchemo-radiotherapy for head and neck cancers. Consensus statement from theAsian Oncology Summit 2009. LancetOncology 2009; 10(11): 1086-1092.

    85.              Tan FL, OoiA, Huang D, Wong JC, Qian CN,Chao C, Ooi L, Tan YM, Chung A, Cheow PC, Zhang Z, Petillo D, Yang XJ, TehBT.  p38delta/MAPK13 as a diagnosticmarker for cholangiocarcinoma and its involvement in cell motility andinvasion.  Internaltional Journal of Cancer 2009; 126(10): 2353-2361.

    86.              Liu TR,Chen FJ, Qian CN, Guo X, ZengMS, Guo ZM, He JH, Cao JY, Yang AK, Zhang GP. Primary salivary gland type carcinoma of the nasopharynx: Therapeuticoutcomes and prognostic factors.  Head and Neck 2010; 32(4): 435-444.

    87.              Qian CN*, Furge K, Knol J, Huang D, Chen J, Dykema KJ, Kort EJ, Massie A, Khoo SK, VandenBeldt K, Resau JH,Anema J, Kahnoski RJ, Morreau H, Camparo P, Comperat E, Sibony M, Denoux Y, Molinie V, Vieillefond A, Eng C, Williams BO, Teh BT*.  Activation of the PI3K/AKT pathway induces transitional cellcarcinoma of the renal pelvis: Identification in human tumors and confirmation in animal models. Cancer Research 2009; 69(21): 8256-8264.

    88.              Hua YJ, Chen MY, Qian CN, Hong MH, Zhao C, Guo L,Guo X, Cao KJ.  Postradiationnasopharyngeal necrosis in the patients with nasopharyngeal carcinoma.  Head and Neck 2009; 31(6):807-12.

    89.              Li J, QianCN, Zeng YX. Regulatory T cells and EBV associated malignancies.  InternationalJournal of Immunopharmacology 2009; 9(5): 590-592.

    90.              Qian CN*, Huang D, Wondergem B, Teh BT*.  Complexity of tumor vasculature in clear cellrenal cell carcinoma.  Cancer 2009; 115(10 Suppl): 2282-2289.

    91.              Chen MY, Wen WP, Guo X, YangAK, Qian CN, Hua YJ, Wan XB, Guo ZM, Li TY, Hong MH. Endoscopicnasopharyngectomy for locally recurrent nasopharyngeal carcinoma. Laryngoscope 2009; 119(3): 516-522.

    92.              Rogers CG, Ditlev JA, Tan MH,Sugimura J, Qian CN, Cooper J, Jewett MAS, Kahnoski RJ, Kort EJ, Teh BT.  Microarray geneexpression profiling using core biopsies of renal neoplasia.  American Journal of Translational Research 2009; 1(1): 55-61.

    93.              Hui Z, Tretiakova M, Zhang Z,Li Y, Wang X, Zhu JX, Gao Y, Mai W, Furge K, Qian CN, Amato R, Butler EB, Teh BT, TehBS.  Radiosensitization by inhibitingSTAT1 in renal cell carcinoma.  Int J Radiat Oncol BiolPhys 2009; 73(1):288-295.

    94.              Chen J, Futami K, Petillo D,Peng J, Wang P, Knol J, Li Y, Khoo SK, Huang D, Qian CN, Zhao P, Dykyma K, Zhang R, Cao B, Yang XJ, Furge K,Williams BO, Teh BT.  Deficiency of FLCNin mouse kidney led to development of polycystic kidneys and renalneoplasia.  PLoS ONE 2008; 3(10):e3581.

    95.              Qin L, Zhang X, Zhang L, FengY, Weng GX, Li MZ, Kong QL, Qian CN, Zeng YX, Zeng MS, Liao DF, Song LB.  Downregulation of BMI-1 enhances5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells.  Biochem Biophys Res Commun 2008; 371(3):531-535.

    96.              Gu AD, XieYB, Mo HY, Jia WH, Li MY, Li M, Chen LZ, Feng QS, Liu Q, Qian CN, Zeng YX.  Antibodies againstEpstein-Barr virus gp78 antigen: a novel marker for serological diagnosis ofnasopharyngeal carcinoma detected by xMAP technology.  Journal of General Virology 2008; 89(Pt 5): 1152-1158.

    97.              Huang D, Ding Y, Luo WM, Bender S, Qian CN, Kort EJ, Zhang CF, VandenBeldt K, Duesbery N, Resau JH, Teh BT.  Inhibition of MAPKkinase signaling pathways suppressed renal cell carcinoma growth andangiogenesis in vivo.  CancerResearch 2008; 68(1): 81-88.

    98.              Yuan TZ, Li XX, Cao Y, Qian CN, Zeng MS, Guo X. Correlation ofepidermal growth factor receptor activation to metastasis-free survival ofnasopharyngeal carcinoma patients. Ai Zheng (Chinese) 2008; 27(5):449-454.

    99.              Zhuang AH, Gan KJ, Liu Q, Qian CN.  Problems and errors on survival curves inpublishing oncology literatures.  Acta Editologica 2008; 6: 24-25(Chinese).

    100.          Bruxvoort KJ,Charbonneau HM, Giambernardi TA, Goolsby JC, Qian CN, Zylstra CR, Robinson DR, Roy-Burman P, Shaw AK, Buckner-BerghuisBD, Sigler RE, Resau JH, Sullivan R, Bushman W, Williams BO.  Inactivationof Apc in the mouse prostate causes prostate carcinoma.  CancerResearch 2007; 67(6):2490-2496.

    101.          Qian CN*, Resau JH, Teh BT*.  Prospects forvasculature reorganization in sentinel lymph nodesCell Cycle 2007;6(5):514-517.

    102.          Yao X, Qian CN, Zhang ZF, Tan MH, Kort EJ, YangXJ, Resau JH, Teh BT.  Two distinct typesof blood vessels in clear cell renal cell carcinoma have contrasting prognosticimplications.  Clinical Cancer Research 2007; 13(1):161-169.

    103.          Qian CN, Berghuis B, Tsarfaty G, Bruch M, Kort EJ, Ditlev J, Tsarfaty I,Hudson E, Jackson DG, Petillo D, Chen J, Resau JH, Teh BT.  Preparing the "soil": The primarytumor induces vasculature reorganization in the sentinel lymph node before thearrival of metastatic cancer cells.  Cancer Research 2006;66(21):10365-10376.

    104.          Guo X, Cao SM, Yu JK, Hong MH,Zhang CQ, Li NW, Xiang YQ, Qian CN, Hu X, Min HQ, Zeng YX. Distinct serumal proteomic patterns between ascending and descendingtypes of loco-regionally advanced nasopharyngeal carcinoma assessed by surfaceenhanced laser desorption ionization and artificial neural network analyses.
    Chinese Medical Journal (Engl) 2005;118(22):1912-1917.

    105.          Hay RV, Cao B, Skinner RS, SuY, Zhao P, Gustafson MF, Qian CN, Teh BT, Knudsen BS, Resau JH, Shen S, Waters DJ, Gross MD, VandeWoude GF.  Nuclear imaging ofMet-expressing human and canine cancer xenografts with radiolabeled monoclonalantibodies (MetSeek).  Clinical Cancer Research 2005; 11(19 Pt2): 7064s-7069s.

    106.          Qian CN, Knol J, Igarashi P, Lin F,Zylstra U, Teh BT, Williams BO. Cystic renal neoplasia following conditionalinactivation of apc in mouse renal tubular epithelium.  The Journal of Biological Chemistry 2005; 280(5):3938-3945.

    107.          Akervall J, Guo X, Qian CN, Schoumans J, Leeser B, Kort E,Cole A, Resau J, Bradford C, Carey T, Wennerberg J, Anderson H, Tennvall J, TehBT. Genetic and expression profiles of squamous cell carcinoma of the head andneck correlate with cisplatin sensitivity and resistance in cell lines andpatients.  Clinical Cancer Research 2004; 10(24):8204-8213.

    108.          Duh FM, Fivash M, Moody M, LiLung M, Guo X, Stanbridge E, Dean M, Voevoda M, Hu LF, Kashuba V, ZabarovskyER, Qian CN,Godbole S, Tean Teh B, Lerman MI. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSGFUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysisof association with nasopharyngeal cancer.  Molecular and Cellular Probes 2004; 18(1): 39-44.

    109.          Gray SG, Qian CN, Furge K, Guo X, Teh BT.  Microarray profiling of the effects ofhistone deacetylase inhibitors on gene expression in cancer cell lines.  International Journal of Oncology 2004; 24(4): 773-795.

    110.          Takahashi M, Yang XJ, SugimuraJ, Backdahl J, Tretiakova M, Qian CN, Gray SG, Knapp R, Anema J, Kahnoski R, Nicol D, Vogelzang NJ,Furge KA, Kanayama H, Kagawa S, Teh BT.  Molecular subclassification of kidney tumors and the discovery of newdiagnostic markers.  Oncogene 2003; 22(43): 6810-6818.

    111.          Qian CN, Takahashi M, Kahnoski RJ, Teh BT. Effect of sildenafil citrate on an orthotopic prostate cancer growth andmetastasis model.  The Journal ofUrology 2003; 170(3): 994-997.

    112.          Guo X, Lui WO, Qian CN, Chen JD, Gray SG, Rhodes D,Haab B, Stanbridge E, Wang HM, Hong MH, Min HQ, Larsson C, Teh BT.  Identifying cancer-related genes innasopharyngeal carcinoma cell lines using DNA and mRNA expression profilinganalyses.  International Journal ofOncology 2002; 21(6): 1197-1204.

    113.          Qian CN, Guo X, Cao B, Kort EJ, Lee CC, Chen, Wang LM, Mai WY, Min HQ, HongMH, Vande Woude GF, Resau JH, Teh BT. Met protein expression level correlates with survival in patients withlate-stage nasopharyngeal carcinoma.  CancerResearch 2002; 62(2): 589-596.

    114.          Su Y,Zhang JM, Xia YF, Zhu R, Qian CN, Mo HY.  Chemotherapy for advanced nasopharyngeal carcinomawith methotrexate, vincristine, cisplatin, and adriamycin.  Chinese Journal of Cancer Research (English) 2002; 14(2): 145-148.

    115.          Zhang XS, Zhu XF, Gao JS, Qian CN, Kuang ZJ, Liu ZC, Zeng YX.  Multiple drug resistance phenotype of humanendothelial cells induced by vascular endothelial growth factor 165.  Acta Pharmacologica Sinica 2001;22(8): 731-735.

    116.          Shi Q, Le X, Abbruzzese JL,Peng Z, Qian CN,Tang H, Xiong Q, Wang B, Li XC, Xie K. Constitutive Sp1 activity is essential for differential constitutiveexpression of vascular endothelial growth factor in human pancreaticadenocarcinoma.  Cancer Research 2001; 61(10): 4143-4154.

    117.          Le X, Shi Q, Wang B, Xiong Q, Qian CN, Peng Z, Li XC, Tang H,Abbruzzese JL, Xie K.  Molecularregulation of constitutive expression of interleukin-8 in human pancreaticadenocarcinoma.  Journal of Interferonand Cytokine Research 2000; 20(11): 935-946.

    118.          Qian CN*, Min HQ, Lin HL, Hong MH.  Combination of angiogenesis inhibitor TNP-470(AGM-1470) with cytotoxic drugs in experimental therapy of nasopharyngealcarcinoma.  Annals of Otology, Rhinology & Laryngology 2000; 109: 641-645.

    119.          Qian CN*, Zhang CQ, Guo X, Hong MH, Cao SM, MaiWY, Min HQ, Zeng YX.   Elevation of serumvascular endothelial growth factor in male patients with metastaticnasopharyngeal carcinoma. Cancer 2000; 88(2): 255-261.

    120.          Qian CN*, Min HQ, Lin HL, Feng GK, Ye YL, WangLG, Kuang ZJ.  Anti-tumor effect ofangiogenesis inhibitor TNP-470 on human nasopharyngeal carcinoma cell lineNPC/HK1.  Oncology 1999; 57(1): 36-41.

    121.          Guo X, Min HQ, Zeng MS, Qian CN, Huang XM, Shao JY, Hou JH.  Nm-23-H1 expression in nasopharyngealcarcinoma: correlation with clinical outcome.  International Journal of Cancer 1998; 79(6): 596-600.

    122.          Qian CN*, Min HQ, Lin HL, Hong MH, Ye YL.  Primary study in experimental antiangiogenictherapy of nasopharyngeal cancer with AGM-1470 (TNP-470).  TheJournal of Laryngology and Otology 1998; 112: 849-853.

    123.          Qian CN*, Min HQ, Liang XM, Zheng SS, LinHL.  Primary study of neovasculaturecorrelating with metastatic nasopharyngeal carcinoma using computer imageanalysis. Journal of Cancer Research and Clinical Oncology 1997; 123: 645-651.

    Guo Xiang
    Title Professor, Chief physician, Director of Department of Nasopharyngeal Carcinoma, Doctoral Advisor
    Profile

    Prof. Guo Xiang was born in December 1963. In June 1988, he graduated from Department of Clinical Medicine of former Sun Yat-sen University of Medical Sciences and received the Doctoral Degree in Clinical Oncology. From September 1997 to January 1998, he further studied in Radiation Oncology of Shanghai Medical College of Fudan University; from June 2000 to June 2002, he received post-doctoral training in Van Andel Research Institute (VARI) in America, primarily engaging himself in the research on the application of gene chips in cancer; from 2002 in April to June 2002, he served as a visiting scholar and studied in William Beaumont Hospital’s Cancer Institute in the United States. Currently, he works as the Chief Physician, doctoral advisor and Associate Chief for Department of Nasopharyngeal Carcinoma, member and secretary of Chinese Society of Nasopharyngeal Carcinoma, Chinese Anti-cancer Association, editorial board member of Chinese Journal of Cancer and expert reviewer to Chinese Journal of Clinical Oncology.
     
    After graduating from the undergraduate program, he worked in school and entered the Head and Neck at the Sun Yat-sen University Cancer Center (SYSUCC), engaging himself in medical treatment, teaching and scientific research. He masters solid theoretical basis for oncology and surgical basic skills and accumulates abundant experience in clinical practice. Since 1995, he has specialized in nasopharynx carcinoma’s clinical diagnosis and treatment, scientific research and teaching. Type of Work: clinical diagnosis, combination therapy, and research on the biological features of nasopharynx carcinoma; surgical treatment of recurrent nasopharynx carcinoma (including minimally invasive surgery of recurrent or residual nasopharyngeal carcinoma, surgical treatment of recurrent or residual cervical lymph nodes and surgical treatment of complications caused by radiotherapy); research on the biological features of nasopharynx carcinoma. He served as editor-in-chief in compilation of one monograph, co-wrote five monographs and published over 20 papers.

    Email guoxiang@sysucc.org.cn
    Phone 020-87343379
    Research Interest(s)

    1. Diagnosis and combination therapy of nasopharynx carcinoma
    2. Rescue surgical treatment of nasopharynx carcinoma
    3. Surgical treatment of complications and sequelae after radiotherapy of nasopharynx carcinoma
    4. Study on the biological characteristics of nasopharynx carcinoma

    Education

    09/1982 – 06/1988: Department of Clinical Medicine of former Sun Yat-sen University of Medical Sciences

    09/1994 – 06/1997: Studied to obtain the Doctoral Degree in Clinical Oncology in former Sun Yat-sen University of Medical Sciences and received the Doctoral Degree

    09/1997 - 01/1998: Further studied in the Radiation Oncology at the Shanghai Medical College of Fudan University

    06/2000 – 06/2002: Studied to obtain the Postdoctoral Degree from Van Andel Research Institute (USA)

    04/2002 – 06/2002: Studied as a visiting scholar at the William Beaumont Hospital’s Cancer Institute in the United States

    Publications

    Main Publications (* Corresponding author):
    1. Wang FL, Guo X*, Yuan ZT, Cao SM, Rao HL, Hong JH, Shao Q, Li NW, Hong MH. Expression and clinical significance of Wnt-1 andβ-catenin in nasopharyngeal carcinoma. Chinese Journal of Cancer, 2009; 28 (1): 91-95.

