Research
    Zhou Zhi-wei
    Title Professor and Director
    Profile

    Dr. Zhi-wei Zhou is professor and director in the Department of Gastric and Pancreatic Surgery in Sun Yat-sen University Cancer Center(SYSUCC). Dr. Zhou obtained his Bachelor in Medicine (equivalent to MD in the US) and PhD at Sun Yat-sen University of Medical Sciences, P. R. China in 1984 and 2007, respectively. He started his residency training in Chinese-Japanese Friendship Hospital in Beijing in 1984 and continued residency in Department of Abdominal Surgery in Sun Yat-sen University Cancer Center from 1986 to 1991. He was promoted to be attending surgeon, associate professor, professor in 1991, 1998 and 2004, respectively. He has been working on and gained lots of experience in the diagnosis and treatment of abdominal malignancies (including gastric cancer, colorectal cancer, pancreatic cancer, retroperitoneal tumors and gastrointestinal tumors), soft tissue malignancies and melanoma for over 30 years, especially the surgical treatment and adjuvant chemotherapy for gastric cancer. 

    Dr. Zhou was appointed as the director of Department of Gastric and Pancreatic Surgery in SYSUCC in 2009 and elected to be the president of Gastric Cancer Speciality Committee of Guangdong Provincial Anti-cancer Association in 2012. 

    His current focus in clinical work is to improve the early diagnosis and multidisciplinary treatments for gastric cancer and to conduct laparoscopic surgeries on gastric cancer patients. His current focus in research work is to study neoadjuvant chemotherapy, chemoradiation and molecular typing for gastric cancer. Dr. Zhou has published 3 editorial books and more than 30 research papers.

    Email zhouzhw@sysucc.org.cn
    Phone +86(20)8734326
    Research Interest(s)

    (1) Neoadjuvant chemotherapy for advanced gastric cancer: conduct both basic and clinical research (including prospective randomized controlled clinical trials) on neoadjuvant chemotherapy for advanced gastric cancer, in order to learn indications and effective regimens of neoajuvant chemotherapy for advanced gastric cancer. 

     (2) Chemoradiation for locally advanced gastric cancer: Conduct both basic and clinical research on chemoradiation for locally advanced gastric cancer in order to gain some experience in this field for currently in China no consensus are reached on the efficacy of chemoradiation in gastric cancer. 

     (3) Translational research on molecular typing of gastric cancer: Explore molecular types of gastric cancer by gene chips, tissue microarray technology and so on in order to better predict prognosis of gastric cancer patients and evaluate their sensitivity to chemotherapy and/or radiotherapy. 


    Ongoing Translational Project 

    Title: Novel Factors Involved in or Regulating Initiation of DNA Replication in early diagnosis of Gastric cancer Time schedule: 01/01/2012-12/31/2015  Role: PI  Funding Source: National Natural Foundation; NO:81172080 

     Title: Novel Factors Involved in or Regulating Initiation of DNA Replication in early diagnosis of Gastric cancer Time schedule: 01/01/2012-12/31/2015 Role: PI Funding Source: Ph.D. Programs Foundation of Ministry of Education of China; 

    Title: Molecular classification and personalized medicine for gastric cancer Time schedule: 01/01/2012-12/31/2014 Role: PI Funding Source: National High-tech R&D Program of China (863 Program); NO:2012AA02A504 

     Title: Suppression of PREX2 reverses Tyrosine-Kinase Inhibitors Resistance in Gastrointestinal Stromal Tumor Time schedule: 01/01/2014-12/31/2017 Role: PI Funding Source: National Natural Foundation; 

     Title: Novel Factors Involved in or Regulating Initiation of DNA Replication in early diagnosis of Gastric cancer Time schedule: 01/01/2012-12/31/2015 Role: PI Funding Source: Ministry of Science and Technology of Guangdong;

    Title: Novel Factors Involved in or Regulating Initiation of DNA Replication in early diagnosis of Gastric cancer Time schedule: 01/01/2012-12/31/2015 Role: PI Funding Source: State key Laboratory of Oncology in South China 

