|Title||Director and Professor|
Dr. Xing Zhang is currently a professor and a chief physician of the department of Immunotherapy and Medical Oncology of Melanoma and Sarcoma in Sun Yat-sen University Cancer Center. She specializes in immunotherapy of solid tumor, molecular targeted drug therapy, medical treatment of bone and soft tissue sarcoma and melanoma. She is one of the Guangdong outstanding young medical talents and principle investigator of 5 National Natural Science Foundation projects. She has published dozens of SCI papers as the first author or correspondent author, including Oncogene, Mol Cancer, Br J Cancer, Clin Cancer Res, etc. She has also participated in the draft and development of 3 national medical treatment guidelines.
She served as group leader of chemoradiotherapy group of Sarcoma Professional Committee of China Anticancer Association, the chairman of Sarcoma Professional Committee of Guangdong anticancer association and the standing member of sarcoma Professional Committee of China Anticancer Association. She has many academic titles, including the member of target and individualized treatment special committee of Guangdong anticancer association, the vice chairman of Guangdong Cell Biology Association, the standing member of bone tumor branch of Guangdong Doctor Association, Guangdong Province Standing committee member of biotherapy special committee of anticancer association, the vice chairman of tumor support and rehabilitation treatment professional committee of Guangzhou anticancer association.
Immunotherapy of solid tumor and molecular targeted drug therapy. Medical treatment of bone and soft tissue sarcoma, melanoma.
Dr. Xing Zhang graduated from Henan Medical University in 1994, majoring in clinical medicine. In 2004, she graduated from Sun Yat-sen University with a doctor's degree in oncology. From 2001 to 2003, she studied in the Medical School of Boston University.
2. LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival.Que Y, Fang Z, Guan Y, Xiao W, Xu B, Zhao J, Chen H, Zhang X, Zeng M, Liang Y, Zhang X#. Cancer Biol Med. 2019 May;16(2):331-340.
3. Chimeric Antigen Receptor-Modified T-cell Therapy for Platelet-Derived Growth Factor Receptor α-positive Rhabdomyosarcoma.Xiao W, Wang J, Wen X, Xu B, Que Y, Yu K, Xu L, Zhao J, Pan Q, Zhou P, Zhang X#. Cancer. 2020 May 1;126 Suppl 9:2093-2100.
4. The changing landscape of phase II/III metastatic sarcoma clinical trials-analysis of ClinicalTrials.gov.Que Y, Xiao W, Xu BS, Wen XZ, Weng DS, Zhang X#. BMC Cancer. 2018 Dec 13;18(1):1251.
5. PD-L1 Expression Is Associated with FOXP3+ Regulatory T-Cell Infiltration of Soft Tissue Sarcoma and Poor Patient Prognosis.Que Y, Xiao W, Guan YX, Liang Y, Yan SM, Chen HY, Li QQ, Xu BS, Zhou ZW, Zhang X#. J Cancer. 2017 Jul 5;8(11):2018-2025.
6. Preoperative platelet - lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma. Que Y, Qiu H, Li Y, Chen Y, Xiao W, Zhou Z, Zhang X#. BMC Cancer. 2015 Oct 2;15(1):648.
7. The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer. Jiang F, Kuang BH, Que Y, Lin ZL, Yuan L, Xiao W, Peng RQ, Zhang XS, Zhang X#. Oncol Rep. 2015 Nov 2.
8. Proline-rich tyrosine kinase 2 and its phosphorylated form pY881 are novel prognostic markers for non-small-cell lung cancer progression and patients' overall survival.Kuang BH, Zhang MQ, Xu LH, Hu LJ, Wang HB, Zhao WF, Du Y, Zhang X#. Br J Cancer. 2013 Sep 3;109(5):1252-63
9. The prognostic value of platelet endothelial cell adhesion molecule-1 in non-small-cell lung cancer patients. Kuang BH, Wen XZ, Ding Y, Peng RQ, Cai PQ, Zhang MQ, Jiang F, Zhang XS, Zhang X#. Med Oncol. 2013 Jun;30(2):536.
10. Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.Zhao WF, Wang HB, Xie B, Hu LJ, Xu LH, Kuang BH, Li MZ, Zhang X#. FEBS J. 2012 Aug; 279(15):2714-26.
11. Cell aggregation induces phosphorylation of PECAM-1 and Pyk2 and promotes tumor cell anchorage-independent growth. Zhang X, Xu LH, Yu Q. Mol Cancer 2010 Jan 14;9(1):7.
Updated July 2020
|Title||Professor, Vice Director of Tumor Biotherapy Department|
1. Comprehensive treatment of melanoma
2. Immunotherapy of Liver cancer, colon cancer, lung cancer, breast cancer and other kinds of tumors
1988 – 1995 Attending Physician, The First Affiliated Hospital of Chongqing Medical University
1995 – 1998 Associate Professor, The First Affiliated Hospital of Chongqing Medical University
2000 – Present Professor & Vice Director of Tumor Biotherapy Department, Sun Yat-Sen University Cancer Center
1979 – 1983 MB, Chongqing Medical University
1983 – 1988 MM, The First Affiliated Hospital of Chongqing Medical University
1995 – 1998 PhD, Chongqing Medical University
1998 – 2000 Post-Doctor, Sun Yat-Sen University Cancer Center
August – October, 2005 Visiting Scholar, Karolinska University, Sweden
Last updated on: May, 2014
|Title||Associate Professor and Deputy Director|
Dr. Desheng Weng is associate professor of cell therapy and healthcare research Center. Dr. Weng obtained his Bachelor in Medicine (equivalent to MD in the US) at First Military Medical University and PhD at Sun Yat-sen University of Medical Sciences, P. R. China in 1998 and 2005, respectively. His postdoctoral training at Boston University Medical School provided him with great opportunities to explore the fields of tumor immune therapy and tumorigenesis. He then joined the Department of Cell therapy and Healthcare Research Center and Department of Biotherapy at Sun Yat-sen University Cancer Center (SYSUCC) as associate professor in 2012. Dr. Weng has published more than 20 research papers.
(1) Cancer genetics studyTumor suppressor gene down-regulation may play an important role in tumor progress and development. We investigated several tumor suppressors such as ING2, TESTIN, BATF2, LZAP and BIN1, et al. expression in primary hepatocellular carcinoma (HCC) or gastric cancer (GC) and evaluated the relationship between these tumor suppressors’ expression and clinicopathological parameters of HCC or GC. Furthermore, by examining in vitro proliferation, clone formation, motility, invasion and apoptosis of tumor cell lines, we also study the functional role of these tumor suppressors in the tumorigenesis of HCC or GC.
(2) Cancer Immunotherapy studyImmunotherapy is an important comprehensive treatment method for cancer patient. Dr. Weng investigated several immuno-effector cells such as cytokines induced killer cells (CIK), natural killer cells (NK), dendritic cells (DC) and DC-CIK for treatment of cancer patients. More ever, he also investigated that DC/tumor fusion vaccines or genetic modified-DC vaccines for the treatment of cancer patients.
1993-1998 M.D. Medicine, First Military Medical University, Guangzhou, P.R. China.
2001-2004 M.S. Pathology, First Military Medical University, Guangzhou, P.R. China.
2005-2008 Ph.D. Oncology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.
2008-2012 Postdoctor. Boston University Medical School, Boston, US.