    2. Mo HY, Deng MQ, Mai HQ, Qi B, Li NW, Guo X, Hong MH. The influences and treatment of deafness in nasopharyngeal carcinoma patients after radiotherapy. Modern Oncology, 17 (10): 1856-58. 

    3. Hua YJ, Chen MY, Qian CN, Hong MH, Zhao C, Guo L, Guo X, Cao KJ. Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma. Head Neck. 2009 Jun;31(6):807-12.

    4. Mai HQ, Mo HY, Deng JF, Deng MQ, Mai WY, Huang XM, Guo X, Hong MH. Endoscopic microwave coagulation therapy for early recurrent T1 nasopharyngeal carcinoma. Eur J Cancer. 2009 May;45(7):1107-10.

    5. Chen MY, Wen WP, Guo X, Yang AK, Qian CN, Hua YJ, Wan XB, Guo ZM, Li TY, Hong MH.  Endoscopic nasopharyngectomy for locally recurrent nasopharyngeal carcinoma. Laryngoscope. 2009 Mar;119(3):516-22. 

    6. Liu TR, Yang AK, Guo X, Li QL, Song M, He JH, Wang YH, Guo ZM, Zhang Q, Chen WQ, Chen FJ. Adenoid cystic carcinoma of the nasopharynx: 27-year experience. Laryngoscope. 2008 Nov;118(11):1981-8.

    7. Qi Z, Guo X *, Li NW, Xiang YQ, Cao SM, Hong MH. Clinical Characteristics and Prognosis of Aged Nasopharyngeal Carcinoma Patients: A Report of 313 Cases. Chinese Journal of Cancer, 2008; 27 (3): 289-294.

    8. Yuan TZ, Guo X *, Zheng L, Cao SM, Li NW, Xiang YQ. Occurrence and Influencing Factors of Paranasal Sinusitis in Nasopharyngeal Carcinoma Patients after Radiotherapy. Chinese Journal of Cancer, 2008; 27 (8): 866-869.

    9. Yuan TZ, Li XX, Cao Y, Qian CN, Zeng MS, Guo X *. Correlation of Epidermal Growth Factor Receptor Activation to Metastasis-free Survival of Nasopharyngeal Carcinoma Patients. Chinese Journal of Cancer, 2008; 27 (5): 449-454.

    10. Yuan TZ, Li NW, Cao SM, Qi Z, Guo X *. Peripheral nerve sheath tumors at the epithelioid cell type of nasopharyngeal skull base: A report of one case and literature review. Chin J Cancer Prev Treat, 2008 April; 15 (8):639-640.

    11. Mr TQ, Mai HQ, Mai WY, Mo HY, Huang XM, Guo X, Hong MH. Endoscopic Microwave Coagulation Therapy for Locally Recurrent Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2008; 27 (7): 734-737.

    12. Cao SM, Guo X *, Chen FuJ, Yang AK, Chen WK, Li NW. Serum Diagnosis of Head and Neck Squamous Cell Carcinoma Using Surface-enhanced Desorption Ionization Mass Spectrometry and Artificial Neural Network Analyses. Chinese Journal of Cancer, 2007; 26 (7): 767-770.

    13. Chen MY, Guo X, Wen WP, Hua YJ, Guo L, Li NW, Chen QY, Sun R, Hong MH. Salvage Surgical Operation via Endoscopic Transnasal Approach for Local Persistent or Recurrent Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2007; 26 (7): 673-678.

    14. Mo HY, Mai HQ, Li NW, Li J, Huang WJ, Guo X, Hong MH. Study of secretory otitis media after radiotherapy in nasopharyngeal carcinoma and inquisition of prevention and treatment. Chin J Cancer Prev Treat, 2007 July; 14 (13) 1005-1007.

    15. Mai HQ, Zeng ZY, Feng KT, Ye YL, Zhang CQ, Liang WJ, Guo X, Mo HY, Hong MH. Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma.Cancer Sci. 2006 Dec; 97(12):1388-95. Epub 2006 Oct 9.

    16. Mai HQ, Zeng ZY, Zhang CQ, Feng KT, Guo X, Mo HY, Deng MQ, Min HQ, Hong MH.  Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma. Cancer. 2006 Apr 1; 106(7):1548-53.

    17. Cao SM, Guo X *, Li NW, Xiang YQ, Hong MH, Min HQ. Clinical analysis of 1142 Hospitalized Cantonese Patients with Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2006 Feb; 25 (2):204-208.

    18. Xiang YQ, Yao HR, Wang SS, Hong MH, He JH, Cao SM, Min HQ, Song EW, Guo X*. Prognostic Value of Survivin and Livin in Nasopharyngeal Carcinoma. Laryngoscope, 2006 Jan; 116(1):126-130.

    19. Guo X*, Cao SM, Yu JK, Hong MH, Zhang CQ, Li NW, Xiang YQ, Qian CN, Hu X, Min HQ, Zeng YX. Distinct serumal proteomic patterns between ascending and descending types of loco-regionally advanced nasopharyngeal carcinoma assessed by surface enhanced laser desorption ionization and artificial neural network analyses. Chin Med J (Engl), 2005 Nov; 118(22):1912-1917.

    20. Xiang YQ, Yao RH, Guo X *, Hong MH, Cao SM, Min HQ. Expression of survival in nasopharyngeal carcinoma and its prognostic significance. Chin J Cancer Prev Treat, 2006 Jan; 13 (2):120-123.

    21. Cao SM, Guo X, Li NW, Hong MH, Min HQ. The Family Clustering Study of Nasopharyngeal Carcinoma Patients in Guangdong. Cancer Research on Prevention and Treatment, 2006 Apr; 33 (4):283-285.

    22. Sun ZY, Mai HQ, Xie CM, Zhao ZJ, Qi B, Hong MH, Guo X, Mo HY.  Prognostic influence of parapharyngeal space involvement in nasopharyngeal carcinoma. Chin J Cancer Prev Treat, 2006; 13 (10): 756-759.

    23. Guo L, Lin HX, Qiu F, Luo HD, Sun R, Guo X, Hong MH. Concurrent Chemoradiotherapy Using Oral Capecitabine and Carboplatin in the Treatment of Elderly Patients with Advanced Nasopharyngeal Carcinoma. Cancer Research on Prevention and Treatment, 2006; 33 (5): 368-370.

    24. Xiang YQ, Zhao HR, Guo X *, Hong MH, Cao SM, Min HQ. Apoptosis of Nasopharyngeal Carcinoma SUNE-1 Cell Lines Induced by inhibitors of Topoismerase II. Chinese Journal of Clinical Oncology, 2005 Dec; 32 (24): 406-1409.

    25. Xiang YQ, Zhao HR, Guo X *, Hong MH, Cao SM, Min HQ. Apoptosis of Nasopharyngeal Carcinoma CNE-2 Cell Lines Induced by Topoismerase II, ADM and THP. Journal of Sun Yat-sen University (Medical Sciences), 2005; 26 (3S): 70-72. 

    26. Akervall J, Guo X (Co-first author), Qian CN, Schoumans J, Leeser B, Kort E, Cole A, Resau J, Bradford C, Carey T, Wennerberg J, Anderson H, Tennvall J, Teh BT. Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. Clinical Cancer Research, 2004 Dec; 10(24): 8204-8013. 

    27. Guo X, Cao SM, Hong MH, Zhang CQ, Han AJ, Xiang YQ, Hou JH, Min HQ. Clinical Value of Vascular Endothelial Growth Factor Detection in Forecasting Distant Metastasis Risk of Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2004; 23 (10): 1171-75.

    28. Xiang YQ, Min HQ, Hong MH, Cao SM, He JH, Hou JH, Guo X*. Expression of Topoisomerase IIα in Nasopharyngeal Carcinoma and Its Clinical Significance. Chinese Journal of Cancer, 2004; 23 (3): 322-325. 

    29. Guo X, Lui WO, Qian CN, Chen JD, Gray SG, Rhodes D, Haab B, Stanbridge E, Wang H, Hong MH, Min HQ, Larsson C, Teh BT.  Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses.  Int J Oncol., 2002 Dec; 21(6):1197-1204.

    30. Hong MH, Min QH, Guo X *, Ma J, Mai HQ, Zhang WT, Zhang F, Zhang JM. To prove the rationality of ’92 staging with results of nasopharyngeal carcinoma treated by stratified multitherapies. Chinese Journal of Cancer, 2000; 19 (5): 460-2.

    31. Guo X *, Min HQ, Huang XM, Zhang JM, Chen FJ. The maxillary swing approach for resection of nasopharyngeal carcinoma. Chinese Journal of Cancer, 1999; 18 (2): 187-189.

    32. Guo X*, Min HQ, Zeng MS, Qian CN, Huang XM, Shao JY, Hou JH. nm23-H1 expression in nasopharyngeal carcinoma: correlation with clinical outcome.  Int J Cancer. 1998 Dec; 18; 79 (6):596-600.

    33. Guo X*, Min Huaqing, Shao Jianyong, Hou Jinhui. Expression of Nm23-H1 Gene Product in Nasophartngeal Carcinoma and Its Clinical Significance. Chinese Journal of Cancer Research, 1998; 10(1): 49-53.

    34. Guo X *, Min HQ, Huang XM, Zhang JM, Chen FJ, Qian CN. Exploration of new approach to salvage surgical operation of nasopharyngeal carcinoma -- the inverted maxillary approach for resection. Chinese Journal of Cancer, 1998; 17 (4): 271-273. 

    35. Guo X *, Min HQ, Zhao JY, Hou JH. Expression and clinical significance of gene products of Nm23-H in the human nasopharyngeal carcinoma. Chinese Journal of Cancer, 1997; 16 (2): 119-122. 

    36. Guo X *, Min QH. Salvage surgical operation of nasopharyngeal carcinoma (Review). China Cancer, 1997; 6 (7): 18-20. 

    37. Guo X *, Min HQ, Zeng ZY, Chen FJ. Esthesioneuroblastoma (clinical analysis of 23 cases). Chinese Journal of Trauma and Distablity Medicine, 1996; 4 (3): 30-31. 

    38. Xial LP, Zeng ZY, Chen ZH, Guo ZM, Guo X, Zhang Q. Surgery for the recurrent and persistent lymph node of nasopharyngeal carcinoma after radiotherapy. Chin J Otorhinolaryngol Head Neck Surg, 2005; 140 (2): 95-99. 

    39. Mai, HQ, Mo HY, Hong MH, Guo X, Deng MQ, Zhang F, Min HQ. Impact of Pre-radiotherapy Hemoglobin Level on Local Control of Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2005; 24 (6): 727-730.

    40. Lindvall C, Furge K, Bjorkholm M, Guo X, Haab B, Blennow E, Nordenskjold M, Teh BT. Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes. Haematologica, 2004 Sep; 89(9):1072-81.

    41. Gray SG, Qian CN, Furge K, Guo X, Teh BT. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int J Oncol, 2004 Apr; 24(4):773-95.

    42. Fuh-Mei Duh, Matthew Fivash, Michele Moody, Maria Li Lung, Xiang Guo, Eric Stanbridge, Michael Dean, Michael Voevoda, Li-Fu Hu, Vladimir Kashuba, Eugene R. Zabarovsky, Chao-Nan Qian, Sharad Godbole, Bin Tean Teh and Michael I. Lerman. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. Molecular and Cellular Probes, 2004; 18(1):39-44.

    43. Cao SM, Min HQ, Gao JS, Hong MH, Xiao XB, Zhang CQ, Liu XD, Zhang AL, Guo X. Significance of Cell-free Epstein-Barr Virus DNA in Monitoring Prognosis of Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2003; 22 (3): 302-6.

    44. Qian CN, Guo X, Cao B, Kort EJ, Lee CC, Chen J, Wang LM, Mai WY, Min HQ, Hong MH, Vande Woude GF, Resau JH, Teh BT. Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma.  Cancer Res., 2002 Jan 15; 62(2):589-96.

    45. Xiang YQ, Guo X, Hong MH. Progress in studying molecule markers of nasopharyngeal carcinoma. Journal of Practical Oncology, 2004; 19 (4): 273-275.

    46. Tao JP, Li MZ, Wang HM, Guo X, Hong MH. Study on the Tumorigenicity of Nasopharyngeal Carcinoma Cells Transfected with Haman IL-18 cDNA in Hu-PBL-SCID Mice. Current Immunology (Shanghai Journal of Immunology), 2002; 22 (6): 408-410.

    47. Gray SG, Guo X, Kedra D, Teh BT, Guo X, Min HQ.  Correspondence re: P. P. Claudio et al., Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Res., 60: 8-12, 2000. Cancer Res. 2001 Aug 1; 61(15):5950-5953.

    48. Mai HQ, Huang XM, Zhang F, Deng MQ, Guo X, Min HQ. Clinical Analysis on Osteoradionecrosis of Skull Base in Patients with Nasopharyngeal Carcinoma after Radiotherapy. China Journal of Cancer, 2001; 20 (1): 69-71.

    49. Qian CN, Zhang CQ, Guo X, Hong MH, Cao SM, Mai WY, Min HQ, Zeng YX.  Elevation of serum vascular endothelial growth factor in male patients with metastatic nasopharyngeal carcinoma.  Cancer, 2000 Jan 15; 88(2): 255-261.

    50. Min HQ, Guo X. Retrospect and prospect of study on nasopharyngeal carcinoma. Foreign Medical Sciences (Cancer Section), 2000; 27 (1): 11-14.

    51. Yang AK, Guo X. Clinical analysis of mucosal malignant melanoma of head and neck. Cancer Research on Prevention and Treatment, 2000; 27 (4): 309-310. 

    52. Min HQ, Hong MH, Guo X, Qian XN. Progress in study of nasopharyngeal carcinoma. China Cancer, 1999; 8 (12): 558-561.

    53. Yang SC, Li SN, Liu F, Mai WY, Guo X. Changes in the Th1 cells in peripheral blood of patients with nasopharyngeal carcinoma and its relation to the course. Chinese Journal of Immunology, 1998; 14 (3): 220-223.

    54. ang SC, Li SN, Liu F, Mai WY, Guo X. Transfection of B7-1 gene nasopharyngeal carcinoma cell lines and the cellular immune responses induced by transfection. Chinese Journal of Immunology, 1998; 14 (3): 172-175.

    55. Guo X, Min HQ. Status of surgical operation in the treatment of nasopharyngeal carcinoma (Review). China Journal of Cancer, 1998; 17 (5): 394-396. 

    56. Zeng MS, Guo X, Wang HM, Li MZ, Song LB, Yun JP, Guo HY. Expression of nm23-H1 mRNA and protein in nasopharyngeal carcinoma. Journal of Sun Yat-sen University, 1998; 19 (1): 7-10.

    Major Monographs:
    1. Hong MH, Guo X. Editor. Nasopharyngeal Carcinoma. China Medical Science Press, 2003. 

    2. Guo X. Research on Screening and Early Diagnosis and Treatment for Nasopharyngeal Carcinoma. Edited by Dong ZW. Progress in China Research on Cancer (VIII). Peking University Medical Press, 2007; Pp401-417.

    3. Guo X. Surgical Treatment for Nasopharyngeal Carcinoma. Edited by Zeng YX, Rong TH, Seminars on Nasopharyngeal Carcinoma. Zhengzhou University Press, 2006; Pp41-45. 

    4. Guo X, Lu TX. Nasopharyngeal Carcinoma. Edited by Wan DS, Clinical Oncology (Second Edition). Science Press, 1999; pp: 217-229.

    5. Guo X. Surgical Treatment. Edited by Hong MH and Guo X, Nasopharyngeal Carcinoma. China Medical Science Press, 2003; pp: 279-296. 

    6. Guo X. Emergency Treatment. Edited by Hong MH and Guo X, Nasopharyngeal Carcinoma. China Medical Science Press, 2003; pp:346-351.   