     Title: Induces gastric cancer cells apoptosis in vivo by transfection AP-2 α gene on a novel pH-sensitive nanocarrier Time schedule: 01/01/2012-12/31/2015 Role: co-PI Funding Source: National Natural Foundation; NO:81201773 

    Completed Project Title: The function and mechanisms study of TESTIN in gastric cancer Time schedule: 01/01/2009-12/31/2012 Role: co- PI Funding Source: National Natural Foundation 

     Title: The relationship of cancer stem cell and sensitivity of pre-operative radiotherapy in gastric cancer. Time schedule: 01/01/2009-12/31/2012 Role: PI Funding Source: Ministry of Science and Technology of Guangdong; 

     Title: Peri-operative lymph-chemotherapy in advanced gastric cancer. Time schedule: 01/01/2009-12/31/2012 Role: PI Funding Source: Ministry of Science and Technology of Guangdong; Ongoing Clinical Trial (Role: PI) 

     Title: Comparison of S-1 Plus Oxaliplatin with S-1 as Adjuvant Chemotherapy After D2 Resection in Patients With Gastric Cancer: A Prospective, Multicentral, Open-label, Randomized, Controlled Clinical Trial Time schedule: 01/01/2012-12/31/2014  Report expected: 2017 

     Title: Pre-operative chemoradiotherapy or chemotherapy following surgery and adjuvant chemotherapy in Patients With Gastric Cancer (5010 study in Sun Yat-sen University) Time schedule: 01/01/2012-12/31/2015 Report expected: 2018 

    Title: Digestive tract re-construction after total gastrectomy in gastric cancer: A Prospective, Multicentral, Open-label, Randomized, Controlled Clinical Trial Time schedule: 01/01/2012-12/31/2014 Report expected: 2017 Title: Trasuzumab combined with XELOX as Neoajuvant in Gastric Cancer. Time schedule: 01/01/2013-12/31/2014 Report expected: 2017 

    Title: Detection of HER2-neu expression in gastric cancer from biopsy specimen of endoscopy: A Prospective, Multicentral, Open-label, Clinical Trial. (co-PI) Time schedule: 03/01/2013-04/30/2013 Report expected: 2014 

     Title: A Randomized, multicenter, controlled study to compare perioperative chemotherapy of Oxaliplatin combined with S-1(SOX) versus SOX or oxaliplatin with capecitabine(XELOX) as post-operative chemotherapy in locally advanced gastric adenocarcinoma with D2 dissection (RESOLVE study). (co-PI) Time schedule: 01/01/2012-12/31/2013 Report expected: 2016

    Education

    Doctorate of Philosophy (Ph.D.) in Surgical Oncology from Sun Yat-sen University, 2007.

    Post Graduate Training in General Surgery, Royal Adelaide Hospital, Australia, 2003.

    Master of Medicine from Sun Yat-sen University of Medical Sciences, 1999.Bachelor of Medicine from Sun Yat-sen University of Medical Sciences, 1984.

    Publications

    1. HuangCY, Chen YM, Zhao JJ, Chen YB, Jiang SS, Yan SM, Zhao BW, Pan K, Wang DD, Lv L,Li YF, Wang W, Zhou ZW, Xia JC. Decreased expression of transcriptionelongation factor a-like 7 is associated with gastric adenocarcinoma prognosis.PLoS One. 2013;8(1):e54671. (corresponding author)   IF=4.092                                           

    2. LiYF, Wang DD, Zhao BW, Wang W, Yuan SQ, Huang CY, Chen YM, Zheng Y, Keshari RP,Xia JC, Zhou ZW. Poor prognosis of gastric adenocarcinoma with decreasedexpression of AHRR. PLoS One. 2012;7(8):e43555. (corresponding author)   IF=4.092                                                                                              

    3. Wang W, Xu DZ, Li YF, Guan YX, Sun XW, Chen YB, Kesari R, Huang CY, LiW, Zhan YQ, Zhou ZW. Tumor-Ratio-Metastasis Staging System as an Alternative tothe 7th Edition UICC TNM System in Gastric Cancer after D2 Resection - Resultsof a Single Institution Study of 1343 Chinese Patients. Ann Oncol. 2011, Sep;22(9):2049-56.  (corresponding author)   IF= IF=6.425                                                                                      