1. Wu Z*, Weng D(co-first), Li G. Quantitative proteome analysis of overexpressed Cripto-1 tumor cell reveals 14-3-3gamma as a novel biomarker in nasopharyngeal carcinoma. J Proteomics, 83C: 26-36, 2013
2. Weng D, Song B, Koido S, Calderwood SK, Gong J*. Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiation. J Immunol, 191(2): 755-763, 2013
3. Weng D, Penzner JH, Song B, Koido S, Calderwood SK, Gong J*. Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers. Breast Cancer Res., 14(1):R18, 2012
4. Weng D, Calderwood SK, Gong J*. Preparation of a heat-shock protein 70-based vaccine from DC-tumor fusion cells. Methods Mol Biol.,787:255-65, 2011
5. Weng D, Song B, Durfee J, Sugiyama V, Wu Z, Koido S, Calderwood SK, Gong J*. Induction of cytotoxic T lymphocytes against ovarian cancer-initiating cells. Int J Cancer., 129(8):1990-2001, 2011
6. Weng D, Cunin MC, Song B, Price BD, Eller MS, Gilchrest BA, Calderwood SK, Gong J*. Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment. Breast Cancer Res., 12(5):R71, 2010
7. Pan K, Wang Q, Liu Q, Zheng H, Li Y, Weng D, Li J, Huang L, He J, Chen S, Ke M, Zeng Y, Xia J*. The phenotype of ex vivo generated cytokine-induced killer cells is associated with overall survival in patients with cancer. Tumour Biol, 35(1): 701-707, 2014
8. Xia, JC*，Weng D. Progress of biotherapy in gastrointestinal carcinomas. Zhonghua Wei Chang Wai Ke Za Zhi 16(1): 22-27, 2013
9. Pan K, Zheng H, Zhao J, Pan Q, Li J, Weng D, Jiang S, Chang AE, Li Q*, Xia J*. OK-432 synergizes with IFN-γ to confer dendritic cells with sustained immunity and activate the p38 and NF-κB pathways. Immunology and Cell Biology, (Epub ahead of print), 2013
10. Lu L, Pan K, Zheng H, Li J, Qiu H, Zhao J, Weng D, Pan Q, Wang D, Jiang S, Chang AE, Li Q*, Xia J*. IL-17A promotes immune effector cell recruitment in human esophageal cancer by inducing tumor cell chemokine production , J Immunotherapy, 36: 451–458, 2013
11. Pan, QZ, Pan K, Weng D, Zhao J, Zhang X, Wang D, Lv L, Jiang S, Zheng H, Xia J*. Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma. Mol Carcinog, (Epub ahead of print), 2013
Last updated on: 2013
Dr. Limin Zheng graduated from Shanghai Medical University and then worked as physician in Hua-Shan Hospital. He obtained his PhD in Immunology from Leiden University, The Netherlands in 1994 and was promoted as Assistant Professor by Swedish Medical Research Council in 1998. Since 2003, he is full Professor at Sun Yat-Sen University. He was awarded the Outstanding Young Scientist Fund from National Natural Science Fund of China in 2004 and honored as Cheung Kong Scholars by Ministry of Education in 2009. He received the State Natural Science Award in 2014 and was included on the list of Most Cited Chinese Researchers (based on the Scopus database from Elsevier) consecutively since 2014.
Tumor immune microenvironments and myeloid cells in human cancer. By paying particular attention to tissue micro-localization, we investigated how human tumor tissues dynamically educated the infiltrating immune cells and their clinical significance, with a focus on macrophages and hepatocellular carcinoma.
1979 – 1984 MD. Shanghai Medical University (SMU), China
1984 – 1990 Resident, Hua-Shan Hospital, SMU, China
1990 – 1994 PhD, Leiden University, The Netherlands
1994 – 1998 Postdoctoral Fellow, Lund and Linkoping University, Sweden
1. Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma. Wu C, Lin J, Weng Y, Zeng DN, Xu J, Luo S, Xu L, Liu M, Hua Q, Liu CQ, Li JQ, Liao J, Sun C, Zhou J, Chen MS, Liu C, Guo Z, Zhuang SM, Huang JH, Zheng L#. J Clin Invest 2020
2. Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma. Chen DP, Ning WR, Jiang ZZ, Peng ZP, Zhu LY, Zhuang SM, Kuang DM, Zheng L#, and Wu Y#. J Hepatol 2019
3. EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma. Xiao G, Jin LL, Liu CQ, Wang YC, Meng YM, Zhou ZG, Chen J, Yu XJ, Zhang YJ, Xu J, and Zheng L#. J Immunother Cancer 2019
4. Immunosuppressive immature myeloid cell generation is controlled by glutamine metabolism in human cancer. Wu WC, Sun HW, Chen J, OuYang HY, Yu XJ, Chen HT, Shuang ZY, Shi M, Wang Z, and Zheng L#. Cancer Immunol Res 2019
5. Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis. Wu C, Ning H, Liu M, Lin J, Luo S, Zhu W, Xu J, Wu WC, Liang J, Shao CK, Ren J, Wei B, Cui J, Chen MS, and Zheng L#. J Clin Invest 2018
6. Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma. Liu CQ, Xu J, Zhou ZG, Jin LL, Yu XJ, Xiao G, Lin J, Zhuang SM, Zhang YJ#, and Zheng L#. Brit J Cancer 2018
7. Vascular CXCR4 expression promotes vessel sprouting and sensitivity to sorafenib treatment in hepatocellular carcinoma. Xu J, Liang J, Meng YM, Yan J, Yu XJ, Liu CQ, Xu L, Zhuang SM, and Zheng L#. Clin Cancer Res 2017
8. Increased autophagy sustains the survival and pro-tumourigenic effects of neutrophils in human hepatocellular carcinoma. Li XF, Chen DP, Ouyang FZ, Chen MM, Wu Y, Kuang DM, and Zheng L#. J Hepatol 2015
9. Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients. Wu WC, Sun HW, Chen HT, Liang J, Yu XJ, Wu C, Wang Z, and Zheng L#. Proc Natl Acad Sci USA 2014
10. B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. Kuang DM, Xiao X, Zhao Q, Chen MM, Li XF, Liu RX, Wei Y, Ouyang FZ, Chen DP, Wu Y, Lao XM, Deng H, and Zheng L#. J Clin Invest 2014
11. Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions. Wu Y, Kuang DM, Pan WD, Wan YL, Lao XM, Wang D, Li XF, and Zheng L#. Hepatology 2013
12. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z, Yin XY, and Zheng L#. J Hepatol 2011
13. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells. Kuang DM, Peng C, Zhao Q, Wu Y, Chen MS, and Zheng L#. Hepatology 2010
14. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, and Zheng L#. J Exp Med 2009
15. Increased intratumoral IL-17-producing cells survival in hepatocellular carcinoma correlate with poor patients. Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C, Li SP, and Zheng L#. J Hepatol 2009
16. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Kuang DM, Wu Y, Chen N, Cheng J, Zhuang SM, and Zheng L#. Blood 2007
Last updated: June 2020
Dr. Jianchuan Xia is professor and director of cell therapy and healthcare research Center. Dr. Xia obtained his PhD at Harbin University of Medical Sciences, P. R. China in 1998. His postdoctoral training at Harvard University provided him with great opportunities to explore the fields of tumor immune therapy and tumorigenesis. He then rejoined the Department of Biotherapy at Sun Yat-sen University Cancer Center (SYSUCC) as a Professor in 2003. In 2013, Dr. Xia was appointed Director of Department of Cell therapy and Healthcare Research Center. Dr. Xia has published more than 80 research papers.
(1) Cancer genetics study: Tumor suppressor gene down-regulation may play an important role in tumor progress and development. We investigated several tumor suppressors such as ING2, TESTIN, BATF2, LZAP and BIN1, et al. expression in primary hepatocellular carcinoma (HCC) or gastric cancer (GC) and evaluated the relationship between these tumor suppressors’ expression and clinicopathological parameters of HCC or GC. Meanwhile, the prognostic value of these tumor suppressors for HCC or GC patients was also investigated. Furthermore, by examining in vitro proliferation, clone formation, motility, invasion and apoptosis of tumor cell lines, he also study the functional role of these tumor suppressors in the tumorigenesis of HCC or GC.
(2) Cancer Immunotherapy study: Immunotherapy is an important comprehensive treatment method for cancer patient. In Dr. Xia’s group, heinvestigated several immuno-effector cells such as cytokines induced killer cells (CIK), natural killer cells (NK), dendritic cells (DC) and DC-CIK for treatment of cancer patients. Furthermore, he investigated negative regulator such as SOCS1 and IDO for the function of DC, and studied whether silencing these negative regulators could enhance the anti-tumor immunity of DC. More ever, he also investigated that DC/tumor fusion vaccines or genetic modified-DC vaccines for the treatment of cancer patients.For information on Professor Xia's laboratory, click here and select: Gene function and regulation.
1980-1984 B.S. Biology, Nanchang University, Jiangxi, P.R. China.