    7. Al-Sarraf, M., and Guo X. Head and Neck Cancers. In Cancer Chemotherapy and Biological Response Modifiers. Annual 21, G. Giaccone, R. Schilsky, and P. Sondel, 2003 Elsevier B.V., pp 430-443. 

    8. Min HQ, Guo X. Nasopharyngeal Carcinoma. Edited by Li SL, New Head and Neck Oncology. Scientific and Technical Documentation Press, 2002; pp: 496-545. 

    9. Guo X. Surgical Treatment of Nasopharyngeal Carcinoma. Edited by Min HQ, New Treatment Specifications of Common Cancers (Nasopharyngeal Carcinoma section). Peking Union Medical College Press,

    10. Guo X. Surgical Treatment of Nasopharyngeal Carcinoma. Edited by Min HQ, Study on Nasopharyngeal Carcinoma. Guangdong Science & Technology Press, 1998: 265-280.

    11. Guo X, Min HQ. Nasopharyngeal Carcinoma. Edited by Wang DS, Clinical Oncology. Science Press, 1998; pp: 122-32.
     

    Research Projects:
    1. Study on screening nasopharyngeal carcinoma metastasis-related genes with the technology of cDNA microarray (an international cooperation project of Guangdong Provincial Department of Science and Technology, undertaker)

    2. Study on screening early nasopharyngeal carcinoma-specific serum protein with protein microarray (Guangdong Provincial Department of Science and Technology, undertaker) 

    3. Study on screening nasopharyngeal carcinoma metastasis-related genes and predicting prognosis with the technology of cDNA microarray (Project 985, undertaker)

    3. Role of IAP family proteins in prognosis of nasopharyngeal carcinoma (Hospital’s fund, undertaker).5. Application of protein microarray technology to screen marker nasopharyngeal carcinoma-specific serum protein markers (Hospital’s fund, undertaker).

    1. Molecular biological characteristics of nasopharyngeal carcinoma in multi-stages of occurrence and development (Project 973, participant).

    2. Research on screening nasopharyngeal carcinoma risk indicators of high-risk group(Health Department of Guangdong Province, participant).

     
    Awards and Honors: 
    1. Series research on prevention and treatment of nasopharyngeal carcinoma (the Second Class Award of State Science and Technology Advancement Award, 2000, No. 6, )

    2. Research on ’92 staging and treatment of nasopharyngeal carcinoma (the First Class Award of Sci-Tech Advancement of Guangdong Province, 1999, No. 3)

    3. Research on ’92 staging and treatment of nasopharyngeal carcinoma (the First Class Award of Health Department of Guangdong Province, 1999, No. 3)

    4. Second-class Prize of “Mr. Deng Anticancer Science Award” (Sun Yat-sen University Cancer Center, 2006, Jan.)

    5. Star of Technology, “Tianheng Cup” Award of Clinical Oncology Research Results (Sun Yat-sen University Cancer Center, 1999) 

    6. Application of transnasal endoscopic surgery in the diagnosis and treatment of nasopharyngeal carcinoma, Third-class Prize in the Medical Achievement Award of Zhongshan School of Medicine (No. 041, Rank No. 2)

    Cao Kajia
    Title Chief Physician, Professor, Advisor of master's degree student, Deputy Director of Nasopharyngeal Carcinoma
    Profile

    Prof. Cao specializes in radiation therapy for nasopharyngeal carcinoma and lung cancer.

    Email caokj@sysucc.org.cn
    Phone +86-020-87343379
    Research Interest(s)

    1. Diagnosis of and combination therapy for nasopharyngeal carcinoma (NPC)

    2. Epidemiology of cancer

    Education 1982 Graduated from Department of Medicine, former Sun Yat-sen University of Medical Sciences
    1988 Obtained a masters degree from former Sun Yat-sen University of Medical Sciences
    1999-2000 Overseas study in France
     
    Publications

    Monographs

    1.Editor-in-chief of Registration and Statistics of Community Cancers

    2.Editor of Nasopharyngeal Carcinoma, Oncological Symposium and other monographs
     
    Papers (as lead author)

    1. Chinese Medical Journal: Long-term results of prophylactic cranial irradiation for limited-stage small-cell lung cancer in complete remission.

    2. Chinese Journal of Oncology: Clinical Research on Prognostic Factors of Nasopharyngeal Carcinoma of Children

    3. Chinese Journal of Oncology: Prognostic factors in nasopharyngeal carcinoma in childhood and adolescence

    4. Chinese Journal of Oncology: Clinical Research on Prophylactic Cranial Irradiation in Small Cell Lung Cancer

    5. Chinese Journal of Radiation Oncology: Long-term results of prophylactic cranial irradiation for limited-stage small-cell lung cancer in complete remission

    6. Chinese Journal of Radiation Oncology: Long-term Outcome of Radiotherapy for Nasopharyngeal Carcinoma

    7. Chinese Journal of Radiation Oncology: Long-term Outcome of the Concurrent Use of Oral Panax Notoginseng and Radiotherapy in treatment for Nasopharyngeal Carcinoma of 60 randomized patients

    8. Cancer: Radiotherapy for Stage III Non-Small-Cell Lung Cancer

    9. Cancer: Impact on the Clinical Effect of Radiotherapy of the Involvement of the Carotid Sheath Area in Nasopharyngeal Carcinoma

    10. Cancer: A Clinical Evaluation of the Concurrent Use of Radiotherapy and Chemotherapy in Treatment for Patients with Middle and Late Stage Nasopharyngeal Carcinoma

    11. Cancer: Impact of Radiotherapy on the Clinical Effect of Chemotherapy in Treatment for Limited Stage and Extended Stage Small Cell Lung Cancer

    12. Cancer: Impact of the Remaining Time of Cervical Lymph Node on the survival rate of patients after the Radiotherapy for Nasopharyngeal Carcinoma

    13. Cancer: Relationship between the Cervical Lymph Node Biopsy and the Metastasis of Nasopharyngeal Carcinoma

    14. Cancer: Evaluation of the Short-term Clinical Effect of Late Course Accelerated Hyperfractionated Radiotherapy in treatment for Non-Small-Cell Lung Cancer

    15. Cancer: Evaluation of the Clinical Effect of Postoperative Radiotherapy for III a (N2) Stage Non-Small-Cell Lung Cancer

    16. Cancer: Effectiveness of Radiotherapy for Patients with AIDS-related Primary Cerebral Lymphoma

    17. Cancer: Long-term Efficacy of Radiotherapy on Children with Nasopharyngeal Carcinoma

    18. Cancer: Long-term Prognostic Analysis of Patients with Malignant Pleural Mesothelioma

    19. Cancer: Radiotherapy on Neck for Nasopharyngeal Carcinoma Patients with Negative Cervical Lymph Node

    20. Cancer: Impact of Dose Boost in Skull Base on the Recurrence in stage T4 of Nasopharyngeal Carcinoma

    21. Cancer: Impact of Amenorrhoea and Radiation Dose after Radiotherapy for Nasopharyngeal Carcinoma

    22. Cancer: Radiotherapy for Recessive Nasopharyngeal Carcinoma

    23. Cancer: Application of Magnetic Resonance Imaging to Clinical Classification of Nasopharyngeal Carcinoma

    24. Cancer: Analysis of Prognostic Factors of Metastatic Nasopharyngeal Carcinoma

    25. Cancer: Comparison between the Examination Staging and the Clinical Effect of CT or MRI before the Radiotherapy for Nasopharyngeal Carcinoma

    26. Cancer: Cancer Incidence and Mortality in Guangzhou City from 2000 to 2002

    27. Cancer: Incidence of colorectal cancer in Guangzhou City from 2000 to 2002

    28. Cancer: Incidence of Children Tumor in Guangzhou City from 2000 to 2002

    29. Chinese Journal of Clinical Oncology: Influence of Postoperative Radiotherapy on the Patients with Completely Resected Non-small Cell Lung Cancer

    30. Tumor: Analysis of Prognostic Factors of Re-course Radiotherapy for Primary Recurrent Nasopharyngeal Carcinoma

    31. Bulletin of Chinese Cancer: Comparison of Effectiveness for Nasopharyngeal Carcinoma Treated with Inducing Chemotherapy Plus Radiotherapy versus Concurrent Radio-chemotherapy

    32. Bulletin of Chinese Cancer: An Analysis of Prognostic Factor for Locally Recurrent Nasopharygeal Carcinoma

    33. Bulletin of Chinese Cancer: Impact of Computed Tomography and Magnetic Resonance Imaging on Staging for Nasopharyngeal Carcinoma

    34. Bulletin of Chinese Cancer: An Analysis of Long-term Response with Radiotherapy in 49 Cases with Nasopharyngeal Carcinoma in Children

    35. Bulletin of Chinese Cancer: An Analysis of Recurrent Site in 111 cases with Nasopharyngeal Carcinoma

    36. Bulletin of Chinese Cancer: Cancer Registration in Guangdong Province

    37. Bulletin of Chinese Cancer: A Contrastive Case-Control Study on the Risk Factors of Breast Cancer in Guangzhou City

    38. Bulletin of Chinese Cancer: An Analysis of Incidence and Mortality of Nasopharyngeal Cancer in Guangzhou City

    39. Bulletin of Chinese Cancer: Incidence and Mortality of Lung Cancer in Guangzhou City from 2000 to 2002

    40. Bulletin of Chinese Cancer: The Role of Medical Records Scanning System in the Administration of Medical Records in Cancer Hospitals

    41. Bulletin of Chinese Cancer: The Role of Tracing System in Computer-managed Medical Records

    42. Bulletin of Chinese Cancer: The Role of Telephone in the Motivation Interview of Cancer Patients

    43. Chinese Journal of Hospital Administration: Improve the quality and administration of Medical Records

    Others

    Having published 38 articles in Health News, Southern Weekly, Southern Metropolis Daily, Anti-Cancer News and other kinds of newspaper

    Mai Haiqiang
    Title Chief physician, Professor, Deputy Director of Department of Nasopharyngeal Carcinoma, Doctoral advisor
    Profile

    Prof. Mai Haiqiang, was born in January 1973. He is a professor, chief physician, deputy director of Department of Nasopharyngeal Carcinoma, doctoral advisor, a member of the Editorial Board of Chinese Journal of Cancer, a member of Committee of Nasopharyngeal Cancer under Chinese Anti-Cancer Association, an evaluation expert of National Natural Science Foundation of China and a special reviewer for BMC Cancer and Tumor Biology. He specializes in nasopharyngeal carcinoma early diagnosis, individualized combination therapy, curative effect prediction and prognosis studies.

    Email maihq@sysucc.org.cn
    Phone 020-87343380
    Research Interest(s)

    Nasopharyngeal carcinoma early diagnosis, individualized combination therapy, curative effect prediction and prognosis study

    Education

    09/1991-06/1998  Seven-Year Master Program of Clinical Medicine, former Sun Yat-sen University of Medical Sciences

    09/2002-06/2005  MD at Sun Yat-sen University

    Publications

    Publications as the first author or corresponding author (*, a mark of corresponding author):

    1. Zhang L, Chen QY, Liu H, Tang LQ, Mai HQ*. Emerging treatment options for nasopharyngeal carcinoma. Drug Des Devel Ther. 2013;7:37-52.

    2. Liu H, Chen QY, Guo L, Tang LQ, Mo HY, Zhong ZL, Huang PY, Luo DH, Sun R, Guo X, Cao KJ, Hong MH, Mai HQ*.Feasibility and efficacy of chemoradiotherapy for elderly patients with locoregionally advanced nasopharyngeal carcinoma: results from a matched cohort analysis. Radiat Oncol. 2013;8(1):70.

    3. Huang PY, Wang CT, Cao KJ, Guo X, Guo L, Mo HY, Wen BX, Wu YS, Mai HQ*, Hong MH. Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: Findings from a randomised trial. Eur J Cancer. 2013 Feb 21. [Epub ahead of print]


    4. Mo HY, Sun R, Sun J, Zhang Q, Huang WJ, Li YX, Yang J, Mai HQ*. Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma. Radiat Oncol. 2012;7(1):149.

    5. Mo HY, Luo DH, Qiu HZ, Liu H, Chen QY, Tang LQ, Zhong ZL, Huang PY, Zhao ZJ, Zhang CQ, Zhang Y, Mai HQ*. Elevated serum endostatin levels are associated with poor survival in patients with advanced-stage nasopharyngeal carcinoma. Clin Oncol. 2013 Jan 2. [Epub ahead of print]

    6. Huang PY, Sun ZY, Xie CM, Chen QY, Wen YF, Li J, Qiu HZ, Liu H, Zhong ZL, Mai HQ*, Mo HY. Prognostic significance of the various classifications for parapharyngeal space involvement in nasopharyngeal carcinoma. Acta Otolaryngol. 2012;132(11):1197-1207.

    7. Li SX, Chen QY, Zhang YJ, Liu ZM, Xiong HL, Guo ZY, Mai HQ*, Liu SH. Detection of nasopharyngeal cancer using confocal Raman spectroscopy and genetic algorithm technique. J Biomed Opt. 2012;17(12):125003.

    8. Huang PY, Cao KJ, Guo X, Mo HY, Guo L, Xiang YQ, Deng MQ, Qiu F, Cao SM, Guo Y, Zhang L, Li NW, Sun R, Chen QY, Luo DH, Hua YJ, Mai HQ*, Hong MH. A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Oral Oncol. 2012;48(10):1038-1044.

    9. Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, Hua YJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ*. Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. J Natl Cancer Inst. 2011;103(23):1761-1770.

    10. Wen YF, Qi B, Liu H, Mo HY, Chen QY, Li J, Huang PY, Ye YF, Zhang Y, Deng MQ, Guo X, Hong MH, Cao KJ, Mai HQ*.Polymorphisms in the endothelin-1 and endothelin a receptor genes and survival in patients with locoregionally advanced nasopharyngeal carcinoma. Clin Cancer Res. 2011;17(8):2451-2458.

    11. Mai HQ, Mo HY, Deng JF, Deng MQ, Mai WY, Huang XM, Guo X, Hong MH. Endoscopic microwave coagulation therapy for early recurrent T1 nasopharyngeal carcinoma. Eur J Cancer. 2009;45(7):1107-1110.

    12. Mai HQ, Zeng ZY, Feng KT, Ye YL, Zhang CQ, Liang WJ, Guo X, Mo HY, Hong MH. Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma. Cancer Sci. 2006;97(12):1388-1395.

    13. Mai HQ, Zeng ZY, Zhang CQ, Feng KT, Guo X, Mo HY, Deng MQ, Min HQ, Hong MH. Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma. Cancer. 2006;106(7):1548-1553.

    14. Mai HQ, May WS, Gao F, Jin Z, Deng X. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem. 2003;278(3):1886-1891.

    15. Mai HQ, Xu LH, Liu H, Mo HY, Huang PY, Tang LQ, Chen QY. Endothelin-1 promotes 6-10B nasopharyngeal carcinoma cell migration by inducing the expression of chemokine receptor CXCR4. Journal of Sun Yat-sen University (Medical Sciences). 2011;32(5):616-622.

    16. Qi B, Guo X, Wen YF, Mo HY, Chen QY, Liu H, Li J, Ye YF, Mai HQ*. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in locoregionally advanced nasopharyngeal carcinoma. Chinese Journal of Cancer Prevention and Treatment. 2010;17(10): 755-758.

    17. Chen QY, Zhang CQ, Mo HY, Deng MQ, Cao SM, Hong MH, Guo X, Mai HQ*. Dynamic changes of serum VEGF of nasopharyngeal carcinoma patients during radiotherapy. Chinese Journal of Cancer Prevention and Treatment. 2009;16(18):1424-1426.

    18. Huang WJ, Mo HY, Deng MQ, Mai HQ*, Qi B, Li J, Hong MH, Guo X. Relationship between cranial nerve involvement in nasopharyngeal carcinoma and the prognosis. Journal of Clinical Otorhinolaryngology Head and Neck Surgery. 2009;23(21):964-967.