    4. WangW, Lv L, Pan K, Zhang Y, Zhao JJ, Chen JG, Chen YB, Li YQ, Wang QJ, He J, ChenSP, Zhou ZW, Xia JC. Reduced Expression of Transcription Factor AP-2α IsAssociated with Gastric Adenocarcinoma Prognosis. PLoS One. 2011; 6(9):e24897.Epub 2011 Sep 26. (corresponding author)   (IF=4.092)                                        

    5. Wang W, Li Y, Zhang Y, Yuan X, Xu D, GuanY, Feng X, Chen Y, Sun X, Li W, Zhan Y, Zhou Z. Incorporation of ExtranodalMetastasis of Gastric Carcinoma into the 7th edition UICC TNM Staging System.Plos One. 2011; 6(6):e19557. Epub 2011 Jun 13. (corresponding author)    IF=4.092                                                             

    6. Wang W, Sun XW, Li CF, Lv L, LiYF, Chen YB, Xu DZ, Kesari R, Huang CY, Li W, Zhan YQ, Zhou ZW. Comparison ofthe 6th and 7th Editions of the UICC TNM Staging System for Gastric Cancer:Results of a Chinese Single-Institution Study of 1,503 Patients. Ann Surg Oncol.2010 Nov 24. [Epub ahead of print] (corresponding author)   IF=4.166             

    7. Qiu HB, Chen G, Keshari RP, Luo HY, Fang W, Qiu MZ, Zhou ZW, XuRH. The extramural metastasis might be categorized in lymph node staging forcolorectal cancer. BMC Cancer. 2011 Sep 26;11(1):414. (correspondingauthor)   IF=3.011  

    8. LiYF, Wang DD, Zhao BW, Wang W, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC,Zhou ZW. High level of COP1 expression is associated with poor prognosis inprimary gastric cancer. Int J Biol Sci. 2012;8(8):1168-77. (correspondingauthor)   IF=2.699                                                                                  

    3. Qiu HB, Zhang LY, KeshariRP, Wang GQ, Zhou ZW, Xu DZ, Wang W, Zhan YQ, Li W. Relationship betweenH.Pylori infection and clinicopathological features and prognosis of gastriccancer. BMC Cancer. 2010 Jul 17; 10: 374. (corresponding author)   IF=3.011                                                                     

    10. Wang W, Wang GQ, Sun XW, Chen G, Li YF, Zhang LY, Qiu HB, Huang CY,Zhan YQ, Zhou ZW. Prognostic values of chromosome 18q microsatellitealterations in stage II colonic carcinoma. World J Gastroenterol. 2010 Dec 21;16(47): 6026-34. (corresponding author)  IF=2.240                                                           

    11. WangW, Li YF, Sun XW, Chen YB, Li W, Xu DZ, Guan XX, Huang CY, Zhan YQ, Zhou ZW.Prognosis of 980 patients with gastric cancer after surgical resection. Chin JCancer. 2010 Nov; 29(11): 923-30. (corresponding author)               

    12. Wang W, Li YF, Sun XW, Chen G,Zhan YQ, Huang CY, Wan DS, Pan ZZ, Zhou ZW. Correlation analysis between lossof heterozygosity at chromosome 18q and prognosis in the stage-II colon cancerpatients. Chin J Cancer. 2010 Aug; 29 (8):761-7. (corresponding author)                                                                     

    13. Qiu HB, Wu XJ, Zhou ZW, Chen G, Wang GQ. The prognostic significanceof peripheral T-lymphocyte subsets and natural killer cells in patients withcolorectal cancer. Hepato-Gastroenterology 2009; 56:1310-1315. (correspondingauthor)   IF=0.9                                                                                   

    14. Yuan SQ, Zhou ZW, Wan DS. The role of half-life of carcinoembryonicantigen (CEA) in prognosis prediction of colorectal cancer patients withpreoperatively elevated CEA. Chin J Cancer, 2008, 27(6):612-617. (correspondingauthor)                    

    15. Zhou ZW,Wang GQ, Wan DS, Lu ZH, Chen YB, Li S, Chen G, Pan ZZ. The Dihydrouracil/UracilRatios in Plasma and Toxicities of 5-Fluorouracil Based Adjuvant Chemotherapyin Colorectal Cancer Patients. Chemotherapy, 2007, 53(2): 127-131.   IF=2.2                                                                                  