1991-1994 M.S. Cancer genetics, Harbin Medical Univercity, Haerbin, P.R.China.
1994-1997 Ph.D. Cancer genetics, Harbin Medical Univercity, Haerbin, P.R.China.
1998-2000 Postdoctoral. Cancer genetics, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.
2000-2003 Postdoctoral. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
1. Lv L, Pan K, Li XD, She KL, Zhao JJ, Wang W, Chen JG, Chen YB, Yun JP, Xia JC (Corresponding). The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma. PLoS One. 2011 Mar 31;6(3):e18219
2. Liang XT, Pan K, Chen MS, Li JJ, Wang H, Zhao JJ, Sun JC, Chen YB, Ma HQ, Wang QJ, Xia JC (Corresponding). Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma. J Gastroenterol Hepatol. 2011 Mar;26(3):544-9.
3. Ma H, Liang X, Chen Y, Pan K, Sun J, Wang H, Wang Q, Li Y, Zhao J, Li J, Chen M, Xia J (Corresponding). Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma. Int J Cancer. 2011 Feb 15;128(4):771-7.
4. Ma H, Weng D, Chen Y, Huang W, Pan K, Wang H, Sun J, Wang Q, Zhou Z, Wang H, Xia J (Corresponding). Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene. Mol Cancer. 2010 Jul 13;9:190.
5. Chen JG, Xia JC (Corresponding), Liang XT, Pan K, Wang W, Lv L, Zhao JJ, Wang QJ, Li YQ, Chen SP, He J, Huang LX, Ke ML, Chen YB, Ma HQ, Zeng ZW, Zhou ZW, Chang AE, Li Q. Intratumoral Expression of IL-17 and Its Prognostic Role in Gastric Adenocarcinoma Patients. Int J Biol Sci. 2011 Jan 11;7(1):53-60.
6. Pan K, Zhao JJ, Wang H, Li JJ, Liang XT, Sun JC, Chen YB, Ma HQ, Liu Q, Xia JC (Corresponding). Comparative analysis of cytotoxic T lymphocyte response induced by dendritic cells loaded with hepatocellular carcinoma -derived RNA or cell lysate. Int J Biol Sci. 2010 Oct 13;6(7):639-48.
7. Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (Corresponding). High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients. World J Gastroenterol. 2010 Sep 28;16(36):4611-5.
8. Wang QJ, Wang H, Pan K, Li YQ, Huang LX, Chen SP, He J, Ke ML, Zhao JJ, Li JJ, Sun JC, Liang XT, Ma HQ, Chen YB, Xia JC (Corresponding). Comparative study on anti-tumor immune response of autologous cytokine-induced killer (CIK) cells, dendritic cells-CIK (DC-CIK), and semi-allogeneic DC-CIK. Chin J Cancer. 2010 Jul;29(7):641-8.
9. Sun JC, Pan K, Chen MS, Wang QJ, Wang H, Ma HQ, Li YQ, Liang XT, Li JJ, Zhao JJ, Chen YB, Pang XH, Liu WL, Cao Y, Guan XY, Lian QZ, Xia JC (Corresponding). Dendritic cells-mediated CTLs targeting hepatocellular carcinoma stem cells. Cancer Biol Ther. 2010 Aug;10(4):368-75.
10. Ma H, Zhang Y, Wang Q, Li Y, He J, Wang H, Sun J, Pan K, Chen M, Xia J (Corresponding). Therapeutic safety and effects of adjuvant autologous RetroNectin activated killer cell immunotherapy for patients with primary hepatocellular carcinoma after radiofrequency ablation. Cancer Biol Ther. 2010 Jun 6;9(11).
11. Zhang H, Ma H, Wang Q, Chen M, Weng D, Wang H, Zhou J, Li Y, Sun J, Chen Y, Liang X, Zhao J, Pan K, Wang H, Xia J (Corresponding). Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array. Oncol Rep. 2010 Feb;23(2):445-55.
12. Ma HQ, Liang XT, Zhao JJ, Wang H, Sun JC, Chen YB, Pan K, Xia JC (Corresponding). Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma. World J Gastroenterol. 2009 Oct 14;15(38):4844-8.