    19. Qi B, Guo X, Wen YF, Mo HY, Chen QY, Liu H, Li J, Ye YF, Mai HQ*. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in locoregionally advanced nasopharyngeal carcinoma. Chinese Journal of Cancer Prevention and Treatment. 2010;17(10):755-758.

    20. Chen QY, Zhang CQ, Mo HY, Deng MQ, Cao SM, Hong MH, Guo X, Mai HQ*. Dynamic changes of serum VEGF of nasopharyngeal carcinoma patients during radiotherapy. Chinese Journal of Cancer Prevention and Treatment. 2009;16(18):1424-1427.

    21. Huang WJ, Mo HY, Deng MQ, Mai HQ*, Qi B, Li J, Hong MH, Guo X. Relationship between cranial nerve involvement in nasopharyngeal carcinoma and the prognosis. Journal of Clinical Otorhinolaryngology Head and Neck Surgery. 2009;23(21):964-967.

    22. Deng MQ, Mai HQ*, Mai WY, Mo HY, Huang XM, Guo X, Hong MH. Endoscopic microwave coagulation therapy for locally recurrent nasopharyngeal carcinoma. Chinese Journal of Cancer. 2008; 27(7):734-737.

    23. Zhao ZJ, Mo HY, Zhang CQ, Qi B, Li J, Hong MH, Mai HQ*. Correlation of pretreatment serum level of endostatin to posttreatment distant metastasis in patients with advanced nasopharyngeal carcinoma. Chinese Journal of Cancer. 2007;26(11):1243-1247.

    24. Mai HQ, Zeng ZY, Zhang HZ, Hou JH, Mo HY, Guo X,Min HQ, Hong MH. Correlation of endothelin a receptor expression to prognosis of nasopharyngeal carcinoma. Chinese Journal of Cancer. 2005;24(5):611-615.

    25. Mai HQ, Mo HY, Hong MH, Guo X, Deng MQ, Zhang F, Min HQ. Impact of pre-radiotherapy hemoglobin level on local control of nasopharyngeal carcinoma. Chinese Journal of Cancer. 2005;24(6):89-92.

    26. Ma J, Mai HQ*, Hong MH, Mo HY, Cui NJ, Lu TX, Min HQ. Clinical evaluation of 1997 UICC staging system for nasopharyngeal carcinoma. Chinese Journal of Cancer. 2001;20(3):301-304.

    27. Mai HQ, Huang XM, Zhang F, Deng MQ, Guo X, Min HQ. Clinical analysis on osteoradionecrosis of skull base in patients with nasopharyngeal carcinoma after radiotherapy. Chinese Journal of Cancer. 2001;20(1):69-71.

    28. Mai HQ, Ma J, Zhang JM, Huang TB, Mo YX. Effect of computed tomography on N-staging for nasopharyngeal carcinoma. Chinese Journal of Cancer. 2000;19(9):907-910.

    29. Ma J, Mai HQ*, Mo HY, Lu TX, Cui NJ, Hong MH. Patterns of treatment failure after primary radiotherapy in patients with nasopharyngeal carcinoma. Chinese Journal of Cancer. 2000;19(11):1016-1018.

    Edited Works:

    1. Mai HQ. ‘Endoscopy and Differential Diagnosis’, in Min HQ, Hong MH, Guo X, Nasopharyngeal Carcinoma. Beijing: China Medical Science Press. 2003;Edition 1:101-114.

    2. Mai HQ. ‘Prognosis and Prognostic Factors’, in Min HQ, Hong MH, Guo X, Nasopharyngeal Carcinoma. Beijing: China Medical Science Press. 2003;Edition 1:379-397.

    3. Mai HQ (Editorial Board Member). ‘Nasopharyngeal Carcinoma’, in International Comparative Study on the Scientific and Technological Innovation Ability of Chinese Modern Medicine, organized by China National Center for Biotechnology Development. Beijing: China Medical Science Press. 2009.

    4. Mai HQ, Huang WL (Eds). Biopharmaceutical “Miracles” -- The Birth and Development of Gene Medicine. Guangzhou: Guangdong Science and Technology Press. 2011.

    5. Mai HQ (Editorial Board Member). ‘Nasopharyngeal Carcinoma’, in A Course in Advanced Clinical Oncology. Beijing: People’s Military Medical Press. 2011.

    6. Mai HQ (Subeditor). Diagnosis and Treatment of Nasopharyngeal Carcinoma. World Publishing Corporation. 2012.

    Honors and Awards:

    1. 2012 The 3rd Guangdong Science and Technology Innovation Excellent Academic Papers First Prize

    2. 2012 The Seventh Batch of Provincial Talents for Guangdong “Ten-Hundred-Thousand” Project

    3. 2011 Ministry of Education Program for New Century Excellent Talents in University

    4. 2009 Dr. Cheng Yu Tung Fellowships awarded by the Li Ka Shing Faculty of Medicine at the University of Hong Kong

    5. 2009 The second National Prize for Progress in Science and Technology with “Research and Application of Comprehensive Treatment of Nasopharyngeal Carcinoma Based on Modern Imaging Technology” (the fourth author)

    6. 2008 The 5th “Ten Outstanding Young Persons of Yunfu City”

    7. 2008 The first Guangdong Provincial Science and Technology Award with “Research of Comprehensive Treatment of Nasopharyngeal Carcinoma Based on Modern Imaging Technology” (the fourth author)

    8. 2008 The second Prize for Progress in Science and Technology of Ministry of Education with “Research of Comprehensive Treatment of Nasopharyngeal Carcinoma Based on Imaging ” (the fourth author)

    9. 2007 The first Science and Technology Award of Chinese Medical Association with “Research of Comprehensive Treatment of Nasopharyngeal Carcinoma Based on Modern Imaging Technology” (the fourth author)

    10. 2007 “Cancer Science Young Scientists Award” of Japanese Cancer Association

    Chong Zhao
    Title Professor
    Profile
    Professor Chong Zhao was awarded his MD degree from Faculty of Medicine, Sun Yat-sen University of Medical Sciences in 1986. Now he is a Chief Physician, Professor and Master supervisor in Sun Yat-sen Cancer Center, Sun Yat-sen University. Prof. Chong Zhao has worked in the area of radiation oncology for more than 20 years. He specializes in the diagnosis, radiotherapy and combined treatment of head and neck cancers and has particular expertise in conventional radiotherapy, intensity modulated radiotherapy and chemoradiotherapy concerning nasopharyngeal carcinoma. He is one of the radiation oncologists who took the lead in investigating intensity modulated radiotherapy and researching the target volumes for nasopharyngeal carcinoma from 2001. He has either managed or participated in about 10 research projects supported by international, national and also provisional funds. He is youth committee member of Chinese Society of Radiation Oncology, Chinese Medical Association, secretary of China Nasopharyngeal Carcinoma Staging Committee, vice-chairmen of Society of Radiation Oncology, Guangdong Provincial Anticancer Association, member of American Society for Therapeutic Radiology and Oncology (ASTRO), corresponding editor of Chinese Journal of Radiological Medicine and Protection, and corresponding editor of Chinese Journal of Clinicians (Electronic Version). He has published around 90 original research papers in oncology and participating in several treatises writing.
    Email zhaochong@sysucc.org.cn
    Phone 86-20-87342638
    Research Interest(s)
    Diagnosis, radiotherapy and combined treatment of head and neck cancers and has particular expertise in intensity modulated radiotherapy and chemo-radiotherapy concerning nasopharyngeal carcinoma.
    Education Dr. Chong Zhao was awarded his MD degree from Faculty of Medicine, Sun Yat-sen University of Medical Sciences in 1986.
    Publications

    1. Long-term Follow-up of a Phase III Study Comparing Radiotherapy with or without Weekly Oxaliplatin for Locoregionally Advanced Nasopharyngeal Carcinoma. Annals Oncology,2013,24:2131-2136

    2. Results of a Phase II Study Examining the Effects of Omitting Elective Neck Irradiation to Nodal Levels IV and Vb in Patients with N0-1 Nasopharyngeal Carcinoma. International Journal of Radiation Oncology•Biology•Physics, 2013,85(4):929-934

    3. Long-term Treatment Outcome of Recurrent Nasopharyngeal Carcinoma Treated with Salvage Intensity Modulated Radiotherapy. European Journal of Cancer, 2012,48:3422-3428

    4. Intensity-Modulated Radiation Therapy Reduces Radiation-induced Trismus in Patients with Nasopharyngeal Carcinoma--A Prospective Study With 5 Years of Follow-Up. Cancer,2011,117(13):2910-2916

    5. Local Control, Survival, and Late Toxicities of Locally Advanced Nasopharyngeal Carcinoma Treated by Simultaneous Modulated Accelerated Radiotherapy Combined with Cisplatin Concurrent Chemotherapy. Cancer, 2011,117(9):1874-1883

    6. Different Clinical Significance of Pre- and Post-treatment Plasma Epstein–Barr Virus DNA Load in Nasopharyngeal Carcinoma Treated with Radiotherapy. Clinical Oncology,2011,23:128-133

    7. The Role of Concurrent Chemoradiotherapy in the Treatment of Locoregionally Advanced Nasopharyngeal Carcinoma among Endemic Population A Meta-analysis of the Phase III Randomized Trials. BMC Cancer,2010,10:558

    Mo Haoyuan
    Title Chief physician, Advisor of master's degree student, Attending Professor
    Profile

    Dr. Mo Haoyuan was born in 1964 and graduated from the six-year program of the Department of Medicine, former Sun Yat-sen University of Medical Sciences in 1987. He is engaged in clinical work of nasopharynx carcinoma, nasopharynx carcinoma diagnosis and biopsy for difficult cases, and radiation therapy, chemotherapy and combination therapy for nasopharynx carcinoma. He is also engaged in teaching undergraduates and graduates, and scientific research. He has rich clinical experience. He has published many papers and undertaken many scientific research projects since he became a doctor.

    Email mohy@sysucc.org.cn
    Phone 020-87343769
    Research Interest(s)
    He is engaged in clinical work of nasopharynx carcinoma, nasopharynx carcinoma diagnosis and biopsy for difficult cases, and radiation therapy, chemotherapy and combination therapy for nasopharynx carcinoma. He is also engaged in teaching undergraduates and graduates, and scientific research. He has rich clinical experience. He has published many papers and undertaken many scientific research projects since he became a doctor.
    Education
    He graduated from the six-year program of the Department of Medicine, former Sun Yat-sen University of Medical Sciences in 1987.
    Publications

    1. Hao-Yuan Mo (lead author), Dong-Hua Luo, Hui-Zhi Qiu, Huai Liu, Qiu-Yan Chen, Lin-Quan Tang,Zong-Liang Zhong, Pei-Yu Huang, Zheng-Jun Zhao,Chang-Qing Zhang,Ying Zhang, Hai-Qiang Mai. Elevated Serum Endostatin Levels Associates with Poor Survival in Patients with Advanced-stage Nasopharyngeal Carcinoma. CLINICAL ONCOLOGY 2013Jan 2.

    2. Sun Rui, Qiu Hui-Zhi, Mai Hai-Qiang , Zhang Qing, Hong ming-huang, Li Yan-Xian , Yang Jing, Sun Jian, Mo Hao-Yuan (corresponding author). Prognostic value and differences of the sixth and seventh editions of the UICC/AJCC staging systems in nasopharyngeal carcinoma. J Cancer Res Clin Oncol. 2012 Oct 16.

    3. Hao-Yuan Mo (lead author), Rui Sun,Jian Sun,Qing Zhang ,Wen-Jin Huang, Yan-Xian Li ,Jing Yang ,Hai-Qiang Mai. Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma. Radiat Oncol. 2012 Sep 7;7(1):149.

    4. Jiang Li ,Hao-Yuan Mo (both as lead authors), Geng Xiong, Lin Zhang, Jia He, Zhou-Feng Huang, Zhi-Wei Liu, Qiu-Yan Chen, Zi-Ming Du, Li-Min Zheng, Chao-Nan Qian, and Yi-Xin Zeng. Tumor microenvironment MIF directs the accumulation of IL-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. The Journal of Biological Chemistry, 2012 Oct 12;287(42):35484-95.

    5. PEI-YU HUANG,ZHE-YU SUN,CHUAN-MIAO XIE, QIU-YAN CHEN,YUE-FENG WEN, JUAN LI, HUI-ZHI QIU, HUAI LIU, ZONG-LIANG ZHONG,HAI-QIANG MAI & HAO-YUAN MO(corresponding author). Prognostic significance of the various classifications for parapharyngeal space involvement in nasopharyngeal carcinoma . Acta Oto-Laryngologica, 2012 Nov;132(11):1197-207.

    6. Hai-Qiang Mai,Hao-Yuan Mo (both as lead authors),Jing-Feng Deng,Man-Quan Deng, Wei-Yuan Mai,Xiao-Ming Huang, Xiang Guo, Ming-Huang Hong. Endoscopic microwave coagulation therapy for early recurrentT1 nasopharyngeal carcinoma. EUROPEAN JOURNAL OF CANCER ,45(2009):1107-1110

    7. Mo Haoyuan, Mai Haiqiang, Li Ningwei, Li Juan, Huang Wenjin, Guoxiang, Hong Minghuang. Study of secretory otitis media after radiotherapy in nasopharyngeal carcinoma and inquisition of prevention and treatment. Chinese Journal of Cancer Prevention and Treatment, 2007, 14 (13):1005-1007

    8. Mo Haoyuan, Zhang Changqing, Feng Kaitao, Zhang Feng, Hong Minghuang, Sun Zheyu. Expression of P53 and PCNA in Nasopharyngeal Carcinoma and Their Relation with Clinical stage, VCA/IgA, EA/IgA, Radiation Sensibility,and Pognosis. Chinese Journal of Cancer, 2004, 23 (11S):1551-1554.

    9. Mo Haoyuan, Zhang Feng, Hong Minghuang, Fan Wei, Zheng Lie, Min Huaqing. Positive Rate of Radionuclide Bone Imaging and Treatment in No Ostalgia Patients with New Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2002, 21 (3):323-325.

    10. Mo Haoyuan, Deng Manquan, Mai Haiqiang, Qi Bin, Li Ningwei, Guo Xiang, Hong Minghuang. The influences and treatments of deafness in nasopharyngeal carcinoma patients after radiotherapy. Journal of Modern Oncology, 2009, 17 (10):1856-1858

    11. Sun Zheyu, Mai Haiqiang, Xie Chuanmiao, Zhao Zhengjun, Qi Bin, Hong Minghuang, Guo Xiang, Mo Haoyuan (corresponding author). Prognostic influence of parapharyngeal space involvement in nasopharyngeal carcinoma. Chinese Journal of Cancer Prevention and Treatment, 2006, 13 (10):756-759

    12. Zhao Zhengjun, Mo Haoyuan (advisor, second author), Zhang Changqing, Qi Bin, Li Juan, Hong Minghuang, Mai Haiqiang. Correlation of Pretreatment Serum Level of Endostatin to Posttreatment Distant Metastasis in Patients with Advanced Nasopharyngeal Carcinoma. Chinese Journal of Cancer, 2007, 26 (11):1243-1247.

    13. Huang Wenjin, Mo Haoyuan (advisor, second author), Deng Manquan, Mai Haiqiang, Qi Bin, Li Juan, Hong Minghuang, Guo Xiang.  Relationship between cranial nerve involvement in nasopharyngeal carcinoma and the prognosis. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2009, 23 (21): 964-967.

    14. Li juan, Mo Haoyuan (corresponding author), Mai Haiqiang, Mo Yunxian, Qiu Huizhi, Guo Xiang.  An investigation into the relationship between magnetic resonance nasopharyngeal carcinoma with parapharyngeal space invasion and prognosis. Journal of Chinese Oncology, 2011, 17 (1): 12-15.

    15. Mai Haiqiang, Sun Zheyu, Xie Chuanmiao, Chen Qiuyan, Qiu Huizhi, Wen Yuefeng, Liu Huai, Zhong Zongliang, Guo Xiang, Mo Haoyuan (corresponding author).   Study on the effect of different degrees of parapharyngeal invasion on prognosis of nasopharyngeal carcinoma. Chinese Journal of Cancer Prevention and Treatment, 2011, 18 (17): 1333-1337.