    16. Zhou ZW, Nick R, Andrew R, Wang GQ, Wan DS. Detection of lymph nodesmicrometastases in Dukes A and B colorectal cancer using anti-cytokeratinantibodies AE1/AE3. World Journal of Gastroenterology, 2005, 11(23):3640-3643.   IF=2.240                                                                              

    17. Zhou ZW,Wan DW, Chen G, Cheng YB, Pan ZZ. Primary malignant tumor of the smallintestine. World Journal of Gastroenterology 1999, 5(3):273-276.   IF=2.240                                                            

    18. Qiu MZ, Wang ZQ, Zhang DS, Liu Q, Luo HY, Zhou ZW, Li YH, Jiang WQ,Xu RH. Comparison of 6th and 7th AJCC TNM Staging Classification for Carcinomaof the Stomach in China. Ann Surg Oncol. 2011 Jan 19. [Epub ahead ofprint]   IF=4.166                                                                                          

    19. Qiu HB, Zhang LY, Li YF, Zhou ZW, Keshari RP, Xu RH. Ratio of Metastatic ToResected Lymph Nodes Enhances To Predict Survival In Patients With Stage IIIColorectal Cancer.Ann Surg Oncol. 2011 Jan 5. [Epub ahead of print]   IF=4.166  

    20. Chen JG, Xia JC, Liang XT, Pan K, Wang W, Lv L, Zhao JJ, Wang QJ, LiYQ, Chen SP, He J, Huang LX, Ke ML, Chen YB, Ma HQ, Zeng ZW, Zhou ZW, Chang AE,Li Q. Intratumoral expression of IL-17 and its prognostic role in gastricadenocarcinoma patients.Int J Biol Sci. 2011 Jan 11;7(1):53-60.   IF=2.865                                                  

    21. Chen S, Zhao BW, Li YF, Feng XY, Sun XW, Li W, Zhou ZW, Zhan YQ,Qian CN, Chen YB. The prognostic value of harvested lymph nodes and themetastatic lymph node ratio for gastric cancer patients: results of a study of1,101 patients. PLoS One. 2012;7(11):e49424. IF= 4.092                                                         

    22. Geng QR, Xu DZ, He LJ, Lu JB, Zhou ZW, Zhan YQ, Lu Y. Beclin-1expression is a significant predictor of survival in patients with lymphnode-positive gastric cancer. PLoS One. 2012;7(9):e45968. IF= 4.092                         

    23. Chen S, Feng XY,Li YF, Zhao BW, Zhou ZW, Chen YB. The prognosis of gastric cancer patients withmarginally elevated carcinoembryonic antigen (CEA) values after D2 radicalgastrectomy. J Surg Oncol. 2013 Jan 7. doi: 10.1002. IF= 2.1   

    24. Chen S, Chen YB, Li YF, Feng XY, ZhouZW, Yuan XH, Qian CN. Normal carcinoembryonic antigen indicates benefit fromperioperative chemotherapy to gastric carcinoma patients. World JGastroenterol. 2012 Aug 7;18(29):3910-6. IF= 2.240 

    25. Chen S, Li YF, Feng XY, Zhou ZW, Yuan XH,Chen YB. Significance of palliative gastrectomy for late-stage gastric cancerpatients. J Surg Oncol. 2012 Dec;106(7):862-71. IF= 2.1                                                     

    26. Ren C, Qiu MZ, Wang DS, Luo HY, Zhang DS, Wang ZQ, Wang FH, Li YH,Zhou ZW, Xu RH. Prognostic effects of 25-hydroxyvitamin D levels in gastriccancer. J Transl Med. 2012 Jan 27;10:16. IF= 3.474                             

    27. Chen YB, HouJH, Feng XY, Chen S, Zhou ZW, Zhang XS, Cai MY. Decreased expression of Beclin1 correlates with a metastatic phenotypic feature and adverse prognosis ofgastric carcinomas. J Surg Oncol. 2012 May;105(6):542-7. IF= 2.1 28. Qiu MZ,Wang ZQ, Luo HY, Zhang DS, Zhou ZW, Li YH, Jiang WQ, Xu RH. Prognostic analysisin node-negative gastric cancer patients in China. Tumour Biol. 2011 Jun;32(3):489-92.    IF=1.94                                        