13. Zhou J, Weng D, Zhou F, Pan K, Song H, Wang Q, Wang H, Wang H, Li Y, Huang L, Zhang H, Huang W, Xia JC (Corresponding). Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses. Cancer Immunology Immunotherapy, 2009 Oct;58(10):1587-97.
14. Pan K, Wang H, Liu W, Zhang H, Zhou J, Li J, Weng D, Huang W, Sun J, Liang X, Xia JC (Corresponding). The pivotal role of p38 and NF-κB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432. Immunobiology, 2009, 214(5):350-358.
15. Zhang HK, Pan K, Wang H, Weng DS, Song HF, Zhou J, Huang W, Li JJ, Chen MS, Xia JC (Corresponding). Decreased Expression of Ing2 Gene and Its Clinicopathological Significance in Hepatocellular Carcinoma. Cancer Lett, 2008, 261(2): 183-192.
16. Weng DS, Zhou J, Zhou QM, Zhao M, Wang QJ, Huang LX, Li YQ, Chen SP, Wu PH, Xia JC (Corresponding). Minimally Invasive Treatment Combined with Cytokine-Induced Killer Cells Therapy Lower the Short-Term Recurrence Rates of Hepatocellular Carcinomas. J Immunother, 2008, 31(1): 63-71.
17. Wang H, Pan K, Zhang HK, Weng DS, Zhou J, Li JJ, Huang W, Song HF, Chen MS, Xia JC (Corresponding). Increased Polycomb-Group Oncogene Bmi-1 Expression Correlates with Poor Prognosis in Hepatocellular Carcinoma. J Cancer Res Clin Oncol. 2008, 134(5): 535-541.
18. Pan K, Wang H, Chen MS, Zhang HK, Weng DS, Zhou J, Huang W, Li JJ, Song HF, Xia JC (Corresponding). Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2008, 134(11):1247-1253
19. Li JJ, Xu GL, Gu MF, Luo GY, Rong Z, Wu PH, Xia JC (corresponding). Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors. World J Gastroenterol. 2007, 13(19):2747-2751.
20. Liu JY, Wu Y, Zhang XS, Yang JL, Li HL, Mao YQ, Wang Y, Cheng X, Li YQ, Xia JC, Masucci M, Zeng YX. Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine. Cancer Immunol Immunother. 2007, 56(10):1597-1604.
21. Weng DS, Li JT, Mai SJ, Pan ZZ, Feng BJ, Feng QS, Huang LX, Wang QJ, Li YQ, Yu XJ, Chen SP, He J, Xia JC (corresponding). Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity. World J Gastroenterol. 2006, 12(15):2437-2440.
22. Xia JC, Weng DS, Li JT, Qin HD, Mai SJ, Feng BJ, Fan Q, Feng QS, Huang LX, Yu XJ, Pan ZZ, Li YQ, Wang QJ, Zhan YQ, Chen SP, He J, Huang WL, Wu PH, Zeng YX. Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31. Cancer Genet Cytogenet. 2006, 166(2):166-172.
23. Liu JY, Zhang XS, Ding Y, Peng RQ, Cheng X, Zhang NH, Xia JC, Zeng YX. The changes of CD4+CD25+/CD4+ proportion in spleen of tumor-bearing BALB/c mice. J Transl Med. 2005, 28;3(1):5.
24. Zhang XS, Wang HH, Hu LF, Li A, Zhang RH, Mai HQ, Xia JC, Chen LZ, Zeng YX. V-val subtype of Epstein-Barr virus nuclear antigen 1 preferentially exists in biopsies of nasopharyngeal carcinoma. Cancer Lett. 2004, 211(1):11-18
25. Tanaka Y, Koido S, Xia JC, Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. Development of Antigen-Specific CD8+ Cytotoxic T Lymphocytes in MHC Class I-Deficient Mice through CD4 to CD8 Conversion. J Immunol, 2004, 172: 7848-7858.
26. Xia JC, Tanaka Y, Koido S, Liu C, Mukherjee P, Gendler SJ, Gong J Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells. J Immunol, 2003, 170 (4):1980-1986.