    16. Qiu Huizhi, Mo Haoyuan (corresponding author), Zhong Zongliang, Hua Yijun, Mai Haiqiang, Guo Xiang. Evaluation on the clinical application of China's 2008 staging and UICC 2002 and 2009 staging of nasopharyngeal cancer. Chinese Journal of Cancer Prevention and Treatment, 2011, 18 (18): 1470-1474.

    17. Zhong Zongliang, Mo Haoyuan (corresponding author), Mai Haiqiang, Li Yanxian, Yang Jing, Cao Qiajia, Guo Xiang.  Clinical paired study of initial treatment of 86 cases of nasopharyngeal carcinoma with dermatomyositis. China Cancer. 2012, 21(3): 220-224.

    18. Mo Haoyuan (lead author), Value of biopsy with nasopharyngeal fibroscopy in patients infected by EB virus without typically clinical symptom. Chinese Journal of Cancer, 2000

    19. Mo Haoyuan (lead author), Clinical trial of five-color glossy ganoderma for relieving nasopharynx carcinoma patients radiotherapy reaction and improving immunity. Chinese Journal of Clinical Oncology, 1999

    20. Mo Haoyuan (lead author), Difference and significance of nasopharyngoscope, CT, pathology biopsy in inspecting single side nasopharynx carcinoma T range -- with reports on 50 clinical cases. Chinese Journal of Cancer, 1998

    Chen Qiu-Yan
    Title Associate Chief Physician
    Profile

    Dr. Qiu-Yan Chen is an associate chief physician of nasopharyngeal carcinoma department of Sun Yat-sen University Cancer Center. Dr.Chen obtained her Bachelor in Medicine (equivalent to MD in the US) and PhD at Sun Yat-sen University of Medical Sciences, P. R. China in 2000 and 2009, respectively. She has been engaged in clinical diagnosis and treatment of nasopharyngeal carcinoma since 2000 and she participated several prospective randomized controlled clinical trials.

    From 2007 November to 2008 November, she participate in the joint doctoral training project to American University of Pittsburgh for one year by the China Scholarship Council funded. She has chaired one national youth fund and one Guangdong Province Science and technology projects, participated in four National Natural Science Foundations. Dr. Chen has published more than 30 research papers.

     

    Email chenqy@sysucc.org.cn
    Phone 020-87343380
    Research Interest(s) Nasopharyngeal carcinoma therapy (radiotherapy, chemotherapy, targeted therapy)in clinical work and research.
    Education

    Sep/1995-Jul/2000  Bachelor in Medicine (equivalent to M.D. in the US)

    Sun Yat-sen University of Medical Sciences,Guangzhou, P. R. China

    Sep/2004-Sep/2006  Master of Medical Science in Oncology

    Sun Yat-sen University ofMedical Sciences, Guangzhou, P. R. China

    Sep/2006-Sep/2009  Ph. D of Medical Science in Oncology

    Sun Yat-sen University ofMedical Sciences, Guangzhou, P. R. China

     

    Publications

    1. Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH,Sun R, DengMQ, Chen MY, Hua YJ, Guo X, Cao KJ, Hong MH, Qian CN, and Mai HQ. Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage IINasopharyngeal Carcinoma: Phase III Randomized Trial. Journal of the National CancerInstitute. 2011;December 7,103(23),1761-70. (IF14.6)

    2. Tang LQ, Chen QY,(co-author),Fan W, Liu H, Zhang L, GuoL, Luo DH, Huang PY, Zhang X, Lin XP, Mo YX, Liu LZ, Mo HY, Li J, Zou RH, CaoY, Xiang YQ, Qiu F, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, CaoKJ, Qian CN, Zeng MS, Mai HQ. Prospective study of tailoring whole-bodydual-modality [18F]fluorodeoxyglucose positron emission tomography/computedtomography with plasma Epstein-Barr virus DNA for detecting distant metastasisin endemic nasopharyngeal carcinoma at initial staging. J Clin Oncol.2013 Aug10;31(23):2861-9.(IF 18.038)

    3. Luo DH, Chen QY,(co-author),Liu H, Xu LH,Zhang HZ, Zhang L, Tang LQ, Mo HY, Huang PY, Guo X, Mai HQ.The independent,unfavorable prognostic factors endothelin A receptor and chemokine receptor 4have a close relationship in promoting the motility of nasopharyngeal carcinomacells via the activation of AKT and MAPK pathways. J Transl Med. 2013 Aug29;11(1):203.(IF 3.46)

    4. Li J,Chen QY,(co-author),Mo HY, Zhang YL,Huang ZF, Zeng YX. Immunophenotyping at the Time of Diagnosis Distinguishes TwoGroups of Nasopharyngeal Carcinoma Patients: Implications for AdoptiveImmuno-therapy. International Journal of Biological Science, 2011; 7(5):607-617. (IF 3.2)

    5. Liu H, Chen QY, (co-author),Guo L, Tang LQ,Mo HY, Zhong ZL, Huang PY, Luo DH, Sun R, Guo X, Cao KJ, Hong MH, Mai HQ.Feasibility and efficacy of chemoradiotherapy for elderly patients withlocoregionally advanced nasopharyngeal carcinoma: results from a matched cohortanalysis. Radiat Oncol. 2013 Mar 22;8(1):70. (IF 2.11)

    6. Cai Z, Chen QY, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q. Monocyte chemotactic protein 1 promotes lungcancer–induced bone resorptive lesions in vivo. Neoplasia, 2009,11(3): 228-236.(IF5.4)

    7. Lu Y, Chen QY, Corey E, Xie W, Fan J, MizokamiA. Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone. Clinical& Experimental Metastasis, 2009,26(2):161-169.(IF4.1)

    8. Zhang L, Chen QY, Liu H, Tang LQ, Mai Hq.Emerging treatment options for nasopharyngeal carcinoma. DrugDes Devel Ther. 2013; 7:37-52. (IF 3.486)

    9. Lu Y, Nie D, Witt WT, Chen QY,  Shen M, Xie H, Lai L,  Dai Y. Expression of the fat-1 gene diminishes prostate cancer growth in vivothrough enhancing apoptosis and inhibiting GSK-3 beta phosphorylation. MolecularCancer Therapeutics, 2008,7(10):3202-3211.(IF5.2)

    10. Wen YF, Qi B, Liu H, Mo HY, Chen QY, Li J, Huang PY, Ye YF, Zhang Y, Deng MQ,  Guo X, Hong MH, Cao KJ,  Mai HQ. Polymorphisms in the Endothelin-1 andEndothelin A Receptor Genes and Survival in Patients with LocoregionallyAdvanced Nasopharyngeal Carcinoma. Clinical Cancer Research, 2011;17(8):2451-2458. (IF 7.3)

    11. He J, Tang XF, ChenQY, Mai HQ, Huang ZF, Li J, Zeng YX. Ex vivo expansion oftumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients foradoptive immunotherapy. Chin J Cancer, 2012, Jan 17. doi:10.5732/cjc.011.10376. [Epub ahead of print]

    12. Chen MY, Wang SL, Zhu YL, Shen GP, Qiu F, Luo DH, Chen QY, Jiang R, Cao KJ, QianCN, Hong MH. Use of a posterior pedicle nasal septum and floor mucoperiosteumflap to resurface the nasopharynx after endoscopic nasopharyngectomy forrecurrent nasopharyngeal carcinoma. Head Neck, 2011, Dec 5. doi:10.1002/hed.21928. [Epub ahead of print]

    13. Li J,Huang ZF, Xiong G, Mo HY, Qiu F, Mai HQ, ChenQY, He J, Chen SP, Zheng LM, Qian CN, Zeng YX. Distribution,characterization, and induction of CD8⁺ regulatory Tcells and IL-17-producing CD8⁺ T cells innasopharyngeal carcinoma. J Transl Med, 2011, Nov 4,9:189.

    14. Lv X, Xiang YQ, Cao SM, Qian CN, Li NW, Guo L, Mai HQ, Chen QY, Huang PY, Luo D, CaoKJ, Hong MH, Guo X. Prospective validation of the prognostic value of elevatedserum vascular endothelial growth factor in patients with nasopharyngealcarcinoma: more distant metastases and shorter overall survival aftertreatment. Head Neck, 2011, 33(6):780-5.

    15. Cao SM, Yu JK, ChenQY, Li NW, Xiang YQ, Qian CN, Hu X, Zhang CQ, Xie D, Guo X. Detection ofnasopharyngeal carcinoma using surface-enhanced laser desorption and ionizationmass spectrometry profiles of the serum proteome. Chin J Cancer, 2010,29(8):721-8.

    16. Kong QL, Hu LJ, Cao JY, Huang YJ, Xu LH, Liang Y, Xiong D,Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ, Shao JY, Qian CN, Xia YF, Song LB, Zeng YX, Zeng MS.Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transitionand increases the number of side population stem-like cancer cells innasopharyngeal carcinoma. PLoS Pathog, 2010, 6(6):e1000940.

    17. Lu X, Guo X, Hong MH, ChenQY, Zeng Q, Xiang YQ. Comparison of the short-term efficacy of twoinductive chemotherapy regimens for locally advanced nasopharyngeal caricinoma:docetaxal plus carboplatin versus 5-fluorouracil plus carboplatin. ChinJ Cancer, 2010, 29(2):140-4.

    18. Guo L, Lin HX, Xu M, ChenQY, Wang CT, Huang PY. Phase I study of TPF neoadjuvant chemotherapyfollowed by radical radiotherapy in advanced nasopharyngeal carcinoma. ChinJ Cancer, 2010, 29(2):136-9.

    19. Li J, Zhang XS, Xie D, Deng HX, Gao YF, Chen QY, Huang WL, Masucci MG, Zeng YX. Expression ofimmune-related molecules in primary EBV-positive Chinese nasopharyngealcarcinoma: associated with latent membrane protein 1 (LMP1) expression. CancerBiol Ther, 2007, 6(12):1997-2004.

    20. Li J, Zeng XH, Mo HY, Rolén U, Gao YF, Zhang XS, Chen QY, Zhang L, Zeng MS, LiMZ, Huang WL, Wang XN, Zeng YX, Masucci MG. Functional inactivation ofEBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumorimmunotherapy. PLoS One, 2007, 2(11):e1122.

    Guo Ling
    Title Associate Professor
    Profile
    Dr. Ling Guo is an Associate Professor of nasopharyngeal carcinoma. She obtained her Bachelor Degree in Medicine at Norman Bethune University of Medical Science, in Changchun City, JiLin Province, P. R. China in 1989. She was trained as specialist of radiotherapy and oncology in Paris XII University from 1997 to 2000. During her 25 years working in oncology, she gained a lot of experience in advanced technique of radiotherapy and especially in the combined treatment of Nasopharygeal carcinoma.
    Email guoling@sysucc.org.cn
    Phone 8620-87342421
    Research Interest(s) Nasopharygeal carcinoma: 1) Mechanism of Metastasis and Prognostic Factors; 2) Combinded treatment for advanced NPC
    Education

    09/1984 - 07/1989  Undergraduate study in Norman Bethune University of Medical Science, Changchun City, JiLin Province, obtained MDdegree.

    07/1989 - 10/1994  Resident doctor, Training as Radiotherapistat Guangdong Provincial People’s Hospital,Guangzhou City,GuangdongProvince.

    11/1994 - 10/1997 Attending doctor, RadiotherapyDepartment, GuangDong Provincial People’s Hospital, Guangzhou City, Guangdong Province.

    11/1997 – 06/2000  Training as Specialist ofRadiotherapy-Oncology in Paris, France: Department of Radiotherapy-Oncology:

    -Henri-Mondor Hospital, XIIth University of Paris;

    -Tenon Hospital, VIth  University of Paris;

    -and EORTC Chronotherapy Center, Department of ClinicalOncology, Paul Brousse Hospital, XIth  University of Paris.

    07/2000 – 01/2001  Attending doctor and Radiotherapist atRadiotherapy Department, Guangdong Provincial People’s Hospital, Guangzhou city, Guangdong Province.

    02/ 2001 – Now  Associate Professor,Department of Nasopharygeal Cancer, Cancer

    Center, Sun Yat-sen University, Guang Zhou City, Guangdong Province.

    Publications

    1.      Huan-Xin Lin,  Rui Sun, Min Xu ,… LingGuo,Clinical Study of Inductionchemotherapy with docetaxel, cisplatin and 5-FU followed by radiotherapy andconcurrent cisplatin in local advanced nasopharyngeal carcinoma. Cancer Research and Clinic. 2010,8 (22):515-8

    2.      Xu Min, Guo Ling, Liao Jiahua, et al. Retrospective analysis of efficacy on radiotherapyalone or concurrent chemoradiotherapy for patients with stage T3N0-1M0nasopharyngeal cancer. Cancer Research and Clinic. 2010,8(22):526-9

    3.      MinXu,Huan-Xin Lin, Rui Sun, Ling Guo, Value of predicting metastasis by1992 staging system and 2008 staging system in nasopharyngeal carcinomapatients. CHIN J CANCER PREV TREAT. 2010,8(17):1293-97

    4.      Guo L, Lin HX, Xu M, et al. Phase Istudy of TPF neoadjuvant chemotherapy followed by radical radiotherapy inadvanced nasopharyngeal carcinoma. Chinese journal of cancer. 2010 Feb; 29(2):136-9.

    5.      Guo Ling, Lin Huanxin. Cancer Chronotherapy –From Basic Research To Clinical Application.Chin J of Clin Oncol, 2004, 31(1): 56-59.

    6.      Guo Ling, Lin Huanxin, Li Fengyan, et al. Phase Istudy of capcitabine with concurrent radiotherapy in early-stage nasopharyngealcarcinoma. Chin J Oncol, April 2004, Vol 26, No 4: 250-253.

    7.      Guo Ling, Lin Huanxin, Qiu Fang, et al. FeasabilityStudy of Chronomodulated Chemotherapy with 5-Fu ± LV and DDPin the Treatment of Advanced Nasopharyngeal Cancer. Chin J of Clin Oncol, 2004,31(13): 721-724.

    8.      Guo Ling, Lin Huanxin, Qiu Fang, et al. ConcurrentChemoradiotherapy Using Oral Capecitabine and Carboplatin in The Treatment ofElderly Patients with Advanced Nasopharyngeal Carcinoma. Cancer Research onPrevention and Treatment. 2006, 33(5): 368-370.

    9.      Guo Ling, Lin Huanxin, Xian Li-jian. Chronotherapywith 5-Fu / LV and L-OHP in the Treatment of Advanced Colorectal CancerPatients Failed by the Same Regimen I Conventional Injection- 5 cases report.Guangzhou Med J. 2001, 32(suppl): 15-19.

    10.  Guo Ling, Lin Huanxin, Pan Qiong, et al. Radiotherapy in the Treatment of CutaneousClassic Kaposi’s Sarcoma. QiLu Zhongliu Zazhi. 1999, 6(1): 23-24.

    11.  Guo Ling, LinHuanxin, Pan Qiong, et al. Epidemic Kaposi’s Sarcoma in Genital Organs- 71Cases Report. Chinese Journal of Cancer, 1999,18(suppl): 461-466.

    12.  JiangYong, Hong Ming-huang, Deng Man-quan, Guo Ling, et al. Phase I Clinical Trial Evaluation of Capcitabine inConcurrent Combination of Radiotherapy in nasopharyngeal carcinoma. ChineseJournal of Cancer, 2004, 23(4):461-466.

    13.  QiuFang, Hua Yi-Jun, Guo Ling, et al.Mucoepidermoid Carcinoma of Nasopharyx: a Report of 12 Cases. Chinese Journalof Cancer, 2005, 24(3):850-854.

    14.  LuoDong-hua, Hong Ming-huang, Guo Ling, et al. Analysis of Oral MucositisRisk Factors During Radiotherapy fornasopharyngeal carcinoma patients and Establishment of a Discriminant Model.Chinese Journal of Cancer, 2005, 24(7):850-854.