    29.QiuMZ, Wang ZQ, Zhang DS, Luo HY, Zhou ZW, Wang FH, Li YH, Jiang WQ, Xu RH.Clinicopathological characteristics and prognostic analysis of gastric cancerin the young adult in China. Tumour Biol. 2011 Jun;32(3):509-14.   IF=1.94 

    30. Qiu MZ, Zhang DS, Ruan DY, Luo HY, Wang ZQ, Zhou ZW, Wang FH, Li YH,Xu RH. A relationship between ABO blood groups and clinicopathologiccharacteristics of patients with gastric adenocarcinoma in China. Med Oncol.2011 Dec;28 Suppl 1:S268-73.   IF=1.227                                                                                  

    31. Qiu MZ, Li ZH, Zhou ZW, Li YH, Wang ZQ, Wang FH, Huang P, Aziz F,Wang DY, Xu RH. Detection of carcinoembryonic antigen messenger RNA in bloodusing quantitative real-time reverse transcriptase-polymerase chain reaction topredict recurrence of gastric adenocarcinoma. J Transl Med. 2010 Oct 31; 8:107.   IF=3.407                              

    32. Xu DZ, GengQR, Tian Y, Cai MY, Fang XJ, Zhan YQ, Zhou ZW, Li W, Chen YB, Sun XW, Guan YX,Li YF, Lin TY. Activated mammalian target of rapamycin is a potentialtherapeutic target in gastric cancer. BMC Cancer. 2010 Oct 7; 10: 536.   IF=2.736                                                                                             

    33. Qiu MZ, Han B, Luo HY, Zhou ZW, Wang ZQ, Wang FH, Li YH, Xu RH. Expressions ofhypoxia-inducible factor-1α and hexokinase-II in gastric adenocarcinoma: theimpact on prognosis and correlation to clinicopathologic features. Tumour Biol.2011 Feb;32(1):159-66. Epub 2010 Sep 16.  IF=1.94                                                 

    34. Chen S, Chen YB, Zhou ZW, Li W, Sun XW, Xu DZ, Li YF, Guan YX, FengXY, Zhan YQ. No Survival Benefit From Postoperative Adjuvant Chemotherapy AfterD2 Radical Resection for the Patients With Stage II Gastric Cancer. Am J ClinOncol. 2010 Sep 10. [Epub ahead of print]  IF=2.2                                                                

    35. Zheng B, Chen YB, Hu Y, Wang JY, Zhou ZW, Fu JH. Comparison oftransthoracic and transabdominal surgical approaches for the treatment ofadenocarcinoma of the cardia. Chin J Cancer. 2010 Aug; 29(8): 747-51.             

    36. Peng RQ, Chen YB, Ding Y,Zhang R, Zhang X, Yu XJ, Zhou ZW, Zeng YX, Zhang XS. Expression of calreticulinis associated with infiltration of T-cells in stage IIIB colon cancer. World JGastroenterol. 2010 May 21; 16(19): 2428-34.  IF=2.240                                                                                                

    37. LuoHY, Xu RH, Wang F, Qiu MZ, Li YH, Li FH, Zhou ZW, Chen XQ. Phase II trial ofXELOX as first-line treatment for patients with advanced gastric cancer.Chemotherapy. 2010; 56(2):94-100. Epub 2010 Mar 30.   IF=2.2

    38. XuDZ, Geng QR, Long ZJ, Zhan YQ, Li W, Zhou ZW, Chen YB, Sun XW, Chen G, Liu QT,Positive Lymph Node Ratio Is an Independent Prognostic Factor in Gastric CancerAfter D2 Resection Regardless of the Examined Number of Lymph Nodes. Ann SurgOncol  2009, 16:319–326   IF=4.166


    Last updated on: 2013

    Chen Yingbo
    Title Chief physician, advisor of master’s degree student
    Profile

    Prof. Chen has been engaged in medical treatment, scientific research and teaching in the Department of Abdominal Surgery at Sun Yat-sen University Cancer Center since 1992. Through the 20 years of medical practices, he has mastered the fundamental theories of oncology and basic surgical techniques and accumulated rich clinical experience in diagnosis and treatment of gastrointestinal tumor. Especially he has been well experienced in lymph node dissection for various radical surgeries of gastric cancer, the digestive tract reconstruction after radical full-stomach & proximal gastrectomy for gastric carcinoma as well as laparoscopic D2 radical gastrectomy for gastric carcinoma.