27. Chen D, Xia JC, Tanaka Y, Chen H, Koido S, Wernet O, Mukherjee P, Gendler SJ, Kufe D, Gong J. Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cell and mucin 1-positive carcinoma cells. Immunology 2003, 109:300-307.
28. Feng BJ, Huang W, Shugart YY, Lee MK, Zhang F, Xia JC, Wang HY, Huang TB, Jian SW, Huang P, Feng QS, Huang LX, Yu XJ, Li D, Chen LZ, Jia WH, Fang Y, Huang HM, Zhu JL, Liu XM, Zhao Y, Liu WQ, Deng MQ, Hu WH, Wu SX, Mo HY, Hong MF, King MC, Chen Z, Zeng YX. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet. 2002, 31(4):395-399
29. Zhang XS, Song KH, Mai HQ, Jia WH, Feng BJ, Xia JC, Zhang RH, Huang LX, Yu XJ, Feng QS, Huang P, Chen JJ, Zeng YX. The 30-bp deletion variant: a polymorphism of latent membrane protein 1 prevalent in endemic and non-endemic areas of nasopharyngeal carcinomas in China. Cancer Lett. 2002, 176(1):65-73
Last updated on: 2011
|Title||Doctor of Medicine and associate chief physician|
After she got a bachelor's degree in medicine in former Sun Yat-sen University of Medical Sciences in 2011, Dr. Peng started to work in the Biotherapy Research Center in Cancer Center. In the same year, she incepted a doctorate in oncology. In 2013, she was promoted to associate chief physican. She mainly focuses on the biotherapy of malignant cander, melanin medical treatment and is familiar with the medical treatment of all sorts of solid tumors.
1. Peng RQ, et al. A pilot study of paclitaxel combined with gemcitabine followed by interleukin-2 and granulocyte macrophage colony-stimulating factor for patients with metastatic melanoma. Cancer Biol Ther. 2012.12.
2. Peng RQ, et al. Co-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer.BMC Cancer. 2010;10:496.
3. Peng RQ, et al. Expression of calreticulin is associated with the infiltration of T-cells in stage IIIB colon cancer.World J Gastroenterol.2010；16（19）2428-2434.
4. Gao YF, Peng RQ, et al. The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer. J Transl Med. 2009;7:71
|Title||Professor and Doctoral Supervisor|
In 1992 Prof. Li graduated from Department of Medicine, Chongqin Medical University and in 2002 she graduated from former Sun Yat-sen University of Medical Sciences as a doctor with PhD. In 2004, she engaged in short-term advanced studies in the Microorganisms and Oncotherapy Center in Karolinska Institutet in Sweden. From 2008 to 2010, she participated in advanced studies in Cell and Gene Therapy Center in Baylor University in USA. Currently she serves as a professor in Sun Yat-sen University Cancer Center and she is also the doctoral supervisor in the Biotherapy Center.
EBV-LMP1 induced the differentiation and functional imbalance of cancer associated immune cells through up-regulation of Warburg effect of nasopharyngeal carcinoma
China National Nature Foundation (81372442，Jiang Li.) 1/1/2014 – 12/31/2018
China National Nature Foundation (81172164，Jiang Li.) 1/1/2012 – 12/31/2015
She studies on the mechanism of immunotherapy of malignant cancer and T lymphocytes, as well as the imunne escape of malignant cander. Antigen specific T lymphocytes immunotherapy is a new development direction of clinical treatment, featuring targeting and safety. The immunological environment formed by a large number of infiltrating lymphocytes around various malignant tumor issue bears a great importance for the immune escape and immunotherapy, in which the CD4 lymphocyte subset influenced the function of CD8+ effector T cells strongly. See mainly researches on T lymphocytes' monitor, therapeutic action and regulatory mechanism of malignant cancer.