    15.  Zeng ZL, Sun J, Guo L, et al. Circadian rhythm in dihydropyrimidine dehydrogenaseactivity and reduced glutathione content in peripheral blood of nasopharyngealcarcinoma patients. Chronobiol Int. 2005; 22(4):741-54.

    16.  Tang Ya-mei, Li Yi, Zhang Yin-yin, Guo Ling, et al. Clinical Analysis and Study on theLife Quality of Patients with Radiation Encephalopathy After Radiotherapy ofNasopharyngeal Cancer inGuangdongProvince. Chin J RadiolMed Prot. August 2005, 25(4): 336-339.

    17.  Qiu Fang, Deng Man-quan, Guo Ling, et al. Clinical Observation of CapsulePing-Xiao concurrent with Radiotherapy in the Treatment of NasopharyngealCarcinoma. J of Mordern Oncol. 2006,3,14(3):336-337.

    18.  HuaYi-jun, Hong Ming-huang, Guo Ling, et al. The Application of Atificial Neural Network to Prediction of 5-yearSurvival in Nasopharyngeal Carcinoma. J of Oncol, 2006, 12(4): 300-304

    19.  ChenMY, Guo X, Wen WP, Hua YJ, Guo L, etal. Salvage surgical operation viaendoscopic transnasal approach for local persistent or recurrent nasopharyngealcarcinoma. Ai Zheng. 2007 Jul;26(7):673-8

    20.  WuMingwei, Zeng Zhaolei, Sun Jian, GuoLing, et al. Circadian Rhythm of the Peripheral Blood Cell Counts inHealthy Volunteers and Nasopharyngeal Carcinoma Parients. Chin J BloodTransfusion. 2008, 21(1): 21-24

    21.  Wu Mingwei, Zeng Zhaolei, Li Su, Guo Ling, et al. Circadian Variation of PlasmaCortisol and Whole Blood Reduced Glutathione Levels in Nasopharyngeal CarcinomaParients. Ai Zheng, 2008 Mar;27(3):237-42

    22.  Yi-Jun Hua, Ming-Yuan Chen, Ming-Huang Hong, Chong Zhao, Ling Guo, Fei Han, Wei Luo, Rui Sun, Yuan-YuanChen and Hui Liu. Short-term efficacy of endoscopy-guided debridement onradiation-related nasopharyngeal necrosis in 20 nasopharyngeal carcinomapatients after radiotherapy. Chinese Journal of Cancer, 2008, 27:7: 52-56

    23.  HuaYi-jun, ....Guo Ling et al.Application of Support Vector Machine to Predict 5-year Survival Status ofPatients with Nasopharyngeal Carcinoma after Treatment. The Chinese-GermanJournal of Clinical Oncology. 2006, Feb, 5(1): 8-12

    24.  Liang WJ, Qiu F, Hong MH, Guo L, et al. Differentially expressed genes between upward anddownward progressing types of nasopharyngeal carcinoma. Ai Zheng. 2008 May;27(5):460-5

    25.  Tang Y, Zhang Y, Guo L, Peng Y, Luo Q,Xing Y. Relationship between individual radiosensitivity and radiationencephalopathy of nasopharyngeal carcinoma after radiotherapy. StrahlentherOnkol. 2008 Oct;184(10):510-4. Epub 2008Oct 1.

    26.  Hua YJ, Chen MY, Qian CN, Hong MH, Zhao C, Guo L,Guo X, Cao KJ. Postradiationnasopharyngeal necrosis in the patients with nasopharyngeal carcinoma. Head Neck. 2009Jun;31(6):807-12

    27.  LONG Zhen, XIEMing-qiang, ZHANG Tao, SHEN Hui, XU Xue-qing, GUO Ling. Effect of targeted therapy withcisplatin-loaded magnetic nanoparticles combined with radiotherapy for nasopharyngealcarcinoma in nude mice. JSouth Med Univ, 2009;299:1827-30

    28.  ZHANGHongzheng, XIE Minqiang, LI Zhonghan, GUOLin. Expression of folate receptor inthe tissues and cells of nasopharyngeal carcinoma. China Journal of ModernMedicine, 2009196):833840

    29.  Pei-Yu Huang,Hai-Qiang Mai Dong-Hua Luo, FangQiu,Ning-Wei Li,Yan-Qun Xiang,Qiu-YanChen,Li Zhang,Rui Sun,Ka-Jia Cao,Ling Guo,Man-Quan Deng,Hao-YuanMo, Xiang Guo,Feng Zhang,Su-Mei Cao,Min-Yuan Chen, Ying Guo,Yu-Ying Fan, Wen-Hu,Yi-Jun Hua,Guo-Feng Xie, and Ming-Huang Hong. Induction-concurrent chemoradiotherapy versus inductionchemotherapy and radiotherapy for locoregionally advancednasopharyngeal carcinoma. Chinese Journal of Cancer, 2009, 28(10): 1033-1042

    30.  Analysisof Respiration Induced Motion on the Accuracy of Three-Dimensional ConformalRadiotherapy Planning in Lung Cancer. Int.J.Radiation Oncology Bio.Phys;2000, 46(3): 745

    31.  Radiotherapiedes Lymphomes Cutanes. (Francais). Cancer-Radiotherapy;1999,  3(2): 105-111.

    32.  ConformalRadiotherapy (CRT) Planning for Lung Cancer Analysis of Intrathoracic OrganMotion During Extreme Phases of Breathing. Int. J. Radiation Oncology Biol.Phys. 2001,51(4): 1081-1092.

    33.  Associationradiochirurgicale conservatrice des cancers du seins de petit volume :intérêt des clips chirurgicaux dans le lit de tumorectomie (Breast-conservingsurgery and irradiation for early breast cancers : value of surgical clipswithin the excision cavity). Cancer-Radiotherapie, 2001, l5(3);255-261.(Francais)

    34.  Ge N, Lin HX, Xiao XS, Guo L, et al. Prognostic significance of Oct4 and Sox2 expression in hypopharyngealsquamous cellcarcinoma. Journal of Translational Medicine 2010 oct 12, 8: 94

    35.   Xiang-Bo Wan,1,2,† Xin-Juan Fan,3,† Ming-Yuan Chen,1,2,†… Ling Guo,1,2,et, al . Elevated beclin 1 expression is correlatedwithHIF-1α in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 6:3,1-10; April 1, 2010;

    36.   Wen-TingLiao, Ling Guo, Yi Zhong, Yan-Heng Wu, Jun Liand Li-Bing Song. Astrocyte elevatedgene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. J Transl Med. 2011 Dec 1; 9:205.  (co-author. IF3.51)

    37.  Lv X, Xiang YQ, Cao SM, Qian CN, Li NW, Guo L,Guo X. Prospective validation of the prognostic value of elevatedserum vascular endothelial growth factor in patients with nasopharyngealcarcinoma: more distant metastases and shorter overall survival aftertreatment. Head Neck. 2011 Jun;33(6):780-5.

    38.  ChenQY, Wen YF, Guo L, Liu H, Huang PY,Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, Hua YJ, Guo X,Cao KJ, Hong MH, Qian CN, Mai HQ.Concurrent Chemoradiotherapy vs RadiotherapyAlone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial. J Natl Cancer Inst. 2011 Dec7;103(23):1761-70. doi: 10.1093/jnci/djr432. Epub 2011 Nov 4. 

    39.  Liao Jiahua, Lin Huanxin, Sun Jian, Sun Rui, Guo Ling. Chrono-chemotherapy of Docetaxel in Nude Mice Bearing Human NasopharyngealCarcinoma. Cancer Research onPrevention and Treatment. 2012, 39(1): 18-22

    40.  RUISUN, QING ZHANG, LING GUO MING YUANCHEN, YING SUN, BRIAN CAO, JIAN SUN. HGF stimulates proliferation through theHGF/c-Met pathway in nasopharyngeal carcinoma cells. Oncol Lett.2012 May; 3(5): 1124-1128. Epub 2012 Feb 20. PMID: 22783404 [PubMed]

    41.   Huan Li, Ling Guo, Shu-Wei Chen, Xiao-HuiZhao, Shi-Min Zhuang, Li-Ping Wang, Li-Bing Song, and Ming Song. GOLPH3overexpression correlates with tumor progression and poor prognosis in patientswith clinically N0 oral tongue cancer. J Transl Med. 2012; 10: 168.

    42.  Huang PY, Cao KJ, Guo X, Mo HY, Guo L, Xiang YQ, Deng MQ, Qiu F, Cao SM, Guo Y, Zhang L, Li NW, SunR, Chen QY, Luo DH, Hua YJ, Mai HQ, Hong MH.A randomized trial of inductionchemotherapy plus concurrent chemoradiotherapy versus induction chemotherapyplus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. OralOncol. 2012 Oct;48(10):1038-44. doi: 10.1016/j.oraloncology.2012.04.006. Epub2012 May 14.PMID: 22591726 PubMed - in process]

    43.  ChenMY, Hua YJ, Wan XB, Sun R, Huang PY, Xiang YQ, Guo L, Mo HY, Yang Y, Hong MH. Aposteriorly pedicled middle turbinate mucoperiosteal flap resurfacing nasopharynxafter endoscopic nasopharyngectomy for recurrent nasopharyngealcarcinoma.Otolaryngol Head Neck Surg. 2012 Mar;146(3):409-11. doi:10.1177/0194599811430918. Epub 2012 Jan 6. No abstract available. PMID:22228599 [PubMed - indexed for MEDLINE]

    44.  ZHUYu-liang,MAI Hai-qiang,GUO Xiang,et al. PRELIMINARY REVEALS ON CORRELATION OF EIF3,EIF5AAND NASOPHARYNGEAL CARCINOMA WITH PROTEOMICS. Modern Preventive Medicine, 2012, Vol.39, NO.3: 667-669

    45.  QIU,Fang, GUOLing,MOHaoyuan, DENG Manquan. Clinical observation of combination of taxotere andnedaplatin in the treatment of PF regimen resistant metastatic and recurrent nasopharyngeal carcinoma. CHIN J CANCER PREV TREAT, Feb,2012,vol.19, No. 3:217-219

    46.  Huai Liu,Qiu-Yan Chen, Ling Guo, Lin-QuanTang, Hao-Yuan Mo, Zong-Liang Zhong, Pei-Yu Huang, Dong-Hua Luo, Rui Sun, XiangGuo, Ka-Jia Cao, Ming-Huang Hong and Hai-Qiang Mai. Feasibility and efficacy ofchemoradiotherapy for elderly patients with locoregionally advanced nasopharyngealcarcinoma: results from a matched cohort analysis. Radiation Oncology 2013,8:70 (第二作者,IF=2.11)

    47.  Lin HX, Hua YJ, Chen QY, Luo DH,Sun R, Qiu F, Mo HY, Mai HQ, Guo X, Xian LJ, Hong MH, Guo L. Randomized study ofsinusoidal chronomodulated versus flat intermittent induction chemotherapy withcisplatin and 5-fluorouracil followed by traditional radiotherapy forlocoregionally advanced nasopharyngeal carcinoma. Chin JCancer. 2013 32(9): 502-511

    48.  WangX, Yang Q, Guo L, Li XH, Zhao XH,Song LB, Lin HX. Flotillin-2 is associated with breast cancer progression andpoor survival outcomes. J Transl Med. 2013 Aug15;11(1):190. [Epub ahead of print]

    49.  San-gangWu, Zhen-yu He, Juan Zhou, Jia-yuan Sun, Feng-yan Li, Qin Lin, Ling Guo,Huan-xin Lin. Serum levels of CEA and CA15-3 in different molecular subtypesand prognostic value in Chinese breast cancer. The Breast, 23 (2014) 88-93. ISSN: 0960-9776

    Chen Mingyuan
    Title Associate Professor, Associate Chief Physician, Doctor of Oncology, Advisor of master’s degree student
    Profile

    After graduated from then the First Affiliated Hospital, Sun Yat-sen University and having acquired his Master of Science Degree in Otorhinolaryngology, Dr. Chen stays and works in Sun Yat-sen University Cancer Center ever since. He received his Doctor of Science Degree in Oncology in his department in 2007. He is now an associate professor, associate chief physician and advisor of master’s degree student in the department. His research interests are in the combination therapy for nasopharyngeal carcinoma. He specializes in radiotherapy for early-stage nasopharyngeal carcinoma, minimally invasive surgery treatment for recurrent nasopharyngeal carcinoma, treatment for the sequelae after the radiotherapy for nasopharyngeal carcinoma and endoscopic skull base surgery.

    Email chenmy@sysucc.org.cn
    Phone 020-87343379
    Research Interest(s)

    1. Radiotherapy and combination therapy for nasopharyngeal carcinoma, especially early-stage nasopharyngeal carcinoma;

    2. Minimally invasive surgery treatment for recurrent nasopharyngeal carcinoma;

    3. Treatment for the distant metastasis of nasopharyngeal carcinoma

    Education

    2001-Present   Resident physician - associate professor/associate chief physician

    Sun Yat-sen University Cancer Center        

    2011-2012      Post-doctoral degree

    College of Medicine, University of Maryland

    06/2009-09/2009    Fellowship

    Department of Otorhinolaryngology,

    Queen Mary Hospital, Hong Kong University

    04/2009-05/2009    Visiting Scholar,

    Department of Otorhinolaryngology,

    Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute

    2004-2007      Doctoral degree

    Sun Yat-sen University Cancer Center                                                                       

    1998-2001      Master’s degree

    Department of Otorhinolaryngology,

    The First Affiliated Hospital, Sun Yat-sen University    

    1993-1998      Bachelor’s degree

    College of Medicine, University of South China                 

    Publications

    Papers (as lead author or corresponding author)

    1. Ming-Yuan Chen; Yi-Jun Hua; Xiang-Bo Wan; Rui Sun; Pei-Yu Huang; Yan-Qun Xiang; Ling Guo; Hao-Yuan; Yue Yang; Ming-Huang Hong. A posteriorly pedicled middle turbinate mucoperiosteal flap resurfacing nasopharynx after endoscopic nasopharyngectomy for recurrent NPC. Otolaryngology-Head and Neck Surgery, 2012, 146(3):409-11.

    2. Ming-Yuan Chen, Sun-Lan Wang, Yu-Liang Zhu, Fang Qiu, Yan-Qiu Chen, Rou Jiang, Ca-Jia, Chao, Hai-Qiang Mai, Ming-Huang Hong. Use of a posterior pedicle nasal septum and floor mucoperiosteum flap to resurface the nasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma. Head & Neck, 2012, 34(10):1383-8. (as the corresponding author)

    3. Xiang-Bo Wan, Xin-Juan Fan, Ming-Yuan Chen, Jin Xiang, Pei-Yu Huang, Ling Guo, Xiang-Yuan Wu, Jie Xu, Zi-Jie Long, Yan Zhao, Wei-Hua Zhou, Hai-Qiang Mai, Quentin Liu, Ming-Huang Hong. Elevated Beclin 1 expression is correlated with HIF-1a in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy, 2010, 6(3):395-404 (as the co-first author)

    4. Ming-Yuan Chen; Wei-Ping Wen; Xiang Guo; An-Kui Yang; Chao-Nan Qian; Yi-Jun Hua; Xiang-Bo Wan; Zhu-Ming Guo; Tian-Ying Li; Ming-Huang Hong. Endoscopic Nasopharyngectomy for Locally Recurrent Nasopharyn- geal Carcinoma. Laryngoscope , 2009, 119(3):516-22.