    Work experience
    1992-1997: Resident physician, Department of Abdominal Surgery at Sun Yat-sen University Cancer Center;

    1997-2004: Attending physician, Department of Abdominal Surgery at Sun Yat-sen University Cancer Center;

    2004-2011: Associate chief physician, Department of Abdominal Surgery at Sun Yat-sen University Cancer Center;

    2011-present: Chief physician, Department of Gastric and Pancreatic Surgery at Sun Yat-sen University Cancer Center.

    Email
    Phone
    Research Interest(s)
     
    Education

    1986-1992: Undergraduate, Department of Medicine at Sun Yat-sen University of Medical Sciences;

    1996-1999: Master’s degree student of Oncology at Sun Yat-sen University of Medical Sciences;

    2010: Advanced studies in Melanoma Institute Australia, Sydney.

    Publications

    1. Comparison of transthoracic and transabdominal surgical approaches for the treatment of adenocarcinoma of the cardia,Chinese journal of cancer,2010,29(8)

    2.No Survival Benefit From Postoperative Adjuvant Chemotherapy After D2 Radical Resection for the Patients With Stage II Gastric Cancer, American Journal of  Clinical Oncology,2011,

    3.Mast cells in the adjacent normal colon mucosa rather than those in the invasive margin are related to the progression of colon cancer ,Chinese Journal of Cancer Research,2011,23(4)

    4.Decreased expression of Beclin 1 correlates with a metastatic phenotypic feature and adverse prognosis of gastric carcinoma, Journal of Surgical Oncology, 2011

    5. Serosa-penetration in human T4aN0M0 gastric carcinoma correlates with worse prognosis after D2 gastrectomy,Chinese Medical Journal,2012

    6. Eficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical  total gastrectomy, Oncology Letters,2012

    Sun Xiao-Wei
    Title Associate Chief Physician
    Profile
    Dr. Xiao-Wei Sun is associate senior doctor of gastric & pancreatic carcinoma. Dr. Sun obtained his Bachelor in Medicine and Master Degree in Oncology at Sun Yat-sen University of Medical Sciences, P. R. China in 1991 and 2002, respectively. As a clinical surgeon, He is responsible for abdominal cancer, such as stomach cancer, pancreatic cancer, colorectal cancer and soft tissue carcinoma. His main work is operation, outpatient service, research and teaching. Dr. Sun has published more than 20 research papers and participated in 3 monographs. He also get research funds 5, and cultivated 2 graduate students.
    Email
    Phone
    Research Interest(s)

    Comprehensive treatment of advanced gastric cancer and clinical and basic study on the gastrointestinal stromal tumors

    Education

    1999.9-2002.7 Sun Yat-Sen University and Cancer Center

    Degree: Masters

    Clinical Oncology Tutor: Zhan You Qing

    Major in investigating synthesis therapy for abdominal carcinoma.

    Learn basic theory, knowledge and laboratorial skill of Medicine, receive training related to scientific research etc.

    Curricular: Clinical Oncology, Pathology, Anatomy, Statistics, English, Literature Searches, Computer and so on.

     

    Publications

    1. Comparison of the 6th and 7th Editions of the UICC TNM Staging System for Gastric Cancer: Results of a Chinese Single-Institution Study of 1,503 Patients. Ann Surg Oncol, 2011,18:1060-1067.

    2. Prognosis of 980 patients with gastric cancer after surgical resection. Chin J Cancer. 2010 Nov; 29(11):923-303. Prognostic values of chromosome 18q microsatellite alterations in stage II colonic carcinoma. World J Gastroenterol. 2010 December 21; 16(47): 6026–6034.


    Last updated on: 2011

     

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