Li J#, Chen QY#, He J, Li ZL, Tang XF, Chen SP, Xie CM, Li YQ, Huang LX, Ye SB, Ke ML, Tang LQ, Liu H, Zhang L, Guo SS, Xia JC, Zhang XS, Zheng LM, Guo X, Qian CN, Mai HQ*, Zeng YX*.Phase I Trial of Adoptively Transferred Tumor-infiltrating Lymphocyte Immunotherapy Following ConcurrentChemoradiotherapy in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma. Oncoimmunology. 2015.Mar 6; 2(4):e976507. (IF = 6.26)
.Ye SB, Li ZL, Luo DH, Huang BJ, Chen YS, Zhang XS, Cui J, ZengYX,Li J*.Tumor-derived exosomes promote tumor progression and T-cell dysfunction throughthe regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014 Jul 30;5(14):5439-52.(IF = 6.67)（Correspondence）
. OuYang LY#, Wu XJ#, Ye SB, Zhang RX, Li ZL, Liao W, Pan ZZ, Zheng LM, Zhang XS, Wang Z, Li Q, Ma G*, Li J*. Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer. JTransl Med. 2015 Feb 1;13(1):47. (IF = 3.99) （Correspondence）
. Zhang L#, Ye SB#, Li ZL, Ma G, Chen SP, He J, Liu WL, Xie D, Zeng YX, Li J*.Increased HIF-1alpha expression in tumor cells and lymphocytes of tumormicroenvironments predicts unfavorable survival in esophageal squamous cellcarcinoma patients. Int J ClinExpPathol. 2014 Jun 15;7(7):3887-97.(IF = 1.78) （Correspondence）
. Zhang L#, Ye SB#, Ma G, Tang XF, Chen SP, He J, Liu WL, Xie D, Zeng YX, Li J*.The expressions of MIF and CXCR4 protein in tumor microenvironment are adverseprognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med. 2013 Mar 8;11:60.(IF = 3.99) （Correspondence）
.Li J#*, Mo HY#, Xiong G, Zhang L, He J, Huang ZF, Liu ZW, Chen QY, Du ZM, Zheng LM, Qian CN*, Zeng YX. Tumor microenvironment MIF directs the accumulation of IL-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. J Biol Chem. 2012 Oct 12;287(42):35484-95. (Correspondence）(IF=4.67)
. He J, Tang XF, Chen QY, Mai HQ, Huang ZF, Li J*, Zeng YX. Ex vivo expansion of tumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients for adoptive immunotherapy. Chin J Cancer. 2012 Jun;31(6):287-94.（Correspondence）
.Li J*, Huang ZF, Xiong G, Mo HY, Qiu F, Mai HQ, Chen QY, He J, Chen SP, Zheng LM, Qian CN, Zeng YX. Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma.JTransl Med. 2011 Nov 4;9(1):189. （Correspondence）(SCI, IF=3.4740(2011))
. Peng RJ, Huang ZF, Zhang YL, Yuan ZY, Xia Y, Jiang WQ, Zeng YX*, Li J*. Circulating and Tumor-Infiltrating Foxp3 Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma. Int J Biol Sci. 2011;7(7):1027-36. （Correspondence）(SCI, IF=4.3)
.Li J#, Chen QY#, Mo H, Zhang YL, Huang ZF, Zeng YX*. Immunophenotyping at the time of diagnosis distinguishes two groups of nasopharyngeal carcinoma patients: implications for adoptive immunotherapy. Int J Biol Sci. 2011;7(5):607-17. (IF=4.3)
. Zhang YL#, Li J#（Co-first author）, Mo HY, Qiu F, Zheng LM, Qian CN, Zeng YX*. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer. 2010 Jan 10; 9: 4. (IF=5.3)
|Title||Master of Medicine, and attending physician|
Obtained a master degree in the Department of Clinical Medicine in Sun Yat-sen University in June, 2003, she serves as a resident physician in the biotherapy endemic area in the Cancer Center of Sun Yat-sen University. Since the end of 2005, she has served as the attending physician of this endemic area. She has studied Oncology for a doctor's degree since September, 2008. She is a master of melanoma treatment and is familiar with the medical treatment of all sorts of cancers, especially the biotherapy of cancer.
09/2005-06/2010 Sun Yat-sen University Cancer Center, Supervised by Professor Zhu Xiaofeng.
09/2000-06/2005 Graduated from the North Compus of Sun Yat-sen University and was conferred upon a Bachelor's degree.
09/2010-07/2012 Sun Yat-sen University Cancer Center, post-doctor with Professor Zhang Xiaoshi as a cooperation supervisor