    5. Yi-Jun Hua; Ming-Yuan Chen; Ming-Huang Hong; Chong Zhao; Fei Han; Wei Luo; Chao-Nan Qian; Hai-Qiang Mai; Hui Liu; Xiang Guo. Radiation-induced Nasopharyngeal Necrosis in Patients with Nasopharyngeal Carcinoma. Head & Neck, 2009, 31(6):807-12. (as the corresponding author)

    6. Xiang-Bo Wan, Zi-Jie Long, Ming-Yuan Chen, Jie Xu, Yi-Jun Hua, Hong Ji, Ming-Huang Hong, Quentin Liu. Inhibition of Aurora-A results in increased cell death in 3-dimensional culture, reduced migration and is associated with enhanced radiosensitivity in human nasopharyngeal carcinoma. Cancer Biology & Therapy, 2009, 8(15):1-6. (as the co-first author)

    7. Yi-Jun Hua, Ming-Yuan Chen, Ming-Huang Hong, Chong Zhao, Ling Guo, Fei Han, Wei Long, Rui Sun, Yuan-Yuan Chen, Hui Liu. Short-term Efficacy of Endoscopy-guided Debridement on Radiation-related Nasopharyngeal Necrosis in 20 Nasopharyngeal Carcinoma Patients after Radiotherapy. Chinese Journal of Cancer, 2008, 27 (7):729-733  (as the corresponding author)

    8. Ming-Yuan Chen; Xiang Guo, Wei-Ping Wen, Yi-Jun Hua, Ling Guo, Ning-Wei Li, Qiu-Yan Chen, Rui Sun, Ming-Huang Hong. Salvage Surgical Operation via Endoscopic Transnasal Approach for Local Persistent or Recurrent Nasopharyngeal Carcinoma. Cancer, 2007, 26(7):673-8

    9. Ming-Yuan Chen; Xin-Ping Cao, Rui Sun, Yi-Jun Hua, Ai-Ju Li, Yu-Ying Liu, Yi Ou-Yang, Ling Guo, Ming-Huang Hong. Application of Interstitial Brachytherapy via Parapharynx Involvement Transnasal Approach to Enhance Dose in Radiotherapy for Nasopharyngeal Carcinoma. Cancer, 2007, 26(5):513-8

    10. Ming-Yuan Chen; Wei-Ping Wen; Ming-Huang Hong; Yong-Gao Mou; Yi-Jun Hua; Xiang-Heng Zhang; Tao-Yu Wang; Xiang-Bo Wan; Hong Ji; Zhong-Ping Chen. Application of Nasal Endoscope via Endonasal Transsphenoidal Approach in treatment for Tumor in Sellar Region. Guangdong Medical Journal, 2008, 29(1):18-20

    11. Ming-Yuan Chen; Liang-Ping Xia; Zhi-Hua Chen; Jian-Hui Wu; Wei-Wei Liu; Gui-Fang Guo; Ru-Hua Xie. Applications of different techniques of implantable central venous port in treatment for cancer patients. Journal of Sun Yat-Sen University:Medical Sciences, 2007, 28(3S):145-7

    12. Ren-Hao Xiang; Ming-Yuan Chen; Yi Zhou. Nursing cooperation of the rescue surgery of nasopharygeal carcinoma with nasal endoscope. Journal of Qiqihar Medical College, 2007, 28(4):483-4 (as the corresponding author)


    Papers (as the second author or the author after the second rank):

    1. Li H, Wang DL, Liu XW, Chen MY, Mo YX, Geng ZJ, Xie CM. MRI signal changes in the skull base bone after endoscopic nasopharyngectomy for recurrent NPC: A serial study of 9 patients. Eur J Radiol. 2013, 82(2):309-15.

    2. Sun R, Zhang Q, Guo L, Chen MY, Sun Y, Cao B, Sun J. HGF stimulates proliferation through the HGF/c-Met pathway in nasopharyngeal carcinoma cells. Oncol Lett. 2012, 3(5):1124-1128.

    3. Wan XB, Fan XJ, Huang PY, Dong D, Zhang Y, Chen MY, Xiang J, Xu J, Liu L, Zhou WH, Lv YC, Wu XY, Hong MH, Liu Q. Aurora-A activation, correlated with hypoxia-inducible factor-1α, promotes radiochemoresistance and predicts poor outcome for nasopharyngeal carcinoma. Cancer Sci. 2012, 103(8):1586-94.

    4. Wan XB, Zhao Y, Fan XJ, Cai HM, Zhang Y, Chen MY, Xu J, Wu XY, Li HB, Zeng YX, Hong MH, Liu Q. Molecular prognostic prediction for locally advanced nasopharyngeal carcinoma by support vector machine integrated approach. PLoS One. 2012;7(3):e31989.

    5. Linn DE, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li W, Xu K, Chen M, Qiu Y. Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases. J Biol Chem. 2012, 29;287(27):22959-68.

    6. Qiu-Yan Chen, Yue-Feng Wen, Lin Guo, Huai Liu, Pei-Yu Huang, Hao-Yuan Mo, Ning-Wei Li, Yan-Qun Xiang, Dong-Hua Luo, Fang Qiu, Rui Sun, Man-Quan Deng, Ming-Yuan Chen, Yi-Jun Hua, Xiang Guo, Ka-Jia Cao, Ming-Huang Hong, Chao-Nan Qian, Hai-Qiang Mai. Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial. J Natl Cancer Inst, 2011, 7;103(23):1761-70.

    7. Xi Yang, Ziyong Guo, Feng Sun, Wei Li, Alan Alfano, Hermelis Shimelis, Mingyuan Chen, Angela M.H. Brodie, Hege Chen, Zhen Xiao, Timothy D. Veenstra, Yun Qiu. A novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells. J Biol Chem. 2011, 286(41):36152-60.

    8. Wen-Hua Lu; Li-Xia Peng; Yin Zhang; Wei-Hua Jia; Yan-Qun Xiang; Qiu-Yan Chen; Yi-Jun Hua; Dong-Hua Luo; Ling Guo; Ming-Yuan Chen; Ning-Wei Li; Pei-Yu Huang; Fang Qiu; Rui Sun; An-Hua Li; Yi-Xin Zeng; Chao-Nan Qian. Experiences and Challenges of the establishment of the database of Nasopharyngeal Carcinoma. China Journal of Modern Medicine, 2011, 21(13):1555-8.

    9. Sun Rui, LI Wan-hu , CAO Ka-jia, GUO Ling , CHEN Ming-yuan, HONG Ming-huang . Correlation of untreatment plasma level of TGF-β1 and posttreatment distant metastasis in patients with nasopharyngeal carcinoma. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(1):22-5

    10. Sun Xin-ru, HU Ying-ying, ZHANG Xu, LIN Xiao-ping, LIANG Pei-yan, FAN Wei, CHEN Ming-yuan, ZHAO Chong. Value of 18F-FDG PET/CT SUV in T Stages of Nasopharyngeal Carcinoma. Journal of Sun Yat-Sen University:Medical Sciences, 2010, 31(4):535-9.

    11. Pei-Yu Huang, Hai-Qiang Mai, Dong-Hua Luo, Fang Qiu, Ning-Wei Li, Yan-Qun Xiang, Qiu-Yan Chen,Li Zhang, Rui Sun,  Ka-Jia Cao,Ling Guo,Man-Quan Deng, Hao-Yuan Mo,Xiang Guo, Feng Zhang , Su-Mei Cao, Ming-Yuan Chen, Ying Guo,  Yu-Ying Fan,Wen-Hu, Yi-Jun Hua, Guo-Feng Xie, and Ming-Huang Hong. Induction-concurrent chemoradiotherapy versus induction chemotherapy and radiotherapy for Iocoregionally advanced nasopharyngeal carcinoma . Cancer, 2009, 28(10):1033-42

    12. Huang Pei-yu, WANG Bo, ZHANG Xing, HONG Ming-huang, WU Xuan, CHEN Ming-yuan, Zhang Li. Expression and clinical significance of c-kit in nasopharyngeal carcinoma on tissue microarrary. Chinese Clinical Oncology, 2009, 14(2):97-101

    13. Xiao-Ping Lin; Chong Zhao; Ming-Yuan Chen; Wei Fan; Xu Zhang; Sheng-Fang Zhi; Pei-Yan Liang. Value of 18F-FDG PET/CT in the diagnosis and staging of Nasopharyngeal Carcinoma. Cancer, 2008, 27(9):974-8

    14. SUN Rui, CHEN Ming-Yuan, SUN Jian, ZHANG Ying, ZHANG Chang-Qing, HOU Jing-Hui, HONG Ming-Huang. Expression and Clinical Significance of TGF-β1 and Its Signaling Pathway Proteins in Nasopharyngeal Carcinoma. Cancer, 2007, 26(9):1005-9

    15. Wei-Ping Wen; Ming-Yuan Chen. Removing loco-regional recurrent nasopharyngeal carcinoma via nasal endoscopic surgery. China Medical Abstracts: Otorhinolaryngologic Science, 2007, 22(4):190-2

    16. Li Tianying, Chert Mingyuan, Lin Zhibing, et al. Expression and significance of intercellular adhesion molecule-1 and soluble ICAM-1 in nasal polyps after glucocorticoid treatment. New Chinese Medicine, 2006, 37(5):299-301

    17. ZHUANG Ai-hua, CHEN Ming-yuan. Some Problems Worth Paying Attention to in Application of Evidence-based Medicine. The Journal of Evidence-Based Medicine, 2005, 5(6):356-8

    18. Wei-Wei Liu; Zhi-Hua Chen; Ming-Yuan Chen; Shen-Ming Qu. Salvage treatment of primary recurrence in patients with laryngeal cancer after definitive radiotherapy. China Oncology, 2004, 14(6):560-2

    19. Yu-Ying Liu; Hui-Ying Xu; Jian-Hui Wu; Yu-You Chen; Zhao-Mei Liu; Ming-Yuan Chen. Nursing for patients with nasopharyngeal carcinoma cured by interstitial brachytherapy. Modern Clinical Nursing, 2008, 7(1):34-3

    20. Zhong-Ping Chen; Yong-Gao Mou; Wei-Ping Wen; Xiang-Heng Zhang; Wang-Ning Zhou; Ming-Yuan Chen; Ke Sai. Endoscope-assisted endonasal transsphenoidal pituitary adenoma microsurgery. Chinese Journal of Neurosurgical Disease Research, 2005, 4(1):55-7

    21. GUO Gui-Fan, XIE Ru-Hua, YANG An-Kui, CHEN Zhi-Hua, WU Qiu-Liang, LIU Wei-Wei, OU Shen-Ming, XIA Liang-Ping, CHEN Ming-Yuan, ZHANG Jin-Xin. Correlation of GST-π and PCNA Expression to Prognosis of Advanced Maxillary Sinus Squamous Cell Carcinoma. Cancer, 2005, 24(10):1267-71

    22. Wu Jianhui, Gu Jingfen, Huang Huichang, Chen Mingyuan, et al. Application and administration of embedded intravenous transfusion harbor. Chinese Nursing Research, 2005, 19(12B):2704-5

    23. Liang-Ping Xia; Zong-Yuan Zeng; Zhi-Hua Chen; Ming-Yuan Chen. An Analysis of The Factors Affecting The Incidence of Positive Surgical Margin in Partial Laryngectomy. Journal of Oncology, 2004, 10(4):220-2

    24. Liang-Ping Xia; Zhi-Hua Chen; Zhong-Ping Chen; Ming-Yuan Chen; Wei-Wei Liu. Conclusion to 16 examples of removing the malignant tumors of skull base via combined intracranial-facial approach. Chinese Journal of Neuro-Oncology, 2004, 2(1):62-6

    25. Gui-Fang Guo; An-Kui Yang; Ru-Hua Xie; Zhi-Hua Chen; Qiu-Liang Wu; Shen-Ming Qu; Wei-Wei Liu; Liang-Ping Xia; Ming-Yuan Chen; Jin-Xin Zhang; Jian-Hui Wu. Prognostic Analysis of 151 Patients with Maxillary Sinus Malignant Neoplasms. Cancer, 2004, 23(11s):1546-50

     
    Luo Donghua
    Title Attending Physician
    Profile

    Dr. Luo Donghua is an attending physician. She graduated with the doctoral degree in Clinical Oncology from Sun Yat-sen University in 2010. At present, she serves as the attending physician in Sun Yat-sen University Cancer Center. Her research interests are in chemotherapy, radiation therapy, combination therapy for nasopharyngeal carcinoma; prevention and treatment of  radiotherapy side reaction; the mechanism of nasopharyngeal carcinoma distant metastasis and its prevention & treatment.

    Email luodh@sysucc.org.cn
    Phone
    Research Interest(s)

    Chemotherapy, radiation therapy, combination therapy for nasopharyngeal carcinoma; prevention and treatment of  radiotherapy side reaction; the mechanism of nasopharyngeal carcinoma distant metastasis and its prevention & treatment.

    Education

    09/1996-07/2001 Undergraduate studies under the Seven-year Program of Clinical Medicine, Zhongshan School of Medicine, SYSU

    09/2001-07/2003 Postgraduate studies (master’s degree) under the Seven-year Program of Clinical Medicine, Zhongshan School of Medicine, SYSU

    09/2007-07/2010 On-job doctoral degree’s program of Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center

     

    Publications

    1. Bao YN, Cao X, Luo DH (Co-first author), Sun R, Peng LX, Wang L, Yan YP, Zheng LS, Xie P, Cao Y, Liang YY, Zheng FJ, Huang BJ, Xiang YQ, Lv X, Chen QY, Chen MY, Huang PY, Guo L, Mai HQ, Guo X, Zeng YX, Qian CN. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13(12):1958-69. (IF 5.25)

    2. Luo DH, Chen QY, Liu H, Xu LH, Zhang HZ, Zhang L, Tang LQ, Mo HY, Huang PY, Guo X, Mai HQ. The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways. J Transl Med. 2013; 11(1):203. (IF 3.5)

    3. Mo HY, Luo DH(Co-first author), Qiu HZ, Liu H, Chen QY, Tang LQ, Zhong ZL, Huang PY, Zhao ZJ, Zhang CQ, Zhang Y, Mai HQ. Elevated serum endostatin levels are associated with poor survival in patients with advanced-stage nasopharyngeal carcinoma. Clin Oncol (R Coll Radiol). 2013;25(5):308-17. doi: 10.1016/j.clon.2012.11.009. (IF 2.1)

    4. Liu H, Huang PY, Tang LQ, Chen QY, Zhang Y, Zhang L, Guo L, Luo DH, Mo HY, Xiang YQ, Qiu F, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, Cao KJ, Qian CN, Hong MH, Mai HQ. Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy. Med Oncol. 2013;30(4):685. doi: 0.1007/s12032-013-0685-6. Epub 2013 Aug 18.

    5. Tang LQ, Chen QY, Fan W, Liu H, Zhang L, Guo L, Luo DH, Huang PY, Zhang X, Lin XP, Mo YX, Liu LZ, Mo HY, Li J, Zou RH, Cao Y, Xiang YQ, Qiu F, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Mai HQ. Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose positron emission tomography/computed tomography with plasma epstein-barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging. J Clin Oncol. 2013;31(23):2861-9. doi: 10.1200/JCO.2012.46.0816. Epub 2013 Jul 15.

    6. Lin HX, Hua YJ, Chen QY, Luo DH, Sun R, Qiu F, Mo HY, Mai HQ, Guo X, Xian LJ, Hong MH, Guo L. Randomized study of sinusoidal chronomodulated versus flat intermittent induction chemotherapy with cisplatin and 5-fluorouracil followed by traditional radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Chin J Cancer. 2013; 32(9):502-11. doi: 10.5732/cjc.013.10004. Epub 2013 Jul 2.

    7. Tang Y, Luo DH, Rong X, Shi X, Peng Y. Psychological disorders, cognitive dysfunction and quality of life in nasopharyngeal carcinoma patients with radiation-induced brain injury. PLoS ONE. 2012;7(6):e36529. (IF 4.1)

    8. Chen MY, Wang SL, Zhu YL, Shen GP, Qiu F, Luo DH, Chen QY, Jiang R, Cao KJ, Qian CN, Hong MH. Use of a posterior pedicle nasal septum and floor mucoperiosteum flap to resurface the nasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma. Head & Neck. 2012; 34(10):1383-8. (IF 2.4)

    9. Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, Hua YJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ. Concurrent chemoradiotherapy vs. radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. J Natl Cancer Inst. 2011 Nov 4. (IF 14.69)

    10. Tang Y, Li Y, Luo DH, Rong X, Ye J, Peng Y. Epilepsy related to radiotherapy in patients with nasopharyngeal carcinoma. Epilepsy Res. 2011;96(1-2):24-8. (IF 2.3)

    11. Tang Y, Luo DH, Peng W, Huang F, Peng Y. Ocular ischemic syndrome secondary to carotid artery occlusion as a late complication of radiotherapy of nasopharyngeal carcinoma. J Neuroophthalmol. 2010;30(4):315-20.(IF 1.08)

    12. Huang PY, Mai HQ, Luo DH, Qiu F, Li NW, Xiang YQ, Chen QY, Zhang L, Sun R, Cao KJ, Guo L, Deng MQ, Mo HY, Guo X, Zhang F, Cao SM, Chen MY, Guo Y, Fan YY, Hu W, Hua YJ, Xie GF, Hong MH. Controlled study on induction-concurrent chemoradiotherapy and induction chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma. Chinese Journal of Cancer. 2009;28(10):1033-1042.

    13. Huang PY, Cao KJ, Guo X, Mo HY, Guo L, Xiang YQ, Deng MQ, Qiu F, Cao SM, Guo Y, Zhang L, Li NW, Sun R, Chen QY, Luo DH, Hua YJ, Mai HQ, Hong MH. A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Oral Oncol. 2012; 48(10):1038-44. (IF 2.857)

    14. Luo DH, Cao JY, Ji H, Zhang H, Zeng MS, Hong MH. Preliminary analysis of the whole-genome-microarray-based results of peripheral blood in nasopharyngeal carcinoma patients. Chinese Journal of Cancer Prevention and Treatment. 2011;18(9):641-646.

    15. Luo DH, Hong MH, Xiao XB. Analysis of the correlation between the saliva epidemal growth factor concentration and oral mucositis during nasopharyngeal carcinoma radiotherapy. Chinese Journal of Radiation Oncology. 2008;17(6):478-479.

    16. Luo DH, Hong MH, Guo L, et al. Multivariable analysis of the oral mucositis during nasopharyngeal carcinoma radiotherapy and the clinical value of constructing the discriminative model. Chinese Journal of Cancer. 2005;24(7):850-854.

    17. Luo DH, Guo L, Hong MH, Zhang F. Nasopharyngeal carcinoma with meningeal intracranial metastases: a case report. Chinese Journal of Oncology. 2005;27(1):62.

    18. Luo DH, Hong MH. The mechanism, prevention and treatment of radioactive oral mucosal injuries. The Journal of Practical Medicine. 2003;19(2)205-207.

    19. Cao KJ, Zhang AL, Ma WJ, Huang PY, Luo DH, Xia WX. Nedaplatin or cisplatin combined with 5-fluorouracil for treatment of stage III-IVa nasopharyngeal carcinoma: a randomized controlled study. Chinese Journal of Oncology. 2011;33(1)50-2

    20. Ma WJ, Cao KJ, Xia WX, Luo DH. The relationship between re-staging and prognosis of recurrent nasopharyngeal carcinoma on the primary focus. China Cancer. 2010;Issue 11.

    21. Huang PY, Hong MH, Zhang X, Mai HQ, Luo DH. The C-KIT expression and mutation in nasopharyngeal carcinoma cell lines and their reaction to Imatinib. Chinese Journal of Cancer. 2010;Issue 2.

    22. Huang PY, Zhang L, Zhang X, Hong MH, Mai HQ, Luo DH. The mutation of C-KIT gene in patients with nasopharyngeal carcinoma. China Oncology. 2009;Issue 4.

    23. Guo L, Lin HX, Qiu F, Luo DH, et al. Clinical experience in treating elderly patients with advanced nasopharyngeal carcinoma by using Capecitabine Tablets plus Paraplatin combined with concurrent chemoradiotherapy. Cancer Research on Prevention and Treatment. 2006;Issue 5.

    24. Hua YJ, Hong MH, Luo DH, et al. Multivariable analysis of prognostic predictors for 406 patients with nasopharyngeal carcinoma. Chinese Journal of Clinical Oncology. 2005;32(8):435-438.

    25. Hong MH, Mai HQ, Luo DH. Cost-effectiveness analysis of the adjuvant chemotherapy for N2-3 patients with nasopharyngeal carcinoma. China Cancer. 2000;9(12):548.

    26. Shi XL, Ma SS, Luo DH, Rong XM, Li ZC, Fu RY, Shen QY, Tang YM. Clinical research on radiation-induced optic neuropathy in patients with nasopharyngeal carcinoma. Chinese Journal of Neuromedicine. 2013;12(1):76-79.

    27. Li Y, Tang YM, Luo DH, Rong XM, Ye JH, Peng Y. Epilepsy related to radiotherapy in patients with nasopharyngeal carcinoma. Chinese Journal of Neuromedicine. 2012;11(10):986-988.

    Huang Pei-Yu
    Title Associate Professor
    Profile
    Dr. Pei-yu Huang has worked in the nasopharyngeal carcinoma(NPC) department of Sun Yat-sen University Cancer Center for more than ten years (as a resident doctor in 2002, as a attending doctor in 2005 and as a associate professor in 2014). He has finished more than 2, 000 nasopharyngeal biopsy and treated more than 1,000 NPC patients in the last ten years. Therefore, he has the full experiences of diagnosis of NPC and multidisciplinary treatment of NPC patients.Dr. Pei-yu Huang is a associate professor of nasopharyngeal carcinoma (NPC) department of Sun Yat-sen University Cancer Center. Dr. Huang obtained his Bachelor in Medicine (equivalent to MD in the US) and PhD at Sun Yat-sen University of Medical Sciences and Sun Yat-sen University, P. R. China in 2000 and 2009, respectively. He has been an active contributor to the field of clinical trials of multidisciplinary treatment of NPC, also he has unordinary interest in signaling pathway and target identifying study in NPC. Besides, Dr. Huang has published more than twenty research papers.
    Email huangpy@sysucc.org.cn
    Phone +86-020-87343379
    Research Interest(s) Clinical trials of multidisciplinary treatment of NPC & signaling pathway and target identifying study in NPC.
    Education
    Obtained Bachelor in Medicine (equivalent to MD in the US) and PhD at Sun Yat-sen University of Medical Sciences and Sun Yat-sen University, P. R. China in 2000 and 2009, respectively.
    Publications

    1. Huang PY, Wang CT, Cao KJ, Guo X, Guo L, Mo HY, Wen BX, Wu YS, Mai HQ, Hong MH *. Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: Findings from a randomised trial. Eur J Cancer. 2013 May;49(8):1923-31. 

     2. Huang PY, Cao KJ, Guo X, et al. A randomized trial of induction chemotherapy plus concurrent chemoradiotherapy versus induction chemotherapy plus radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Oral Oncol. 2012 Oct; 48(10):1038-1044. 

    3. Huang PY, Li Y, Mai HQ, et al. Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy. Oral Oncol. 2012 Oct; 48(10): 964-968. 

     4. Wan XB, Fan XJ, Huang PY (Co-first author), et al. Aurora-A activation, correlated with hypoxia-inducible factor-1α, promotes radiochemoresistance and predicts poor outcome for nasopharyngeal carcinoma. Cancer Sci. 2012 Aug;103(8):1586-94. 

     5. Wu,X, Huang PY (Co-first author), Peng, PJ,Han F, Zhao C, Zhang L*. Long term follow up of a PhaseIII Study Comparing Radiotherapy with or without Weekly Oxaliplatin for Locoregionally Advanced Nasopharyngeal Carcinoma.Ann Oncol. 2013 Aug;24(8):2131-6. 

    6. Xue C, Huang Y, Huang PY(Co-first author), et al. Phase II study of sorafenib in combination with cisplatin and 5-fluorouracil to treat recurrent or metastatic nasopharyngeal carcinoma. Ann Oncol. 2013 Apr;24(4):1055-61. 

     7. Huang PY, Mai HQ, Luo DH, Induction-concurrent chemoradiotherapy versus induction chemotherapy and radiotherapy for locoregionally advanced nasopharyngealcarcinoma.Ai Zheng(Chinese). 2009 Oct;28(10):1033-42.

     8. Huang PY, Hong MH, Zhang X, et al. C-KIT overexpression and mutation in nasopharyngeal carcinoma cell lines and reactivity of Imatinib on these cell lines. Chin J Cancer(Chinese). 2010 Feb;29(2):131-5. 

     9. Huang PY, Wang B, Zhang X, et al. Expression and clinical significance of c-kit in nasopharyngeal carcinoma on tissue microarrary. Chinese Clinical Oncology (Chinese), 2009,14(2):97-101. 

     10. Huang PY, Zhang L, Zhang X, et al. C-KIT mutation exists in nasopharyngeal carcinoma. China Oncology (Chinese), 2009,19(4):266-269.

    Sun Hui
    Title Associate Professor
    Profile
    Dr. Rui Sun is the associate professor of nasopharyngeal carcinoma of Sun Yat-sen University Cancer Center. Dr. Sun obtained her PhD at Sun Yat-sen University of Oncology, P. R. China in 2008. Her visiting shcolarship training at Van Andel Research Institute in Michigan provided her with great opportunities to explore the fields of tumorigenesis and tumor metastasis. She joined the Department of Nasopharyngeal Carcinoma at Sun Yat-sen University Cancer Center in 2001, associate professor of SYSUCC in November 2012. Dr. Sun has published more than 20 research papers.
    Email sunrui@sysucc.org.cn
    Phone
    Research Interest(s)
    Education

    2004.9-2008.6:Sun Yat-sen University 

    1998.9-2001.6:Harbin Medical University 

    1993.9-1998.6:Harbin Medical University 

    2007.4-2008.4:Van Andel Research Institute in Michigan of USA

    Publications

    1. RuiSun, Huizhi Qiu, Haiqiang Mai, Qing Zhang, Minghuang Hong, Yanxian Li,Jing Yang, Jian Sun, Haoyuan Mo. Prognostic Value and Differences of the Sixthand Seventh Editions of the UICC/AJCC Staging Systems in NasopharyngealCarcinoma. Journal of cancer research and clinical oncology. 2013

    2. Qiong Wang*, RuiSun*(co-first author), Leyan Wu,  Junfeng Huang, Ping Wang, Hailong Yuan,Feifei Qiu, Xiaohong Xu, Di Wu, Ying Yu, Xin Liu, Qing Zhang. Identificationand characterization of an alternative splice variant of Mp1 with a highaffinity for TPO and its activation of ERK1/2 signaling. The internationaljournal of biochemistry & cell biology. 2013

    3. RuiSun, Qing Zhang, Ling Guo, Mingyuan Chen, Ying Sun, Brian Cao, JianSun. HGF simulates proliferation by HGF/c-Met pathway in NasopharyngealCarcinoma cells. Oncology letters. 2012

    4.Haoyuan Mo*, Rui Sun*(co-first author), Jian Sun, Qing Zhang, Wenjin Huang,Yanxian Li, Jing Yang, Haiqiang Mai. Prognostic value of pretreatment andrecovery duration of cranial nerve palsy in nasopharyngeal carcinoma. Radiationoncology. 2012


     

     

    Yijun Hua
    Title Attending Physician
    Profile

    Dr. Hua obtained his Bachelor in Medicine at Wuhan Tongji Medical College and PhD at Sun Yat-sen University of Medical Sciences, P. R. China in 2003 and 2013, respectively. Dr Hua worked as a visiting fellow in Ingham Institute of University of Western University from 2013 to 2014. Dr. Hua has published more than 10 research papers that mostly focus on radiotherapy and prognosis with nasopharyngeal carcinoma in recent years.

    Email huayj@sysucc.org.cn
    Phone 02087343155
    Research Interest(s)

    Radiotherapy and comprehensive therapy for nasopharyngeal carcinoma; clinical trials for nasopharyngeal carcinoma

    Education

    2013-2014 University of Western University, Visiting Scholar

    2010-2013 Sun Yat-sen University Cancer Center, Guangzhou, P.R. China, Attending Physician.  MD., Ph.D.(Radiation oncology)

    2006-2009  Sun Yat-sen University Cancer Center, Guangzhou, P.R. China, resident physician in training.(Radiation oncology)

    2003-2006  Sun Yat-sen University, Guangzhou, P.R. China, MS.

    1998-2003  Tongji Medical University, Wuhan, P.R. China, Bachelor in Medicine.

     

    Publications

    1. Chen MY, Mai HQ, Sun R, Guo X, Zhao C, Hong MH, Hua YJ. Clinical findings and imaging features of 67 nasopharyngeal carcinoma patientswith postradiation nasopharyngeal necrosis. Chin J Cancer. 2013,32(10): 533-8

    2. Hua YJ, Han F, Lu LX,etal. Long-term treatment outcome of recurrent nasopharyngeal carcinoma treatedwith salvage intensity modulated radiotherapy, Eur J Cancer. 2012,48(18): 3422-8 (in English)

    3. Chen MY, Hua YJ, Wan XB,et al. A posteriorly pedicled middle turbinate mucoperiosteal flap resurfacingnasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngealcarcinoma. OtolaryngolHead Neck Surg. 2012 Mar; 146(3):409-11. Epub 2012 Jan 6. (In English)

    4. Yi-Jun Hua, Ming-Yuan Chen, Chao-Nan Qian, Ming-Huang Hong, ChongZhao, Ling Guo, Xiang Guo,Kao-jia Cao. Postradiation Nasopharyngeal Necrosis inthe Patients with Nasopharyngeal Carcinoma. Head & Neck. 2009,6(31):807-812 (in English)

    5. Yi-Jun Hua, Shu Yu, Ming-Huang Hong,Xiao-Wei Yang, Fang Qiu, Ling Guo,Pei-Yu Huang,Guo-Yi Zhang. Application of Support Vector Machine to predict5-Year Survival Status of Patients with Nasopharyngeal Carcinoma afterTreatment. The Chinese-German journal of clinical oncology. 2006.5:8-12 (in English)

    6. Yi-Jun Hua, Ming Huang Hong, Chong Zhao, et al.Short-term Efficacy of Endoscopy-guided Debridement on Radiation-relatedNasopharyngeal Necrosis in 20 Nasopharyngeal Carcinoma Patients afterRadiotherapy. The Chinese Journal of Cancer, 2008,27(7)734-738 (in English)

    7. Hua YJ, Hong MH, Guo L, Chen QY, Xiang YQ,Huang PY.  The Application of ArtificialNeural Network to Prediction of 5-year Survival in NasopharygealCarcinoma.  Journal of Oncoloy (Chinese)2006; 12(4): 300-304. (in Chinese)

    8. Ming-Yuan Chen, MD, PhD;Wei-Ping Wen, MD, PhD; Xiang Guo, MD, PhD; An-Kui Yang, MD;Chao-Nan Qian, MD,PhD; Yi-JunHua, MD; Xiang-Bo Wan, MD; Zhu-Ming Guo, MD;Tian-Ying Li, MD;Ming-Huang Hong, MD. Endoscopic Nasopharyngectomy for Locally Recurrent NasopharyngealCarcinoma. The Laryngoscope. , 2009, 119(3):516-22 (in English)

    9. Hua YJ, Hong MH. Shared decision-making.Evidence based Medicine (Chinese).2005, 5(2):110-112 (in Chinese)

    10. Hua YJ, Hong MH, Luo DH, et al.Multivariable Analysis of Prognostic Predictors of 406 Patients withNasopharyngeal Carcinoma. Chinese Journal of Clinical Oncology, 2005,32(8):435-438 (in Chinese)

    11. Hua YJ, Hong MH. Advancemant of strataltherapy for the Primary Diagnosed Nasopharyngeal Carcinoma. China Cancer,2006,15(12):804-807 (in Chinese)

    12. Hua YJ, Hong MH. The application ofartificial neural networks in medicine. The Journal of Practical Medicine.2005, 21(3): 330-332 (in Chinese)

     

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